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ASCITES and COZAAR

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ASCITES Symptoms and Causes

Cirrhosis is scarring of the liver. Scar tissue forms because of injury or long-term disease. Scar tissue cannot do what healthy liver tissue does - make protein, help fight infections, clean the blood, help digest food and store energy. Cirrhosis can lead to

  • Easy bruising or bleeding, or nosebleeds
  • Swelling of the abdomen or legs
  • Extra sensitivity to medicines
  • High blood pressure in the vein entering the liver
  • Enlarged veins called varices in the esophagus and stomach. Varices can bleed suddenly.
  • Kidney failure
  • Jaundice
  • Severe itching
  • Gallstones

A small number of people with cirrhosis get liver cancer.

Your doctor will diagnose cirrhosis with blood tests, imaging tests, or a biopsy.

Cirrhosis has many causes. In the United States, the most common causes are chronic alcoholism and hepatitis. Nothing will make the scar tissue disappear, but treating the cause can keep it from getting worse. If too much scar tissue forms, you may need to consider a liver transplant.

NIH: National Institute of Diabetes and Digestive and Kidney Diseases

Check out the latest treatments for ASCITES

ASCITES treatment research studies

COZAAR clinical trials, surveys and public health registries


Find Drug Side Effect reports



COZAAR Side Effects

Renal Failure Acute (100)
Dizziness (94)
Blood Pressure Increased (93)
Dyspnoea (80)
Rhabdomyolysis (72)
Renal Failure (67)
Hypotension (67)
Hyperkalaemia (63)
Malaise (56)
Asthenia (56)
Fall (55)
Fatigue (54)
Headache (53)
Nausea (52)
Hypertension (52)
Myocardial Infarction (51)
Cough (51)
Diarrhoea (51)
Cardiac Failure (48)
Blood Creatine Phosphokinase Increased (47)
Cerebrovascular Accident (47)
Atrial Fibrillation (46)
Cardiac Arrest (45)
Chest Pain (45)
Pneumonia (44)
Blood Creatinine Increased (44)
Hypoglycaemia (42)
Palpitations (41)
Pain (41)
Loss Of Consciousness (40)
Dehydration (40)
Hyponatraemia (39)
Anaemia (39)
Death (38)
Pain In Extremity (38)
Rash (38)
Overdose (36)
Cardiac Failure Congestive (36)
Arthralgia (36)
Alanine Aminotransferase Increased (33)
Myalgia (32)
Pruritus (32)
Oedema Peripheral (32)
Feeling Abnormal (32)
Back Pain (32)
Anxiety (31)
Blood Pressure Decreased (31)
Heart Rate Increased (31)
Adverse Event (30)
Abdominal Pain Upper (29)

➢ More


Common Meds

Abilify (10132)
Adderall (1304)
Amlodipine (6664)
Amoxicillin (4387)
Benadryl (1568)
Celebrex (12876 )
Celexa (1342)
Cialis (2975)
Cipro (8580)
Citalopram (7792)
Crestor (18839)
Cymbalta (14373)
Doxycycline (1757)
Effexor (7289)
Flexeril (435)
Flomax (2177)
Fluoxetine (4261)
Gabapentin (4593)
Hydrocodone (2469)
Ibuprofen (8222)
Lantus (10968)
Lexapro (3499)
Lipitor (17769)
Lisinopril (8919)
Lyrica (27148)
Medrol (650)
Mirena (41254)
Mobic (957)
Morphine (5356)
Naproxen (538)
Neurontin (6501)
Oxycodone (4438)
Pradaxa (13372)
Prednisone (5926)
Prilosec (2631)
Prozac (1954)
Seroquel (27216)
Simvastatin (8348)
Synthroid (4452)
Tamiflu (5585)
Topamax (3748)
Tramadol (5054)
Trazodone (1458)
Viagra (5394)
Vicodin (1153)
Wellbutrin (6324)
Xanax (2847)
Zocor (5718)
Zoloft(6792)
Zyrtec(1669)

Recent Reviews

Am a 76 year-old hypertensive with CKD; was given 'Cozaar' and 6 months into therapy developed excessive swelling of ankles/feet. Asked for GFR., and the result was 38, when I had been at a level of 54 for the previous 5 years. Ceased 'Cozaar' 4 mont

Back pain, horrible itching, confusion, insomnia, headache, did I mention back pain? It did bring down my blood pressure, No way I would even THINK of taking again. All this happened in 2 weeks! One of the WORST experiences of my life.

Do I need to register or hold membership to ask questions and get answers?

Got fluid ,back pain &headachs relly bad .dont want any more of this

Hello, Sorry to hear about you problems with this drug! YOU HAVE TO CHANGE YOUR MEDICIN ASAP!!! Ther is a lot of blood pressure medicin; hard to improv (I have done several times, use right now Coozar 50mg since 3 year, have to change asap becaus

I don't want to say my side-effects are from Cozaar alone, but I do feel a little different. I also take Metoprolol for my high blood. Anyway, I can't walk normally anymore. I'm a Carpenter by trade and that makes it 10 's harder. I walk with a limp.

I have been in a very debilitating state as far as sever muscle pain and injuries to the point i could barely walk i discontiued cozaar and am slowy getting back i believe with all my being it was due to cozaar and had to try to convince my dr. over

I have taken Cozaar for 8 years, never had a problem. My dose was 100 mg at night and 50 mg in morning. Suddenly out of the blue my blood pressure spiked to 185/135 and my heart went into a continuous fibrilation that lasted 2 hou

Ishave been on the same two med' and i too have had trouble with my legs. It is as you say, they are tired and I also get a burning feeling. I am taking 100 mg of cozaar and I am going to have the doc take me off.

I am searching for how oxycodone affects ascites.

Dear sir I want to inform that in using gliclazid in a patient with mild degree of hepatosplenomegally diagnosed as mild liver cirrhosis the patient state is detorated and develop mild ascites and moderate to severe lower limbe oedema

I have long term liver disease and ascites due to alcohol excess when I was younger. My doc has prescribed Aldactone 25 (three a day because I also have high blood pressure) but my oedema seems to be getting worse instead of better. I have noticed

My father developed Ascites but physicians do not think it is related to Revlimid. I am not sure but the timing of it coincides with the initial dosing of the medication.

ASCITES Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Unknown  Human Albumin for the Treatment of Ascites in Patients With Hepatic Cirrhosis
Conditions: Liver Cirrhosis;   Ascites
Interventions: Drug: Diuretics plus human albumin;   Drug: Diuretics (standard medical treatment)
Outcome Measures: Mortality;   Incidence of cirrhosis-related clinical complications;   Number of total paracentesis;   Number of patients potentially needing TIPS (3 paracentesis/month);   Quality of life;   Analysis of the cost/effectiveness ratio;   Incidence of refractory Ascites according to the IAC criteria
2 Recruiting ALFApump System Versus Standard of Care in Ascites Treatment
Condition: Refractory or Recurrent Ascites
Interventions: Device: ALFApump removal of Ascites;   Procedure: Large volume paracentesis
Outcome Measures: Paracentesis free survival;   Non-inferiority of cirrhosis related complication in the patient group treated with the ALFApump system;   Quality of Life;   Body weight;   Nutritional profile;   Resource utilisation;   Survival;   Assess the need for repeat evacuation paracentesis
3 Unknown  Infrared Ray Heat Treatment in Liver Cirrhosis Patients With Refractory Ascites
Conditions: Liver Cirrhosis;   Refractory Ascites
Interventions: Radiation: Infrared ray heat treatment;   Other: conventional treatment
Outcome Measure: Ascites pressure
4 Unknown  Albumin 4 gr/L vs 8 gr/L in the Prevention of Post-Paracentesis Circulatory Dysfunction
Condition: Tense Ascites in Cirrhosis
Interventions: Drug: albumin 4 gr/L Ascites removed;   Drug: albumin 8 gr/L Ascites removed
Outcome Measures: renin-angiotensin-aldosterone activation;   renal function
5 Recruiting Tolvaptan for Ascites in Cirrhotic Patients
Conditions: Ascites;   Cirrhosis
Intervention: Drug: Tolvaptan
Outcome Measures: Number of patients with worsening Ascites;   Number of patients with reduction of Ascites;   Number of Patients with Potentially Clinically Significant Abnormal Labs
6 Not yet recruiting Tolvaptan for Hyponatremia in Cirrhotic Patients With Ascites
Conditions: Hyponatremia;   Ascites
Interventions: Drug: Tolvaptan;   Drug: placebo
Outcome Measures: the change in the average daily area under the curve (AUC) for the serum sodium concentration from baseline to day 28 after intervention;   the change in the average daily area under the curve (AUC) for the serum sodium concentration from baseline to day 4;   the time to normalization of the serum sodium concentration;   the time to first paracentesis, number of paracentesis, the volume of ascitic fluid obtained from paracentesis;   Abdominal discomfort based on a 100-mm visual analogue scales (VAS);   The change in the dose of concomitant diuretics from baseline at day 28;   the number of participants with serious adverse events;   the time to Ascites improvement;   the time of worsening of Ascites
7 Recruiting Terlipressin in Cirrhotic Patients With Recidivation Ascites Treated With Paracentesis and Albumin
Condition: Cirrhosis
Interventions: Drug: Terlipressin;   Drug: Placebo
Outcome Measures: Mean number of paracentesis between the 2 groups over a 6 months period;   Total Ascites retrieval;   Number of cirrhosis complications groups;   Liver transplantation and deaths;   Terlipressin safety;   Mean number of days of hospitalization;   Delay between inclusion and the first rehospitalisation for Ascites retrieval
8 Recruiting Phase I Trial of Intraperitoneal Bevacizumab in Refractory Malignant Ascites
Condition: Refractory Malignant Ascites
Intervention: Drug: bevacizumab
Outcome Measures: adverse events;   Maximum tolerated dose;   Objective response rate;   time to treatment failure(TTF);   time to death(TTD)
9 Recruiting Conservative Treatment Versus Elective Repair of Umbilical Hernia in Patients With Ascites and Liver Cirrhosis
Conditions: Umbilical Hernia;   Liver Cirrhosis;   Ascites
Interventions: Procedure: Conservative treatment;   Procedure: Surgical repair
Outcome Measures: complications;   Recurrence;   Mortality;   Length of hospital stay;   Quality of life;   Cost effectiveness
10 Recruiting Eplerenone Versus Spironolactone as Treatment of Ascites Due to Liver Cirrhosis; a Study of Efficacy and Side Effects
Conditions: Ascites;   Cirrhosis
Intervention: Drug: Eplerenone
Outcome Measure: Ascites
11 Recruiting Evaluation of the Strip PeriScreen for the Fast Diagnosis of the Spontaneous Infection of the Liquid of Ascites During the Cirrhosis
Conditions: Cirrhosis;   Liquid of Ascites;   Infection
Intervention: Other: strip Peri Screen
Outcome Measure: liquid of Ascites spontaneous infection
12 Unknown  Adrenal Insufficiency in Cirrhotics With Ascites. Effects of Hydrocortisone on Renal and Haemodynamic Function
Condition: Cirrhosis With Ascites
Interventions: Drug: hydrocortisone;   Drug: dextrose solution 5%
Outcome Measure: renal function
13 Recruiting Endostar and/or Cisplatin for Treatment of Malignant Pleural Effusion or Ascites
Conditions: Malignant Pleural Effusion;   Malignant Ascites
Interventions: Drug: Endostar;   Drug: Cisplatin
Outcome Measures: Objective Response Rate;   Time to Progression;   Quality of Life;   Incidence of Adverse Events
14 Recruiting Clinical Trial on the Effects of Long Term Administration of 20% Albumin in the Cardiovascular and Renal Function, And Hepatic Hemodynamics in Advanced Patients With Cirrhosis and Ascites.
Conditions: Cirrhosis;   Ascites
Intervention: Drug: Albumin
Outcome Measures: To asses plasma renin activity and plasma concentration of noradrenaline;   Glomerular filtration;   Portal hypertension;   Cardiac Function
15 Recruiting VSL#3 and Spontaneous Bacterial Peritonitis
Condition: Decompensated Cirrhosis With Ascites.
Interventions: Drug: cotrimoxazole;   Drug: VSL#3 active;   Drug: VSL#3 placebo
Outcome Measures: Liver-related mortality and liver related morbidity;   Incidence of SBP, variceal bleeding, any non-SBP sepsis (e.g. pneumonia, urinary tract infection), clinical episodes of encephalopathy and the incidence of C. difficile infection.
16 Recruiting Body Composition Analysis in Cirrhotic Treated With Paracentesis
Conditions: Liver Cirrhosis;   Ascites
Intervention: Behavioral: Body composition in paracentesis
Outcome Measure: Body composition
17 Unknown  Prevention of Decompensation in Liver Cirrhosis
Conditions: Alcoholic Liver Cirrhosis;   Ascites
Intervention: Drug: losartan (drug)
Outcome Measures: Death;   varices;   need for therapeutic Ascites drainage;   gastrointestinal bleeding episodes
18 Recruiting Intestinal Decontamination With Rifaximin. The Inflammatory and Circulatory State in Patients With Cirrhosis
Conditions: Liver Cirrhosis;   Ascites
Interventions: Drug: Rifaximin;   Drug: placebo
Outcome Measures: Change from baseline in Hepatic venous pressure gradient (HVPG);   Change from baseline in Glomerular filtration rate (GFR)
19 Recruiting Effect of Samsca on Control of Hyponatremia and Extracellular Fluid in Cirrhotic Patients With Ascites
Condition: Hyponatremia and Extracellular Fluid in Cirrhotic
Interventions: Drug: Tolvaptan;   Drug: Placebo
Outcome Measures: Serum Na;   BCM (body composition monitoring);   body weight;   A composite endpoint of Ascites worsening;   Serum Na normalization rate;   Biochemistry;   ECG;   Adverse event;   Physical examination;   Vital signs;   Blood coagulation;   Urinalysis
20 Recruiting Clinical Study in Treatment of Malignant Ascites of Ovarian Cancer With Intraperitoneal Injection Bevacizumab Combined With Intraperitoneal Hyperthermic Perfusion Chemotherapy
Condition: Ovarian Cancer With Malignant Ascites
Interventions: Drug: Bevacizumab;   Drug: TC:paclitaxel + carboplatin
Outcome Measure: objective response rate