| Rank |
Status |
Study |
| 1 |
Recruiting
|
Clinical Trial to Evaluate Short-term Efficacy of Palliative Methylphenidate in Asthenia in Advanced Cancer Patients
| Condition: |
Asthenia |
| Intervention: |
Drug: methylphenidate |
| Outcome Measures: |
Intensity of Asthenia assessed with the verbal numeric scale (VNS) included on the Edmonton Symptom Assessment System (ESAS); Intensity of Asthenia assessed with the subscale for fatigue of the Functional Assessment of Cancer Therapy (FACT-F); Intensity of Asthenia assessed with the verbal numeric scale (VNS) included on the Edmonton Symptom Assessment System (ESAS) and the subscale for fatigue of the Functional Assessment of Cancer Therapy (FACT-F).; Intensity of other symptoms assessed with the Edmonton Symptom Assessment System (ESAS); Number of participants with treatment-related adverse events and severity of these adverse events.; Cognitive level. |
|
| 2 |
Recruiting
|
Transforming Growth Factor Beta Signalling in the Development of Muscle Weakness in Pulmonary Arterial Hypertension
| Conditions: |
Muscle Weakness; Pulmonary Arterial Hypertension |
| Intervention: |
|
| Outcome Measures: |
Plasma growth and differentiation factor 15 levels in participants with and without muscle wasting; Correlation of plasma Growth and differentiation factor 15 levels with muscle strength; Change in fibre type in muscle biopsy; GDF-15 levels in biopsy specimens; Correlation of plasma Growth and differentiation factor 15 levels with brain natriuretic protein levels; Correlation of plasma Growth and differentiation factor 15 levels with fat free mass index; Correlation of plasma Growth and differentiation factor 15 levels with quality of life; Correlation of plasma Growth and differentiation factor 15 levels with exercise tolerance; Correlation of plasma Growth and differentiation factor levels 15 with physical activity levels; Correlation of plasma Growth and differentiation factor levels 15 with echocardiographic measures of severity of pulmonary hypertension; Correlation of GDF-15 levels in biopsy specimens with muscle wasting and weakness; Determine the contribution of atrophy and autophagy to muscle wasting in PAH; Determine the contribution of SMAD and non-SMAD signalling pathways to the development of muscle weakness and wasting in PAH |
|
| 3 |
Unknown †
|
Use of Neuromuscular Electrostimulation (NMES) for Treatment or Prevention of ICU-Associated Weakness
| Conditions: |
Intensive Care Unit; Muscle Weakness |
| Interventions: |
Device: Neuromuscular Electrostimulation (NMES) CareStim Muscle Stimulation Device (Care Rehab; McLean, VA); Device: Sham |
| Outcome Measures: |
Lower extremity strength, at hospital discharge, of 3 bilateral muscle groups (pretibial, triceps surae, and quadriceps) measured via MMT using a composite Medical Research Council (MRC) score; Individual muscle strength: Pretibial, triceps surae, and quadriceps (MRC score) between those who receive NMES vs. sham sessions; Overall body strength: 6 bilateral muscle groups in arms and legs (MRC composite score) between those who receive NMES vs. sham sessions; Overall body strength: Hand grip between those who receive NMES vs. sham sessions; Respiratory muscle strength: Maximum Inspiratory Pressure (MIP) between those who receive NMES vs. sham sessions; Functional status as measured by modified Functional Independence Measurement (FIM) score between those receiving NMES vs. sham sessions; Duration of mechanical ventilation; ICU and hospital length of stay; ICU and in-hospital mortality; Total hospital charges; Hospital discharge destination (e.g., home, rehab facility); Mean change in subject's lower extremity MRC composite score from baseline; ICU Delirium; Subgroup analysis |
|
| 4 |
Recruiting
|
Muscular Electrostimulation of the Sedated and Mechanically Ventilated Critically Ill Patient. Analysis of the Effect on Acquired Muscular Weakness and Its Clinical Consequences.
| Condition: |
Polyneuropathy |
| Intervention: |
Procedure: Muscular electrostimulation and percutaneus muscular biopsy. |
| Outcome Measures: |
muscular weakness; time of weaning |
|
| 5 |
Recruiting
|
Study on Moebius Syndrome and Other Congenital Facial Weakness Disorders
| Conditions: |
Brain Disorders; Birth Defects; Craniofacial Differences |
| Intervention: |
|
| Outcome Measures: |
Characterize the phenotype of Moebius syndrome and other congenital facial weakness disorders to determine the prevalence of associated malformations and inform subsequent genetic studies.; Obtain imaging studies to explore cranial nerve structure and associated brain/brainstem and white matter tract anomalies and associate with the neurocognitive and behavioral phenotype of the patients. |
|
| 6 |
Recruiting
|
Does Residual Muscular Weakness Lead to an Increase in Respiratory Complications in Bariatric Patients?
| Conditions: |
Respiratory Complication; Morbid Obesity |
| Interventions: |
Device: Accelomyography; Drug: Neostigmine; Device: Qualitative Monitor |
| Outcome Measure: |
Respiratory Events (RE) |
|
| 7 |
Unknown †
|
A Randomized, Double Blind, Placebo Controlled Trial L-carnitine and Piracetam in the Treatment of Weakness, Muscle Fatigue and Muscle Pain in the Postpoliomyelitis Syndrome
| Condition: |
Postpoliomyelitis Syndrome |
| Interventions: |
Drug: L-carnitine and piracetam; Drug: Placebo |
| Outcome Measures: |
Changes in Muscle Weakness; Changes in fatigue; Changes in muscle pain; Changes in daytime sleepiness; Changes in quality of life; Changes in daily function; Changes in depressive mood; Changes in oxidative capacity in skeletal muscle; Occurrence of adverse events |
|
| 8 |
Unknown †
|
The Effects of the Inspiratory Muscle Plus Aerobic Training Compare to Aerobic Training Alone in Heart Failure Patients.
| Condition: |
Heart Failure |
| Intervention: |
Other: Inspiratory muscle added by aerobic to aerobic alone |
| Outcome Measures: |
To compare effects of inspiratory muscle training added by aerobic training to aerobic training alone in heart failure patients with inspiratory muscle weakness.; To compare effects between the training groups evaluating strength and endurance of inspiratory muscles; functional capacity; the physical and psychological perceptions of quality of life and heart rate variability and sleep apnea. |
|
| 9 |
Unknown †
|
Angiotensin-converting Enzyme (ACE)-Inhibition and Mechanisms of Skeletal Muscle Weakness in Chronic Obstructive Pulmonary Disease (COPD)
| Condition: |
Chronic Obstructive Pulmonary Disease |
| Interventions: |
Drug: Fosinopril; Other: lactose |
| Outcome Measures: |
Changes in phosphorylation of components of the atrogene pathway; Quadriceps endurance assessed non-volitionally; Effect of ACE-I on quadriceps maximum voluntary contraction force; Effect of ACE-I on quadriceps bulk (cross-sectional area); Effect of ACE-I on systemic inflammation and serum IGF-1 |
|
| 10 |
Recruiting
|
Vibrational-proprioceptive Resistance Exercise Training Versus Neuromuscular Electrical Stimulation Training in Elderly People With Muscle Weakness
| Conditions: |
Muscle Weakness Condition; Therapy Effect |
| Interventions: |
Device: Vibrational-proprioceptive Resistance Exercise Training; Device: Neuromuscular Electrical Stimulation Training |
| Outcome Measure: |
Maximum voluntary knee extension torque |
|
| 11 |
Recruiting
|
EKSO Trial: Powered Exoskeleton for Ambulation in Subjects With SCI
| Condition: |
Spinal Cord Injuries or Similar Neurological Weakness. |
| Intervention: |
Device: Ekso exoskeleton |
| Outcome Measures: |
Change in 6 Minute Walk Test from baseline in distance, RPE and oxygen uptake; change in 10 meter walk test from baseline in gait speed; Ratio of number of steps/walking time; 2 Minute Walk Test; Walk time to stand time ratio on a particular assistive device |
|
| 12 |
Unknown †
|
Muscle Atrophy in Sepsis
| Conditions: |
Atrophy; Sepsis; Weakness |
| Intervention: |
|
| Outcome Measures: |
Electrical stimulation will be associated with upregulation of anabolic signaling molecules and genes, downregulation of catabolic signaling molecules and genes within skeletal muscle of patients with sepsis; Electrical stimulation will be associated with improvement of histologic and electrophysiologic and strength parameters within skeletal muscle of patients with sepsis |
|
| 13 |
Recruiting
|
Memantine for Enhanced Stroke Recovery
| Conditions: |
Ischemic Stroke; Upper Extremity Weakness |
| Interventions: |
Drug: Memantine; Drug: Placebo (for memantine) |
| Outcome Measures: |
Fugl-Meyer Assessment; Adverse events; Adverse Events; Motor Activity Log (MAL); Ten Meter Walk Test; Stroke Impact Scale (SIS); Cancellation Tests; Cancellations Tests; Grip Strength Test; Montreal Cognitive Assessment (MoCA©) |
|
| 14 |
Unknown †
|
Vitamin D 2 to Dialysis Patients
| Conditions: |
Kidney Disease; Muscle Weakness; Pain; Fractures, Bone |
| Intervention: |
Drug: Ergocalciferol (Vitamin D 2) |
| Outcome Measures: |
We hypothesize that a large proportion of the study population will be 25-hydroxyvitamin D insufficient (< 25ng/ml), and performance on the muscle function tests will correlate with 25OHD levels.; We expect a 25% improvement in mean TUG values at twelve weeks in the treatment group when compared to the placebo group. |
|
| 15 |
Recruiting
|
The Effect of Activity-based Training in Patients With Hand-related Injuries Grouped Using Sense of Coherence Scores
| Condition: |
Hand Related Injuries |
| Interventions: |
Other: Joint mobility exercises hand therapy; Other: activity-based hand therapy |
| Outcome Measures: |
Disabilities of the Arm, Shoulder, and Hand questionnaire; The EQ-5D Quality of life questionnaire; Sense of Coherence Questionnaire; Canadian Occupational Performance Measure (COPM) Canadian Occupational Performance Measure (COPM); Satisfaction with daily living and rehabilitation |
|
| 16 |
Unknown †
|
Evaluation of the Effects of L-Carnitine Injection in Patients Undergoing Hemodialysis
| Conditions: |
Cardiac Complications; Signs and Symptoms; Muscle Weakness; Anemia; Hypotension |
| Intervention: |
Drug: L-Carnitine Injection |
| Outcome Measures: |
weakness; improvement of hypotension and hematology profile; reduction of erythropoietin requirement; increase of plasma carnitine concentration; including all the components of the primary endpoints for their further assessment; improvement of the nutritional indexes; intradialytic complications (muscle symptoms, dyspnea, palpitations); quality of life |
|
| 17 |
Recruiting
|
TryCYCLE: A Pilot Study of Early In-bed Leg Cycle Ergometry in Mechanically Ventilated Patients
| Conditions: |
Intensive Care Unit Acquired Weakness; Critical Care; Mechanical Ventilation; Respiratory Failure |
| Intervention: |
Device: In-bed leg cycle ergometry |
| Outcome Measures: |
Number of in-bed leg cycling research sessions terminated (composite outcome); Number of adverse events: Intravascular catheter or tube dislodgement rate during in-bed cycling; Daily research session delivery rate; Rate of outcome measure ascertainment in assessable patients at ICU awakening; Rate of outcome measure ascertainment in assessable patients at ICU discharge; Rate of outcome measure ascertainment in assessable patients at hospital discharge; Consent rate feasibility |
|
| 18 |
Unknown †
|
The Effects of a Walking Program on Balance, Falls and Well Being in Individuals Residing in Long-term Care
| Conditions: |
Accidental Falls; Muscle Weakness; Gait; Depression; Behavior |
| Interventions: |
Behavioral: Interpersonal Interaction; Behavioral: Walking Program |
| Outcome Measures: |
Falls; Fitness; Balance; Grip Strength; Gait speed; Physical Activities of Daily Living; Depression; Behavioral problems; Vital signs |
|
| 19 |
Recruiting
|
ICU Acquired Neuromyopathy and Diaphragm Function
| Conditions: |
Critical Illness Myopathy; Respiratory Paralysis |
| Intervention: |
Other: Non invasive phrenic nerve stimulation |
| Outcome Measures: |
Twitch tracheal pressure during airway occlusion (expressed in cmH2O); extubation success (defined as no need reintubation during the 48h after extubation) |
|
| 20 |
Recruiting
|
Contralateral Strength-training After Anterior Cruciate Ligament (ACL) Reconstruction
| Condition: |
Muscle Weakness After ACL Reconstruction |
| Interventions: |
Behavioral: Neuromuscular electrical stimulation; Behavioral: eccentric training |
| Outcome Measures: |
Change in bilateral quadriceps muscle strength [Nm]; Change in quadriceps muscle activation; Change in muscle architecture; Change in self-reported questionnaire outcomes (KOOS, WOMAClk); functional test outcomes |
|
