BLISTER and Doxycycline


BLISTER Symptoms and Causes

What are Blisters?

Blisters are fluid-filled sacs on the outer layer of your skin. They form because of rubbing, heat, or diseases of the skin. They are most common on your hands and feet.

Other names for Blisters are vesicles (usually for smaller Blisters) and bulla (for larger Blisters).

How do you get Blisters?

Blisters often happen when there is friction - rubbing or pressure - on one spot. For example, if your shoes don't fit quite right and they keep rubbing part of your foot. Or if you don't wear gloves when you rake leaves and the handle keeps rubbing against your hand. Other causes of Blisters include

  • Burns
  • Sunburn
  • Frostbite
  • Eczema
  • Allergic reactions
  • Poison ivy, oak, and sumac
  • Autoimmune diseases such as pemphigus
  • Epidermolysis bullosa, an illness that causes the skin to be fragile
  • Viral infections such as varicella zoster (which causes chickenpox and shingles) and herpes simplex (which causes cold sores)
  • Skin infections including impetigo
What are the treatments for Blisters?

Blisters will usually heal on their own. The skin over the Blister helps keep out infections. You can put a bandage on the Blister to keep it clean. Make sure that there is no more rubbing or friction on the Blister.

You should contact your health care provider if

  • The Blister looks infected - if it is draining pus, or the area around the Blister is red, swollen, warm, or very painful
  • You have a fever
  • You have several Blisters, especially if you cannot figure out what is causing them
  • You have health problems such as circulation problems or diabetes

Normally you don't want to drain a Blister, because of the risk of infection. But if a Blister is large, painful, or looks like it will pop on its own, you can drain the fluid.

How can I prevent Blisters?

There are some things you can do to prevent friction Blisters:

  • Make sure that your shoes fit properly
  • Always wear socks with your shoes, and make sure that the socks fit well. You may want to wear socks that are acrylic or nylon, so they keep moisture away from your feet.
  • Wear gloves or protective gear on your hands when you use any tools or sports equipment that cause friction.

Check out the latest treatments for BLISTER

BLISTER treatment research studies

Doxycycline clinical trials, surveys and public health registries

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Doxycycline Side Effects

Headache (181)
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Rash (131)
Pain (125)
Dyspnoea (125)
Vomiting (125)
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Haemorrhage (116)
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Abdominal Pain Upper (71)
Depression (41)
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Anaemia (38)
Stevens-johnson Syndrome (35)
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Confusional State (32)
Vision Blurred (31)
Oesophagitis (31)
Oedema Peripheral (31)
Dyspepsia (30)
Hypotension (30)
Pancreatitis (30)
Syncope (30)
Benign Intracranial Hypertension (29)
Paraesthesia (28)
Palpitations (28)
Arthralgia (27)
Erythema (27)
Visual Impairment (27)
Intracranial Pressure Increased (27)
Pulmonary Embolism (27)
Dysphagia (26)
Blister (26)
Abdominal Discomfort (25)
Pancreatitis Acute (25)
Renal Failure Acute (25)
Panic Attack (25)
Hypersensitivity (24)
Swollen Tongue (24)

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Recent Reviews

I am 11 days into a 20 day regime of Doxycycline for Staph. I am 51 and have not had a period in 2 years. 2 days ago I had some breast tenderness and this morning I woke to classic menstrual bleeding with abdominal cramps. Could the Doxycyclin

I am a 45 year old women who developed acne 4 years agao after my hysterectomy.Ihave been using doxycycline for the last 10 months......the only side effects I have experienced are nausea if pill tkn in empty stomach and weight gain ( which

I am anaemic and i've been treating my acne with doxycycline but instead my anaemia got worse i'm drowzy,my head feels heavy and i have a headache from hell.

I had these 100mg tablets for a sinus infection its gone now i take the last 1 tomorrow but after the few few days on them i ad to take 8 2 to start with then 1 a day. so after a few days on them i got 2 complaints my anus was a bit sore and neck an

I have just taken myself off Doxycycline. I had so much pressure in my skull - unable to stand for very long, felt really weak and thought I was going to pass out..A Few pains in my kidney area.

I took doxycycline for 10 days for perioral dermatitis. A week after completing the medicine I went to the ER with a burning in my chest. Then I lost my appetite, was nauseousand started losing weight. Three weeks later I was diagnosed with

I was taking doxycycline for an MRSA staph infection. I had tightness in my chest and worsening difficulty breathing, sore tongue, burning palms and soles of my feet, and extreme exhaustion. At the end of my 9th day on the medication, I had excruti

I was taking doxycycline for meibomitis and a little over 2 weeks after I started I came ill with severe head pressure,tinnitus,chills,nausea,flulike symptoms and after 2 emergency room visits and 6 different doctors (who were trying to treat me for

I was taking them as an anti-malarial. Caused a duodenal ulcer and a bleed on the brain, either of which could have killed me. Both nearly did, I had 3 months in hospital and 8 operations before I was discharged. I will probably never be properly wel

I'm currently taking doxycycline for Lyme disease, and about a week into my month prescription, I started having severe itching all over my body. It keeps me up at night, and when I asked if there was anything else I could switch to, I was told that

63 yo man received Zostavax injection in the left upper arm 12/13/11. Developed painful blister on the right shoulder and pain at the right lower ribs 12/10/11.

And it has blister now ,,,im afraid i dont know what to do,,,

I am 30 year old female. I have painful blister at the anal region. I was prescribed etoricoxib thiocolchicoside as a pain killer. I have been experiencing burning abdominal burning sensation and gastric problems.

I am facing a problem with cefuroxime axetil tablet 500 mg. Problem is blister pouch become gaseous with tablet on storage. need help.

I am on it for second day too. Only side effects I have had was diarrhea, slight headache, and for some reason I have a herpes blister on my hand, which is where the virus lies dormant (until now). I am hoping the blister will go away right after I g

I bit my lip and had 2 canker sores. so i applied orajel 4 times a day for 2 days----now my lip has huge blister sores and it looks like someone beat me up. i must be allergic to the stuff---no more. my son said he had t

I cracked my tooth and used to help numb the pain. about an hour latter the whole side of my mouth from which i use turned in to what i can only assume is a giant blister. literally ate the skin in my mouth, im fairly certain this in no way a safe pr

I have been getting these little blister sores that bust and turn into scap little sores. I have noticed it since about a month or so after found out my thyroid is not working right. Could this be a side effect from the medication

I just got back from Italy and developed cellulitus from the mosquito bites. I've been on antibiotics for three days and I see improvements on the red patches and swelling. But I have a blister on my ankle the size of a quarter that is raised about

I just noticed today when I woke up that I have some sort of rash on my hands. The rash is located on my right index finger and my left hand and index finger. On my right index finger it seems to be slightly swollen. There is a small blister on my ri

BLISTER Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting Evaluation and Comparison of Keloids and Second Degree Burns Blisters Fluid
Conditions: Blisters;   Second Degree Burns;   Wounds
Outcome Measure: comparison of inflamation cells and proteins (proteomic evaluation) between Blisters caused by heat and Blisters caused by cryo injury
2 Recruiting An Exploratory Evaluation of Biomarkers in Blister Fluid in Healthy Volunteers and Irradiated Skin
Conditions: Breast Cancer;   Healthy Volunteer;   Prostate Cancer
Outcome Measures: To determine if cytokine levels in Blister fluid change following exposure of the skin to low or high dose radiation.;   To compare Blister fluid cytokine levels in Blister fluid from unirradiated skin in normal controls, breast cancer patients, and prostate cancer patients;   To determine if there are differences within circulating and skin proteome and cytokine patterns between participants with cancer and healthy normal controls;   To determine how proteomic pattern changes in skin correlate with circulating proteomic patterns.;   To determine if changes in the proteome in Blister fluid occur following exposure of the skin to low or high dose radiation.;   To evaluate the reproducibility of cytokine assays in simultaneously collected Blister fluid samples from normal patients.;   To determine how cytokine levels in skin correlate with circulating and urinary cytokine levels.;   To determine if cytokine levels and changes at the proteome level measured in Blister fluid correlate with absorbed radiation skin dose, acute RTOG skin toxicity (& gt; Grade 3), or late RTOG skin toxicity (& gt; Grade 2).
3 Recruiting Effect of Darapladib on Cantharidin-Induced Inflammatory Blisters in Subjects With Type 2 Diabetes Mellitus (T2DM)
Condition: Atherosclerosis
Intervention: Drug: Darapladib
Outcome Measures: Macrophage cell count and surface expression of markers of M1 and M2 polarization in Blister fluid;   Number of monocytes and surface expression of markers of M1 or M2 polarization in peripheral blood;   Enzymatic activity of Lp-PLA2 in Blister fluid;   Total cell count, lymphocyte count, neutrophil count and macrophage count in Blister fluid;   Concentrations of soluble mediators of macrophage polarization;   Time to healing of cantharidin-induced Blisters
4 Unknown  Subconjunctival Bevacizumab Effect on Bleb Vascularity
Conditions: Bleb Vascularity;   Bleb Fibrosis;   Trabeculectomy Failure
Intervention: Drug: Bevacizumab
Outcome Measures: Bleb vascularity grading;   Indiana Bleb Appearance Grading Scale (IBAGS);   Intra-ocular pressure;   Indication for subconjunctival Mitomycin C injection or revision of surgery = yes / no
5 Unknown  Comparison of Subconjunctival 5-Fluorouracil (FU) Injection and Mitomycin C for Treatment of Early Bleb Failure
Condition: Bleb
Intervention: Drug: 5-FU and Mitomycin
Outcome Measures: Iop and Bleb height,extent and vascularity;   complication of 5-FU injection or Mitomycin drop in treatment of early bleb failure
6 Recruiting DIVERT: Diversion of Flow in Intracranial VErtebral and Blood Blister-like Ruptured Aneurysms Trial: A Randomized Trial Comparing Pipeline Flow Diversion and Best-Standard-Treatment
Condition: Ruptured Aneurysm of Intracranial Artery
Interventions: Device: Flow Diversion;   Device: Best Standard Therapy
Outcome Measures: Neurological status of the patient;   Modified Rankin Scale score;   Successful PED FD deployment/aneurysm clip-ligation/aneurysm coiling, with patency of parent arteries;   Peri-operative complications;   Angiographic outcome;   Number of days of hospitalization;   Discharge disposition/location;   Any new stroke, neurological symptom or sign;   Hospital re-admission;   Hemorrhagic complications;   Re-treatment of the index aneurysm
7 Unknown  Treatment of Failing Blebs With Ranibizumab
Conditions: Glaucoma, Open-Angle;   Failing Bleb Following Trabeculectomy
Intervention: Drug: Ranibizumab (Lucentis)
Outcome Measure:
8 Not yet recruiting Prevention Trial Assessing Paper-Tape in Endurance Distances II (Pre-TAPED II)
Condition: Foot Friction Blister
Intervention: Device: Paper-Tape
Outcome Measure: occurrence of a foot Blister
9 Recruiting Visual Distraction as a Means of Enhancing Child Resistance
Condition: Unintentional Ingestion of Drugs Contained Within Prescription Vials and Blisters.
Intervention: Other: Visual distractor
Outcome Measures: Package selection;   Time to opening;   Time to selection (continuous variable);   Success/Failure to open
10 Not yet recruiting Clinical Trial to Evaluate Blister Graft Utilizing a Novel Harvesting Device for Treatment of Venous Leg Ulcers
Conditions: Impaired Wound Healing;   Venous Insufficiency of Leg;   Diabetic Ulcers
Intervention: Device: Harvesting Device (CelluTome©)
Outcome Measures: Time to healing in patients treated with epidermal grafting and standard of care vs. standard of care alone.;   Percentage of venous leg ulcers that have healed each week.;   Cost effectiveness of epidermal grafting versus standard of care.;   Incidence of adverse events with epidermal grafting versus standard of care.;   Correlation between protease level and healing rate.;   Pain scores as reported by subjects.
11 Recruiting Evaluating Sirolimus to Treat Autoimmune Blistering Dermatosis Pemphigus
Condition: Pemphigus
Intervention: Drug: Sirolimus (formerly known as Rapamycin)
Outcome Measures: Improvement of ABSIS Score while reducing Steroid Dosage;   Statistical Measures
12 Unknown  Study of Inflammatory Mechanisms in Epidermolysis Bullosa Simplex- Dowling Meara
Condition: Epidermolysis Bullosa Simplex Dowling Meara
Intervention: Procedure: Taking of liquid and top of Blisters
Outcome Measures: Markers of inflammation in epidermis in patients with severe DM-BS;   clinical characterization of DM-EBS Genotype-phenoty
13 Not yet recruiting Investigating Immune Mechanisms in Atopic Eczema
Condition: Atopic Dermatitis
Interventions: Procedure: Skin biopsy;   Procedure: Skin suction Blister;   Biological: Mantoux test
Outcome Measure: Number of regulatory T cells in lesional skin of atopic dermatitis patients compared to healthy volunteers
14 Unknown  Use of the Epidermal Micrografts for Wound Healing After Mohs or Excisional Surgery for Skin Cancer
Condition: Neoplasm of Skin
Intervention: Device: Momelan Technologies Epidermal Graft Harvesting System
Outcome Measures: Wound healing/scarring;   Incidence of adverse events;   Physician global satisfaction;   Subject global satisfaction
15 Unknown  Use of Epidermal Expansion System for Epidermal Grafting on Hypopigmented Skin and Surgical Wounds
Conditions: Surgical Wound;   Hypo-pigmented Skin
Intervention: Device: Momelan Technologies Epidermal Graft Harvesting System
Outcome Measures: Wound healing/pigmentation;   Patient Satisfaction;   Physician Satisfaction;   Incidence of adverse events
16 Recruiting Comparison of Immune Response in Normal Volunteers and Patients With Helminth Infections
Conditions: Healthy;   Helminthiasis
Outcome Measure:
17 Recruiting Inflammatory Responses in Normal Volunteers and Patients With Abnormal Immune Responses
Conditions: Healthy;   Inflammation;   Vasculitis
Outcome Measure:
18 Recruiting Nutrition Interventions to Support the Immune System in Response to Stress
Condition: Mitigation of Immune Function Decrements in Response to Stress
Interventions: Dietary Supplement: Immune-enhancing nutritional beverage;   Dietary Supplement: Probiotics (BB-12)
Outcome Measures: Skin barrier restoration;   Suction Blister cytokine response
19 Unknown  Treatment of Dowling Maera Type of Epidermolysis Bullosa Simplex by Oral Erythromycin
Condition: Epidermolysis Bullosa
Intervention: Drug: Oral erythromycin
Outcome Measures: number of patients with decrease of Blisters' number of at least 20% after 3 months of treatment by oral erythromycin;   Secondary end points are : effect of 3 months of oral erythromycin on - Global tolerance of treatment.;   Secondary end points are : effect of 3 months of oral erythromycin on - Involved area;   Secondary end points are : effect of 3 months of oral erythromycin on - pruritus,
20 Recruiting Bronchoscopic Intrabullous Autologous Blood Instillation (BIABI) for Emphysema
Condition: Bullous Emphysema
Intervention: Procedure: Bronchoscopic intrabullous autologous blood instillation
Outcome Measures: Change in the Residual Volume (RV) following treatment;   Change in TLC 6 months following treatment;   Change in RV/TLC ratio 6 months following treatment;   Changes in FEV1 and FVC 6 months following treatment;   Change in the intrathoracic gas volume 6 months following treatment;   Change in DLCOc 6 months following treatment;   Change in the SGRQ score 6 months following treatment;   Change in the mMRC score 6 months following treatment;   Change in the 6MWD 6 months following treatment;   Change in CT measured lung volumes 6 months following treatment;   Adverse events