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BLOOD CHOLESTEROL INCREASED and Atenolol

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BLOOD CHOLESTEROL INCREASED Symptoms and Causes

What is cholesterol?

Cholesterol is a waxy, fat-like substance that's found in all the cells in your body. Your liver makes cholesterol, and it is also in some foods, such as meat and dairy products. Your body needs some cholesterol to work properly. But if you have too much cholesterol in your blood, you have a higher risk of coronary artery disease.

How do you measure cholesterol levels?

A blood test called a lipoprotein panel can measure your cholesterol levels. Before the test, you'll need to fast (not eat or drink anything but water) for 9 to 12 hours. The test gives information about your

  • Total cholesterol - a measure of the total amount of cholesterol in your blood. It includes the two types - low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol.
  • LDL (bad) cholesterol - the main source of cholesterol buildup and blockage in the arteries
  • HDL (good) cholesterol - HDL helps remove cholesterol from your arteries
  • Non-HDL - this number is your total cholesterol minus your HDL. Your non-HDL includes LDL and other types of cholesterol such as VLDL (very-low-density lipoprotein).
  • Triglycerides - another form of fat in your blood that can raise your risk for heart disease, especially in women
What do my cholesterol numbers mean?

Cholesterol numbers are measured in milligrams per deciliter (mg/dL). Here are the healthy levels of cholesterol, based on your age and gender:

Anyone age 19 or younger:

Type of CholesterolHealthy LevelTotal CholesterolLess than 170mg/dLNon-HDLLess than 120mg/dLLDLLess than 100mg/dLHDLMore than 45mg/dL

Men age 20 or older:

Type of CholesterolHealthy LevelTotal Cholesterol125 to 200mg/dLNon-HDLLess than 130mg/dLLDLLess than 100mg/dLHDL40mg/dL or higher

Women age 20 or older:

Type of CholesterolHealthy LevelTotal Cholesterol125 to 200mg/dLNon-HDLLess than 130mg/dLLDLLess than 100mg/dLHDL50mg/dL or higher

Triglycerides are not a type of cholesterol, but they are part of a lipoprotein panel (the test that measures cholesterol levels). A normal triglyceride level is below 150 mg/dL. You might need treatment if you have triglyceride levels that are borderline high (150-199 mg/dL) or high (200 mg/dL or more).

How often should I get a cholesterol test?

When and how often you should get a cholesterol test depends on your age, risk factors, and family history. The general recommendations are:

For people who are age 19 or younger:

  • The first test should be between ages 9 to 11
  • Children should have the test again every 5 years
  • Some children may have this test starting at age 2 if there is a family history of high blood cholesterol, heart attack, or stroke

For people who are age 20 or older:

  • Younger adults should have the test every 5 years
  • Men ages 45 to 65 and women ages 55 to 65 should have it every 1 to 2 years
What affects my cholesterol levels?

A variety of things can affect cholesterol levels. These are some things you can do to lower your cholesterol levels:

  • Diet. Saturated fat and cholesterol in the food you eat make your blood cholesterol level rise. Saturated fat is the main problem, but cholesterol in foods also matters. Reducing the amount of saturated fat in your diet helps lower your blood cholesterol level. Foods that have high levels of saturated fats include some meats, dairy products, chocolate, baked goods, and deep-fried and processed foods.
  • Weight. Being overweight is a risk factor for heart disease. It also tends to increase your cholesterol. Losing weight can help lower your LDL (bad) cholesterol, total cholesterol, and triglyceride levels. It also raises your HDL (good) cholesterol level.
  • Physical Activity. Not being physically active is a risk factor for heart disease. Regular physical activity can help lower LDL (bad) cholesterol and raise HDL (good) cholesterol levels. It also helps you lose weight. You should try to be physically active for 30 minutes on most, if not all, days.
  • Smoking.Cigarette smoking lowers your HDL (good) cholesterol. HDL helps to remove bad cholesterol from your arteries. So a lower HDL can contribute to a higher level of bad cholesterol.

Things outside of your control that can also affect cholesterol levels include:

  • Age and Gender. As women and men get older, their cholesterol levels rise. Before the age of menopause, women have lower total cholesterol levels than men of the same age. After the age of menopause, women's LDL (bad) cholesterol levels tend to rise.
  • Heredity. Your genes partly determine how much cholesterol your body makes. High blood cholesterol can run in families.
  • Race. Certain races may have an increased risk of high blood cholesterol. For example, African Americans typically have higher HDL and LDL cholesterol levels than whites.
How can I lower my cholesterol?

There are two main ways to lower your cholesterol:

  • Heart-healthy lifestyle changes, which include:
    • Heart-healthy eating. A heart-healthy eating plan limits the amount of saturated and trans fats that you eat. Examples include the Therapeutic Lifestyle Changes diet and the DASH Eating Plan.
    • Weight Management. If you are overweight, losing weight can help lower your LDL (bad) cholesterol.
    • Physical Activity. Everyone should get regular physical activity (30 minutes on most, if not all, days).
    • Managing stress. Research has shown that chronic stress can sometimes raise your LDL cholesterol and lower your HDL cholesterol.
    • Quitting smoking.Quitting smoking can raise your HDL cholesterol. Since HDL helps to remove LDL cholesterol from your arteries, having more HDL can help to lower your LDL cholesterol.
  • Drug Treatment. If lifestyle changes alone do not lower your cholesterol enough, you may also need to take medicines. There are several types of cholesterol medicines available, including statins. The medicines work in different ways and can have different side effects. Talk to your health care provider about which one is right for you. While you are taking medicines to lower your cholesterol, you should continue with the lifestyle changes.

NIH: National Heart, Lung, and Blood Institute

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Atenolol Side Effects

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BLOOD CHOLESTEROL INCREASED Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Unknown  Study to Assess Efficacy of Nicorandil+Atenolol vs Atenolol in Treatment of Chronic Stable Angina.
Condition: Chronic Stable Angina
Interventions: Drug: Nicorandil;   Drug: Atenolol
Outcome Measures: SPECT Tc99m- Tetrofosmin (MYOVIEW);   Exercise ECG Testing - Bruce protocol
2 Recruiting Comparison Study of the Effect of Aliskiren Versus Negative Controls on Aortic Stiffness in Patients With Marfan Syndrome Under Treatment With Atenolol
Condition: Marfan Syndrome
Interventions: Drug: Aliskiren;   Drug: Atenolol
Outcome Measures: Central aortic PWV(pulsed wave velocity);   Central aortic distensibility by MRI at week 24
3 Recruiting A Study Examining the Effects of Nebivolol Compared to Atenolol on Endothelial Function
Condition: Hypertension
Interventions: Drug: Nebivolol;   Drug: Atenolol;   Drug: placebo
Outcome Measures: Comparing effects of nebivolol against Atenolol and placebo on endothelial function;   Evaluate effects of nebivolol as compared to Atenolol and placebo
4 Recruiting Genetically Determined Response to Atenolol in Patients With Persistent Atrial Fibrillation
Condition: Atrial Fibrillation
Intervention: Drug: Atenolol
Outcome Measure: Ventricular rate response during exercise.
5 Recruiting Clinical Study to Evaluate the Antihypertensive Efficacy and Changes of Neurohormonal Markers of Fimasartan and Atenolol With Exaggerated Blood Pressure Response During Exercise in Essential Hypertensive Patients
Condition: Hypertension
Interventions: Drug: Fimasartan;   Drug: Atenolol
Outcome Measures: The difference of sitting Systolic Blood Pressure(SiSBP) between at the peak compared to at resting;   The difference of sitting Diastolic Blood Pressure(SiDBP) at the peak compared to at resting;   The difference of sitting Systolic Blood Pressure(SiSBP) at each exercising stage compared to at resting;   The difference of sitting Systolic Blood Pressure(SiSBP) among at resting, each exercising stage and recovery
6 Recruiting Hemodynamic Changes of Patients Receiving Atenolol/Bisoprolol
Conditions: Hypertension;   Metabolic Syndrome
Interventions: Drug: Atenolol;   Drug: Bisoprolol
Outcome Measures: central blood pressure;   peripheral resistance;   cardiac index;   pulse wave velocity
7 Recruiting Beta Blockers and Angiotensin Receptor Blockers in Bicuspid Aortic Valve Disease Aortopathy (BAV Study)
Condition: Cardiac Disease
Interventions: Drug: Atenolol;   Drug: Telmisartan
Outcome Measures: Change from baseline in ascending aorta size, as evaluated by MRI;   Rate of change in ascending aorta size evaluated by transthoracic echocardiography (TEE).
8 Unknown  Examining Genetic Influence on Response to Beta-Blocker Medications in People With Type 2 Diabetes
Condition: Diabetes Mellitus, Type 2
Intervention: Drug: Atenolol
Outcome Measures: Change in diastolic function (annular tissue velocity [Em]);   Change in free fatty acid kinetics;   Change in insulin sensitivity, glucose effectiveness, glucose, insulin, high-density lipoprotein (HDL), or triglycerides
9 Unknown  A Randomized, Open-label, LOSARTAN Therapy on the Progression of Aortic Root Dilation in Patients With Marfan Syndrome
Condition: Marfan Syndrome
Interventions: Drug: Losartan and Atenolol or Propranolol;   Drug: Atenolol or Propranolol
Outcome Measure: Echocardiograms
10 Recruiting Study of Glucagon, Ghrelin and Growth Hormone as Counterregulatory Hormones
Condition: Healthy
Interventions: Drug: Saline;   Drug: Glucagon;   Drug: Placebo;   Drug: Atenolol
Outcome Measures: Circulating acyl-ghrelin concentration after glucagon stimulation with and without beta-adrenergic blockade;   Association between circulating acyl-ghrelin concentration and GH and cortisol after glucagon administration with and without beta-adrenergic blockade
11 Recruiting Genetic Mechanisms in Human Hypertension Renin-angiotensin-aldosterone System (RAAS) Inhibition Study
Condition: Hypertension
Intervention: Drug: Lisinopril, Atenolol
Outcome Measure: One type of blood pressure medication will better treat individuals with certain genetic backgrounds.
12 Recruiting Comparison of Beta-blocker Versus Angiotensin Receptor Blocker for Suppression of Aneurysm Expansion in Patients With Small Abdominal Aortic Aneurysm
Condition: Small Abdominal Aortic Aneurysm
Interventions: Drug: Beta-blocker-Atenolol 50mg, PO(peroral), Once daily;   Drug: Angiotensin receptor blocker-Valsartan 80mg, PO(peroral), Once daily
Outcome Measure: Annual aneurysm growth of abdominal aortic aneurysm
13 Not yet recruiting Single Pill to Avert Cardiovascular Events
Condition: Cardiovascular Disease
Interventions: Drug: polipillV1;   Drug: polipillV2;   Drug: usual care
Outcome Measures: compliance with treatment;   changed in blood pressure;   changes in LDL-cholesterol levels;   the main reason for non compliance with treatment;   safety of poli pill measures by laboratorial tests;   combined outcome
14 Recruiting Prognostic Value of the Circadian Pattern of Ambulatory Blood Pressure for Cardiovascular Risk Assessment
Conditions: Essential Hypertension;   Cardiovascular Disease;   Stroke;   Chronic Kidney Disease
Interventions: Drug: Any antihypertensive medication alone or in combination;   Device: Ambulatory blood pressure monitoring
Outcome Measures: To evaluate the impact of circadian time of treatment in cardiovascular, cerebrovascular and renal risk assessment.;   To evaluate the influence of circadian time of treatment in BP control of hypertensive patients.;   To evaluate the prevalence of an altered (non-dipper) BP profile in patients with resistant hypertension as a function of the circadian time of treatment.;   To evaluate the influence of diabetes and circadian time of treatment in the prevalence of an altered (non-dipper) BP profile.;   To evaluate the influence of age and circadian time of treatment in the prevalence of an altered (non-dipper) BP profile.;   To evaluate, for all groups of interest, the prevalence and cardiovascular risk profile of white-coat hypertension.;   To evaluate, for all groups of interest, the prevalence and cardiovascular risk profile of masked hypertension.;   To evaluate, for all previous objectives, potential differences between men and women.;   To evaluate the impact of changes in ambulatory BP in cardiovascular, cerebrovascular and renal risk assessment.
15 Recruiting Atrial Substrate Modification With Aggressive Blood Pressure Lowering to Prevent AF
Condition: Atrial Fibrillation
Intervention: Other: Aggressive Blood Pressure control
Outcome Measures: Time to recurrent Atrial fibrillation;   Recurrence of AF at one year
16 Unknown  Heart Rate Reduction in Heart Failure
Condition: Heart Failure
Interventions: Drug: ivabradine;   Drug: Carvedilol/Ivabradine;   Drug: Carvedilol
Outcome Measures: Exercise tolerance assessed by 6 minute walking test;   Quality of life
17 Unknown  Anglo-Scandinavian Cardiac Outcomes Trial: Post Trial Follow-Up Study
Conditions: Hypertension;   Diabetes;   Death From Cardiovascular Disease;   Myocardial Infarction;   Stroke
Intervention:
Outcome Measures: Number of participants who have died from cardiovascular disease and the number who have suffered a non-fatal myocardial infarction (MI) and/or non-fatal stroke since the end of the ASCOT study;   Number of participants who have developed diabetes since the end of the ASCOT trial;   Number of participants who have undergone coronary/peripheral re-vascularisation procedures since the end of the ASCOT trial;   Number of participants who have required renal replacement therapy (dialysis or kidney transplant) since the end of the ASCOT trial;   Number of participants who have experienced a transient ischaemic attack since the end of the ASCOT trial
18 Recruiting The International Polycap Study 3 (TIPS-3)
Conditions: Cardiovascular Disease;   Fractures;   Cancers
Interventions: Drug: Polycap DS;   Drug: enteric coated aspirin;   Drug: cholecalciferol
Outcome Measures: Composite of major CVD (CV death, non-fatal stroke, non-fatal MI), plus heart failure, resuscitated cardiac arrest, or revascularization with evidence of ischemia in participants taking Polycap versus placebo;   Composite of CV events (CV death, MI or stroke) and cancer in participants taking aspirin versus placebo;   Risk of fractures in participants taking vitamin D versus placebo;   Composite of CV death, non-fatal stroke, and nonfatal MI in participants taking Polycap versus placebo;   Composite outcome of CV events and cancers after 10 years of follow up in participants taking aspirin versus placebo;   Composite outcome of CV events, fractures and cancers, and the risk of the falls at 10 years of follow up in participants taking vitamin D versus placebo
19 Recruiting Catheter Ablation vs Anti-arrhythmic Drug Therapy for Atrial Fibrillation Trial
Conditions: Atrial Fibrillation;   Arrhythmia
Interventions: Device: Left atrial ablation;   Drug: Rate or Rhythm Control Therapy
Outcome Measures: LA catheter ablation is superior to rate or rhythm control drug therapy for decreasing the incidence of the composite endpoint of total mortality, disabling stroke, serious bleeding, or cardiac arrest in patients warranting therapy for AF.;   LA catheter ablation is superior to rate or rhythm control drug therapy for reducing total mortality;   Total mortality or cardiovascular hospitalization;   Cardiovascular death;   Cardiovascular death or disabling stroke;   Arrhythmic death or cardiac arrest;   Heart failure death;   Freedom from recurrent AF;   Cardiovascular hospitalization;   Medical costs, resource utilization, and cost effectiveness;   Quality of Life;   Composite adverse events;   Left atrial size, morphology and function and its relationship to morbidity and mortality