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BLOOD CHOLESTEROL INCREASED and Diazepam

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BLOOD CHOLESTEROL INCREASED Symptoms and Causes

table th, table td {text-align: left; padding: 3px 15px} What is cholesterol?

Cholesterol is a waxy, fat-like substance that's found in all the cells in your body. Your liver makes cholesterol, and it is also in some foods, such as meat and dairy products. Your body needs some cholesterol to work properly. But if you have too much cholesterol in your blood, you have a higher risk of coronary artery disease.

How do you measure cholesterol levels?

A blood test called a lipoprotein panel can measure your cholesterol levels. Before the test, you'll need to fast (not eat or drink anything but water) for 9 to 12 hours. The test gives information about your

  • Total cholesterol - a measure of the total amount of cholesterol in your blood. It includes the two types - low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol.
  • LDL (bad) cholesterol - the main source of cholesterol buildup and blockage in the arteries
  • HDL (good) cholesterol - HDL helps remove cholesterol from your arteries
  • Non-HDL - this number is your total cholesterol minus your HDL. Your non-HDL includes LDL and other types of cholesterol such as VLDL (very-low-density lipoprotein).
  • Triglycerides - another form of fat in your blood that can raise your risk for heart disease, especially in women
What do my cholesterol numbers mean?

Cholesterol numbers are measured in milligrams per deciliter (mg/dL). Here are the healthy levels of cholesterol, based on your age and gender:

Anyone age 19 or younger:

Type of CholesterolHealthy LevelTotal CholesterolLess than 170mg/dLNon-HDLLess than 120mg/dLLDLLess than 100mg/dLHDLMore than 45mg/dL

Men age 20 or older:

Type of CholesterolHealthy LevelTotal Cholesterol125 to 200mg/dLNon-HDLLess than 130mg/dLLDLLess than 100mg/dLHDL40mg/dL or higher

Women age 20 or older:

Type of CholesterolHealthy LevelTotal Cholesterol125 to 200mg/dLNon-HDLLess than 130mg/dLLDLLess than 100mg/dLHDL50mg/dL or higher

Triglycerides are not a type of cholesterol, but they are part of a lipoprotein panel (the test that measures cholesterol levels). A normal triglyceride level is below 150 mg/dL. You might need treatment if you have triglyceride levels that are borderline high (150-199 mg/dL) or high (200 mg/dL or more).

How often should I get a cholesterol test?

When and how often you should get a cholesterol test depends on your age, risk factors, and family history. The general recommendations are:

For people who are age 19 or younger:

  • The first test should be between ages 9 to 11
  • Children should have the test again every 5 years
  • Some children may have this test starting at age 2 if there is a family history of high blood cholesterol, heart attack, or stroke

For people who are age 20 or older:

  • Younger adults should have the test every 5 years
  • Men ages 45 to 65 and women ages 55 to 65 should have it every 1 to 2 years
What affects my cholesterol levels?

A variety of things can affect cholesterol levels. These are some things you can do to lower your cholesterol levels:

  • Diet. Saturated fat and cholesterol in the food you eat make your blood cholesterol level rise. Saturated fat is the main problem, but cholesterol in foods also matters. Reducing the amount of saturated fat in your diet helps lower your blood cholesterol level. Foods that have high levels of saturated fats include some meats, dairy products, chocolate, baked goods, and deep-fried and processed foods.
  • Weight. Being overweight is a risk factor for heart disease. It also tends to increase your cholesterol. Losing weight can help lower your LDL (bad) cholesterol, total cholesterol, and triglyceride levels. It also raises your HDL (good) cholesterol level.
  • Physical Activity. Not being physically active is a risk factor for heart disease. Regular physical activity can help lower LDL (bad) cholesterol and raise HDL (good) cholesterol levels. It also helps you lose weight. You should try to be physically active for 30 minutes on most, if not all, days.
  • Smoking.Cigarette smoking lowers your HDL (good) cholesterol. HDL helps to remove bad cholesterol from your arteries. So a lower HDL can contribute to a higher level of bad cholesterol.

Things outside of your control that can also affect cholesterol levels include:

  • Age and Gender. As women and men get older, their cholesterol levels rise. Before the age of menopause, women have lower total cholesterol levels than men of the same age. After the age of menopause, women's LDL (bad) cholesterol levels tend to rise.
  • Heredity. Your genes partly determine how much cholesterol your body makes. High blood cholesterol can run in families.
  • Race. Certain races may have an increased risk of high blood cholesterol. For example, African Americans typically have higher HDL and LDL cholesterol levels than whites.
How can I lower my cholesterol?

There are two main ways to lower your cholesterol:

  • Heart-healthy lifestyle changes, which include:
    • Heart-healthy eating. A heart-healthy eating plan limits the amount of saturated and trans fats that you eat. Examples include the Therapeutic Lifestyle Changes diet and the DASH Eating Plan.
    • Weight Management. If you are overweight, losing weight can help lower your LDL (bad) cholesterol.
    • Physical Activity. Everyone should get regular physical activity (30 minutes on most, if not all, days).
    • Managing stress. Research has shown that chronic stress can sometimes raise your LDL cholesterol and lower your HDL cholesterol.
    • Quitting smoking.Quitting smoking can raise your HDL cholesterol. Since HDL helps to remove LDL cholesterol from your arteries, having more HDL can help to lower your LDL cholesterol.
  • Drug Treatment. If lifestyle changes alone do not lower your cholesterol enough, you may also need to take medicines. There are several types of cholesterol medicines available, including statins. The medicines work in different ways and can have different side effects. Talk to your health care provider about which one is right for you. While you are taking medicines to lower your cholesterol, you should continue with the lifestyle changes.

NIH: National Heart, Lung, and Blood Institute

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BLOOD CHOLESTEROL INCREASED Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting Comparison of Absorption of Vaginal Diazepam Using Different Delivery Systems
Condition: Metabolism, Drug
Interventions: Drug: Diazepam tablet, 5 mg, vaginal;   Drug: Diazepam Suppository, 5 mg, vaginal;   Drug: Diazepam Cream, 5 mg, Vaginal
Outcome Measures: Serum Diazepam levels measured over time;   Side effects observed with each of three types of vaginal Diazepam
2 Recruiting Vaginal Diazepam for the Treatment of Female Pelvic Pain
Conditions: Pelvic Floor Disorders;   Pelvic Pain
Interventions: Drug: Diazepam;   Drug: Placebo
Outcome Measures: Change from baseline in Visual Analog Pain Scale score at 4 weeks, 12 weeks, and 24 weeks.;   Change from baseline in Pelvic Floor Distress Inventory-20 Questionnaire score at 4 weeks, 12 weeks, and 24 weeks.;   Change from baseline in McGill Pain Questionnaire score at 4 weeks, 12 weeks, and 24 weeks.;   Change from baseline in Global Response Assessment score at 4 weeks, 12 weeks, and 24 weeks.
3 Recruiting Lofexidine for Inpatient Opiate Detox in Singapore
Condition: Opiate Dependent Patients Who Are Undergoing Inpatient Detoxification in Singapore
Interventions: Drug: Lofexidine;   Drug: Diazepam;   Drug: Placebo for Lofexidine;   Drug: Placebo for Diazepam
Outcome Measures: To evaluate differences in OOWS (Objective Opiate Withdrawal Scale);   To evaluate differences in SOWS (Short Opiate Withdrawal Scale);   To evaluate differences in pupil sizes;   To evaluate differences in craving on the Visual Analogue Scale;   To evaluate differences in time to drop-out (length of stay on the ward);   To evaluate differences in emotional/psychological symptoms
4 Unknown  Performance Study of the SOLO 2.0 Insulin Pump
Condition: Type 1 Diabetes
Intervention: Device: SOLO insulin pump
Outcome Measures: Device related safety issues;   SOLO use errors;   Device-related adverse outcome;   Diabetes-related adverse outcome;   Satisfaction iwth SOLO;   Product quality (MTBF)
5 Recruiting Safety and Feasibility Study of Enhanced Recovery in Pancreaticoduodenectomy
Condition: Pancreaticoduodenectomy (E04.210.760)
Interventions: Behavioral: Enhanced recovery after surgery protocol;   Procedure: Standard perioperative care;   Drug: PONV prophylaxis with Ondansetron + Dexamethasone;   Other: Postoperative mobilization program;   Drug: Epidural analgesia with naropin + sufentanil;   Drug: Pre-anesthetic medication with Diazepam;   Behavioral: Preadmission counselling;   Drug: Preoperative bowel preparation with sodium phosphate
Outcome Measures: Adherence to the pathway;   Postoperative outcome
6 Recruiting A Prospective Trial to Reduce Post-Operative Pain in Implant Based Breast Reconstruction
Condition: Post-operative Pain
Interventions: Drug: Bupivacaine;   Drug: Botulinum Toxins;   Drug: Analgesics
Outcome Measure: Pain Score Questionnaire
7 Recruiting Perioperative Δ9-THC for Postsurgical Pain
Condition: Pain
Interventions: Drug: Namisol;   Drug: Diazepam/placebo
Outcome Measures: Analgesic efficacy;   Incidence of persistent continuous or intermittent postsurgical abdominal pain
8 Unknown  The Effect of Prescription Medications in Marijuana Users
Condition: Marijuana Abuse
Intervention: Drug: bupropion, Diazepam, dronabinol, ramelteon (Investigational Drug)
Outcome Measures: marijuana withdrawal;   subjective effects of smoked marijuana;   cognitive performance
9 Recruiting The PROOF Study: The PICC Related Obstruction Of Flow Study
Condition: Patients Indicated for a PICC for Any Medical Condition
Interventions: Device: BioFlo™ Peripherally Inserted Central Catheter (PICC);   Device: Bard® Dual-Lumen PowerPICC SOLO2®
Outcome Measures: Incidence of catheter-related venous thrombosis as confirmed by diagnostic ultrasound;   Incidence of other catheter-related complications
10 Not yet recruiting Implementing Health Plan-Level Care Management for Solo & Small Practices
Conditions: Bipolar Disorder;   Depression
Interventions: Behavioral: Chronic Care Model for Mood Disorders;   Other: Educational Control
Outcome Measures: Quality of Life;   Reduced Mood Disorder Symptoms;   Improved Guideline-Concordant Care;   Reduced Hospitalizations;   Improved Work Productivity
11 Unknown  Positron Emission Mammography (PEM) Flex Solo II Positron Emission Tomography (PET) Scanner and Stereo Navigator Biopsy Accessory for the Diagnosis of Breast Cancer
Condition: Breast Cancer
Intervention: Procedure: PEM Breast Biopsy
Outcome Measures: Evidence that breast biopsy can be performed using PEM and Stereo Navigator software;   Evidence that breast biopsy can be performed in less clinical visits than if biopsy is performed using MRI, mammogram, and/or ultrasound
12 Unknown  Quality of Sleep in Patients With Rheumatoid Arthritis
Condition: Rheumatoid Arthritis
Intervention: Drug: Diazepam, melatonin
Outcome Measure:
13 Recruiting Optimization of Procedural Sedation Protocol Used for Dental Care Delivery in People With Mental Disability
Condition: Dental Care for Disabled
Interventions: Drug: Midazolam Mylan;   Drug: Lorazepam Mylan;   Drug: Valium + Akineton + Dehydrobenzperidol + Atropine sulfate
Outcome Measures: Level of cooperation of patient when receiving regular dental care;   Recording of vital parameters during regular dental care delivery;   Level of patient comfort and possible side-effects after dental treatment session
14 Recruiting Tolerance of PICC Line Versus Implanted Port for Adjuvant Chemotherapy in Early Breast Cancer
Condition: Early Stage Breast Carcinoma
Interventions: Device: implanted port for chemo administration (X-port isp);   Device: Use of a PICC line for chemo administration (PowerPICC SOLO²)
Outcome Measures: Probability of occurrence of a significant adverse event related to the central venous device;   Patients' satisfaction for the use of their central venous device
15 Unknown  Continuation Electroconvulsive Therapy (C-ECT) for Relapse Prevention in Major Depression
Condition: Depression
Interventions: Device: Thrymatron System IV device (CONSOLIDATION ELECTROCONVUsLIVE THERAPY) plus PHARMACOTHERAPY;   Drug: PHARMACOTHERAPY
Outcome Measures: Hamilton Depression Rating Scale 21 items (HDRS-21);   Mini-Mental State Examination (MMSE 35);   UKU - Adverse effects rating scales;   Demographical Data Memory (MEDABI-20);   Rey Figure;   Trail Making Test A;   Trail Making Test B;   Stroop Test;   Direct and inverse digits (WAIS, Weschler Adults Intelligence Sacle).;   Vocabulary WAIS (Weschler Adults Intelligence Scale);   Frequency Hospitalization Quotient;   Hospital Day Quotient (HDQ)
16 Recruiting RCT of Mesh Versus Jet Nebulizers on Clinical Outcomes During Mechanical Ventilation in the Intensive Care Unit
Condition: Respiratory Insufficiency
Interventions: Device: Vibrating Mesh Nebulizer Arm;   Device: Jet Nebulizer Arm
Outcome Measures: Venilator Associated Events;   Bacterial Count and type;   Length of Stay in Intensive Care Unit;   Days on Mechanical Ventilation;   Ventilator-Associated Tracheobronchitis
17 Recruiting Gabapentin Treatment of Benzodiazepine Dependence
Condition: Benzodiazepine Dependence
Interventions: Drug: gabapentin;   Drug: Placebo
Outcome Measure: Abstinence from Benzodiazepine use
18 Recruiting Electrical Status Epilepticus in Sleep: Response of Neuropsychological Deficits and Epileptiform Activity to Clobazam Treatment
Condition: Electrical Status Epilepticus in Sleep
Intervention: Drug: ESES treated with clobazam
Outcome Measures: Cognitive ability;   Language;   Executive function;   Adaptive/development skills;   Behavior;   Interictal epileptiform activity
19 Recruiting Carbon Dioxide (Carbogen) for the Treatment of Febrile Seizures
Condition: Febrile Seizure
Interventions: Drug: Carbogen;   Drug: Placebo
Outcome Measures: number of patients which need Diazepam;   number of severe adverse events;   manageability of the application assessed by the parents;   changes in quality of life of the parents and children after use of study medication;   contentment and anxiety of the parents
20 Unknown  Extended-release Epidural Morphine for Acute Post-operative Analgesia Following Selective Dorsal Rhizotomy in Children
Condition: Spastic Cerebral Palsy
Interventions: Drug: Extended-release Epidural morphine (EREM) 80;   Drug: Extended-release Epidural Morphine (EREM) 120;   Drug: Control: Saline
Outcome Measures: Quantity of fentanyl administered;   Adequacy of analgesia as judged by age-adjusted pain scales.;   Incidence of respiratory depression;   Hemodynamic instability;   Rate of CSF leak;   Rate of infection;   Urinary retention;   Nausea and/or vomiting;   Pruritis