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BLOOD CHOLESTEROL INCREASED and Medication

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BLOOD CHOLESTEROL INCREASED Symptoms and Causes

What is an inactive lifestyle?

Being a couch potato. Not exercising. A sedentary or inactive lifestyle. You have probably heard of all of these phrases, and they mean the same thing: a lifestyle with a lot of sitting and lying down, with very little to no exercise.

In the United States and around the world, people are spending more and more time doing sedentary activities. During our leisure time, we are often sitting: while using a computer or other device, watching TV, or playing video games. Many of our jobs have become more sedentary, with long days sitting at a desk. And the way most of us get around involves sitting - in cars, on buses, and on trains.

How does an inactive lifestyle affect your body?

When you have an inactive lifestyle,

  • You burn fewer calories. This makes you more likely to gain weight.
  • You may lose muscle strength and endurance, because you are not using your muscles as much
  • Your bones may get weaker and lose some mineral content
  • Your metabolism may be affected, and your body may have more trouble breaking down fats and sugars
  • Your immune system may not work as well
  • You may have poorer blood circulation
  • Your body may have more inflammation
  • You may develop a hormonal imbalance
What are the health risks of an inactive lifestyle?

Having an inactive lifestyle can be one of the causes of many chronic diseases. By not getting regular exercise, you raise your risk of

  • Obesity
  • Heart diseases, including coronary artery disease and heart attack
  • High blood pressure
  • High cholesterol
  • Stroke
  • Metabolic syndrome
  • Type 2 diabetes
  • Certain cancers, including colon, breast, and uterine cancers
  • Osteoporosis and falls
  • Increased feelings of depression and anxiety

Having a sedentary lifestyle can also raise your risk of premature death. And the more sedentary you are, the higher your health risks are.

How can I get started with exercise?

If you have been inactive, you may need to start slowly. You can keep adding more exercise gradually. The more you can do, the better. But try not to feel overwhelmed, and do what you can. Getting some exercise is always better than getting none. Eventually, your goal can be to get the recommended amount of exercise for your age and health.

There are many different ways to get exercise; it is important to find the types that are best for you. You can also try to add activity to your life in smaller ways, such as at home and at work.

How can I be more active around the house?

There are some ways you can be active around your house:

  • Housework, gardening, and yard work are all physical work. To increase the intensity, you could try doing them at a more vigorous pace.
  • Keep moving while you watch TV. Lift hand weights, do some gentle yoga stretches, or pedal an exercise bike. Instead of using the TV remote, get up and change the channels yourself.
  • Work out at home with a workout video (on your TV or on the internet)
  • Go for a walk in your neighborhood. It can be more fun if you walk your dog, walk your kids to school, or walk with a friend.
  • Stand up when talking on the phone
  • Get some exercise equipment for your home. Treadmills and elliptical trainers are great, but not everyone has the money or space for one. Less expensive equipment such as yoga balls, exercise mats, stretch bands, and hand weights can help you get a workout at home too.
How can I be more active at work?

Most of us sit when we are working, often in front of a computer. In fact, less than 20 percent of Americans have physically active jobs. It can be challenging to fit physical activity into your busy workday, but here are some tips to help you get moving:

  • Get up from your chair and move around at least once an hour
  • Stand when you are talking on the phone
  • Find out whether your company can get you a stand-up or treadmill desk
  • Take the stairs instead of the elevator
  • Use your break or part of your lunch hour to walk around the building
  • Stand up and walk to a colleague's office instead of sending an email
  • Have "walking" or standing meetings with co-workers instead of sitting in a conference room

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BLOOD CHOLESTEROL INCREASED Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting Using Novel Canadian Resources to Improve Medication Reconciliation at Discharge
Conditions: Medication Reconciliation;   Adverse Drug Events
Intervention: Other: Electronic Medication Reconciliation
Outcome Measures: Adverse Drug Event;   Emergency Room Visit/Hospital Readmission;   Failure to re-start community Medications used for chronic conditions after discharge from hospital.;   Readiness for hospital discharge;   Time to complete medication history and discharge medication reconciliation with prescription.;   Therapy Duplication
2 Recruiting Pharmacokinetic Study of Antiretroviral Drugs and Related Drugs During and After Pregnancy
Condition: HIV Infections
Interventions: Drug: Current ARV Medications;   Drug: Current TB Medications;   Drug: Current hormonal contraceptive Medications
Outcome Measures: Drug parameter: Area under the curve from 0 to 12 hours (AUC 0-12);   Drug parameter: Area under the curve from 0 to 24 hours (AUC 0-24);   Drug parameter: Maximum concentration (Cmax);   Drug parameter: Pre-dose concentration (Cdose);   Drug parameter: Minimum concentration (Cmin);   Drug parameter: Time after administration of drug when maximum plasma concentration is reached (Tmax);   Drug parameter: Clearance over systemic availability (Cl/F);   Drug parameter: Volume of distribution over systemic availability (V/F);   Drug parameter: Half-life (t1/2);   ARV concentrations in vaginal secretions;   ARV concentrations in plasma;   For contraceptives: plasma concentration;   Ratio of cord blood concentration to maternal blood concentration;   Ratio of unbound/total drug concentrations;   Rate of detection of study drugs in vaginal secretions;   Ratio of vaginal drug concentrations to simultaneous blood concentrations;   Rate of detection of HIV RNA/DNA in vaginal secretions and comparison to level in blood;   ARV exposure (as measured by area under the curve or other PK parameters) during pregnancy and postpartum according to genotype;   Adverse events of grade 3 or higher;   Infant neurological events of grade 1 or higher;   Adverse pregnancy outcome: preterm birth;   Adverse pregnancy outcome: low birth weight;   Adverse pregnancy outcome: fetal demise;   Adverse pregnancy outcome: congenital anomalies;   Infant HIV infection status
3 Unknown  Monitoring and Adjustment of Medication Therapy for Patients With Heart Disease
Conditions: Coronary Heart Disease;   Myocardial Infarction
Interventions: Other: Titration of Medications;   Behavioral: Lifestyle Counseling;   Behavioral: Medication Counseling;   Other: Usual Care with Medication Reconciliation
Outcome Measures: Percentage of patients at guideline goal for both blood pressure and lipids;   Composite cardiovascular morbidity and all-cause mortality;   Patient Satisfaction with Clinical Pharmacist Services;   Change in Adherence with 8-item Morisky Adherence Tool
4 Not yet recruiting Clinical Decision Support System for Quality Assurance in Potassium-Increasing Drug-Drug-Interactions
Condition: Hyperkalemia
Intervention: Behavioral: decision support in potassium-inc. drug-drug-interactions
Outcome Measures: Impact on serum potassium monitoring during potassium-increasing drug-drug-interactions;   Frequency of hyperkalemia during potassium-increasing drug-drug-interactions;   Frequency of potassium-increasing drug-drug-interactions ordered in the presence of hyperkalemia;   Frequency of transfers to the ICU during potassium-increasing drug-drug-interactions in function of the serum potassium level;   Frequency of death during potassium-increasing drug-drug-interactions in the presence or absence of hyperkalemia;   Change in frequency distribution of serum potassium monitoring intervals;   Response of physicians to the computer-based alerts and reminders
5 Recruiting The Effect of Medication Reminder Technology on Medication Adherence and Hypertension Outcomes
Conditions: Medication Adherence;   Blood Pressure
Intervention: Device: Medication reminder
Outcome Measures: self-reported medication adherence using the Morisky 8-Item Medication Adherence Scale(MMAS-8) tool;   systolic blood pressure in mmHg using a valid automated device
6 Recruiting Multidisciplinary Program "Optimization of Drug Prescription" : Impact on the Quality of Drug Prescription in Hospitalized Elderly Patients
Condition: Potentially Inappropriate Medications
Intervention: Other: " Optimisation de la Prescription MEDicamenteuse " ("Optimization of drug prescribing")
Outcome Measures: Proportion of potentially inappropriate Medications (PIM) prescribed in discharge of hospitalized patients from 75 years old.;   Total number of drugs prescribed per discharge prescription sheet;   Number of rehospitalization within 12 months following discharge;   Number of emergency admission within 12 months following hospitalization;   Mortality within 12 months after hospitalization
7 Recruiting Multi-Center Medication Reconciliation Quality Improvement Study
Conditions: Adverse Drug Events;   Medication Administered in Error
Intervention: Other: Mentored medication reconciliation quality improvement
Outcome Measures: The primary outcome will be unintentional medication discrepancies in admission orders and discharge orders with potential for patient harm;   Patient satisfaction;   Administrative outcomes
8 Not yet recruiting A Randomized Comparative Effectiveness Research Trial of Three Treatments for COPD Patients
Condition: Pulmonary Disease, Chronic Obstructive
Interventions: Drug: Salbutamol (Ventolin®);   Drug: Formoterol (Oxis Turbuhaler®);   Drug: Salmeterol / fluticasone (Seretide®);   Drug: Bufei granule;   Drug: Bufeijianpi granule;   Drug: Bufeiyishen granule;   Drug: Yiqizishen granule;   Drug: conventional medicine + TCM
Outcome Measures: the frequency of exacerbation;   Forced expiratory volume in one second;   Dyspnea;   6 Minutes Walking Distance Test(6MWD);   Quality of life;   Economic Evaluation
9 Recruiting Improving Communication of Medication Instructions to Parents
Conditions: Medication Errors;   Medication Adherence
Intervention: Other: HELPix
Outcome Measure: Medication dosing error (observed)
10 Recruiting The Effect of a Pharmacist Home Visit on Drug-related Problems Post-discharge.
Conditions: Adverse Drug Event;   Patient Readmission;   Patient Compliance
Intervention: Behavioral: HomeCoMe-program
Outcome Measures: Identifying and solving adverse drug events (ADEs) and other drug-related problems (DRPs) post-discharge;   Improvement of adherence to medication at hospital discharge;   Patient assessment of medication knowledge at time of home visit;   Types of interventions made at the pharmacist home visit;   Patient satisfaction with the pharmacist home visit;   Assessment of patient reported health rating;   General practitioners satisfaction with the pharmacist home visit
11 Not yet recruiting Pharmacists and Pharmacy Technicians to Improve Admission Medication History Accuracy
Condition: Adverse Drug Events
Interventions: Other: Pharmacist obtains admission medication history;   Other: Pharmacy technician obtains admission medication history
Outcome Measure: Medication History Errors, or Medication Order Errors
12 Recruiting the Pharmacy Intervention Team Hospital-based (PITH) for People Study: Effect on Clinical and Economic Outcomes
Conditions: Adverse Drug Reaction;   Medication Administered in Error
Intervention: Other: integrated medicines management
Outcome Measures: number of rehospitalizations;   numbers of ADEs;   numbers of DRPs;   cost per prevented re-hospitalization;   general health care use
13 Recruiting Regional Data Exchange to Improve Medication Safety
Condition: Drug Toxicity
Intervention: Other: Medication reconciliation enhanced by regional health information exchange
Outcome Measures: Transition drug risk;   Adverse drug events;   Care duplication;   Transitional care satisfaction "Care Transitions Measure"
14 Recruiting Comparison of Drug Eluting Balloon and Drug Eluting Stent
Conditions: Coronary Artery Disease;   Stable Angina;   Unstable Angina;   NSTEMI
Interventions: Device: Drug eluting balloon + Bare metal stent;   Device: drug eluting stent (Zotarolimus-eluting stent)
Outcome Measures: in-segment late loss;   stent thrombosis;   angiographic and procedure success;   MACE
15 Not yet recruiting Supplemental Transcranial Magnetic Stimulation (TMS) vs. Standard Medication Monotherapy for Treating Major Depression: An Exploratory Field Study
Condition: 1. Major Depressive Disorder.
Interventions: Device: Supplemental TMS;   Drug: Standard Medication Monotherapy
Outcome Measures: Montgomery-Åsberg Depression Rating Scale (MADRS);   Hamilton Rating Scale for Depression (HRSD)
16 Recruiting Pharmacist-led Medicines Management Outpatient Service
Condition: High Risk of Medication-related Problems
Intervention: Other: Medicines Management Outpatient service
Outcome Measures: Time to readmission to hospital;   Number of Readmission;   Number of GP consultations and GP home visits;   Number of Accident and Emergency (A&E) visits;   Medication Appropriateness Index (MAI) score;   Health-related quality of life (HRQOL);   Medication Adherence Assessments;;   Cost Utility Analysis
17 Unknown  Enhancing the Detection and Management of Adverse Drug Events in Nursing Homes
Condition: Adverse Drug Event
Intervention: Behavioral: Active medication monitoring
Outcome Measures: Adverse drug event detection;   Adverse drug event response time
18 Not yet recruiting ADHD Medication and Predictors of Treatment Outcome
Condition: Attention Deficit Disorder With Hyperactivity (ADHD)
Interventions: Drug: methylphenidate medication;   Drug: atomoxetine medication;   Drug: lisdexamphetamine medication
Outcome Measures: change in SNAP-IV Teacher and Parent rating scale (Swanson, Nolan and Pelham ADHD Rating Scale);   change in P-SEC (Pediatric Side Effects Checklist);   change in CGI-S (Clinical Global Impression- of Severity);   change in C-GAS (Children´s global assessment scale);   change in SNAP-IV Teacher and Parent rating scale;   change in Spence Children's Anxiety Scale (SCAS);   change in heart rate;   change in systolic blood pressure;   change in diastolic blood pressure;   change in weight z-score;   change in height z-score
19 Recruiting Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis for Liberia
Conditions: Lymphatic Filariasis;   Onchocerciasis;   Soil Transmitted Helminth (STH) Infections
Intervention: Drug: Annual versus Semiannual Albendazole plus Ivermectin Mass Drug Administration
Outcome Measures: Microfilaria prevalence based on results of microscopic examination of blood smears and skin snips.;   Prevalence of filarial antigenemia in blood and intensity of filarial and intestinal worm infections based on results of microscopy.
20 Not yet recruiting Observational Study to Reduce Medication Errors
Condition: Medication Errors
Intervention:
Outcome Measures: Number of participants with adverse drug reactions due to medication errors occurring during hospitalization;   Number of participants with preventable ADRs due to medication errors