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BLOOD CHOLESTEROL INCREASED and Zoloft

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BLOOD CHOLESTEROL INCREASED Symptoms and Causes

What is cholesterol?

Cholesterol is a waxy, fat-like substance that's found in all the cells in your body. Your liver makes cholesterol, and it is also in some foods, such as meat and dairy products. Your body needs some cholesterol to work properly. But if you have too much cholesterol in your blood, you have a higher risk of coronary artery disease.

How do you measure cholesterol levels?

A blood test called a lipoprotein panel can measure your cholesterol levels. Before the test, you'll need to fast (not eat or drink anything but water) for 9 to 12 hours. The test gives information about your

  • Total cholesterol - a measure of the total amount of cholesterol in your blood. It includes the two types - low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol.
  • LDL (bad) cholesterol - the main source of cholesterol buildup and blockage in the arteries
  • HDL (good) cholesterol - HDL helps remove cholesterol from your arteries
  • Non-HDL - this number is your total cholesterol minus your HDL. Your non-HDL includes LDL and other types of cholesterol such as VLDL (very-low-density lipoprotein).
  • Triglycerides - another form of fat in your blood that can raise your risk for heart disease, especially in women
What do my cholesterol numbers mean?

Cholesterol numbers are measured in milligrams per deciliter (mg/dL). Here are the healthy levels of cholesterol, based on your age and gender:

Anyone age 19 or younger:

Type of CholesterolHealthy LevelTotal CholesterolLess than 170mg/dLNon-HDLLess than 120mg/dLLDLLess than 100mg/dLHDLMore than 45mg/dL

Men age 20 or older:

Type of CholesterolHealthy LevelTotal Cholesterol125 to 200mg/dLNon-HDLLess than 130mg/dLLDLLess than 100mg/dLHDL40mg/dL or higher

Women age 20 or older:

Type of CholesterolHealthy LevelTotal Cholesterol125 to 200mg/dLNon-HDLLess than 130mg/dLLDLLess than 100mg/dLHDL50mg/dL or higher

Triglycerides are not a type of cholesterol, but they are part of a lipoprotein panel (the test that measures cholesterol levels). A normal triglyceride level is below 150 mg/dL. You might need treatment if you have triglyceride levels that are borderline high (150-199 mg/dL) or high (200 mg/dL or more).

How often should I get a cholesterol test?

When and how often you should get a cholesterol test depends on your age, risk factors, and family history. The general recommendations are:

For people who are age 19 or younger:

  • The first test should be between ages 9 to 11
  • Children should have the test again every 5 years
  • Some children may have this test starting at age 2 if there is a family history of high blood cholesterol, heart attack, or stroke

For people who are age 20 or older:

  • Younger adults should have the test every 5 years
  • Men ages 45 to 65 and women ages 55 to 65 should have it every 1 to 2 years
What affects my cholesterol levels?

A variety of things can affect cholesterol levels. These are some things you can do to lower your cholesterol levels:

  • Diet. Saturated fat and cholesterol in the food you eat make your blood cholesterol level rise. Saturated fat is the main problem, but cholesterol in foods also matters. Reducing the amount of saturated fat in your diet helps lower your blood cholesterol level. Foods that have high levels of saturated fats include some meats, dairy products, chocolate, baked goods, and deep-fried and processed foods.
  • Weight. Being overweight is a risk factor for heart disease. It also tends to increase your cholesterol. Losing weight can help lower your LDL (bad) cholesterol, total cholesterol, and triglyceride levels. It also raises your HDL (good) cholesterol level.
  • Physical Activity. Not being physically active is a risk factor for heart disease. Regular physical activity can help lower LDL (bad) cholesterol and raise HDL (good) cholesterol levels. It also helps you lose weight. You should try to be physically active for 30 minutes on most, if not all, days.
  • Smoking.Cigarette smoking lowers your HDL (good) cholesterol. HDL helps to remove bad cholesterol from your arteries. So a lower HDL can contribute to a higher level of bad cholesterol.

Things outside of your control that can also affect cholesterol levels include:

  • Age and Gender. As women and men get older, their cholesterol levels rise. Before the age of menopause, women have lower total cholesterol levels than men of the same age. After the age of menopause, women's LDL (bad) cholesterol levels tend to rise.
  • Heredity. Your genes partly determine how much cholesterol your body makes. High blood cholesterol can run in families.
  • Race. Certain races may have an increased risk of high blood cholesterol. For example, African Americans typically have higher HDL and LDL cholesterol levels than whites.
How can I lower my cholesterol?

There are two main ways to lower your cholesterol:

  • Heart-healthy lifestyle changes, which include:
    • Heart-healthy eating. A heart-healthy eating plan limits the amount of saturated and trans fats that you eat. Examples include the Therapeutic Lifestyle Changes diet and the DASH Eating Plan.
    • Weight Management. If you are overweight, losing weight can help lower your LDL (bad) cholesterol.
    • Physical Activity. Everyone should get regular physical activity (30 minutes on most, if not all, days).
    • Managing stress. Research has shown that chronic stress can sometimes raise your LDL cholesterol and lower your HDL cholesterol.
    • Quitting smoking.Quitting smoking can raise your HDL cholesterol. Since HDL helps to remove LDL cholesterol from your arteries, having more HDL can help to lower your LDL cholesterol.
  • Drug Treatment. If lifestyle changes alone do not lower your cholesterol enough, you may also need to take medicines. There are several types of cholesterol medicines available, including statins. The medicines work in different ways and can have different side effects. Talk to your health care provider about which one is right for you. While you are taking medicines to lower your cholesterol, you should continue with the lifestyle changes.

NIH: National Heart, Lung, and Blood Institute

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BLOOD CHOLESTEROL INCREASED Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting Sequencing CBT for Child Anxiety: CBT Plus Sertraline Versus Switch to Sertraline
Condition: Anxiety Disorder of Adolescence
Interventions: Drug: Sertraline;   Behavioral: Cognitive Behavioral Therapy
Outcome Measures: Clinical Global Impression Severity & Improvement Scales;   Multidimensional Anxiety Scale for Children
2 Recruiting Optimizing Posttraumatic Stress Disorder Treatment: Prolonged Exposure (PE) Versus PE Plus Sertraline
Condition: Posttraumatic Stress Disorder
Interventions: Behavioral: Prolonged exposure (PE);   Other: PE plus Sertraline
Outcome Measures: Posttraumatic stress disorder (PTSD) Symptoms;   Depression symptoms
3 Recruiting PROlonGed ExpoSure Sertraline
Condition: Posttraumatic Stress Disorder
Interventions: Drug: Sertraline;   Behavioral: Prolonged Exposure Therapy
Outcome Measures: Posttraumatic stress disorder (PTSD) symptoms as measured by the Clinician Administered Posttraumatic Stress Disorder Scale (CAPS);   Posttraumatic stress disorder (PTSD) related psychopathology, including depression, alcohol and substance abuse, and general anxiety
4 Recruiting Chronic Kidney Disease Antidepressant Sertraline Trial
Conditions: Chronic Kidney Disease;   Depression
Interventions: Drug: Sertraline;   Drug: placebo
Outcome Measures: Improvement in depression symptom severity as measured by the QIDS-C-16 score.;   Response to treatment defined as a decline of 50% in the baseline QIDS-C-16 score and remission of depression defined as a QIDS-C-16 score of 5;   Improvement in overall function as assessed by the Work and Social Adjustment Scale;   Improvement in quality of life;   Serious adverse events;   Reduction in platelet aggregation and activation in sertraline vs. placebo group, and whether this reduction correlates with higher plasma sertraline levels.;   Determine if sertraline treatment vs. placebo will improve: a. nutritional status; b. adherence to prescribed medications; c. cognitive functioning; and d. markers of inflammation.
5 Recruiting Adjunctive Sertraline for the Treatment of HIV-Associated Cryptococcal Meningitis
Conditions: Cryptococcal Meningitis;   Fungal Meningitis
Intervention: Drug: Sertraline
Outcome Measures: Survival;   Safety;   Intolerance;   Microbiologic;   Neurocognitive Performance;   Early Fungicidal Activity;   IRIS and Relapse Incidence
6 Unknown  The Influence of the Menstrual Cycle on Lithium and Sertraline Blood Levels
Conditions: Bipolar Affective Disorders;   Cyclothymic Disorder;   Schizoaffective Disorder;   Major Depressive Disorder;   Dysthymic Disorder;   Obsessive-Compulsive Disorder;   Panic Disorder;   Posttraumatic Stress Disorder;   Premenstrual Dysphoric Disorder;   Social Anxiety Disorder
Intervention:
Outcome Measures: blood levels of lithium or sertraline;   Fluctuations in symptom severity;   Correlations between Symptom Severity and Blood Levels of Drugs
7 Recruiting Verapamil vs. Sertraline for Vestibular Migraine & Chronic Subjective Dizziness
Conditions: Vestibular Migraine;   Chronic Subjective Dizziness
Interventions: Drug: Verapamil;   Drug: Sertraline
Outcome Measures: Change in severity of headache and dizziness in Daily Symptom Dairy;   Change in score of Migraine Disability Assessment (MIDAS);   Change in score of Dizziness Handicap Inventory (DHI);   Change in score of Migraine-Specific Quality of Life (MSQ)
8 Recruiting Trial of Sertraline to Treat Children With Fragile X Syndrome
Condition: Fragile X Syndrome
Interventions: Drug: Sertraline;   Drug: Placebo
Outcome Measures: Mullen Scales of Early Learning;   Clinical Global Impression;   Autism Diagnostic Observation Schedule;   Visual Analog Scale;   Eye tracking;   Preschool Language Scale;   Sensory Processing Measure;   Sensory Profile
9 Recruiting Sertraline in Generalized Social Phobia With Co-Occurring Anxiety and Mood Disorders
Conditions: Phobia, Social;   Panic Disorder;   Agoraphobia;   Obsessive-Compulsive Disorder;   Anxiety Disorders;   Major Depressive Disorder
Interventions: Drug: Sertraline;   Drug: Placebo
Outcome Measures: Clinical Global Impression - Improvement ≤ 2;   Liebowitz Social Anxiety Scale [LSAS] (mean change from baseline);   Mean change from baseline on the following scales: Quality of Life and Employment Satisfaction Questionnaire;   Sheehan Disability Scale;   Social Phobia Scale;   Brief Social Phobia Scale;   Penn State Worry Questionnaire;   Panic and Agoraphobia Scale;   Davidson Trauma Scale;   Social Anxiety Spectrum Self-Report (SHY-SR);   Yale-Brown Obsessive Compulsive Scale;   Montgomery-Asberg Depression Rating Scale (MADRS)
10 Recruiting Riluzole Augmentation Pilot in Depression (RAPID) Trial
Condition: Major Depressive Disorder
Interventions: Drug: Riluzole;   Drug: Sertraline;   Other: placebo
Outcome Measures: Mean change in Hamilton Depression Rating Scale (HDRS) score from baseline to endpoint at 8 weeks;   Proportion of patients experiencing an antidepressant response (>50% reduction in HDRS) at endpoint of 8 weeks;   Proportion of patients experiencing remission from depression (HDRS<7) at endpoint of 8 weeks;   Mean change in Hamilton Anxiety Rating Scale (HARS) score from baseline to endpoint at 8 weeks;   Mean change in Clinical Global Impression (CGI) scale from baseline to endpoint at 8 weeks
11 Unknown  The Effects of Sertraline on Depression in Parkinson's Disease
Conditions: Depression;   Parkinson's Disease
Intervention: Drug: Sertraline
Outcome Measures: change from baseline in Hamilton Depression Rating Scale;   change from baseline in questionnaire of PDQ-39
12 Not yet recruiting Antibiotic Treatment and Intravenous Immunoglobulin Trial for PANDAS
Condition: Pandas
Interventions: Drug: Sertraline+Antibiotic (penicillin/azithromycin);   Drug: Sertraline+placebo;   Biological: IVIG
Outcome Measures: The improvement of OC/tic symptoms will be superior in patients treated with SSRI+AB and in case with IVIG, compared with those treated with SSRI+placebo, as assessed by the YBOCS/YGTSS;   The degree of treatment response is expected to correlate with the percentage reduction in antibodies titers following IVIG administration;   The degree of treatment response is also expected to correlate with decreased inflammation in specific regions of the brain, as demonstrated by macroscopic changes and microstructural alterations on MRI and serum and CSF cytokines and chemokines
13 Recruiting Sertraline Pediatric Registry for the Evaluation of Safety (SPRITES)
Condition: Obsessive Compulsive Disorder
Interventions: Drug: sertraline;   Behavioral: psychotherapy
Outcome Measures: change in cognitive function as measured by Trails B (Trail Making Test) and BRIEF (Behavior Rating Inventory of Executive Function) exams;   change in emotional regulation as measured by the emotional regulation factor from the BRIEF (Behavior Rating Inventory of Executive Function) exam;   change in suicide/aggression as measured by the HoNOSCA (Health of the Nation Outcome Scale for Children and Adolescents);   change in physical development as measured by height and weight;   change in pubertal development as measured by the PDS (Pubertal Development Scale);   change in clinical global impression scale -Improvement (CGI-I);   change in clinical global impression scale - Acceptability/Tolerability (CGI-A/T);   change in clinical global impression scale -Effectiveness (CGI-E);   change in clinical global impression scale -Severity (CGI-S);   change in clinical global assessment schedule -(CGAS);   Change in adverse event burden;   suicide-related events as measured by the Columbia-Suicide Severity Rating Scale (C-SSRS)
14 Recruiting Does Vilazodone Help With Antidepressant-associated Sexual Dysfunction?
Conditions: Sexual Dysfunction;   Major Depressive Disorder
Interventions: Drug: Vilazodone;   Drug: Sertraline
Outcome Measure: Changes in Sexual Functioning Questionnaire (CSFQ (c))
15 Unknown  Treatment Strategy to Prevent Mood Disorders Following Traumatic Brain Injury
Condition: Traumatic Brain Injury
Interventions: Drug: Placebo;   Drug: Sertraline
Outcome Measures: Time to onset of DSM-IV defined mood and anxiety disorders; Total Community Integration Questionnaire scores at baseline, 3, and 6 months; Executive function composite will measure cognitive impairment.;   Overt Aggression Scale-Modified total score will quantify the degree of aggressive behavior.;   DSM-IV defined Personality change due to TBI (disinhibited, aggressive or combined types).;   Iowa Gambling Test score will measure the quality of decision making.;   Memory function composite will measure cognitive impairment.;   Neuroimaging variables;   SFE scores will measure the degree of satisfaction with social functioning at one year follow-up.;   Fractional anisotropy of frontal white matter will measure white matter integrity.
16 Recruiting The Role of Dopamine Metabolism in the Antidepressant Effects of Sleep Deprivation and Sertraline in Depressed Patients
Conditions: Major Depressive Disorder;   Bipolar Disorder
Interventions: Other: chronobiological augmentation;   Drug: sertraline, lithium;   Radiation: one night of sleep deprivation and two FDG PET scans
Outcome Measure: Hamilton Rating Score for Depression
17 Recruiting The Effect of Problem Solving Therapy and Antidepressant Therapy on Cerebral Perfusion and Brain Derived Neurotropic Factor (BDNF) in Depressed Elders
Condition: Major Depressive Disorder
Interventions: Behavioral: problem solving therapy;   Drug: Sertraline
Outcome Measures: change in cerebral perfusion;   Change in cognitive measures of memory, learning, and executive dysfunction;   Change in BDNF
18 Unknown  Randomized Double Blinding Controlled Study on" Jia Wei Xiao Yao Jiaonang" Treating Mild to Moderate Major Depressive Disorder
Condition: Depressive Disorder
Interventions: Drug: Sertraline plus placebo of JWXYJN;   Drug: JWXYJN plus placebo of Sertraline
Outcome Measure: HAMD scale
19 Recruiting Brain Markers of Anxiety Disorders and SSRI/CBT Treatment in Children and Adolescents
Conditions: Social Phobia;   Generalized Anxiety Disorder;   Separation Anxiety Disorder
Intervention: Drug: Sertraline
Outcome Measures: Clinical Global Impression (CGI) Scale;   Liebowitz Social Anxiety Scale (LSAS)
20 Unknown  Sertraline vs. Placebo for Symptoms Following Traumatic Brain Injury
Condition: Traumatic Brain Injury
Intervention: Drug: sertraline
Outcome Measures: Gouvier-PCSC;   Post Concussive Scale;   Hamilton Depression Scale;   Montgomery Asberg Depression Rating;   Diagnosis of PCD by DSM-IV;   Smell Identification Test