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BURNING SENSATION and Propranolol

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BURNING SENSATION Symptoms and Causes

What is chlamydia?

Chlamydia is a common sexually transmitted disease. It is caused by bacteria called Chlamydia trachomatis. It can infect both men and women. Women can get chlamydia in the cervix, rectum, or throat. Men can get chlamydia in the urethra (inside the penis), rectum, or throat.

How do you get chlamydia?

You can get chlamydia during oral, vaginal, or anal sex with someone who has the infection. A woman can also pass chlamydia to her baby during childbirth.

If you've had chlamydia and were treated in the past, you can get re-infected if you have unprotected sex with someone who has it.

Who is at risk of getting chlamydia?

Chlamydia is more common in young people, especially young women. You are more likely to get it if you don't consistently use a condom, or if you have multiple partners.

What are the symptoms of chlamydia?

Chlamydia doesn't usually cause any symptoms. So you may not realize that you have it. People with chlamydia who have no symptoms can still pass the disease to others. If you do have symptoms, they may not appear until several weeks after you have sex with an infected partner.

Symptoms in women include

  • Abnormal vaginal discharge, which may have a strong smell
  • A burning sensation when urinating
  • Pain during intercourse

If the infection spreads, you might get lower abdominal pain, pain during sex, nausea, or fever.

Symptoms in men include

  • Discharge from your penis
  • A burning sensation when urinating
  • Burning or itching around the opening of your penis
  • Pain and swelling in one or both testicles (although this is less common)

If the chlamydia infects the rectum (in men or women), it can cause rectal pain, discharge, and/or bleeding.

How do I know if I have chlamydia?

There are lab tests to diagnose chlamydia. Your health care provider may ask you to provide a urine sample. For women, providers sometimes use (or ask you to use) a cotton swab to get a sample from your vagina to test for chlamydia.

Who should be tested for chlamydia?

You should go to your health provider for a test if you have symptoms of chlamydia, or if you have a partner who has a sexually transmitted disease. Pregnant women should get a test when they go to their first prenatal visit.

People at higher risk should get checked for chlamydia every year:

  • Sexually active women 25 and younger
  • Older women who have new or multiple sex partners, or a sex partner who has a sexually transmitted disease
  • Men who have sex with men (MSM)
What are the complications of chlamydia?

In women, an untreated infection can spread to your uterus and fallopian tubes, causing pelvic inflammatory disease (PID). PID can cause permanent damage to your reproductive system. This can lead to long-term pelvic pain, infertility, and ectopic pregnancy. Women who have had chlamydia infections more than once are at higher risk of serious reproductive health complications.

Men often don't have health problems from chlamydia. Sometimes it can infect the epididymis (the tube that carries sperm). This can cause pain, fever, and, rarely, infertility.

Both men and women can develop reactive arthritis because of a chlamydia infection. Reactive arthritis is a type of arthritis that happens as a "reaction" to an infection in the body.

Babies born to infected mothers can get eye infections and pneumonia from chlamydia. It may also make it more likely for your baby to be born too early.

Untreated chlamydia may also increase your chances of getting or giving HIV/AIDS.

What are the treatments for chlamydia?

Antibiotics will cure the infection. You may get a one-time dose of the antibiotics, or you may need to take medicine every day for 7 days. Antibiotics cannot repair any permanent damage that the disease has caused.

To prevent spreading the disease to your partner, you should not have sex until the infection has cleared up. If you got a one-time dose of antibiotics, you should wait 7 days after taking the medicine to have sex again. If you have to take medicine every day for 7 days, you should not have sex again until you have finished taking all of the doses of your medicine.

It is common to get a repeat infection, so you should get tested again about three months after treatment.

Can I prevent chlamydia?

The only sure way to prevent chlamydia is to not have vaginal, anal, or oral sex.

Correct usage of latex condoms greatly reduces, but does not eliminate, the risk of catching or spreading chlamydia.

Centers for Disease Control and Prevention

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BURNING SENSATION Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting Safety and Efficacy of Propranolol Eye Drops in Treating Retinopathy of Premature
Condition: Retinopathy of Prematurity
Intervention: Drug: Propranolol eye drops
Outcome Measures: Incidence rate of progression from stage 2 ROP to more severe stage ROP (stage 2 or 3 with plus, stage 4 and stage 5);   Plasma concentrations of Propranolol at the steady state;   Number of newborns who progress to Stage 3 without plus ROP;   Number of newborns who progress to Stage 4 or 5 ROP with total or partial retinal detachment;   Number of newborns who need laser treatment;   Number of newborns who need rescue treatment with bevacizumab;   Number of newborns who need vitrectomy;   Collection of adverse events due to eye drop Propranolol treatment
2 Not yet recruiting Efficacy of Propranolol Treatment to Prevent Melanoma Progression
Conditions: Stages III Skin Melanoma;   Stages II Skin Melanoma;   Stage IB Skin Melanoma
Interventions: Drug: Propranolol hydrochloride;   Drug: Placebo pill
Outcome Measures: Efficacy of Propranolol on progression free survival for patients suffering from a primary melanoma with a high risk of recurrence;   Use of serum microRNA profile as a predictor for recurrence;   Overall survival
3 Recruiting Propanolol and Red Cell Adhesion Non-asthmatic Children Sickle Cell Disease
Condition: Sickle Cell Disease
Intervention: Drug: Propranolol
Outcome Measures: measurement of the sickle red cell response to epinephrine;   Safety data regarding the use of propanolol in children with sickle cell disease
4 Recruiting Study of Propranolol in Newly Diagnosed Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy
Condition: Locally Advanced Breast Cancer
Interventions: Drug: Propranolol;   Other: Breast imaging - Diffuse Optical Tomography (DOT)
Outcome Measures: Percentage of patients who are compliant with taking > 80% take the drug while on chemotherapy.;   Changes in angiogenesis;   Changes in stress levels;   Number of Patients with Adverse Events;   Change in DOT-derived parameters;   Changes in tumor proliferation
5 Unknown  Propranolol Treatment of Traumatic Memories (PTTM)
Conditions: Traumatic Memory;   Posttraumatic Stress Disorder
Interventions: Drug: Propranolol Hydrochloride;   Drug: Placebo
Outcome Measures: The primary endpoint will be changes between the pretreatment and posttreatment scores in the Clinician Assessment Posttraumatic Scale (CAPS), Impact of Event Scale (IES) and Traumatic Memory Description Measure (TMDM) instruments.;   The secondary endpoint will be changes between the treatment and posttreatment score in the other scales used - MINI, ZAS, ZDS and NIHS.
6 Recruiting Perioperative Propranolol in Patients With Post Traumatic Stress Disorder (PTSD)
Condition: Post-traumatic Stress Disorder
Interventions: Drug: Propranolol Hydrochloride;   Other: Placebo
Outcome Measures: ICU length of stay;   Hospital length of stay;   Postoperative delirium;   Postoperative renal dysfunction;   Perioperative complications;   Pain intensity;   Pain unpleasantness;   Analgesics use;   Length of intubation and mechanical ventilation;   Post Traumatic Stress Disorder symptomatology;   Quality of Life;   Functional status;   Sleep Quality;   Depression symptoms;   Postoperative Neurocognitive Dysfunction Score;   30-day, 3-month, and 1-year mortality;   Postoperative complications
7 Recruiting Efficacy of Clonidine and Propranolol in Dentistry (AAA)
Condition: Anxiety
Interventions: Drug: Clonidine;   Drug: Propranolol;   Drug: Placebo
Outcome Measures: Change from baseline in modified dental anxiety scale(MDAS)and vital signs (blood pressure, heart rate, respiratory rate, oxygen saturation) until four hours post treatment;   Changes in Verbal Numerical Rating Scale (VNRS) at three, six, and twenty-four hours post treatment
8 Unknown  Reducing Reconsolidation of Trauma Memories With Propranolol
Condition: Posttraumatic Stress Disorder
Interventions: Drug: Propranolol;   Drug: Short acting + long acting Propranolol + memory reactivation
Outcome Measures: Electromyogram;   Heart rate;   Skin conductance;   PTSD symptom levels;   Quality of life;   Memory Experience;   Psychophysiological assessments
9 Unknown  Endoscopic Band Ligation (EBL) Versus Propranolol for Primary Prophylaxis of Variceal Bleeding
Conditions: Variceal Bleeding;   Cirrhosis
Interventions: Procedure: Endoscopic band ligation;   Drug: Propranolol;   Procedure: endoscopic band ligation and Propranolol
Outcome Measures: First esophageal variceal bleeding;   Mortality; Significant esophageal variceal bleeding; Upper gastrointestinal bleeding except esophageal bleeding; Adverse events
10 Unknown  A Psychophysiologic Study of Weakening Traumatic Combat Memories With Post-Reactivation Propranolol
Condition: Post-Traumatic Stress Disorder
Intervention: Drug: Propranolol
Outcome Measure: Psychophysiologic responses during script-driven imagery of combat events
11 Unknown  A Novel Treatment For Chronic Posttraumatic Stress Disorder (PTSD) Using Post-Reactivation Propranolol
Condition: Stress Disorders, Post-Traumatic
Intervention: Drug: Propranolol is available in generic form as the Wyeth product under the trade name Inderal.
Outcome Measures: Clinician-Administered PTSD Scale (CAPS) for DSM-IV;   Mini International Neuropsychiatric Interview (MINI);   Peritraumatic Distress Inventory (PDI);   The Peritraumatic Dissociative Experiences Questionnaire;   PTSD Check List (PCL) civilian version;   Script-driven imagery psychophysiological measurement
12 Recruiting Propranolol in Severely Burned Children
Condition: Burn
Interventions: Drug: Propranolol;   Drug: Placebo
Outcome Measures: Resting heart rate multiplied by the systolic blood pressure measurement= rate pressure product;   Number of deaths
13 Recruiting Propranolol Versus Prednisolone for Treatment of Symptomatic Hemangiomas
Condition: Hemangioma of Infancy
Interventions: Drug: Propranolol;   Drug: Prednisolone
Outcome Measures: reduction in size of hemangioma;   Tolerability of medication
14 Recruiting The Safety and Efficiency of Propranolol as an Initial Treatment for Pediatric Hemangioma
Condition: Hemangioma
Interventions: Drug: Prednisolone;   Drug: Propranolol
Outcome Measures: Hemangioma volume measured by MRI or SONO;   Size changes from baseline;   Heart rate change from Baseline at 16 weeks;   Change from Baseline in color;   Changes in Size of Ulceration;   Whether or not Re-epithelized in 16weeks;   Stop time of proliferation;   Time of regression;   Drug compliance within 16 weeks;   Change from Baseline in systolic blood pressure at 16 weeks;   Changes from baseline in Glucose level at 16 weeks;   Whether the facial edema occurs within 16 weeks;   Whether growth retardation occurs within 16 weeks;   Whether the Gastroesophageal reflux occurs within 16 weeks;   Number of Participants with Adverse drug reaction
15 Recruiting Protective Effects of Propranolol in Adults
Condition: Burn
Interventions: Drug: Propranolol;   Drug: Placebo
Outcome Measures: Cardiac rate pressure product;   Mortality rates
16 Recruiting Rifaximin and Propranolol Combination Therapy Versus Propranolol Monotherapy in Cirrhotic Patients
Conditions: Liver Cirrhosis;   Portal Hypertension
Interventions: Drug: Rifaximin + Propranolol;   Drug: Propranolol + Placebo
Outcome Measures: Hepatic vein pressure gradient(HVPG);   occurence of gastrointestinal bleeding
17 Recruiting Efficacy and Safety of Propranolol Versus Acebutolol on the Proliferative Phase of Infantile Hemangioma
Condition: Hemangioma
Interventions: Drug: Acebutolol;   Drug: Propanolol
Outcome Measures: Hemangioma size;   Tolerance of treatment;   Proportion of patients requiring treatment with corticosteroids because of the evolution of a 'serious' hemangioma
18 Recruiting Early Propranolol After Traumatic Brain Injury: Phase II
Condition: Traumatic Brain Injury
Intervention: Drug: Propranolol
Outcome Measure: Determine in patients with traumatic brain injury (TBI) the safe dosing of early Propranolol.
19 Unknown  Propranolol for Diabetic Retinopathy
Condition: Proliferative Diabetic Retinopathy
Intervention: Drug: Propranolol
Outcome Measures: Area of retinal neovascularization on fundus photography;   Retinopathy level in contralateral eye;   Optical coherence tomography macular thickness of treated and fellow eye;   Amount of fluorescein leakage on angiography;   Early Treatment Diabetic Retinopathy Study visual acuity in study and fellow eye
20 Recruiting Treatment of PTSD by Reduction of Traumatic Memory Reconsolidation by Propranolol : a Multisite Trial
Condition: Post-traumatic Stress Disorder
Interventions: Drug: Propranolol;   Other: Trauma reactivation;   Drug: placebo
Outcome Measure: PTCD CheckList (PCL) total score.