Rank |
Status |
Study |
1 |
Recruiting
|
A Study of Cephalexin Capsules in Healthy Participants
Condition: |
Healthy Volunteers |
Intervention: |
Drug: Cephalexin |
Outcome Measures: |
Pharmacokinetics: Area Under the Concentration Versus Time Curve of Cephalexin From Time Zero to Infinity [AUC(0-∞)] of Cephalexin Following a Single Dose; Pharmacokinetics: Maximum Concentration (Cmax) of Cephalexin; Pharmacokinetics: Time to Reach Maximum Observed Concentration (Tmax) of Cephalexin Following a Single Dose Maximum |
|
2 |
Recruiting
|
A Study of Cephalexin in Healthy Participants
Condition: |
Healthy Volunteers |
Intervention: |
Drug: Cephalexin |
Outcome Measures: |
Pharmacokinetics: Area Under the Concentration Versus Time Curve From Time Zero to Infinity [AUC(0-∞)] of Cephalexin Following a Single Dose; Pharmacokinetics: Time to Reach Maximum Observed Concentration (Tmax) of Cephalexin Following a Single Dose Maximum; Pharmacokinetics: Maximum Concentration (Cmax) of Cephalexin |
|
3 |
Recruiting
|
A Study of Cephalexin Suspension in Healthy Participants
Condition: |
Healthy Volunteers |
Intervention: |
Drug: Cephalexin |
Outcome Measures: |
Pharmacokinetics: Area Under the Concentration Versus Time Curve From Time Zero to Infinity [AUC(0-∞)] of Cephalexin Following a Single Dose; Pharmacokinetics: Maximum Concentration (Cmax) of Cephalexin; Pharmacokinetics: Time to Reach Maximum Observed Concentration (Tmax) of Cephalexin Following a Single Dose Maximum |
|
4 |
Not yet recruiting
|
A Study of Cephalexin Liquid for Pediatrics in Healthy Adults Participants
Condition: |
Healthy Volunteers |
Intervention: |
Drug: Cephalexin |
Outcome Measures: |
Pharmacokinetics: Area Under the Concentration Versus Time Curve From Time Zero to Infinity [AUC(0-∞)] of Cephalexin Following a Single Dose; Pharmacokinetics: Time to Reach Maximum Observed Concentration (Tmax) of Cephalexin Following a Single Dose Maximum; Pharmacokinetics: Maximum Concentration (Cmax) of Cephalexin |
|
5 |
Recruiting
|
Comparison of Intravenous Cefazolin Plus Oral Probenecid With Oral Cephalexin for the Treatment of Cellulitis
Condition: |
Cellulitis |
Interventions: |
Drug: IV cefazolin plus oral probenecid and placebo Cephalexin; Drug: Oral Cephalexin and saline IV plus probenecid placebo |
Outcome Measure: |
The proportion of patients failing therapy after 72 hours of antibiotic treatment with oral Cephalexin or intravenous cefazolin plus oral probenecid. |
|
6 |
Recruiting
|
The SCOUT Study: Short Course Therapy for Urinary Tract Infections in Children
Condition: |
Urinary Tract Infections |
Interventions: |
Drug: Trimethoprim sulfamethoxazole, amoxicillin-clavulanate, cefixime, or Cephalexin; Drug: Placebo |
Outcome Measures: |
Occurrence of treatment failures between short-course and standard-course therapies; Occurrence of recurrent infections; Occurrence of colonization with antimicrobial resistant bacteria; Occurrence of asymptomatic bacteriuria; Occurrence of clinical symptoms; Occurrence of positive urine cultures |
|
7 |
Not yet recruiting
|
Orthognathic Surgery and Postoperative Antibiotic Use
Condition: |
Dentofacial Deformity |
Intervention: |
Drug: Cefazolin, Cephalexin, Clindamycin |
Outcome Measures: |
Rate of infection; Side effect from antibiotic use |
|
8 |
Unknown †
|
Prophylactic Use of Antibiotics for Through and Through Lacerations of the Lip
Condition: |
Through-and-through Lip Lacerations |
Interventions: |
Drug: keflex; Drug: placebo |
Outcome Measures: |
infection; scar formation |
|
9 |
Recruiting
|
Antibiotic Prophylaxis for Clean Intermittent Catheterisation
Condition: |
Urinary Tract Infection: [Site Not Specified] or [Recurrent] |
Interventions: |
Drug: Nitrofurantoin or Trimethoprim or Cefalexin; Other: No prophylaxis |
Outcome Measure: |
Relative incidence of symptomatic antibiotic‐treated UTI |
|
10 |
Recruiting
|
The Role of Antibiotics in Full Thickness Skin Graft Survival for Facial Reconstructive Surgery
Condition: |
Facial Defect |
Intervention: |
Drug: Cephalexin |
Outcome Measures: |
Graft failure rate; Percentage surface area of graft failure |
|
11 |
Not yet recruiting
|
Antibiotic Prophylaxis in Prosthetic Breast Reconstructions
Condition: |
Surgical Site Infections |
Interventions: |
Drug: Prolonged antibiotic treatment; Drug: Short antibiotic course (standard of care) |
Outcome Measure: |
surgical site infection |
|
12 |
Unknown †
|
Examination of the Efficacy of Preventive Antibiotic Treatment During the Puerperium Among Pregnant Women With Recurrent Urinary Tract Infections
Condition: |
Pregnancy Complications |
Interventions: |
Drug: Preventive antibiotic treatment- NITROFURANTOIN; Drug: Preventive antibiotic treatment- Cephalexin; Drug: PREVENTIVE TREATMENT- AMOXICILLIN; Drug: PREVENTIVE TREATMENT- AMOXICILLIN AND CLAVULANATE POTASSIUM; Drug: PREVENTIVE TREATMENT- CEFUROXIME; Drug: PREVENTIVE TREATMENT SULFAMETHOXAZOLE AND TRIMETHOPRIM |
Outcome Measure: |
Urinary tract complications |
|
13 |
Recruiting
|
Prevention of Arrhythmia Device Infection Trial (PADIT)
Condition: |
Arrhythmia |
Interventions: |
Drug: Incremental; Drug: Conventional |
Outcome Measures: |
Hospitalization attributed to device infection; 1. Proven device infection not requiring surgical intervention (medically treated device infection).; 2. Any treatment with antibiotics for suspected device infection.; 3. Antibiotic-related adverse events including culture or antigen proven C. difficile infection.; 4. Prolongation of hospitalization due to proven or suspected adverse events from the antibiotic therapy.; Cost benefit analysis; 6. Rate of device/lead extraction 12 months post patient's procedure (regardless of the cause). |
|
14 |
Unknown †
|
Comparing Healthcare Utilization Between Adenotonsillectomy Patients With and Without Postoperative Antibiotic Use
Conditions: |
Snoring; Strep Throat |
Interventions: |
Other: No postoperative antibiotic; Drug: Amoxicillin; Drug: Amoxicillin/clavulanate potassium; Drug: Azithromycin; Drug: Cefaclor; Drug: Cephalexin; Drug: Cefdinir; Drug: Clindamycin |
Outcome Measure: |
Healthcare Utilization |
|
15 |
Recruiting
|
Effects of Treatments on Atopic Dermatitis
Conditions: |
Dermatitis, Atopic; Human Volunteers; Eczema; Atopic Dermatitis |
Interventions: |
Drug: Trimethoprim/sulfamethoxazole; Drug: Cephalexin; Drug: Doxycycline; Other: Sodium hypochlorite (bleach) |
Outcome Measures: |
To characterize microbiome alterations in healthy adult volunteers (Cohorts 1 and 2) and pediatric patients with AD and associated active bacterial infection (Cohort 3) after treatment.; To obtain samples from healthy adult volunteers to evaluate and refine genomic analysis of human microbes. To examine how different treatments may alter the human microbiome. |
|
16 |
Not yet recruiting
|
Antibiotics and Tissue Expanders in Breast Reconstruction
Condition: |
Complications; Breast Prosthesis, Infection or Inflammation |
Intervention: |
Drug: antibiotic |
Outcome Measures: |
Surgical site infection; Surgical site infection requiring implant/expander removal |
|
17 |
Unknown †
|
Moxifloxacin Versus Ceftriaxone in the Treatment of Primary Pyogenic Liver Abscess
Condition: |
Liver Abscess |
Interventions: |
Drug: Moxifloxacin (Avelox); Drug: ceftriaxone (Rocephin/Cefin) |
Outcome Measures: |
Treatment efficacy; Clinical response; Clinical and radiological response; All cause mortality; Mortality attributable to liver abscess during treatment; Rates of complication (metastatic infections to the central nervous system and/or eyes); Rates of gastrointestinal colonization of Klebsiella pneumoniae in patients and rates of resistance post-antibiotic use. |
|
18 |
Not yet recruiting
|
Prophylactic Antibiotic Treatment for Hand Lacerations Involving Flexor and/or Extensor Tendon
Conditions: |
Hand Laceration; Tendon Involved; Clean Laceration; No Bone Involved |
Intervention: |
Drug: Antibiotic-Cefamezin |
Outcome Measure: |
rate of wound infections |
|