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CHEST DISCOMFORT and Propranolol

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CHEST DISCOMFORT Symptoms and Causes

Each year almost 800,000 Americans have a heart attack. A heart attack happens when blood flow to the heart suddenly becomes blocked. Without the blood coming in, the heart can't get oxygen. If not treated quickly, the heart muscle begins to die. But if you do get quick treatment, you may be able prevent or limit damage to the heart muscle. That's why it's important to know the symptoms of a heart attack and call 9-1-1 if you or someone else is having them. You should call, even if you are not sure that it is a heart attack.

The most common symptoms in men and women are

  • Chest discomfort. It is often in center or left side of the chest. It usually lasts more than a few minutes. It may go away and come back. It can feel like pressure, squeezing, fullness, or pain. It also can feel like heartburn or indigestion.
  • Shortness of breath. Sometimes this is your only symptom. You may get it before or during the chest discomfort. It can happen when you are resting or doing a little bit of physical activity.
  • Discomfort in the upper body. You may feel pain or discomfort in one or both arms, the back, shoulders, neck, jaw, or upper part of the stomach.

You may also have other symptoms, such as nausea, vomiting, dizziness, and lightheadedness. You may break out in a cold sweat. Sometimes women will have different symptoms then men. For example, they are more likely to feel tired for no reason.

The most common cause of heart attacks is coronary artery disease (CAD). With CAD, there is a buildup of cholesterol and other material, called plaque, on their inner walls or the arteries. This is atherosclerosis. It can build up for years. Eventually an area of plaque can rupture (break open). A blood clot can form around the plaque and block the artery.

A less common cause of heart attack is a severe spasm (tightening) of a coronary artery. The spasm cuts off blood flow through the artery.

At the hospital, health care providers make a diagnosis based on your symptoms, blood tests, and different heart health tests. Treatments may include medicines and medical procedures such as coronary angioplasty. After a heart attack, cardiac rehabilitation and lifestyle changes can help you recover.

NIH: National Heart, Lung, and Blood Institute

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Propranolol Side Effects

Completed Suicide (157)
Cardiac Arrest (133)
Bradycardia (109)
Hypotension (104)
Overdose (76)
Dizziness (70)
Respiratory Arrest (69)
Dyspnoea (57)
Cardio-respiratory Arrest (57)
Sinus Bradycardia (51)
Toxicity To Various Agents (47)
Circulatory Collapse (45)
Hypoglycaemia (45)
Convulsion (43)
Nausea (41)
Hyperhidrosis (40)
Loss Of Consciousness (38)
Cardiogenic Shock (37)
Death (37)
Fall (37)
Intentional Overdose (37)
Headache (35)
Tachycardia (34)
Hypertension (34)
Fatigue (32)
Palpitations (32)
Heart Rate Decreased (32)
Poisoning (31)
Asthenia (31)
Chest Pain (31)
Blood Pressure Increased (30)
Condition Aggravated (29)
Diarrhoea (29)
Vomiting (29)
Metabolic Acidosis (28)
Suicide Attempt (28)
Malaise (28)
Anxiety (28)
Syncope (27)
Shock (26)
Coma (26)
Weight Increased (25)
Multi-organ Failure (24)
Grand Mal Convulsion (24)
Unresponsive To Stimuli (22)
Tremor (21)
Blood Pressure Decreased (21)
Hypokalaemia (20)
Somnolence (20)
Insomnia (20)

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Recent Reviews

Hi, i have been taken Deralin 40 for migraine i have been experimenting like a low blood pressure at night and also I'm worried of gain weigh because i have back problems what do you think about that

I have been taking 80mg per day for anxiety for two years with no side effects. Three weeks ago my doctor increased my dose to 120mg. After two weeks of being on the higher dose I started to experience head tremors. I went to my doctor who seemed to

I plan to ask my doctor if I can get off it. I am pesenly taking Plavix and baby aspirin as I had surgery for an aneurysm

It makes me feel tired, I have stomach aches and flatulance and diahreae and sometimes dizzy.

Tiredness, dizziness, ligtheaded, diahrea gas and stomach pain :'( >:o :'(

After using Clobetasol for a two week cycle, my doctor suggested I use it one day during the week, applying it twice that day. Since that time, I have experinced severe chest pain. I recently saw my doctor for heart attack symptoms before I reali

After the second day taking Lekoklar XL chest pains started and have not let up (I am on 4th day of medication). My cough has gotten better but temperature is still up and am feeling weaker now than ever.

I am real tired I've been on coreg about two weeks, I don't know if Ican keep taking it. I am so sleepy all the time don't want to do anything my chest hurts. Don't know what to do, if Idon't take it my heart want work right. JUST STUCK

When I eat or drink this burning feeling in my chest going up like I am about vomiting.what is happening? And something I and chest pain too! And I am 14 and a girl

Emotional Anxciety then chest pain, jaw pain on left side and headaches, I am not taking it no more. there has to be something else less tramatising to my system. It was bad enugh that i was at work when the emotional anxiety hit. not cool at all.

Intersting on the Bicor . i have been on it since march this year , starting with 2.5 , then to 5.0 , 7.5 and 10mg for the last 3 months . always felt tired in the increse dosage as advised . but now have had a fe w joint aches , chest pains and cur

Recently in the ultrasound by the radio logist the report says I have mild pyelocaliectasia . I am ok except freqiency in urine at night or when i take rice. There as such no visible sign or discomfort.

>:o Took my first dose today,it left me covered in a red itchy rash on neck,chest,back and sides within 10 minutes of consuming.This product is now sitting in the trash can. :(

When lying down, become chest congested and must get rid of mucous. No or little problem during day. Is this common? does any one else have this. Should I be scared?

one 10 mg pill cuased presure in thechest bad muslespasms in the back think past doses has sent me skizzo

CHEST DISCOMFORT Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting Safety and Efficacy of Propranolol Eye Drops in Treating Retinopathy of Premature
Condition: Retinopathy of Prematurity
Intervention: Drug: Propranolol eye drops
Outcome Measures: Incidence rate of progression from stage 2 ROP to more severe stage ROP (stage 2 or 3 with plus, stage 4 and stage 5);   Plasma concentrations of Propranolol at the steady state;   Number of newborns who progress to Stage 3 without plus ROP;   Number of newborns who progress to Stage 4 or 5 ROP with total or partial retinal detachment;   Number of newborns who need laser treatment;   Number of newborns who need rescue treatment with bevacizumab;   Number of newborns who need vitrectomy;   Collection of adverse events due to eye drop Propranolol treatment
2 Not yet recruiting Efficacy of Propranolol Treatment to Prevent Melanoma Progression
Conditions: Stages III Skin Melanoma;   Stages II Skin Melanoma;   Stage IB Skin Melanoma
Interventions: Drug: Propranolol hydrochloride;   Drug: Placebo pill
Outcome Measures: Efficacy of Propranolol on progression free survival for patients suffering from a primary melanoma with a high risk of recurrence;   Use of serum microRNA profile as a predictor for recurrence;   Overall survival
3 Recruiting Propanolol and Red Cell Adhesion Non-asthmatic Children Sickle Cell Disease
Condition: Sickle Cell Disease
Intervention: Drug: Propranolol
Outcome Measures: measurement of the sickle red cell response to epinephrine;   Safety data regarding the use of propanolol in children with sickle cell disease
4 Recruiting Study of Propranolol in Newly Diagnosed Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy
Condition: Locally Advanced Breast Cancer
Interventions: Drug: Propranolol;   Other: Breast imaging - Diffuse Optical Tomography (DOT)
Outcome Measures: Percentage of patients who are compliant with taking > 80% take the drug while on chemotherapy.;   Changes in angiogenesis;   Changes in stress levels;   Number of Patients with Adverse Events;   Change in DOT-derived parameters;   Changes in tumor proliferation
5 Unknown  Propranolol Treatment of Traumatic Memories (PTTM)
Conditions: Traumatic Memory;   Posttraumatic Stress Disorder
Interventions: Drug: Propranolol Hydrochloride;   Drug: Placebo
Outcome Measures: The primary endpoint will be changes between the pretreatment and posttreatment scores in the Clinician Assessment Posttraumatic Scale (CAPS), Impact of Event Scale (IES) and Traumatic Memory Description Measure (TMDM) instruments.;   The secondary endpoint will be changes between the treatment and posttreatment score in the other scales used - MINI, ZAS, ZDS and NIHS.
6 Recruiting Perioperative Propranolol in Patients With Post Traumatic Stress Disorder (PTSD)
Condition: Post-traumatic Stress Disorder
Interventions: Drug: Propranolol Hydrochloride;   Other: Placebo
Outcome Measures: ICU length of stay;   Hospital length of stay;   Postoperative delirium;   Postoperative renal dysfunction;   Perioperative complications;   Pain intensity;   Pain unpleasantness;   Analgesics use;   Length of intubation and mechanical ventilation;   Post Traumatic Stress Disorder symptomatology;   Quality of Life;   Functional status;   Sleep Quality;   Depression symptoms;   Postoperative Neurocognitive Dysfunction Score;   30-day, 3-month, and 1-year mortality;   Postoperative complications
7 Recruiting Efficacy of Clonidine and Propranolol in Dentistry (AAA)
Condition: Anxiety
Interventions: Drug: Clonidine;   Drug: Propranolol;   Drug: Placebo
Outcome Measures: Change from baseline in modified dental anxiety scale(MDAS)and vital signs (blood pressure, heart rate, respiratory rate, oxygen saturation) until four hours post treatment;   Changes in Verbal Numerical Rating Scale (VNRS) at three, six, and twenty-four hours post treatment
8 Unknown  Reducing Reconsolidation of Trauma Memories With Propranolol
Condition: Posttraumatic Stress Disorder
Interventions: Drug: Propranolol;   Drug: Short acting + long acting Propranolol + memory reactivation
Outcome Measures: Electromyogram;   Heart rate;   Skin conductance;   PTSD symptom levels;   Quality of life;   Memory Experience;   Psychophysiological assessments
9 Unknown  Endoscopic Band Ligation (EBL) Versus Propranolol for Primary Prophylaxis of Variceal Bleeding
Conditions: Variceal Bleeding;   Cirrhosis
Interventions: Procedure: Endoscopic band ligation;   Drug: Propranolol;   Procedure: endoscopic band ligation and Propranolol
Outcome Measures: First esophageal variceal bleeding;   Mortality; Significant esophageal variceal bleeding; Upper gastrointestinal bleeding except esophageal bleeding; Adverse events
10 Unknown  A Psychophysiologic Study of Weakening Traumatic Combat Memories With Post-Reactivation Propranolol
Condition: Post-Traumatic Stress Disorder
Intervention: Drug: Propranolol
Outcome Measure: Psychophysiologic responses during script-driven imagery of combat events
11 Unknown  A Novel Treatment For Chronic Posttraumatic Stress Disorder (PTSD) Using Post-Reactivation Propranolol
Condition: Stress Disorders, Post-Traumatic
Intervention: Drug: Propranolol is available in generic form as the Wyeth product under the trade name Inderal.
Outcome Measures: Clinician-Administered PTSD Scale (CAPS) for DSM-IV;   Mini International Neuropsychiatric Interview (MINI);   Peritraumatic Distress Inventory (PDI);   The Peritraumatic Dissociative Experiences Questionnaire;   PTSD Check List (PCL) civilian version;   Script-driven imagery psychophysiological measurement
12 Recruiting Propranolol in Severely Burned Children
Condition: Burn
Interventions: Drug: Propranolol;   Drug: Placebo
Outcome Measures: Resting heart rate multiplied by the systolic blood pressure measurement= rate pressure product;   Number of deaths
13 Recruiting Propranolol Versus Prednisolone for Treatment of Symptomatic Hemangiomas
Condition: Hemangioma of Infancy
Interventions: Drug: Propranolol;   Drug: Prednisolone
Outcome Measures: reduction in size of hemangioma;   Tolerability of medication
14 Recruiting The Safety and Efficiency of Propranolol as an Initial Treatment for Pediatric Hemangioma
Condition: Hemangioma
Interventions: Drug: Prednisolone;   Drug: Propranolol
Outcome Measures: Hemangioma volume measured by MRI or SONO;   Size changes from baseline;   Heart rate change from Baseline at 16 weeks;   Change from Baseline in color;   Changes in Size of Ulceration;   Whether or not Re-epithelized in 16weeks;   Stop time of proliferation;   Time of regression;   Drug compliance within 16 weeks;   Change from Baseline in systolic blood pressure at 16 weeks;   Changes from baseline in Glucose level at 16 weeks;   Whether the facial edema occurs within 16 weeks;   Whether growth retardation occurs within 16 weeks;   Whether the Gastroesophageal reflux occurs within 16 weeks;   Number of Participants with Adverse drug reaction
15 Recruiting Protective Effects of Propranolol in Adults
Condition: Burn
Interventions: Drug: Propranolol;   Drug: Placebo
Outcome Measures: Cardiac rate pressure product;   Mortality rates
16 Recruiting Rifaximin and Propranolol Combination Therapy Versus Propranolol Monotherapy in Cirrhotic Patients
Conditions: Liver Cirrhosis;   Portal Hypertension
Interventions: Drug: Rifaximin + Propranolol;   Drug: Propranolol + Placebo
Outcome Measures: Hepatic vein pressure gradient(HVPG);   occurence of gastrointestinal bleeding
17 Recruiting Efficacy and Safety of Propranolol Versus Acebutolol on the Proliferative Phase of Infantile Hemangioma
Condition: Hemangioma
Interventions: Drug: Acebutolol;   Drug: Propanolol
Outcome Measures: Hemangioma size;   Tolerance of treatment;   Proportion of patients requiring treatment with corticosteroids because of the evolution of a 'serious' hemangioma
18 Recruiting Early Propranolol After Traumatic Brain Injury: Phase II
Condition: Traumatic Brain Injury
Intervention: Drug: Propranolol
Outcome Measure: Determine in patients with traumatic brain injury (TBI) the safe dosing of early Propranolol.
19 Unknown  Propranolol for Diabetic Retinopathy
Condition: Proliferative Diabetic Retinopathy
Intervention: Drug: Propranolol
Outcome Measures: Area of retinal neovascularization on fundus photography;   Retinopathy level in contralateral eye;   Optical coherence tomography macular thickness of treated and fellow eye;   Amount of fluorescein leakage on angiography;   Early Treatment Diabetic Retinopathy Study visual acuity in study and fellow eye
20 Recruiting Treatment of PTSD by Reduction of Traumatic Memory Reconsolidation by Propranolol : a Multisite Trial
Condition: Post-traumatic Stress Disorder
Interventions: Drug: Propranolol;   Other: Trauma reactivation;   Drug: placebo
Outcome Measure: PTCD CheckList (PCL) total score.