| Rank |
Status |
Study |
| 1 |
Recruiting
|
The Effect of Pirfenidone on Cough in Patients With Idiopathic Pulmonary Fibrosis
| Condition: |
Idiopathic Pulmonary Fibrosis |
| Intervention: |
Other: Cough monitor |
| Outcome Measures: |
Change in Cough frequency measured by Cough recorder at week 12 compared to baseline; Impact of Cough on quality of life; Change in Cough frequency measured by Cough recorder at 4 weeks compared to baseline |
|
| 2 |
Not yet recruiting
|
Comparison of Efficacy and Tolerability of Two Cough Syrups in Cough Due to Cold in Children.
| Conditions: |
Cough; Upper Respiratory Tract Infection |
| Interventions: |
Device: protective Cough syrup; Drug: carbocisteine Cough syrup |
| Outcome Measures: |
reduction in night Cough severity; reduction in day Cough severity |
|
| 3 |
Recruiting
|
Cough Determinants in Mechanically Ventilated Patients
| Condition: |
Mechanical Ventilation |
| Intervention: |
Other: Functional respiratory evaluation |
| Outcome Measures: |
Interest of systematically Cough evaluation before extubation; Correlation between success of extubation and respiratory parameters |
|
| 4 |
Not yet recruiting
|
An Investigation Into the Mechanism of Inhalation Cough Challenge
| Condition: |
Cough |
| Interventions: |
Other: Nebulised citric acid in serial dilutions; Other: Nebulised ATP solution in serial dilutions; Other: Nebulised TRPA1 agonist solution in serial dilutions |
| Outcome Measure: |
Difference in mean C5 (concentration of inhaled substance required to elicit 5 Coughs) between the chronic Cough arm and the normal volunteer arm. |
|
| 5 |
Unknown †
|
Evaluation of Efficacy and Safety in Control Cough and the Relief of Nasal Symptoms in Children 2-12 Years Old,Suffering From Cough and Acute Rhinitis
| Conditions: |
Inflammation; Cough; Rhinitis |
| Interventions: |
Drug: diphenhydramine + dropropizine + pseudoephedrine; Drug: Dropropizine and fixed dose combination of pseudoephedrine hydrochloride + brompheniramine maleate (Dimetapp® elixir). |
| Outcome Measures: |
Improvement of nasal congestion and Cough; Improvement of non-obstructive nasal symptoms; Reduction of the frequency of nighttime awakenings of parent/guardian/roommate of the child; Reduction of vomiting frequency episodes triggered by Coughing; Improvement of acute rhinitis signs; Use of rescue medication; Overall impression of improvement by the investigator; Safety descriptive about occurence of adverse events, evaluation of results of general physical examination. |
|
| 6 |
Not yet recruiting
|
The Use of Capsaicin Challenge for Diagnosis, Monitoring and Follow-up of Chronic Cough.
| Condition: |
Chronic Cough |
| Intervention: |
Other: capsaicin challenge |
| Outcome Measure: |
Cough reflex hypersensitivity |
|
| 7 |
Recruiting
|
Cough Assist in Bronchiolitis
| Conditions: |
Bronchiolitis; Respiratory Syncytial Virus |
| Intervention: |
Device: Cough Assist |
| Outcome Measures: |
Oxygen requirement; Atelectasis; Bronchoscopy; Hypercapnia; Hospitalization length |
|
| 8 |
Recruiting
|
GSK2339345 Hypertussive Challenge Study
| Condition: |
Cough |
| Interventions: |
Drug: GSK2339345; Drug: Placebo |
| Outcome Measures: |
Total Cough counts in Part A.; Number of Coughs following each dose of capsaicin, following a single dose of GSK2339345 or placebo; Number of Coughs following each dose of citric acid, following a single dose of GSK2339345 or placebo; Cough counts following GSK2339345 or placebo at Visits 1, 2 and 3 over shorter epochs (e.g. 1 hour or 15 minute intervals); Urge to Cough visual analogue scale (VAS) 1 hour post-last dose at Visits 1, 2 and 3; Cough severity VAS 1 hour post-last dose at Visits 1, 2 and 3; To assess the safety profile of GSK2339345 versus placebo; The systemic pharmacokinetics (PK) profile of GSK2339345. |
|
| 9 |
Recruiting
|
Physiology of Cough in Asthma: Comparison of Sensory-Mechanical Responses to Mannitol and Methacholine Challenge Tests
| Conditions: |
Asthma; Cough Variant Asthma |
| Interventions: |
Drug: high-dose methacholine challenge test; Other: mannitol challenge test |
| Outcome Measures: |
PD15 (15% fall in forced expiratory volume in one second (FEV1) from baseline during challenge test visits); %ΔFEV1 (percentage change in forced expiratory volume in one second); Plateau response; Dose-response slope; Expiratory Flow Limitation (EFL) |
|
| 10 |
Unknown †
|
Evaluation of the Efficacy and Tolerability of ABO/MEG-B-09 in Children With Acute Cough
| Condition: |
Cough |
| Interventions: |
Device: AboMeg-B-09; Other: Placebo |
| Outcome Measures: |
Cough score variation; Cough reflex sensitivity; Objective breath sounds; The ventilation of the various pulmonary zones; Quality of life |
|
| 11 |
Unknown †
|
Study to Evaluate the Efficacy and Safety of Fixed Dose Combination of Diphenhydramine + Pseudoephedrine + Dropropizine in the Control of Cough and the Relief of Nasal Symptoms, Suffering From Non-productive Cough and Acute Rhinitis
| Conditions: |
Nasal Congestion; Cough |
| Interventions: |
Drug: Group 1; Drug: Group 2 |
| Outcome Measures: |
Primary efficacy criteria; Secondary efficacy criteria |
|
| 12 |
Unknown †
|
Bromelin, a Compound Prepared With Ananas Comocus Extract and Honey, for Acute Cough
| Condition: |
Cough, Acute |
| Interventions: |
Drug: Bromelin; Drug: Placebo |
| Outcome Measures: |
Change in score in a Cough evaluation questionnaire; Change in Occurrence of gastric symptoms |
|
| 13 |
Unknown †
|
Sputum and Plasma Levels of Nociceptin and Substance P in Patients With Asthma, COPD and Chronic Cough
| Conditions: |
Asthma; COPD; Cough |
| Intervention: |
|
| Outcome Measure: |
|
|
| 14 |
Recruiting
|
Comparison Between Oxomemazine, Guaifenesin and Potassium Iodate Versus Guaifenesin Monotherapy in Acute Cough Treatment
| Condition: |
Cough |
| Interventions: |
Drug: Syrup of oxomemazine, guaifenesin and potassium iodate; Drug: Syrup of guaifenesin |
| Outcome Measures: |
Reduction/improvement of Cough symptoms; Tolerance |
|
| 15 |
Unknown †
|
Comparative Efficacy of the Suppository Versus Guaiacol Suppository Versus Guaifenesin Syrup in Pediatric Patients With Cough Due the Infectious Origin
| Condition: |
Cough |
| Interventions: |
Drug: Guaiacol, eucalyptol, menthol and camphor suppository; Drug: guaiacol suppository; Drug: Guaifenesin syrup |
| Outcome Measures: |
Improvement of Cough of infectious origin.; Analysis of parameters for the improvement of infectious Cough. |
|
| 16 |
Recruiting
|
Peak Cough Flow and Cough Clearance
| Condition: |
Duchenne Muscular Dystrophy |
| Intervention: |
|
| Outcome Measure: |
Spontaneous Cough clearance |
|
| 17 |
Unknown †
|
Efficacy and Safety Study of Procaterol Hydrochloride to Treat Patients With Cough Variant Asthma (CVA)
| Condition: |
Cough Variant Asthma |
| Interventions: |
Drug: Procaterol hydrochloride; Drug: Meptin placebo |
| Outcome Measures: |
Patient Cough symptom score; Therapy duration; Rates of adverse events; LCQ Life Quality Score |
|
| 18 |
Recruiting
|
The Effect of Bronchodilator on Eosinophilic Bronchitis and Cough Variant Asthma
| Conditions: |
Eosinophilic Bronchitis; Cough Variant Asthma |
| Intervention: |
Drug: Bambuterol Hydrochloride tablets |
| Outcome Measures: |
Day-time and night-time Cough symptom total-score changes from baseline to day 3.; Cough sensitivity from baseline to day 3 |
|
| 19 |
Recruiting
|
Bronchodilating and Bronchoprotective Effects of Deep Inspirations
| Conditions: |
Asthma; Cough |
| Intervention: |
Other: Methacholine Challenge Testing |
| Outcome Measures: |
Mid expiratory flows; percent fall in FEV1; respiratory system reactance (X5); peripheral resistance (R5-R20); Central airway resistance; Forced vital capacity (FVC); FEV1/FVC |
|
| 20 |
Recruiting
|
Cough and Swallow Rehab Following Stroke
| Condition: |
Ischemic Stroke |
| Interventions: |
Behavioral: Expiratory muscle strength training; Behavioral: Placebo expiratory training; Drug: Measures perfomed on all subjects; Behavioral: Pulmonary function test; Radiation: Fluoroscopic swallow study |
| Outcome Measures: |
Maximum Expiratory Pressure; Cough expiratory airflow |
|
