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DECREASED APPETITE and Promethazine

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DECREASED APPETITE Symptoms and Causes

What is marijuana?

Marijuana is a green, brown, or gray mix of dried, crumbled parts from the marijuana plant. The plant contains chemicals which act on your brain and can change your mood or consciousness.

How do people use marijuana?

There are many different ways that people use marijuana, including

  • Rolling it up and smoking it like a cigarette or cigar
  • Smoking it in a pipe
  • Mixing it in food and eating it
  • Brewing it as a tea
  • Smoking oils from the plant ("dabbing")
  • Using electronic vaporizers ("vaping")
What are the effects of marijuana?

Marijuana can cause both short-term and long-term effects.

Short term:

While you are high, you may experience

  • Altered senses, such as seeing brighter colors
  • Altered sense of time, such as minutes seeming like hours
  • Changes in mood
  • Problems with body movement
  • Trouble with thinking, problem-solving, and memory
  • Increased appetite

Long term:

In the long term, marijuana can cause health problems, such as

  • Problems with brain development. People who started using marijuana as teenagers may have trouble with thinking, memory, and learning.
  • Coughing and breathing problems, if you smoke marijuana frequently
  • Problems with child development during and after pregnancy, if a woman smokes marijuana while pregnant
Can you overdose on marijuana?

It is possible to overdose on marijuana, if you take a very high dose. Symptoms of an overdose include anxiety, panic, and a rapid heartbeat. In rare cases, an overdose can cause paranoia and hallucinations. There are no reports of people dying from using just marijuana.

Is marijuana addictive?

After using marijuana for a while, it is possible to get addicted to it. You are more likely to become addicted if you use marijuana every day or you started using it when you were a teenager. If you are addicted, you will have a strong need to take the drug. You may also need to smoke more and more of it to get the same high. When you try to quit, you may have mild withdrawal symptoms such as

  • Irritability
  • Trouble sleeping
  • Decreased appetite
  • Anxiety
  • Cravings
What is medical marijuana?

The marijuana plant has chemicals that can help with some health problems. More states are making it legal to use the plant as medicine for certain medical conditions. But there isn't enough research to show that the whole plant works to treat or cure these conditions. The U.S. Food and Drug Administration (FDA) has not approved the marijuana plant as a medicine. Marijuana is still illegal at the national level.

However, there have been scientific studies of cannabinoids, the chemicals in marijuana. The two main cannabinoids that are of medical interest are THC and CBD. The FDA has approved two drugs that contain THC. These drugs treat nausea caused by chemotherapy and increase appetite in patients who have severe weight loss from AIDS. There is also a liquid drug that contains CBD. It treats two forms of severe childhood epilepsy. Scientists are doing more research with marijuana and its ingredients to treat many diseases and conditions.

NIH: National Institute on Drug Abuse

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Promethazine Side Effects

Poisoning (63)
Toxicity To Various Agents (47)
Pain (45)
Nausea (37)
Completed Suicide (36)
Cardiac Arrest (36)
Cholecystitis Chronic (36)
Respiratory Arrest (34)
Confusional State (33)
Anxiety (27)
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Injury (20)
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Recent Reviews

1st day was hell, had about every side effect in the book. 2nd day was better, side effects decreased greatly 5th day is going well so far- feeling a little 'edgy & apprehensive' but better than the alternative

40mg per dose 3 days a week Nausea and tiredness and fatigue and loss of appetite 30 mg - doing better But has anyone else experienced a sore tender neck with radiating sore ear jaw and headache

Afater taking glifage for 5 months, stopped because of complete lack of appetite and taste, loss of 20 lbs. and thinking process affected.

After 1 day I developed sevre flu-like body aches and total loss of appetite. It was 4 days before I remembered to read the side effect fact sheet and realized what this drug was putting me through. I had shortness of breath wnen I tried to

After a few weeks on Piascledine, knee and back pain decreased considerably with no side effects noted. Not perfect, but much better. I was walking like an old man.

After a nasty experience with citalapram i was advised by my doc to try mirtazapine and it has suitedme very well. only side effect i canreport is an appetite increase. However as i don't carry much weight that isnt a problem.&

After dealing with nausea for days, total lack of appetite I then started with a temp.of 101.5 and it went up to 103. That lasted for 3 days ( my sinuss infection at this point was cleard up, so I stopped taking the meds. NOW, I am experiencing very

After having stilnoct for atleast 6 months, there is occuring of head heaviness,fever, dry mouth,constipation, lack of appetite.

Age 79, sciatic, pain relief with 2 to 3 per day. slight loss of appetite

Am on Klacid, two tablets daily. Experiencing increase in heart rate, Chest pains, Bitter taste in the mouth day and night; also everything tastes bitter, Lack of appetite, stomach ache, abdominal pains,stomach bloated; tired yet anxious. Sleepless n

DECREASED APPETITE Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Not yet recruiting Study of Promethazine for Treatment of Diabetic Gastroparesis
Condition: Diabetic Gastroparesis
Interventions: Drug: Promethazine;   Drug: Sugar pill
Outcome Measures: Change in patient-reported symptoms as measured by the Gastroparesis Cardinal Symptom Index score (GCSI, 14) from week 0 to week 4.;   Occurrence of adverse events;   Use of rescue medication;   The impact on work activity as measured by the Work Productivity and Activity Impairment Questionnaire. (WPAI).
2 Unknown  Morphine Versus Morphine-Promethazine Combination for Acute Low Back Pain Relief in the Adult Emergency Department
Condition: Low Back Pain
Interventions: Drug: Morphine-Promethazine;   Drug: morphine
Outcome Measures: Pain relief;   Ambulatory status
3 Recruiting Pharmacogenetic Factors and Side Effects of Metoclopramide and Diphenhydramine
Condition: Drug Metabolism, Poor, CYP2D6-RELATED
Interventions: Drug: Diphenhydramine;   Drug: Metoclopramide
Outcome Measures: Area under curve of metoclopramide (MCP);   Area under curve of diphenhydramine(DPH);   Cmax of metoclopramide;   Tmax of metoclopramide;   Cmax of diphenhydramine;   Tmax of diphenhydramine
4 Unknown  Does Thiamine Help Vomiting and Nausea in Pregnancy?
Condition: Hyperemesis Gravidarum
Intervention: Drug: thiamine & Promethazine
Outcome Measure: the improvement in nausea and/or vomiting after treatment
5 Unknown  Adjunct Sedatives in Procedures Involving Endoscopic Ultrasound (EUS) and Endoscopic Retrograde Cholangiopancreatography (ERCP)
Conditions: Endoscopic Ultrasound (EUS);   Endoscopic Retrograde Cholangiopancreatography (ERCP)
Interventions: Drug: Saline;   Drug: Diphenhydramine;   Drug: Promethazine
Outcome Measures: Sedation Level;   Time to achieve adequate level of sedation to begin procedure;   Time for Recovery;   Adverse Symptoms From Sedative Agents
6 Recruiting Diphenhydramine for Acute Migraine
Condition: Migraine
Interventions: Drug: metoclopramide;   Drug: diphenhydramine;   Drug: placebo
Outcome Measure: Sustained headache relief
7 Recruiting Antitussive Effect of a Naturally Flavored Syrup Containing Diphenhydramine, Compared With Dextromethorphan and Placebo
Condition: Cough Reflex Sensitivity
Interventions: Drug: Phenylephrine;   Drug: Diphenhydramine;   Drug: Dextromethorphan
Outcome Measure: change in cough reflex sensitivity to capsaicin
8 Not yet recruiting Diphenhydramine as an Adjunctive Sedative in Patients on Chronic Opioids
Conditions: Colonoscopy;   Adjunct Anesthesia Medication
Interventions: Drug: Diphenhydramine;   Drug: Placebo
Outcome Measures: Dosage of Fentanyl and Midazolam;   Quality of sedation;   Duration of Procedure;   Adverse events;   24 hour follow up
9 Not yet recruiting Randomized Trial of Diphenhydramine Versus Continued Midazolam in "Difficult-to-sedate" Patients Undergoing Colonoscopy
Conditions: Sedation;   Endoscopy
Interventions: Drug: Diphenhydramine;   Drug: Midazolam
Outcome Measure: Proportion of patients who achieve adequate sedation to allow colonoscopy (defined as MOAA/S ≤3)
10 Recruiting Ketamine as a Rapidly-Acting Antidepressant in Depressed Emergency Department Patients
Condition: Depression
Interventions: Drug: Ketamine;   Drug: Diphenhydramine
Outcome Measures: Evaluate the effects of ketamine on depressive symptomatology;   Evalaute the effects of ketamine on treatment alliance;   Evalaute the effects of ketamine on suicidal ideation
11 Not yet recruiting Countermeasures to Reduce Sensorimotor Impairment and Space Motion Sickness Resulting From Altered Gravity Levels
Condition: Vestibular
Interventions: Drug: Promethazine;   Behavioral: Hyper gravity training;   Drug: Placebo;   Behavioral: No hypergravity training
Outcome Measure: Rate of recovery of roll tilt perception errors after exposure to hypergravity
12 Not yet recruiting Histamine Glutamate Antagonism in Stroke
Conditions: Acute Cerebrovascular Accident;   Cerebral Edema
Interventions: Drug: Diphenhydramine;   Drug: Pantoprazole;   Drug: Famotidine;   Drug: Dextromethorphan
Outcome Measures: Modified Rankin Score;   National Institutes of Health Stroke Severity (NIHSS) Scale;   Neurological examination of the subject;   All cause mortality data
13 Not yet recruiting Psilocybin-facilitated Treatment for Cocaine Use
Condition: Cocaine-Related Disorders
Interventions: Drug: Psilocybin;   Drug: Diphenhydramine
Outcome Measure: The difference between the treatment and placebo groups in the number of participants with biochemically verified cocaine abstinence.
14 Recruiting Pazopanib Versus Temsirolimus in Poor-Risk Clear-Cell Renal Cell Carcinoma (RCC)
Condition: Kidney Cancer
Interventions: Drug: Pazopanib;   Drug: Temsirolimus;   Behavioral: Quality of Life Assessment;   Drug: Benadryl
Outcome Measure: Progression Free Survival (PFS)
15 Not yet recruiting First-time-in-man, to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BP1.5375
Condition: Healthy Male Volunteers
Interventions: Drug: BP1.5375 suspension;   Drug: Diphenhydramine;   Drug: Placebo
Outcome Measures: Single Ascending Dose - safety and tolerability (Part 1);   Proof of Concept - effect on polysomnography (Part 2)
16 Not yet recruiting A Double-Blind Trial of Psilocybin-Assisted Treatment of Alcohol Dependence
Condition: Alcohol Dependence
Interventions: Drug: Psilocybin;   Drug: Diphenhydramine;   Behavioral: Motivational Enhancement and Taking Action (META)
Outcome Measures: percent heavy drinking days;   Changes in vital signs;   adverse events;   Percent days abstinent;   drinks per drinking day;   days to first drinking day;   Days to first heavy drinking day;   consequences of drinking;   craving;   self efficacy;   Motivation to change drinking behavior
17 Recruiting Study Looking at End Expiratory Pressure for Altitude Illness Decrease (SLEEP-AID)
Condition: Acute Mountain Sickness
Interventions: Device: Theravent;   Device: Control
Outcome Measures: Incidence of acute mountain sickness;   number of nocturnal desaturations;   acute mountain sickness severity;   nocturnal awakenings;   subjective quality of sleep
18 Recruiting The Role of Intravenous (IV) Lidocaine in the Management of Chronic Neuropathic Pain of Peripheral Nerve Origin
Condition: Neuropathic Pain
Interventions: Drug: Lidocaine;   Drug: Diphenhydramine
Outcome Measures: Changes from Baseline Pain scores on the Visual Analog Scale at 6 weeks;   Hospital Anxiety and Depression Scale;   Modified Brief Pain Inventory;   Leeds Sleep Evaluation Questionnaire;   Patient Global Satisfaction with Treatment and Impression of Change;   Side Effects;   Quality of Life Health Outcome Instrument
19 Recruiting FUS1-nanoparticles and Erlotinib in Stage IV Lung Cancer
Condition: Lung Cancer
Interventions: Drug: DOTAP:Chol-fus1;   Drug: Erlotinib;   Drug: Dexamethasone;   Drug: Diphenhydramine
Outcome Measures: Maximum Tolerated Dose (MTD) Level for Drug Treatment Combination;   Response Rate
20 Unknown  Efficacy and Safety of the Herbal Medicine Sominex ® (Passiflora Incarnata L., Valeriana Officinalis L. and Crataegus Oxyacantha L.), Manufactured by the Laboratory EMS S / A in Patients With Psychophysiological Insomnia
Condition: Insomnia
Interventions: Drug: Sominex;   Drug: Placebo
Outcome Measures: Improvement in sleep efficiency;   Improvement of the values obtained by the answers of the questionnaires obtained during the treatment