DEPRESSION and Amitriptyline


DEPRESSION Symptoms and Causes

Depression is a serious medical illness. It's more than just a feeling of being sad or "blue" for a few days. If you are one of the more than 19 million teens and adults in the United States who have Depression, the feelings do not go away. They persist and interfere with your everyday life. Symptoms can include

  • Feeling sad or "empty"
  • Loss of interest in favorite activities
  • Overeating, or not wanting to eat at all
  • Not being able to sleep, or sleeping too much
  • Feeling very tired
  • Feeling hopeless, irritable, anxious, or guilty
  • Aches or pains, headaches, cramps, or digestive problems
  • Thoughts of death or suicide

Depression is a disorder of the brain. There are a variety of causes, including genetic, biological, environmental, and psychological factors. Depression can happen at any age, but it often begins in teens and young adults. It is much more common in women. Women can also get postpartum Depression after the birth of a baby. Some people get seasonal affective disorder in the winter. Depression is one part of bipolar disorder.

There are effective treatments for Depression, including antidepressants, talk therapy, or both.

NIH: National Institute of Mental Health

Check out the latest treatments for DEPRESSION

DEPRESSION treatment research studies

Amitriptyline clinical trials, surveys and public health registries

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Amitriptyline Side Effects

Completed Suicide (98)
Toxicity To Various Agents (72)
Overdose (61)
Cardiac Arrest (57)
Somnolence (48)
Pain (47)
Convulsion (45)
Anxiety (44)
Headache (44)
Death (42)
Confusional State (40)
Vomiting (40)
Dizziness (39)
Intentional Overdose (39)
Dyspnoea (38)
Loss Of Consciousness (38)
Nausea (35)
Fatigue (35)
Coma (33)
Respiratory Arrest (33)
Depression (32)
Hypotension (31)
Agitation (31)
Hallucination (29)
Malaise (29)
Fall (28)
Cardio-respiratory Arrest (28)
Syncope (27)
Diarrhoea (26)
Insomnia (26)
Tremor (26)
Pyrexia (25)
Grand Mal Convulsion (25)
Delirium (24)
Asthenia (24)
Abdominal Pain (23)
Feeling Abnormal (23)
Suicide Attempt (23)
Dysarthria (22)
Depressed Level Of Consciousness (21)
Constipation (21)
Deep Vein Thrombosis (21)
Electrocardiogram Qt Prolonged (21)
Serotonin Syndrome (21)
Palpitations (21)
Weight Decreased (20)
Gait Disturbance (20)
Dry Mouth (19)
Metabolic Acidosis (19)
Rash (19)

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Recent Reviews

im on amitriptyline 25mg,i have my xmas party this weekend and wanted to drink alchol. i wonder is it a good idea

After having been on elavil for 9 years, mostly at 100mg/night, I spent the last 6 months weaning off. Shortly after stopping amitriptyline I now have high blood pressure. Before stopping, and for years before starting, my usual pressure was 115/65,

Be safe !!

Been on amitrip 25mg at night for 8 nights now and have felt and look alot better. although i have diarrihea now and felt abit of nausea here and there . feel a tad tired throughout the day but i think for me the postives outweigh

Can amitriptyline can cause thrombocytopenia ?

Doc gave me 25mg to help me sleep after quitting the weed. not as good as zoplicone though

Does Amtriptyline help tinnitus. I'm taking it at a low dose for jaw problems and fibromyalgia. the 25 mg dose seems to make my tinnitus worse but my pain better. I don't know what to do?

For the past 18 mnths myfifteen year old takes Pizotifen for migraine.Even on low dose it hasvirtually seen off the migraine episodes and apart from initial tiredness for the first few weeks on it, we are not aware of an

Hey i took 500mg of amitriptyline and overdosed and almost Died.. Dont take that much

Hi i have anxiety an manic depressionbut its all under control nowwith my medication, im having trouble enjoying sex or even getting turned on im not sure if its all in ,my head because of my anxiety i worry bout every l

Zosert was prescribed by my cardilogist, but luckily seeing the side effects in this net, I have not started taking the tabs. Further when I am not having depression, I don't understand, why I have been prescribed this dangerous medicine

Although I have had a lifetime problem with depression (no treatment) I have noticed that since I started taking Zolipdem the depression is much worse even though I am sleeping better.

hi im 14 weeks pregnant and have taken 5mg cipralex for five days now at night for depression and anxiety,i feel better though very sleepy even during the day but im concerned for my unborn baby

Side effects I have from Nadolol are confusion, dizziness, lightheaded, increased depression and anxiety, and mild nausea.

Have just taken my first does of Loxalate 20mg for severe depression

When I read your literature, does it mean that bif vI have major depression and am taking cardizem and have photophobia that vthere is a chance for CHF, and myocarditis and that the medication should be changed? Beta blockers are out of the question

i had pounding heart and severe depression and anxiety while takeing candersartan. im waiting to see a cardioligist to see if i have done any damage. feel so much better now i have stopped takeing them

Thankyou for witing out this article I have been on 120mgs of Zeldox since November 2010 at first it seemed to work and now it has me stuck in a depression state . I was prior to that on olanzapine which held me also in a depressed state I

<span style=' '>Lexapro is a permanent life long cure for any depression if you can survive the treatment.<span style='mso-spacerun: yes;'> I was prompted by a marriage counselor to go to my doctor and requ

<span style='font-family: Calibri; '>I am experiencing severe irritability and moderate depression since I started taking Fenofibrate 160 mg 3 weeks ago, which is not at all normal for me.

DEPRESSION Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting Evaluation of a Stepped Care Approach to Manage Depression in Diabetes
Conditions: Major Depressive Disorder;   Minor Depressive Disorder;   Sub-Threshold Depression;   Diabetes Mellitus
Interventions: Behavioral: Step 1: Diabetes-Specific CBT (5 group sessions);   Behavioral: Step 2: Depression-Specific CBT (6 single sessions);   Behavioral: Step 3: Referral to Psychotherapist and/or Psychiatrist;   Behavioral: Standard Diabetes Education
Outcome Measures: Depressive Mood - Hamilton Rating Scale for Depression (HAMD);   Diabetes-Related Distress - The Problem Areas in Diabetes Questionnaire (PAID);   Psychological/ Emotional Well-Being - The WHO-5 Well-being Index (WHO-5);   Health-Related Quality of Life - The Short Form-36 Health Survey (SF-36);   Diabetes Self-Care Behavior - The Summary of Diabetes Self-Care Activities Measure (SDSCA);   Glycaemic Control (HbA1c);   Health-Related Quality of Life - The EuroQol-5D (EQ-5D);   Diabetes Self-Care Behavior - The Diabetes Self-Management Questionnaire (DSMQ)
2 Recruiting Psychological Mindedness as a Predictor of Success in Cognitive Behavior Therapy for Depression
Conditions: Major Depressive Disorder;   Dysthymia
Intervention: Behavioral: Cognitive Behavior Therapy for Depression
Outcome Measure: Level of Depression as measured by the Hamilton Rating Scale for Depression
3 Recruiting Depression Management at the Workplace
Condition: Depression
Interventions: Other: Depression Product Detailing;   Other: Depression HEDIS detailing
Outcome Measures: employer purchase of Depression management product;   fidelity of Depression management model purchased to evidence-based models
4 Recruiting New Clinical Applications for Internet-based Cognitive Behavior Therapy for Insomnia and Depression
Conditions: Insomnia;   Major Depression;   Minor Depression
Interventions: Behavioral: Therapist guided Internet-CBT for insomnia w. extra support;   Behavioral: Therapist guided Internet-CBT for insomnia;   Behavioral: Therapist guided Internet-CBT for insomnia and Depression;   Behavioral: Therapist Guided Internet-CBT for Depression plus insomnia placebo
Outcome Measures: Change (from baseline) in Insomnia Severity Index (ISI);   Change (from baseline) in Montgomery Asberg Depression Rating Scale, MADRS-S;   Change (from baseline) in Sleep Diary;   Changes (from baseline) in Actigraph data;   Change (from baseline) in Trimbos and Institute of Medical Technology Assessment Cost Questionnaire for Psychiatry (TIC-P);   Change (from baseline) in Cognitive functioning;   Change (from baseline) in EuroQuol. EQ-5D;   Change (from baseline) in Sheehan Disability Scale;   Change (from baseline) in Clinical Outcome in Routine Evaluation - 10, CORE-OM
5 Not yet recruiting Blended Collaborative Care for Heart Failure and Co-Morbid Depression
Conditions: Heart Failure, Systolic;   Depression;   Cardiovascular Disease
Interventions: Behavioral: Collaborative Care for Heart Failure;   Behavioral: Collaborative Care for Depression
Outcome Measures: Medical Outcomes Study (MOS) 12-Item Short Form Health Survey Mental Component Summary (SF-12 MCS);   Kansas City Cardiomyopathy Questionnaire (KCCQ-12);   Hamilton Rating Scale for Depression (17-Item);   Incidence of Rehospitalization;   Mortality;   Health Care Costs;   Employment
6 Recruiting Prevalence Study of Depression in Chinese Patients With Type 2 Diabetes (HK13)
Conditions: Diabetes;   Depression
Interventions: Other: Psychiatrist Interview;   Other: Depression screening - control
Outcome Measures: Depression and psychological well-being;   Percentage of patients who attain 2 or more of the 'ABC' targets;   Self care and Efficacy;   Quality of life
7 Recruiting Can Genetics Predict Treatment Response to a Computerized Self-help Program for Depression?
Conditions: Major Depressive Disorder;   Mood Disorders
Intervention: Behavioral: Computerized self-help program for Depression
Outcome Measures: Quick Inventory of Depressive Symptomatology (Self-Report) (QIDS-SR-16);   Hamilton Depression Rating Scale (HAM-D);   Inventory of Depression and Anxiety Symptoms (IDAS);   Psychiatric Diagnostic Screening Questionnaire (PDSQ);   Risky Families Questionnaire (RFQ);   Massachusetts General Hospital Antidepressant Treatment History Questionnaire (ATRQ);   Sheehan Disability Scale (SDS)
8 Recruiting Management of Depression in Primary Care
Condition: Depression
Intervention: Behavioral: Structured patient-centered follow up of Depression
Outcome Measures: Change in Depressive symptoms;   Change in Quality of life;   Prescriptions for antidepressants;   Change in Activity/work ability;   sick-listing data
9 Unknown  Low Intensity Versus Self-guided Internet-delivered Psychotherapy for Major Depression
Condition: Depression
Interventions: Other: Low Intensity Internet-delivered psychotherapy;   Other: Self-guided Internet delivered psychotherapy;   Other: Improved treatment as usual
Outcome Measures: Severity of depressive symptomatology measured by Beck Depression Inventory II;   Socio-demographic variables.;   Mini-International Neuropsychiatric Interview (MINI).;   EuroQoL-5D questionnaire (EQ-5D - Spanish version);   Client Service Receipt Inventory - adapted (CSRI - Spanish version);   Overall Depression Severity and Impairment Scale;   Positive and Negative Affect Scale (PANAS);   Credibility/expectancy questionnaire
10 Recruiting Study of Web- Based Cognitive Behavioral Therapy for Depressed Korean Adolescents
Conditions: Depression;   Mental Disorder in Adolescence;   Cognitive Behavioral Therapy
Interventions: Behavioral: web-based CBT;   Behavioral: supportive care
Outcome Measures: The Center for Epidemiological Studies of Depression (CES-D) Scale;   Subjective depressed mood scale;   The Korean youth self report (K-YSR);   Acceptability and adherence of Web-based cognitive behavioral treatment program for adolescents with Depression;   satisfaction of Web-based cognitive behavioral treatment program of both adolescents with Depression and their parents;   Columbia suicide severity rating scale;   Adolescent's characteristics that moderate the impact of the program
11 Not yet recruiting Healthy Moms-Healthy Kids: Reducing Maternal Depression for Better Outcomes in Head Start Children
Conditions: Maternal Depression;   Parenting Behavior;   Health;   Interpersonal Relationships;   Goal Directed Behavior,;   Child Behavior;   Child School Readiness
Intervention: Behavioral: Interpersonal Psychotherapy for Depression -Group
Outcome Measure: Beck Depression Inventory
12 Not yet recruiting A Family Depression Prevention Program
Condition: Depression
Interventions: Behavioral: Family Cognitive Behavioral Prevention;   Behavioral: Written information
Outcome Measures: In children, the primary outcome is onset of a depressive episode. In parents, the primary outcome is time in a depressive episode.;   Parents: Patient Health Questionnaire - 9 (PHQ-9);   Children: Youth Self-report (YSR) anxiety/Depression subscale
13 Unknown  Outcome of Postnatal Depression Screening Using Edinburgh Postnatal Depression Scale
Condition: Depression, Postpartum
Intervention: Procedure: Edinburgh Postnatal Depression Scale
Outcome Measures: Mother's mental health at 6 months postpartum, as measured on the EPDS and General Health Questionnaire-12 (GHQ-12), both being self-report questionnaires.;   Mother's parenting stress (measured by the Parenting Stress Index, a self-report questionnaire);   Marital relationship satisfaction (measured by the Chinese Kansas Marital Satisfaction Scale, a self-report questionnaire);   Marital status and employment status (both father and mother, where applicable) at 6 and 18 months postpartum;   Child health measures, including weight at 6 and 18 months, number of hospitalizations and visits to doctors within the first 6 and 18 months as reported by mother;   Mother's mental health outcome (EPDS and GHQ scores) at 18 months postpartum
14 Not yet recruiting African American Depression Intervention Trial (AADI)
Condition: Major Depressive Disorder
Intervention: Behavioral: Coping with Depression Course (CWD) and Oh Happy Day Class (OHDC)
Outcome Measures: Center for Epidemiologic Studies Depression Scale (CES-D);   Quick Inventory of Depressive Symptomatology (QIDS)
15 Not yet recruiting A Family-based Primary Care Intervention to Enhance Older Men's Depression Care
Condition: Major Depression
Interventions: Behavioral: Family-based Depression intervention;   Behavioral: Usual care plus educational materials
Outcome Measures: Depressive symptoms;   Medication adherence;   Family caregiver satisfaction;   Health-related functional disability;   Family self-management support
16 Unknown  Evaluating the Efficacy of Adjunctive Minocycline for the Treatment of Bipolar Depression
Conditions: Bipolar Disorder;   Bipolar Depression;   Bipolar I Depression;   Bipolar II Depression
Intervention: Drug: Minocycline
Outcome Measures: Change from baseline to week 8 on the Montgomery Asberg Depression Rating Scale (MADRS);   Change from baseline to week 8 on the Hamilton Depression Rating Scale 17-item (HAMD-17);   Change from baseline to week 8 on the Somatic Symptom Inventory (SSI);   Change from baseline to week 8 on the Clinical Global Impression (CGI) Rating Scale;   Change from baseline to week 8 in the in neurocognitive function;   Monitoring of Side-effects from baseline to week 8 with the Toronto Side Effect Scale (TSES);   Monitoring of suicide severity from baseline to week 8 with the Columbia Suicide Severity Rating Scale (C-SSRS).;   Change from baseline to week 8 in concentrations of pro-and anti-inflammatory cytokines (i.e. TNFα, IL-1β, IL-2, IL-6, IL8, IFNγ, IL-4, IL-5, IL-10)
17 Recruiting Phenotype Depression Study
Condition: Major Depressive Disorder
Outcome Measures: We are using clinician administered and self report psychiatric measurements to compare relevant symptom domains in patients with major Depression and increased inflammation versus patients with major Depression without increased inflammation.;   We are measuring immune markers for the identification of relevant immunologic patterns of activation in patients with major Depression and increased inflammation versus patients with major Depression without increased inflammation.
18 Not yet recruiting Evaluation of an Integrated Microfinance and Depression Care Program for Women
Conditions: Depression;   Anxiety
Interventions: Behavioral: LIFE-DM;   Drug: Guideline Antidepressant Care
Outcome Measures: Change in Patient Health Questionnaire-9;   Change in MINI Diagnostic Interview;   Change in Quality of Life Enjoyment and Satisfaction Questionnaire;   Change in Self-Efficacy;   Change in Medical Outcome Study (MOS)-Social Support Survey;   Change in Medical Outcomes Study (MOS) 12-Item Short Form Health Survey (SF-12);   Change in Generalized Anxiety Disorder (GAD-7);   Change in Behavior Activation for Depression Scale (BADS);   Change in income
19 Recruiting Fevarin® Effectiveness in Treatment of Depression in Patients With Neurological Disorder
Condition: Depression
Outcome Measures: Prevalence of different neurological disorders associated with Depression treated with fluvoxamine (Fevarin®).;   Demographics of patients (age, gender, race, family status, education, employment).;   Change in the Hospital Anxiety and Depression Scale (HADS) Depression Subscale Score;   Number and proportion of patients with Depression symptoms change measured by Hospital Anxiety and Depression Scale (HADS);   Change in the Hospital Anxiety and Depression Scale (HADS) Anxiety Subscale Score;   Global severity of illness and change in the clinical condition measured by Clinical Global Impression scale;   Number and proportion of patients with change in Clinical Global Impression scale;   Anxiety and Depression symptoms score measured by Hospital Anxiety and Depression Scale (HADS);   Number and proportion of patients with anxiety symptoms change measured by Hospital Anxiety and Depression Scale (HADS)
20 Recruiting Bending Adolescent Depression Trajectories Through Personalized Prevention
Condition: Depression
Interventions: Behavioral: Interpersonal Psychotherapy- Adolescent Skills Training;   Behavioral: Coping with Stress
Outcome Measures: Presence of a Major Depressive Episode or Dysthymia on the Schedule for Affective Disorders for School Aged Children - Present and Life Time Version (K-SADS-PL);   Presence of A Major Depressive Episode or Dysthymia on the Schedule for Affective Disorders for School Aged Children - Present and Life Time Version (K-SADS-PL);   Children's Depression Inventory (CDI);   Children's Global Assessment Scale (CGAS)