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DIABETES MELLITUS and SPIRONOLACTONE

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DIABETES MELLITUS Symptoms and Causes

Diabetes is a disease in which your blood glucose, or blood sugar, levels are too high. Glucose comes from the foods you eat. Insulin is a hormone that helps the glucose get into your cells to give them energy. With type 1 diabetes, your body does not make insulin. With type 2 diabetes, the more common type, your body does not make or use insulin well. Without enough insulin, the glucose stays in your blood. You can also have prediabetes. This means that your blood sugar is higher than normal but not high enough to be called diabetes. Having prediabetes puts you at a higher risk of getting type 2 diabetes.

Over time, having too much glucose in your blood can cause serious problems. It can damage your eyes, kidneys, and nerves. Diabetes can also cause heart disease, stroke and even the need to remove a limb. Pregnant women can also get diabetes, called gestational diabetes.

Blood tests can show if you have diabetes. One type of test, the A1C, can also check on how you are managing your diabetes. Exercise, weight control and sticking to your meal plan can help control your diabetes. You should also monitor your blood glucose level and take medicine if prescribed.

NIH: National Institute of Diabetes and Digestive and Kidney Diseases

Check out the latest treatments for DIABETES MELLITUS

DIABETES MELLITUS treatment research studies

SPIRONOLACTONE clinical trials, surveys and public health registries


Find Drug Side Effect reports



SPIRONOLACTONE Side Effects

Hyperkalaemia (208)
Renal Failure Acute (103)
Dyspnoea (81)
Dehydration (59)
Asthenia (56)
Gynaecomastia (55)
Diarrhoea (52)
Nausea (50)
Blood Potassium Increased (50)
Blood Creatinine Increased (48)
Fatigue (46)
Hypotension (43)
Renal Failure (41)
Dizziness (40)
Pain (37)
Bradycardia (36)
Vomiting (33)
Hyponatraemia (33)
Oedema Peripheral (31)
Atrial Fibrillation (28)
Renal Impairment (28)
Condition Aggravated (27)
Malaise (26)
Chest Pain (25)
Cardiac Failure (25)
Cough (25)
Fall (25)
Anaemia (24)
Pyrexia (23)
Pruritus (23)
Back Pain (22)
Rash (22)
Death (21)
Hypertension (21)
Blood Urea Increased (20)
Anxiety (20)
Blood Pressure Decreased (20)
Cardiac Failure Congestive (20)
Headache (20)
Weight Increased (19)
Pulmonary Embolism (18)
Blood Pressure Increased (18)
Breast Pain (18)
Confusional State (17)
Weight Decreased (17)
Hypokalaemia (17)
Syncope (16)
Pneumonia (16)
Myocardial Infarction (16)
Oedema (15)

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Abilify (10132)
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Recent Reviews

How long do you have to keep taking it?

I am a female patient from NY, age 33. I am being treated for Hashimoto Thyroiditis with Synthroid and Cytomel. I was concerned that after 11 years since my diagnosis, my hair is still falling out at an alarming rate. My doctor noticed that my testos

I received an injection of zostavax in August 2005 and approx 3 months later I was diagnosed with TYPE 1 DIABETES. No one in my entire family history has ever had diabetes. I was and still am 185 lbs.

I started taking Spiro A YEAR AGO for my adult acne that no other medications have successfully treated. Spiro dried up all my oil and cleared my skin in 2 months! I have also gotten bigger breasts (but no complaints,here). The only downsides a

I was on Spironolactone (12.5 daily) . Hindsight, almost immediately I began suffering from ED. Mixed symptoms thought at the time from Diabetes T2 . Was also on Ace Inhibitors, Digoxin, Ibuprofenm Furosemide. After 18 months suddenly developed M

I'm 27 f female from aust, i have been taking spironolactone for about four months now. I have been prescribed this due to hair loss (thining really quickly) and i have found it to be amazing! I have been having mood swings as a result and headache

Mid morningstablets of 25 mg working very well at reducing excess water -edema-but have bouts of diarrhorea

Painful intercorse

Hello, I was given Azastin or Avastin for macular edema. I also have retinopathy from diabetes. I was given this shot in my eye in April of this yr. Within 2 days, I had cellulitis in both legs. Horrible pain. Dark red all over from my knees to my

Another thing, can a patient with diabetes type 1 and previously suffered and recovered from Multiple sclerosis ( M-S ) use Spasfon ???

Before I took atenolol i had a perfect glucose numbers after taking it I came down with diabetes. I am 102lbs, 4'11, have always eaten healthy, exercise my whole life. I am 76. I was taken off atenolol after5 years...and NO ONE in my family for ge

Burning sensation, confusion, mental states changes, lethargy, chest pain, pain, communication difficulty.88 years old with astma, high blood pressure, diabetes, prostate enlargement,

Can I take ciprofloxacin with my medicines for diabetes

Can taking of Neuleptil unregularely by father couse a 1st level diabetes for his son?

Dont get discouraged, I am 21 years old and got diagnosed with diabetes when i was 15. I hated it for a little while then i thought well i have to live with it so i better make the best of it. I, just like anyone, wanted to live an ordinary teen life

Good effects on diabetes. weight reduction -rapid and moderate to excessive hair fall after 3 months of use

Hi, I'm 21 years old, recently released from the hospital for possible brain infection (took a variety of antibiotics and anti-virals). I have possible diabetes and I recently developed tinnitus I think, and the possible causes for it is my prolonged

I am 14 and type one diabetic, and i just want it to go away so i can live a normal happy life, i would like to drink to see what its like (typical teen) but i really dont want diabetes , so i don't really care about it, my mum and dad get worried be

DIABETES MELLITUS Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting Effects of Spironolactone on Collagen Metabolism in Patients With Pulmonary Arterial Hypertension
Condition: Pulmonary Hypertension
Interventions: Drug: Spironolactone;   Drug: Placebo
Outcome Measures: Change in biomarker levels in the Spironolactone treated as compared to placebo treated group.;   Number of adverse events in patients treated with Spironolactone as compared to placebo.;   Change in six-minute walk distance from baseline to week 8 and week 16.;   Composite end-point
2 Recruiting Acetazolamide and Spironolactone to Increase Natriuresis in Congestive Heart Failure
Condition: Heart Failure
Interventions: Drug: Combination therapy with acetazolamide and low-dose loop diuretics;   Drug: High-dose loop diuretics;   Drug: Upfront therapy with oral Spironolactone
Outcome Measures: Acetazolamide arm: natriuresis 24 h;   Spironolactone arm: incidence of hypo- (serum potassium <3.5 mmol/L) or hyperkalemia (serum potassium >5.0 mmol/L);   NT-proBNP change after 72 h;   Worsening renal function;   Persistent renal impairment;   Peak plasma aldosterone concentration after 72 h;   Peak plasma renin activity after 72 h
3 Recruiting Determining the Effect of Spironolactone on Electrolyte Supplementation in Preterm Infants With Chronic Lung Disease
Conditions: Chronic Lung Disease;   Bronchopulmonary Dysplasia
Interventions: Drug: Spironolactone;   Drug: Placebo
Outcome Measures: Dose of potassium chloride in milliequivalents/kg/day;   Requirement of electrolyte supplementation;   Analyze the use of furosemide rescue doses;   Number of furosemide doses utilized;   Escalation in respiratory support
4 Unknown  Effects of Spironolactone in Dialysis
Condition: Renal Failure
Intervention: Drug: Spironolactone
Outcome Measures: Reduction of Left Ventricular Hypertrophy;   To evaluate the safety and efficacy of the use of Spironolactone at a dose of 25mg in patients with chronic kidney disease on hemodialysis.
5 Unknown  Spironolactone for Paroxysmal Atrial Fibrillation
Condition: Atrial Fibrillation
Interventions: Drug: Spironolactone;   Drug: Placebo
Outcome Measures: time to a first electrocardiographically confirmed AF;   1. Response rate: Improvement of any symptom scores and/or SF36 scores more than 50 % (compared with re-randomization scores) 2. Difference of mean episodes of documented AF between the Spironolactone and placebo groups.
6 Not yet recruiting L-Arginine and Spironolactone Trial in Dialysis-Dependent ESRD
Conditions: End Stage Renal Disease;   Hemodialysis
Interventions: Drug: Spironolactone;   Dietary Supplement: L-arginine;   Drug: Placebo
Outcome Measures: Change in coronary Flow Reserve (PET);   Change in left ventricular diastolic function;   Association between coronary flow reserve (CFR) and tissue doppler index (E');   Change in resting myocardial blood flow;   Change in left ventricular mass index;   Change in coronary vascular resistance;   Association between change in coronary flow reserve (CFR) and change in diastolic function-tissue doppler index (E');   Change in early diastolic function (E');   Combined cardiovascular safety;   Cardiovascular death;   Hyperkalemia;   Hypotension;   Change in early coronary flow reserve;   Change in hyperemic myocardial blood flow
7 Recruiting The Effect of Spironolactone on Pain in Older People With Osteoarthritis
Condition: Osteoarthritis, Knee
Intervention: Drug: Spironolactone
Outcome Measures: Between group difference in change in WOMAC pain subscale (5 items);   Between group difference in change in WOMAC stiffness subscale.
8 Unknown  Effect of Spironolactone on Adrenal or Ovarian Androgen Production in Overweight Pubertal Girls With Androgen Excess
Conditions: Obesity;   Hyperandrogenemia;   Polycystic Ovary Syndrome
Interventions: Drug: Spironolactone;   Drug: Dexamethasone;   Drug: Cosyntropin;   Drug: r-hCG (Ovidrel)
Outcome Measures: Changes in free testosterone and 17 OH progesterone levels after ACTH and r-hCG administration respectively, before and after Spironolactone administration for 12 weeks;   Changes in adrenal and ovarian steroid precursors after ACTH and r-hCG; body composition via air displacement plethysmography, BMI, and glucose tolerance testing results; baseline and after 12 weeks of Spironolactone administration
9 Recruiting Use of Spironolactone for the Prevention of Electrolyte Abnormalities in Patients Treated With Amphotericin B
Condition: Patients With Indications for AmB Treatment
Interventions: Drug: Spironolactone 100mg;   Drug: Spironolactone 200mg;   Drug: Placebo
Outcome Measures: Incidence of hypokalemia ≤3.5mEq/L;   Average potassium supplementation;   Incidence of hyperkalemia;   Acute kidney injury;   Incidence of renal tubular damage;   Incidence of hypomagnesemia
10 Unknown  Effect of Spironolactone in Treating Chronic Non-resolutive Central Serous Chorioretinitis
Condition: Central Serous Chorioretinitis
Interventions: Drug: Spironolactone;   Drug: Placebo
Outcome Measure: Change in Central macular thickness
11 Recruiting Spironolactone in Adult Congenital Heart Disease
Conditions: Congenital Heart Disease;   Heart Failure;   Endomyocardial Fibrosis
Interventions: Drug: Spironolactone;   Other: Placebo
Outcome Measures: "Fibrosis Index" or the volume of distribution of gadolinium in the myocardium measured by MRI.;   PCIIINP, PCINP, MMP-2, TIMP-1, 6-minute walk distance, ejection fraction, and degree of diastolic function
12 Unknown  Addition of Spironolactone in Patients With Resistant Arterial Hypertension
Condition: Hypertension
Intervention: Drug: Spironolactone
Outcome Measures: Average daytime systolic and diastolic blodd pressure evaluated by ABPM (ambulatory blood pressure monitoring);   changes of serum potassium, natrium, creatinine, body weight, casual blood pressure in office, treatment response for different baseline levels of aldosterone and aldosterone/PRA ratio
13 Recruiting Comparison of Effects of Eplerenone Versus Spironolactone in Heart Failure Patients With Glucose Intolerance or Type 2 Diabetes
Conditions: Heart Failure;   Type 2 Diabetes;   Glucose Intolerance
Interventions: Drug: Eplerenone;   Drug: Spironolactone
Outcome Measures: Glycated hemoglobin;   Fasting glucose and lipid profile;   Plasma insulin;   Cortisol;   Adiponectin;   NT-proBNP;   PIIINP
14 Unknown  Efficacy of Therapy With the Spironolactone Pills Compared to Minoxidil Lotion in Female Pattern Hair Loss
Condition: Female Pattern Hair Loss
Interventions: Drug: Spironolactone;   Drug: Minoxidil
Outcome Measures: hair density;   percentage of subjects who experience side effects;   subject assessment of treatment effect
15 Recruiting Spironolactone for Pulmonary Arterial Hypertension
Condition: Pulmonary Arterial Hypertension
Interventions: Drug: Spironolactone;   Drug: Placebo
Outcome Measures: Change in placebo corrected 6-minute walk distance;   Clinical worsening;   Change in placebo corrected VO2 max;   Change in right ventricular function;   Biomarkers of vascular inflammation;   Rate of study drug discontinuation due to hyperkalemia, renal insufficiency, or other side effects such as breast pain and gynecomastia
16 Recruiting Mineralocorticoid Receptor Antagonists in End Stage Renal Disease
Condition: End Stage Renal Disease / Hemodialysis
Intervention: Drug: Spironolactone
Outcome Measures: Left Ventricular Mass Index;   Cardiac function parameters;   Office and 24h blood pressure;   Clinical measures of heart failure severity;   Vascular function;   Biomarkers of heart failure, inflammation and fibrosis;   Quality of Life;   Cardiac death and/or hospitalization for heart failure;   Safety measures
17 Recruiting ALdosterone Antagonist Chronic HEModialysis Interventional Survival Trial
Condition: End Stage Renal Failure on Dialysis
Interventions: Drug: Spironolactone;   Drug: Placebo
Outcome Measures: The time to onset of the first incident :non-fatal MI or hospitalization for heart failure or nonfatal stroke or cardiovascular (CV) death;   The cumulate rate of nonfatal MI, hospitalization for heart failure, nonfatal stroke or CV death;   The time to onset of death from i) any cause and ii) from a CV event and iii) from a non CV cause;   The time of survival without a major CV event (nonfatal MI, hospitalization for heart failure, non-fatal stroke, cardiac arrest resuscitation);   Incidence of procedures related to stenosis or vascular access thrombosis for hemodialysis (HD);   Incidence of coronary or peripheral revascularizations (including lower limb amputations);   Blood pressure and its inter visit variability;   The occurrence of atrial fibrillation;   Incidence of hyperkalemia> 6 mmol/l;   Estimation of the effect of treatment on quality of life.
18 Recruiting Proteomic Prediction and Renin Angiotensin Aldosterone System Inhibition Prevention Of Early Diabetic nephRopathy In TYpe 2 Diabetic Patients With Normoalbuminuria
Conditions: Diabetic Nephropathy;   Diabetic Retinopathy
Interventions: Drug: Spironolactone;   Drug: Placebo;   Drug: Standard care
Outcome Measures: Albuminuria;   Cardiovascular disease and mortality;   Retinopathy;   Change in albuminuria;   Microalbuminuria;   Macroalbuminuria;   Change in CKD class;   Slope of estimated GFR
19 Unknown  Clinical and Therapeutic Implications of Fibrosis in Hypertrophic Cardiomyopathy
Conditions: Myocardial Fibrosis;   Hypertrophic Cardiomyopathy
Intervention: Drug: Spironolactone
Outcome Measures: changes in serum markers of collagen turnover;   measures of diastolic function by echocardiography;   cardiac mass and fibrosis by cardiac magnetic resonance imaging (CMR);   exercise tolerance by exercise VO2max and Holter
20 Unknown  Cardiovascular Protective Effect of Spironolactone in Hemodialysis
Condition: Hemodialysis
Intervention: Drug: Spironolactone (drug)
Outcome Measure: