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DRUG HYPERSENSITIVITY and Diclofenac

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DRUG HYPERSENSITIVITY Symptoms and Causes

Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions.

One problem is interactions, which may occur between

  • Two drugs, such as aspirin and blood thinners
  • Drugs and food, such as statins and grapefruit
  • Drugs and supplements, such as ginkgo and blood thinners
  • Drugs and diseases, such as aspirin and peptic ulcers

Interactions can change the actions of one or both drugs. The drugs might not work, or you could get side effects.

Side effects are unwanted effects caused by the drugs. Most are mild, such as a stomach aches or drowsiness, and go away after you stop taking the drug. Others can be more serious.

Drug allergies are another type of reaction. They can be mild or life-threatening. Skin reactions, such as hives and rashes, are the most common type. Anaphylaxis, a serious allergic reaction, is more rare.

When you start a new prescription or over-the-counter medication, make sure you understand how to take it correctly. Know which other medications and foods you need to avoid. Ask your health care provider or pharmacist if you have questions.

Check out the latest treatments for DRUG HYPERSENSITIVITY

DRUG HYPERSENSITIVITY treatment research studies

Diclofenac clinical trials, surveys and public health registries


Find Drug Side Effect reports



Diclofenac Side Effects

Renal Failure Acute (154)
Abdominal Pain (139)
Diarrhoea (136)
Vomiting (128)
Dyspnoea (103)
Haemoglobin Decreased (103)
Gastrointestinal Haemorrhage (102)
Nausea (88)
Blood Creatinine Increased (88)
Anaemia (86)
Malaise (83)
Dehydration (82)
Pruritus (79)
Abdominal Pain Upper (77)
Blood Urea Increased (76)
Dizziness (72)
Gastric Ulcer (68)
Gastrointestinal Disorder (68)
Haematemesis (64)
Anaphylactic Reaction (62)
Pyrexia (61)
Erythema (60)
Fatigue (60)
Pain (60)
Hypotension (57)
Melaena (56)
Embolia Cutis Medicamentosa (54)
Chest Pain (54)
Arthralgia (53)
Rash (53)
Oedema Peripheral (51)
Asthenia (50)
Loss Of Consciousness (49)
Alanine Aminotransferase Increased (49)
Fall (48)
Headache (47)
Blood Alkaline Phosphatase Increased (47)
Metabolic Acidosis (46)
Gastritis (46)
Renal Failure (45)
Cardiac Arrest (44)
Confusional State (43)
Back Pain (43)
C-reactive Protein Increased (43)
Convulsion (43)
Urticaria (43)
Blood Pressure Decreased (41)
Weight Decreased (41)
Peritonitis (41)
Aspartate Aminotransferase Increased (40)

➢ More


Common Meds

Abilify (10132)
Adderall (1304)
Amlodipine (6664)
Amoxicillin (4387)
Benadryl (1568)
Celebrex (12876 )
Celexa (1342)
Cialis (2975)
Cipro (8580)
Citalopram (7792)
Crestor (18839)
Cymbalta (14373)
Doxycycline (1757)
Effexor (7289)
Flexeril (435)
Flomax (2177)
Fluoxetine (4261)
Gabapentin (4593)
Hydrocodone (2469)
Ibuprofen (8222)
Lantus (10968)
Lexapro (3499)
Lipitor (17769)
Lisinopril (8919)
Lyrica (27148)
Medrol (650)
Mirena (41254)
Mobic (957)
Morphine (5356)
Naproxen (538)
Neurontin (6501)
Oxycodone (4438)
Pradaxa (13372)
Prednisone (5926)
Prilosec (2631)
Prozac (1954)
Seroquel (27216)
Simvastatin (8348)
Synthroid (4452)
Tamiflu (5585)
Topamax (3748)
Tramadol (5054)
Trazodone (1458)
Viagra (5394)
Vicodin (1153)
Wellbutrin (6324)
Xanax (2847)
Zocor (5718)
Zoloft(6792)
Zyrtec(1669)

Recent Reviews

I injected diclofenac injection without any accident

Im general practioner i gave on intra mascular diclofenac for fever and body and about 8 or less he is dead inspite of using diclofeac tablet before and there is no prblem

What is an effective alternative to diclofenac ?

What is Diclac Gastro-resistant tablets and for what they are?

What treetment purple spot in all the body cause of diclofenac inj

Chantix caused me to haveseizures I would not recommend anyone to take this drug find a different way to quit smoking that is safe.

I HAD 1 SHOT OF THIS AND WITHIN 12 HOURS I WENT FROM A VERY NORMAL BLOOD PRESSURE TO WAKING AT 5 A.M. NEXT DAY WITH 198/110 AND 104 PULSE RATE. IT HAS CONTINUED ALL WEEK AFTER AND I'M NOW ON A BLOOD PRESSURE DRUG TO TRY AND CONTROL IT. EVEN WITH DR

can advagraf makke you look like you are pregnant? Can this drug affect your eye site--blurry vision

Does anyone else have insomnia problems, with this drug, was fine before taking it, but now having major trouble getting to sleep and staying asleep.

I have experienced panic attacks, light headedness and pasty mouth taking this drug at 400mg's.

Impact of this drug on blood pressure. Should I be worried?

My symptoms were tired, weak, unable to sleep. Was prescribed half of a 15 MG Mirtazapine nightly to help me sleep. Has this drug been successful used as a sleeping aid?

WHAT ARE SIDE EFFECT OF COTRIMOXAXOLE DRUG

<!--StartFragment--> I have advanced Rheumatoid Arthritis. My Left wrist swelled painfully. Had a negative X-ray so Dr (fully informed for current drug regimens and allergies--Aspirin, Penicillin, Thoradamides, Ornate, Iodine, Latex)

<b>Describe Your Levoxacin Experience Here:</b> My mother is taking the drug and has started shaking. Is this common?

DRUG HYPERSENSITIVITY Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting An Investigator Initiated, Within-Subject, Proof of Concept Study to Assess the Analgesic Efficacy and Safety of Voltaren Gel (1% Diclofenac Sodium) Compared to Placebo in Subjects Experiencing Delayed Onset Muscle Soreness
Condition: Delayed Onset Muscle Soreness
Interventions: Drug: 1% Diclofenac sodium gel;   Drug: Placebo
Outcome Measure: To assess analgesic efficacy of Topical Voltaren® gel compared to placebo
2 Recruiting Safety Study of Flector Patch in Children With Minor Soft Tissue Injuries
Condition: Athletic Injuries
Intervention: Drug: Diclofenac hydroxyethylpyrrolidine
Outcome Measures: Dermatologic assessment at the patch application site;   Investigator assessment of the global response to therapy on a 5-point scale;   Patient assessment of pain on a 6-point scale;   Plasma concentration of Diclofenac
3 Recruiting Study Comparing a Generic Diclofenac Sodium Topical Gel, 1% to Voltaren in the Treatment of Subjects With Osteoarthritis of the Knee
Condition: Osteoarthritis
Interventions: Drug: Diclofenac Sodium Topical Gel, 1%;   Drug: Voltaren Topical Gel, 1%;   Drug: Vehicle Diclofenac Sodium Topical Gel
Outcome Measure: WOMAC Pain Score
4 Recruiting Treatment of Knee Pain With Topical Diclofenac Cream 8% or Diclofenac Gel 1%
Conditions: Knee Pain Chronic;   Knee Injuries
Interventions: Drug: Diclofenac Cream 8%;   Drug: Diclofenac Gel 1%
Outcome Measure: Descrete Response Scale Pain Scores
5 Unknown  Comparison of the Effect of Etoricoxib and Diclofenac on Early Morning Activity in Rheumatoid Arthritis (RA)
Condition: Rheumatoid Arthritis
Interventions: Drug: Etoricoxib;   Drug: Diclofenac
Outcome Measures: To explore the effect of Etoricoxib compared to Diclofenac on physical activity in RA subjects with Early morning pain and stiffness.;   To explore the effect of Etoricoxib compared to Diclofenac on average daily pain scores, fatigue scores, and quality of life.
6 Recruiting Efficacy of Diclofenac on Pain During Endometrial Sampling
Condition: Abnormal Uterine Bleeding Unrelated to Menstrual Cycle
Interventions: Drug: Diclofenac Potassium;   Drug: Folic Acid
Outcome Measure: Effectiveness of Diclofenac Potassium for additional acute pain control in patient undergoing fractional curettage under paracervical block due to abnormal uterine bleeding
7 Recruiting A Multicenter Efficacy Study of a Diclofenac+Menthol Gel in Subjects With Ankle Sprain
Condition: Ankle Sprain
Interventions: Drug: 1% Diclofenac sodium plus 3% menthol;   Drug: 1% Diclofenac sodium plus 0.09% menthol;   Drug: 3% menthol;   Drug: Placebo with 0.09% menthol gel
Outcome Measures: AUC (1-3 days);   Pain Intensity Difference (PID) on movement;   PID at rest;   Pain Relief Score (PRS);   Sum of Pain Intensity Difference (SPID);   Time of Onset of Pain Relief (TOPR);   Time of Onset of Meaningful Pain Relief (TOMR);   Time of Onset of Cooling Sensation (TOCS);   Total Pain Relief (TOTPAR);   Skin Temperature;   Ankle Swelling;   Time to complete Recovery;   Patient's Global Assessment in Response to Treatment (PGART);   Adverse events (AEs)
8 Recruiting Effects of Topical Diclofenac on Tumor Metabolism
Condition: Actinic Keratoses
Intervention: Drug: 3% Diclofenac in 2.5% hyaluronic acid gel
Outcome Measures: Lactate level in skin biopsies of actinic keratoses;   Lactate level in skin biopsies of healthy skin in a subpopulation;   Glycolysis-relevant proteins evaluated using PCR and Westernblot techniques;   Metabolic changes (e.g. glucose, amino acids)
9 Not yet recruiting Supersaturation and Precipitation of Diclofenac in the Stomach of Healthy Volunteers
Condition: Supersaturation and Precipitation in the Stomach
Intervention: Drug: Diclofenac potassium 50 mg
Outcome Measure: Area under the Concentration - Time Curve
10 Recruiting Diclofenac for Submassive PE
Condition: Pulmonary Embolism
Interventions: Drug: Diclofenac;   Drug: Placebo
Outcome Measure: Right ventricular dysfunction assessed by transthoracic echocardiography
11 Unknown  Use of Etoricoxib Compared to Diclofenac in the Perioperative Treatment of Patients After Total Hip Arthroplasty
Conditions: Coxarthrosis;   Arthroplasties Hip Replacement;   Perioperative Blood Loss
Interventions: Drug: Etoricoxib;   Drug: Diclofenac
Outcome Measure:
12 Recruiting Efficacy and Safety of Diclofenac DDEA 2.32 % in Patient Suffering From Knee Osteoarthritis (OA)
Condition: Osteoarthritis, Knee
Intervention: Drug: Diclofenac diethylamine, DDEA 2.32% gel
Outcome Measures: Measure: Pain On Movement (POM);   Measure POM regarding onset of efficacy
13 Recruiting Intramuscular Diclofenac in the Prevention of Post-ERCP Pancreatitis
Condition: Post ERCP Pancreatitis
Interventions: Drug: Diclofenac;   Drug: normal saline
Outcome Measure: Incidence of post ERCP pancreatitis
14 Not yet recruiting In Vivo Inhibition Profile of CYP2C9 by Pineapple Juice
Condition: Healthy Volunteers
Intervention: Dietary Supplement: pineapple juice (Carrefour n°1) 500 ml/day 5 days
Outcome Measures: a) AUC 4-OH-Diclofenac / AUC Diclofenac quantified in plasma, on days 1 (without pineapple juice) and 11 (after pretreatment with pineapple juice);   (b) AUC 4-OH-Diclofenac/ AUC Diclofenac quantified in urine, on days 1 (without pineapple juice) and 11 (after pretreatment with pineapple juice)
15 Unknown  The Comparison Between the Therapeutic Affect of Intravitreal Diclophenac and Triamcinolone in Persistent Uveitic Cystoids Macular Edema
Conditions: Uveitis;   Cystoid Macular Edema
Interventions: Drug: Diclophenac;   Drug: Triamcinolone
Outcome Measure:
16 Unknown  Efficacy of Diclofenac BCG Irrigations
Condition: Bladder Cancer
Interventions: Drug: Abitren;   Drug: Placebo
Outcome Measures: Change in weekly COOP Questionnaire 1;   Change in weekly COOP Questionnaire 2;   Change in weekly COOP Questionnaire 3;   Change in weekly Bladder symptoms Questionnaire;   Change in weekly time schedule questionnaire
17 Unknown  Intravitreal Diclofenac Versus Avastin as Primary Treatment of Diffuse Diabetic Macular Edema
Condition: Diffuse Diabetic Macular Edema
Interventions: Drug: Bevacizumab;   Drug: Diclofenac
Outcome Measure:
18 Not yet recruiting Diclofenac add-on to Treatment as Usual for Suicidal Patients
Condition: Depression Suicidal
Interventions: Drug: sugar pill;   Drug: Diclofenac
Outcome Measures: Suicide Assessment Scale (differences in scores before and after treatment);   Montgomery Asberg Rating Scale (differences in scores before and after treatment);   Barratt Impulsiveness Scale (differences in scores before and after treatment);   Montgomery Asberg depression Ratin scale (changes in suicidality item before and after treatment);   Montgomery Asberg Rating Scale (changes in concentration item before and after treatment);   Comprehensive Psychopathological Rating Scale (changes in aggressive feelings item before and after treatment);   Comprehensive Psychopthological Rating Scale (changes in fatigue item before and after treatment)
19 Recruiting Post ERCP Pancreatitis Prevention in Average Risk Patients
Condition: Pancreatitis
Intervention: Procedure: Ceftazidime
Outcome Measure: Incidence of PEP in the group of patients receiving Ceftazidime versus incidence of PEP in the group of patients receiving Diclophenac potassium
20 Recruiting OASIS: Osteoarthritis Sensitivity Integration Study
Conditions: Osteoarthritis;   Chronic Pain
Intervention: Drug: duloxetine, Diclofenac
Outcome Measure: Pain