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DRUG INTERACTION and Clonidine

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DRUG INTERACTION Symptoms and Causes

Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions.

One problem is interactions, which may occur between

  • Two drugs, such as aspirin and blood thinners
  • Drugs and food, such as statins and grapefruit
  • Drugs and supplements, such as ginkgo and blood thinners
  • Drugs and diseases, such as aspirin and peptic ulcers

Interactions can change the actions of one or both drugs. The drugs might not work, or you could get side effects.

Side effects are unwanted effects caused by the drugs. Most are mild, such as a stomach aches or drowsiness, and go away after you stop taking the drug. Others can be more serious.

Drug allergies are another type of reaction. They can be mild or life-threatening. Skin reactions, such as hives and rashes, are the most common type. Anaphylaxis, a serious allergic reaction, is more rare.

When you start a new prescription or over-the-counter medication, make sure you understand how to take it correctly. Know which other medications and foods you need to avoid. Ask your health care provider or pharmacist if you have questions.

Check out the latest treatments for DRUG INTERACTION

DRUG INTERACTION treatment research studies

Clonidine clinical trials, surveys and public health registries


Find Drug Side Effect reports



Clonidine Side Effects

Blood Pressure Increased (136)
Completed Suicide (121)
Hypotension (117)
Hypertension (95)
Product Adhesion Issue (72)
Headache (68)
Product Substitution Issue (64)
Dizziness (62)
Dyspnoea (55)
Product Quality Issue (54)
Poisoning (53)
Bradycardia (52)
Death (49)
Cardiac Arrest (47)
Nausea (45)
Somnolence (43)
Dry Mouth (42)
Fatigue (41)
Anxiety (40)
Asthenia (39)
Overdose (38)
Pain (35)
Agitation (34)
Feeling Abnormal (32)
Suicide Attempt (31)
Lethargy (31)
Depression (30)
Heart Rate Increased (30)
Sinus Bradycardia (30)
Loss Of Consciousness (29)
Hypertensive Crisis (29)
Vomiting (28)
Respiratory Arrest (28)
Chest Pain (26)
Blood Pressure Decreased (25)
Syncope (25)
Convulsion (24)
Cardio-respiratory Arrest (24)
Rash (23)
Application Site Rash (23)
Blood Pressure Inadequately Controlled (22)
Insomnia (22)
Cerebrovascular Accident (22)
Hyperhidrosis (21)
Accidental Overdose (20)
Tachycardia (20)
Application Site Pruritus (20)
Hypersensitivity (19)
Tremor (19)
Sedation (19)

➢ More


Common Meds

Abilify (10132)
Adderall (1304)
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Amoxicillin (4387)
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Mirena (41254)
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Viagra (5394)
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Wellbutrin (6324)
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Zocor (5718)
Zoloft(6792)
Zyrtec(1669)

Recent Reviews

After taking clonidine 0.1mg cut 9in half, for two dauys, twicw a day: it felt like a I had a terrible gastric ulcer. i TOOK IYT WITH A MEAL AND DRANK 10 OUNCES OF WATER. i took it again the next day with the same result. Do they

Anxiety and waking dreams about mouth. The dryness of mouth so annoying tha the reason for taking med not worth discomfort.

Head, ears, throat, too tired, hate to take it.....Dr. said it is a nasty pill but still prescribed it. also, constipation/ loose stools. stomach discomfort....leg / foot spasms at night

I am feeling drowsy,weak, and my heart is racing. is that suppose to happen?

I find this medication terrible. I dont know aboutanyone else but I have found that my body has become addictived to this drug. I have only been on this drug since June 18, 2010. I am on the patch 2mg plusone 1 mg tablet 2x per da

I just started on Clonidine for excessive sweating of the scalp and face, but also for insomnia. I had to take .3 mg to get sleepy. I woke up this morning with several canker like sores on the inside of my lips. Anyone else had this happen? I als

I started with taking 1 at bedtime .1mg then bp went up then went to .1 4 per day didn't last then tried Transdermal system this didn't stick to my skin result no medicine delivered i went thru withdraw ?

I take 0*1 mg Clonidine for high BP and have the sensation that my esophagus or chest muscles are spasming. Also my heart rate is accelerated. Are these expected side effects of this medication.

I take only a portion of a 0.1 mg Clonidine once a day. Since I have been taking this medicine, the have been times that my skin feels that needles are sticking in it---this is all over my body. Has anyone else had this happen? I don't know for su

My goodness. I believe every one of those persons talking about this medicine. It is so true and I've only been on it not even a month and I have all of those symptoms. I am so tired of falling asleep anywhere.

Chantix caused me to haveseizures I would not recommend anyone to take this drug find a different way to quit smoking that is safe.

I HAD 1 SHOT OF THIS AND WITHIN 12 HOURS I WENT FROM A VERY NORMAL BLOOD PRESSURE TO WAKING AT 5 A.M. NEXT DAY WITH 198/110 AND 104 PULSE RATE. IT HAS CONTINUED ALL WEEK AFTER AND I'M NOW ON A BLOOD PRESSURE DRUG TO TRY AND CONTROL IT. EVEN WITH DR

can advagraf makke you look like you are pregnant? Can this drug affect your eye site--blurry vision

Does anyone else have insomnia problems, with this drug, was fine before taking it, but now having major trouble getting to sleep and staying asleep.

I have experienced panic attacks, light headedness and pasty mouth taking this drug at 400mg's.

Impact of this drug on blood pressure. Should I be worried?

My symptoms were tired, weak, unable to sleep. Was prescribed half of a 15 MG Mirtazapine nightly to help me sleep. Has this drug been successful used as a sleeping aid?

WHAT ARE SIDE EFFECT OF COTRIMOXAXOLE DRUG

<!--StartFragment--> I have advanced Rheumatoid Arthritis. My Left wrist swelled painfully. Had a negative X-ray so Dr (fully informed for current drug regimens and allergies--Aspirin, Penicillin, Thoradamides, Ornate, Iodine, Latex)

<b>Describe Your Levoxacin Experience Here:</b> My mother is taking the drug and has started shaking. Is this common?

DRUG INTERACTION Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Not yet recruiting Safety of Clonidine in Infants With Hypoxic Ischemic Encephalopathy During Therapeutic Hypothermia
Condition: Encephalopathy, Hypoxic-Ischemic
Intervention: Drug: Clonidine (Duraclon®)
Outcome Measures: Maximum-tolerated dose of Clonidine;   Clonidine Plasma levels;   Time to onset of shivering after Clonidine;   shivering
2 Not yet recruiting The Effect of Clonidine-enhanced Sedation on Delirium in Ventilated Critically Ill Patients
Condition: Delirium
Interventions: Drug: Clonidine;   Drug: SodiumChloride
Outcome Measures: CAM-ICU (Confusion Assessment Method for the Intesive Care Unit);   Signs of agitation;   Opiate use;   Sedative use;   Anti-psychotic use;   Ventilation free days;   Sedation free days
3 Not yet recruiting Comparison of Epidural Fentanyl and Clonidine for Breakthrough Pain
Condition: Labor Pain
Interventions: Drug: Clonidine or Fentanyl;   Drug: Clonidine or fentanyl
Outcome Measures: Pain Score on a VAS scale;   Maternal blood pressure;   Maternal heart rate;   Neonatal Apgar score;   Number of spontaneous vaginal deliveries
4 Recruiting A Comparison of Ropivacaine Alone Versus Combination of Dexamethasone and Clonidine for Block
Condition: Upper Extremity Fracture
Interventions: Drug: Ropivacaine;   Drug: Ropivacaine and dexamethasone;   Drug: Ropivacaine, dexamethasone, Clonidine;   Drug: Ropivacaine and Clonidine
Outcome Measures: Duration of the supraclavicular block;   Postoperative analgesia
5 Recruiting Combination of Dronabinol and Clonidine for Cannabis Dependence in Patients With Schizophrenia
Conditions: Cannabis Dependence;   Marijuana Dependence
Interventions: Drug: Dronabinol;   Drug: Clonidine;   Drug: Placebo
Outcome Measures: Change from baseline in cannabis use at 10 weeks;   Change in withdrawal symptoms from baseline at 10 weeks;   Change from baseline in cannabis use at 14 weeks;   Change in withdrawal symptoms from baseline at 14 weeks
6 Unknown  Use of Transdermal Clonidine in Trauma Patients
Condition: Delirium
Interventions: Drug: Clonidine;   Drug: Placebo
Outcome Measures: Duration of mechanical ventilation following administration of the first dose of Clonidine or placebo;   Incidence and duration in hours of delirium currently used;   Time to pass first SBT following administration of the first dose of Clonidine or placebo;   Mean incidence and duration of delirium
7 Recruiting Effectiveness of Perineural Clonidine as an Adjuvant With Ropivacaine for Popliteal Nerve Block in Patients Undergoing Foot and Ankle Surgery
Condition: Pain
Interventions: Drug: Clonidine;   Drug: ropivacaine
Outcome Measures: Compare the onset of sensory and motor block between the control group and the control group;   Compare the duration of sensory and motor block between the control group and the control group;   Compare the mean VAS scores at 24 hours post procecure to determine the effectiveness of perineural Clonidine on duration of postoperative analgesia;   Compare the number of subjects taking postoperative opioids to determine the effect of perineural Clonidine versus placebo;   Compare the subjects mean blood pressure effect of perineural Clonidine versus placebo;   number of subjects in each group requiring sedation;   Determine the effect of perineural Clonidine versus placebo on time to discharge;   Determine the effect of perineural Clonidine versus placebo on postoperative time to first analgesic intake;   Compare the mean VAS scores at 24 hours post procedure to determine the patient satisfaction of perineural Clonidine on duration of postoperative analgesia
8 Recruiting Solifenacin Compared to Clonidine for Reducing Hot Flashes Among Breast Cancer Patients
Conditions: Hot Flashes;   Breast Cancer
Interventions: Drug: solifenacin;   Drug: Clonidine
Outcome Measures: hot flash composite and frequency scores (daily diary);   number of clinician-rated adverse events;   daily functioning (Hot Flash-Related Daily Interference score);   sleep (Insomnia Severity Index);   quality of life (Illness Cognition Questionnaire, SF-12)
9 Recruiting Efficacy of Clonidine and Propranolol in Dentistry (AAA)
Condition: Anxiety
Interventions: Drug: Clonidine;   Drug: Propranolol;   Drug: Placebo
Outcome Measures: Change from baseline in modified dental anxiety scale(MDAS)and vital signs (blood pressure, heart rate, respiratory rate, oxygen saturation) until four hours post treatment;   Changes in Verbal Numerical Rating Scale (VNRS) at three, six, and twenty-four hours post treatment
10 Unknown  Neonatal Spinal Anesthesia: Effects of the Addition of Clonidine
Conditions: Spinal Anesthesia;   Neonates
Intervention: Drug: Clonidine
Outcome Measures: number of "rescue" general anesthesia;   apnea and desaturation occurrence;   duration of spinal anesthesia
11 Recruiting The Addition of Clonidine to 0.2% Ropivacaine for Wound Instillation After Minor Lower Abdominal Surgery in Children
Conditions: Hernia, Inguinal;   Hydrocele
Intervention: Drug: Clonidine
Outcome Measures: Time to first analgesia after procedure;   continuous pain scores (modified Children's Hospital of Eastern Ontario Pain Score [mCHEOPS], modified Wong-Baker Faces);   sedation scores;   emergence delirium score (Pediatric Anesthesia Emergence Delirium [PAED]);   total analgesics consumed;   total sedation consumed
12 Recruiting Assessment of the Effect of Clonidine for Cataract Surgery
Conditions: Pain;   Arrythmia
Interventions: Drug: Clonidine;   Drug: placebo
Outcome Measures: intensity of pain;   intraocular pressure
13 Recruiting Added Value of Local Clonidine for Spine Postoperative Pain Control, in Addition to Bupivacaine
Condition: Post-operative Pain
Interventions: Drug: Bupivacaine;   Drug: Clonidine
Outcome Measures: Mean Area under curve;   Area under Curve (AUC) of pain;   Daily rescue opiates consumption;   Global subjective patient satisfaction of post-operative wound pain control
14 Not yet recruiting Oral Clonidine & Gabapentin: Improving Recovery and Pain Management After Outpatient With Major Orthopedic Surgery
Conditions: Shoulder Arthroscopy;   Knee Arthroscopy
Interventions: Drug: Sugar pill;   Drug: Gabapentin;   Drug: Clonidine
Outcome Measures: Postoperative Pain using a Verbal Rating Scale (VRS);   Opioid consumption obtained from the recorded data;   postoperative nausea and vomiting using a Verbal Rating Scale;   return to normal activities of daily living using follow up questionnaires;   Patient satisfaction using a verbal rating scale from 0 to 100
15 Recruiting Clonidine for Relapse Prevention in Buprenorphine-Maintenance Patients
Condition: Opioid-Related Disorders
Interventions: Drug: Clonidine;   Drug: Placebo
Outcome Measures: Opiate-negative urine screens;   HIV risk behaviors;   Craving
16 Unknown  Clonidine in Femoral Nerve Block Surgery in Children
Condition: Other Reconstructive Surgery
Interventions: Drug: Ropivacaine;   Drug: Clonidine
Outcome Measures: Pain;   Heart rate;   Blood pressure;   Oxygen saturation
17 Recruiting The Oslo Study of Clonidine in Elderly Patients With Delirium
Condition: Delirium
Interventions: Drug: Clonidine;   Drug: Placebo
Outcome Measures: MDAS (Memorial delirium assessment scale);   Time-to-first delirium;   Incidence of "full-scale" delirium;   Severity of delirium;   Delirium subtype;   The use of "rescue medication";   Length of hospital stay;   Patient distress;   Side effects of Clonidine;   Pharmacokinetic response to Clonidine;   Pharmacodynamic response to Clonidine;   Biomarkers;   Institutionalization;   Survival;   Cognitive function/ independence
18 Recruiting The Value of Adding Either Meperdine or Fentanyl to Clonidine-bupivacaine
Condition: Amputation Stumps
Interventions: Drug: Meperdine;   Drug: Fentanyl
Outcome Measures: the hemodynamic effects .;   the analgesic efficacy.
19 Recruiting Efficacy and Safety Study of Clonidine Lauriad® to Treat Oral Mucositis
Condition: Oral Mucositis
Interventions: Drug: Clonidine Lauriad® 50µg;   Drug: Clonidine Lauriad® 100µg;   Drug: Placebo Lauriad®
Outcome Measures: Percentage of patients with an oral mucositis score≥ 3 using the WHO scale at cumulative radiation dose of 50 Gy;   Percentage of patients with an oral mucositis score≥ 3 using the WHO scale at cumulative radiation doses of 40 Gy and 60 Gy
20 Recruiting Safety and Efficacy Study of Clonidine Hydrochloride Topical Gel, 0.1% in the Treatment of Pain Associated With Diabetic Neuropathy
Conditions: Painful Diabetic Neuropathy;   Diabetic Neuropathy;   Neuropathy
Intervention: Drug: Clonidine Gel 0.1%
Outcome Measures: Change in average pain score over time.;   Mean daily average pain intensity Numeric Pain Rating Scale scores over time.;   Mean daily worst pain intensity Numeric Pain Rating Scale scores