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DRUG INTERACTION and Tramadol

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DRUG INTERACTION Symptoms and Causes

Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions.

One problem is interactions, which may occur between

  • Two drugs, such as aspirin and blood thinners
  • Drugs and food, such as statins and grapefruit
  • Drugs and supplements, such as ginkgo and blood thinners
  • Drugs and diseases, such as aspirin and peptic ulcers

Interactions can change the actions of one or both drugs. The drugs might not work, or you could get side effects.

Side effects are unwanted effects caused by the drugs. Most are mild, such as a stomach aches or drowsiness, and go away after you stop taking the drug. Others can be more serious.

Drug allergies are another type of reaction. They can be mild or life-threatening. Skin reactions, such as hives and rashes, are the most common type. Anaphylaxis, a serious allergic reaction, is more rare.

When you start a new prescription or over-the-counter medication, make sure you understand how to take it correctly. Know which other medications and foods you need to avoid. Ask your health care provider or pharmacist if you have questions.

Check out the latest treatments for DRUG INTERACTION

DRUG INTERACTION treatment research studies

Tramadol clinical trials, surveys and public health registries


Find Drug Side Effect reports



Tramadol Side Effects

Completed Suicide (527)
Toxicity To Various Agents (447)
Nausea (385)
Convulsion (369)
Vomiting (346)
Death (325)
Dizziness (319)
Overdose (292)
Confusional State (282)
Somnolence (253)
Pain (231)
Headache (216)
Serotonin Syndrome (209)
Dyspnoea (209)
Hyperhidrosis (208)
Fall (202)
Loss Of Consciousness (194)
Intentional Overdose (191)
Cardio-respiratory Arrest (191)
Hallucination (190)
Anxiety (124)
Tremor (123)
Insomnia (118)
Malaise (115)
Grand Mal Convulsion (109)
Suicide Attempt (107)
Cardiac Arrest (105)
Fatigue (100)
Tachycardia (96)
Constipation (95)
Agitation (90)
Respiratory Arrest (86)
Withdrawal Syndrome (84)
Diarrhoea (80)
Poisoning (79)
Abdominal Pain (78)
Feeling Abnormal (78)
Asthenia (77)
Delirium (77)
Chest Pain (72)
Hypotension (71)
Hypertension (70)
Hypoglycaemia (69)
Depression (68)
Coma (64)
Unresponsive To Stimuli (64)
Hyponatraemia (64)
Pruritus (62)
Back Pain (61)
Depressed Level Of Consciousness (60)

➢ More


Common Meds

Abilify (10132)
Adderall (1304)
Amlodipine (6664)
Amoxicillin (4387)
Benadryl (1568)
Celebrex (12876 )
Celexa (1342)
Cialis (2975)
Cipro (8580)
Citalopram (7792)
Crestor (18839)
Cymbalta (14373)
Doxycycline (1757)
Effexor (7289)
Flexeril (435)
Flomax (2177)
Fluoxetine (4261)
Gabapentin (4593)
Hydrocodone (2469)
Ibuprofen (8222)
Lantus (10968)
Lexapro (3499)
Lipitor (17769)
Lisinopril (8919)
Lyrica (27148)
Medrol (650)
Mirena (41254)
Mobic (957)
Morphine (5356)
Naproxen (538)
Neurontin (6501)
Oxycodone (4438)
Pradaxa (13372)
Prednisone (5926)
Prilosec (2631)
Prozac (1954)
Seroquel (27216)
Simvastatin (8348)
Synthroid (4452)
Tamiflu (5585)
Topamax (3748)
Tramadol (5054)
Trazodone (1458)
Viagra (5394)
Vicodin (1153)
Wellbutrin (6324)
Xanax (2847)
Zocor (5718)
Zoloft(6792)
Zyrtec(1669)

Recent Reviews

BEEN vomiting ever since i started taking Tramadol i can't eat anything without throwing it back up .

First two months were fine but I have noticed recently after a day or two of not taking them that I have severe restlesnness in my legs and twitching, tingling feelings running up and down my legs at night. Insomnia when taking them. The restlessness

I broke out in a rash like the measles and itched. Then for several days now I have been having a lot of pain in my abdomen. Swelling and hardness in my abdomen and it is very tender to the touch. I feel raw inside.&

I have received TRAMADOL from my doctors for quite some years due a back condition called MORBUS FORESTIERS. My usage escalated slowly until i reached a dosis of 30x50mg instead og the prescribe 3x50mg. I finally realised I couldnt go on like that an

I just start taking Tramadol when I pass urine I see a lot of blood is that one of the side effects

I love this drug. It really helps the pain I experience. I take 4 50mg per day and I love it. Helps my leg tremors as well. Greatt for restless leg syndrum. Some of you are killing your liver taking too much at one time. $ per day is plenty. If you t

I started taking tramadol for chronic pain and sleep issues. It really did help me sleep. Did not help my sciatic pain. It made me sweat profusely! I won't take this again. On to the next thing1

I take blook pressure meds, and when I was recently prescribed tramadol my ankle swelled up and is still swollen. Does this medicine interfer with other meds and cause them not to work as well?

I took 2 Tramadol with my own medication of plavix, atenenol the Tramadol was a friend of mine medication. It really messed me up for over 24 hours. I was in so much pain I thought it would work but I really thought I was going to die. It was sca

I took this drug for extensive pain in my shoulder after an operation and it was fabulous, BUT I never stayed on them long. I sweated at night like crazy as I took them at night....and I was still high as a kite when I was walking to work... I am

Chantix caused me to haveseizures I would not recommend anyone to take this drug find a different way to quit smoking that is safe.

I HAD 1 SHOT OF THIS AND WITHIN 12 HOURS I WENT FROM A VERY NORMAL BLOOD PRESSURE TO WAKING AT 5 A.M. NEXT DAY WITH 198/110 AND 104 PULSE RATE. IT HAS CONTINUED ALL WEEK AFTER AND I'M NOW ON A BLOOD PRESSURE DRUG TO TRY AND CONTROL IT. EVEN WITH DR

can advagraf makke you look like you are pregnant? Can this drug affect your eye site--blurry vision

Does anyone else have insomnia problems, with this drug, was fine before taking it, but now having major trouble getting to sleep and staying asleep.

I have experienced panic attacks, light headedness and pasty mouth taking this drug at 400mg's.

Impact of this drug on blood pressure. Should I be worried?

My symptoms were tired, weak, unable to sleep. Was prescribed half of a 15 MG Mirtazapine nightly to help me sleep. Has this drug been successful used as a sleeping aid?

WHAT ARE SIDE EFFECT OF COTRIMOXAXOLE DRUG

<!--StartFragment--> I have advanced Rheumatoid Arthritis. My Left wrist swelled painfully. Had a negative X-ray so Dr (fully informed for current drug regimens and allergies--Aspirin, Penicillin, Thoradamides, Ornate, Iodine, Latex)

<b>Describe Your Levoxacin Experience Here:</b> My mother is taking the drug and has started shaking. Is this common?

DRUG INTERACTION Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting Postoperative Tramadol/Gabapentin/Acetaminophen Versus Tramadol/Placebo/Acetaminophen
Condition: Pain
Interventions: Drug: gabapentin;   Drug: Tramadol;   Drug: Ibuprofen
Outcome Measures: Efficacy of scheduled Tramadol + PRN ibuprofen vs. scheduled Tramadol + scheduled gabapentin + PRN ibuprofen;   Side effects of scheduled Tramadol + PRN ibuprofen vs. scheduled Tramadol + scheduled gabapentin + PRN ibuprofen
2 Recruiting Comparison of Tramadol Orally Versus an Optimized Dose of Intravenous Tramadol for Postoperative Pain Relief in Ambulatory Surgery
Condition: Pain
Interventions: Drug: Tramadol per os (Tradonal Odis® orodispersible tablets);   Drug: Tramadol IV (Tradonal® IV)
Outcome Measures: Difference in pain score between groups;   Difference in side-effects between the groups
3 Recruiting Evaluation of the Role of Tramadol 50mg as an Analgesic During Outpatient Hysteroscopy
Condition: Pain
Interventions: Drug: Tramadol;   Drug: Placebo
Outcome Measures: Pain perceived by the patient during the procedure;   Pain perceived by the patient 30 minutes after the procedure.
4 Recruiting Tramadol Extended-Release (ER) for Posttraumatic Stress Disorder (PTSD)
Condition: Post-Traumatic Stress Disorder
Interventions: Drug: Tramadol;   Drug: Placebo
Outcome Measures: Efficacy as measured by a reduction in PTSD symptoms.;   Efficacy as measured by a reduction in anxiety, "nervousness", irritability, mood, sleep, and pain.;   Efficacy as measured by a reduction in depressive symptoms.
5 Recruiting Tramadol Versus Celecoxib for Reducing Pain in Outpatient Hysteroscopy
Condition: Pain
Interventions: Drug: Tramadol;   Drug: Celecoxib;   Drug: Placebo
Outcome Measures: Pain perception during the procedure;   Pain perception after the procedure
6 Recruiting Mepivacaine-Tramadol on the Success of Inferior Alveolar Nerve Block in Symptomatic Irreversible Pulpitis
Condition: Symptomatic Irreversible Pulpitis
Interventions: Drug: Mepivacaine;   Drug: Mepivacaine plus Tramadol
Outcome Measures: success of the inferior alveolar nerve block;   Anesthetic effect duration
7 Recruiting Tramadol Infiltration for Tonsillectomy
Condition: Postoperative Pain
Interventions: Drug: Tramadol 2mg/kg;   Drug: Saline solution
Outcome Measure: Analgesic effect
8 Not yet recruiting Penthrox Versus Tramadol for SCDF
Condition: Acute Pain
Interventions: Drug: Penthrox Inhaler;   Drug: Tramadol Injection
Outcome Measures: Change in Pain Score assessed by Visual Analogue Scale (VAS);   Change in Ramsay sedation Scores
9 Unknown  RCT on Ketorolac and Tramadol in Bone Fractures Pain of Child
Conditions: Fracture;   Pain
Interventions: Drug: ketorolac;   Drug: Tramadol
Outcome Measures: estimation of pain reduction in every arm of the trial with linear 1-10 pain scale or for children 4 - 6 years old with analogic MacGrath type scale;   comparison between the two groups on effectiveness on pain, measured with linear and analogic scale (see above)
10 Recruiting Usage of Tramadol With Levobupivacaine for Pain Treatment After Cesarean Section
Condition: Postoperative Pain Following Cesarean Section
Interventions: Drug: Tramadol infusion via wound catheter;   Drug: Levobupivacaine
Outcome Measures: lowering of pain as measured by visual analogue scores;   total additional analgesic consumption
11 Unknown  Comparison of Tramadol Vs Remifentanyl Patient Controlled Analgesia for Second Trimester Abortions
Condition: Abortion,Induced
Interventions: Drug: Tramadol;   Drug: remifentanyl;   Device: patient contolled analgesia
Outcome Measures: Satisfaction;   VAS scores;   Nausea;   Sedation
12 Unknown  Safety and Effectiveness of Tramadex-OD After Knee Arthroscopy
Condition: Postoperative Pain
Interventions: Drug: extended-release Tramadol;   Drug: paracetamol
Outcome Measures: Safety and effectiveness of TRAMADEX-OD will be evaluated by recording adverse events and using a visual analogue score for pain evaluation;   Patient satisfaction will be evaluated by a telephone interview
13 Recruiting Compare the Efficacy and Safety of NORSPAN to Tramadol/Acetaminophen With Prolonged Postoperative Pain (PASSION)
Condition: Pain
Intervention: Drug: buprenorphine, Tramadol/acetaminophen
Outcome Measures: efficacy;   life of quality
14 Recruiting Combined Behavioral and Analgesic Trial for Fibromyalgia
Condition: Fibromyalgia
Interventions: Drug: Tramadol;   Drug: Placebo;   Behavioral: Cognitive Behavior Therapy for FM;   Behavioral: Health Education
Outcome Measure: Change in mean pain severity derived from 5-days of daily pain diaries and change in physical function assessed from the Fibromyalgia Impact Questionnaire-Revised (FIQ-R).
15 Unknown  The Effect of Adding Pain Relievers to Local Anesthesia Before Preforming Drainage in Peritonsillar Abscess
Condition: Peritonsillar Abscess
Intervention: Drug: dypiron, Tramadol
Outcome Measure: the vas scale
16 Recruiting Effect of COX-2 Selective Inhibitors on Postoperative Insulin Resistance After Gastrointestinal Laparoscopic Surgery
Condition: Gastrointestinal Cancer
Intervention: Drug: parecoxib
Outcome Measures: Insulin resistance in perioperative period of gastrointestinal laparoscopic surgery;   The consumption of total and incremental Tramadol after surgery.;   The tolerated dose of enteral nutrition every day after surgery;   Postoperative inflammatory factors (IL-4, IL-6 and TNF-α) and levels of stress hormone (glucocorticoids and catecholamines) in perioperative period of gastrointestinal laparoscopic surgery;   Rest energy metabolism was measured in perioperative period to evaluate the caloric and substrate needs of our patients;   The time of the first bowel movements and anal exhaust time after surgery;   Pain intensity at rest and during leg raising recorded daily after surgery using Visible Numeric Rating Scale;   Incidence of adverse events throughout the treatment period including nausea, vomiting, headache, urinary retention, somnolence, flatulence, and pruritus;   Liver and renal function tests in perioperative period;   Self-rating anxiety scale and self-rating questionnaire for depression before surgery
17 Unknown  Assessment and Prevention of Acute Post-herniotomy Pain
Condition: Hernia
Intervention: Drug: postoperative analgesic treatment
Outcome Measures: Assessment of the acute post-herniotomy pain during the treatment with two different therapeutical protocols per os: ketorolac versus association of acetaminophene+Tramadol;   Number of participants with adverse events as a measure of safety and tolerability;   Difference in recovering daily activity;   Assessment of any connections between the two therapeutical strategies and the recurrence of surgical complications;   Development of persistent postoperative pain
18 Recruiting Medications Development for Drug Abuse Disorders
Conditions: Opioid Related Disorders;   Opioid Dependence;   Opioid Addiction
Interventions: Drug: Buprenorphine/naloxone;   Drug: Clonidine;   Drug: Tramadol ER
Outcome Measure: change between groups over time in scores on a standard measure of opioid withdrawal signs and symptoms
19 Recruiting Opioid-based Analgesic Regimen Versus Non-opioid Analgesic Regimen for Better Immune Responses After Laparoscopic Colorectal Surgery
Condition: Colorectal Surgery
Intervention: Drug: opioid based analgesia (fentanyl and pethidine) versus non-opioid based analgesia (ropivacaine and Tramadol)
Outcome Measures: NK cell activity;   Cytokine level
20 Unknown  Patient Preferences, Analgesic Delivery Method and Pain Reduction in Spine Patients
Condition: Pain Relief
Interventions: Drug: Diclofenac hydroxyethylpyrrolidine;   Drug: orphenadrine;   Drug: Tramadol;   Drug: Dipyrone
Outcome Measures: pain scores on visual analog scale;   Patient Questionnaire assessing pain and pain relief;   patient preference Questionnaire