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DRUG WITHDRAWAL SYNDROME and Clindamycin

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DRUG WITHDRAWAL SYNDROME Symptoms and Causes

Opioids, sometimes called narcotics, are a type of drug. They include strong prescription pain relievers, such as oxycodone, hydrocodone, fentanyl, and tramadol. The illegal drug heroin is also an opioid. Some opioids are made from the opium plant, and others are synthetic (man-made).

A doctor may give you a prescription opioid to reduce pain after you have had a major injury or surgery. You may get them if you have severe pain from health conditions like cancer. Some doctors prescribe them for chronic pain.

Opioids can cause side effects such as drowsiness, mental fog, nausea, and constipation. They may also cause slowed breathing, which can lead to overdose deaths. If someone has signs of an overdose, call 9-1-1:

  • The person's face is extremely pale and/or feels clammy to the touch
  • Their body goes limp
  • Their fingernails or lips have a purple or blue color
  • They start vomiting or making gurgling noises
  • They cannot be awakened or are unable to speak
  • Their breathing or heartbeat slows or stops

Other risks of using prescription opioids include dependence and addiction. Dependence means feeling withdrawal symptoms when not taking the drug. Addiction is a chronic brain disease that causes a person to compulsively seek out drugs, even though they cause harm. The risks of dependence and addiction are higher if you abuse the medicines. Abuse can include taking too much medicine, taking someone else's medicine, taking it in a different way than you are supposed to, or taking the medicine to get high.

Opioid abuse, addiction, and overdoses are serious public health problems in the United States. Another problem is that more women are abusing opioids during pregnancy. This can lead to babies being addicted and going through withdrawal, known as neonatal abstinence syndrome (NAS). Opioid abuse may sometimes also lead to heroin use, because some people switch from prescription opioids to heroin.

The main treatment for prescription opioid addiction is medication-assisted treatment (MAT). It includes medicines, counseling, and support from family and friends. MAT can help you stop using the drug, get through withdrawal, and cope with cravings. There is also a medicine called naloxone which can reverse the effects of an opioid overdose and prevent death, if it is given in time.

To prevent problems with prescription opioids, be sure to follow your doctor's instructions when taking them. Do not share your medicines with anyone else. Contact your doctor if you have any concerns about taking the medicines.

NIH: National Institute on Drug Abuse

Check out the latest treatments for DRUG WITHDRAWAL SYNDROME

DRUG WITHDRAWAL SYNDROME treatment research studies

Clindamycin clinical trials, surveys and public health registries


Find Drug Side Effect reports



Clindamycin Side Effects

Diarrhoea (245)
Rash (142)
Nausea (108)
Pruritus (101)
Vomiting (79)
Pyrexia (77)
Clostridium Difficile Colitis (68)
Dyspnoea (67)
Urticaria (61)
Erythema (59)
Abdominal Pain Upper (58)
Clostridial Infection (55)
Renal Failure Acute (50)
Abdominal Pain (49)
Dizziness (49)
Pain (48)
Dysphagia (43)
Headache (41)
Dyspepsia (41)
Hypersensitivity (39)
Asthenia (38)
Chest Pain (38)
Weight Decreased (35)
Rash Pruritic (35)
Fatigue (34)
Malaise (33)
Rash Erythematous (33)
Swelling Face (32)
Pseudomembranous Colitis (30)
Angioedema (30)
International Normalised Ratio Increased (29)
Dysgeusia (29)
Dehydration (28)
Oedema Peripheral (28)
Hypotension (27)
Chills (27)
Pancytopenia (26)
Rash Maculo-papular (25)
Stevens-johnson Syndrome (25)
Skin Exfoliation (25)
Colitis (24)
Arthralgia (23)
Abdominal Discomfort (23)
Abdominal Distension (22)
Alanine Aminotransferase Increased (22)
Pharyngeal Oedema (20)
Haematochezia (20)
Blister (20)
Gastrointestinal Disorder (19)
Renal Failure (19)

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Recent Reviews

I was given Clindamycin (150 MG Capsule) to take for 10 days 4 times daily for tooth extractions aftercare. It gives me splitting headaches and acid reflux . Evdokia

After taking Clindamycin 4 days for my tooth infection, I started heart burn pain, cough, difficult swollen food. Now I have stoped the drug 4 days, but I only can drink fluid. Any solid food cause me severe chest pain.

After taking the Clindamycin Capsules, I have nausea then it feels as if my chest is about to burst open, like i am about to choke which lasts at least 3 hours. I never felt like this in my life. Help!

Clindamycin has caused me such horrible heartburn. It effects everything I drink or eat. I have burning in my throat and tightness in my chest tonight as well. My ears itch and burn deep inside them and they are red and hot to the touch. Horrible fee

Clindamycin is a safe medicine. If you have an abcess or tooth infection it can be VERY dangerous to NOT take the antibiotic. You can alleviate a lot of the stomach discomfort by taking high quality PRO-BIOTICS and consuming a LOT of unsweetened yo

Does clindamycin interact with Fentanyl or "industrial-strength" diuretics? Is it possible for clindamycin by itself, or with one of the other 2, or both, to cause a sleep that is almost like unconciousness? My Dad had this happen recently

Have been taking clindamycin for 10 days now, I am usually very sensitive to antibiotics, have been loading myself up with pro-biotics which has helped, I do have quite a sore throat from it though bu it is bearable

Headaches, red rash on legs, fatigue

Hello. I went to a Dentist for "Tooth Infection". I was prescribed Clindamycin. It has been 9 days since I stopped taking the medication. About every 3 days I get stomach pain, then diarhea. I have also had flatulance. My only

How many days should we take it? I have an ear infection and my doctor wanted me to take it for 3 days. Antibiotics should be taken 7 days right?

Chantix caused me to haveseizures I would not recommend anyone to take this drug find a different way to quit smoking that is safe.

I HAD 1 SHOT OF THIS AND WITHIN 12 HOURS I WENT FROM A VERY NORMAL BLOOD PRESSURE TO WAKING AT 5 A.M. NEXT DAY WITH 198/110 AND 104 PULSE RATE. IT HAS CONTINUED ALL WEEK AFTER AND I'M NOW ON A BLOOD PRESSURE DRUG TO TRY AND CONTROL IT. EVEN WITH DR

can advagraf makke you look like you are pregnant? Can this drug affect your eye site--blurry vision

Does anyone else have insomnia problems, with this drug, was fine before taking it, but now having major trouble getting to sleep and staying asleep.

I have experienced panic attacks, light headedness and pasty mouth taking this drug at 400mg's.

I have sjogren's syndrome. Can i use arcalion or is it not good for me?

Impact of this drug on blood pressure. Should I be worried?

My symptoms were tired, weak, unable to sleep. Was prescribed half of a 15 MG Mirtazapine nightly to help me sleep. Has this drug been successful used as a sleeping aid?

WHAT ARE SIDE EFFECT OF COTRIMOXAXOLE DRUG

<!--StartFragment--> I have advanced Rheumatoid Arthritis. My Left wrist swelled painfully. Had a negative X-ray so Dr (fully informed for current drug regimens and allergies--Aspirin, Penicillin, Thoradamides, Ornate, Iodine, Latex)

DRUG WITHDRAWAL SYNDROME Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting Adjunctive Clindamycin for Cellulitis: Clinical Trial Comparing Flucloxacillin With or Without Clindamycin for the Treatment of Limb Cellulitis (C4C Trial).
Condition: Cellulitis
Interventions: Drug: Flucloxacillin and Clindamycin;   Drug: Flucloxacillin and placebo
Outcome Measures: Improvement based on a composite of systemic and local features;   Decrease in pain;   Quality of life;   Physiological recovery
2 Recruiting Comparison Between Oral Clindamycin Vs Metronidazole for the Treatment of Abnormal Vaginal Flora in High Risk Pregnancies
Conditions: Abnormal Vaginal Flora;   Clindamycin Vs Metronidazole;   High Risk Pregnancies for Preterm Labor
Interventions: Drug: Clindamycin;   Drug: Metronidazole
Outcome Measures: To compare the efficacy between oral Clindamycin Vs Metronidazole in the eradication of abnormal vaginal flora;   The prevalence of adverse effects;   The prevalence of late abortions and preterm deliveries;   Assessing the correlation between Nugent score , physical examination and Ph indicators
3 Recruiting Safety and Pharmacokinetics of Clindamycin in Pediatric Subjects With BMI ≥ 85th Percentile
Conditions: Bacterial Infections;   Obesity
Intervention: Drug: Clindamycin
Outcome Measures: Clearance (Cl);   Volume of distribution (Vd);   Area under the curve (AUCtau);   Oral apparent clearance (Cl/F);   Oral apparent volume of distribution (V/F);   Number of Adverse Events
4 Unknown  A Study Comparing Combination Clindamycin Phosphate/Tretinoin Gel Alone Versus With Benzoyl Peroxide Foaming Cloths for Facial Acne
Condition: Acne Vulgaris
Interventions: Drug: Clindamycin phosphate 1.2%/tretinoin 0.025% gel alone;   Drug: Clindamycin phosphate 1.2%/tretinoin 0.025% gel plus benzoyl peroxide 6% foaming cloths
Outcome Measures: Change in PGA scores of patients using combination Clindamycin phosphate 1.2%/tretinoin 0.025% gel with or without benzoyl peroxide 6% foaming cloths for facial acne;   Change in Postinflammatory hyperpigmentation score at each study visit and from baseline to final visit.;   Total number of adverse events.;   Change in Subject Self Assessment Scoring Scale;   Change in Acne-Specific Quality of Life Questionnaire (Acne-QoL)
5 Recruiting Clindamycin to Reduce Preterm Birth in a Low Resource Setting
Conditions: Pregnancy;   Prematurity;   Preterm Birth;   Bacterial Vaginosis
Interventions: Drug: Clindamycin;   Drug: Placebo
Outcome Measures: Preterm birth prior to 37 weeks;   Preterm birth prior to 34 weeks;   Late Miscarriage;   Low Birth weight;   Very Low birth Weight;   Neonatal complications through 42 days after delivery;   Maternal complications through 42 days postpartum;   The utility of vaginal pH tests for identification of women at elevated risk for preterm delivery
6 Recruiting Asymptomatic Colonization With S. Aureus After Therapy With Linezolid or Clindamycin for Acute Skin Infections
Conditions: Skin Diseases, Bacterial;   Abscess
Interventions: Biological: Linezolid;   Biological: Clindamycin
Outcome Measures: The presence of Staphylococcus aureus after treatment with linezolid versus Clindamycin;   Clinical response of skin infections to treatment;   The type of of Staphylococcus aureus present at the diagnosis will be compared to the type of Staphylococcus aureus present after treatment
7 Recruiting Comparison of the Efficacy and Safety of Clindamycin + Benzoyl Peroxide Formulation With Azelaic Acid Formulation in the Treatment of Acne Vulgaris
Condition: Acne Vulgaris
Interventions: Drug: Clindamycin + BPO;   Drug: Azelaic acid
Outcome Measures: Change from Baseline of inflammatory lesion counts at Week 4;   Change from Baseline of lesion counts;   Change from Baseline of lesions by Investigator's Static Global Assessment (ISGA);   Time to 50% reduction in total lesion count;   Change from Baseline of local tolerability as assessed by investigator;   Subject's global change assessment (SGCA) of skin;   Change from Baseline of local tolerability as assessed by subject;   Subject satisfaction score at Week 12;   Measured adherence to study medication at Week 12;   Quality of Life Assessments;   Number of treatment related adverse events (AEs) and serious adverse events (SAEs)
8 Unknown  Evaluation of Fosmidomycin and Clindamycin in the Treatment of Acute Uncomplicated Plasmodium Falciparum Malaria
Condition: Malaria
Intervention: Drug: Fosmidomycin and Clindamycin
Outcome Measures: Cure rate;   cure rate
9 Recruiting To Compare the Efficacy and Safety of Clindamycin Phosphate 1.2% / Benzoyl Peroxide 5% Gel of CHL Versus DUAC® Gel
Condition: Acne Vulgaris
Interventions: Drug: Clindamycin Phosphate 1.2% / Benzoyl Peroxide 5% Gel;   Drug: DUAC® Gel;   Drug: Placebo
Outcome Measures: Mean percent change from baseline to week 11 (study Day 77) for inflammatory (papules and pustules) lesions.;   Mean percent change from baseline to week 11 in the non-inflammatory lesion count;   Proportion of subjects with a clinical response of "success" at week 11
10 Unknown  Evaluate Efficacy, Tolerability & Safety of Combination of Clindamycin and Ketoconazole for the Treatment of Mixed-Type Vaginosis, Bacterial Vaginosis and Candidiasis
Conditions: Candidiasis;   Bacterial Vaginosis
Interventions: Drug: Clindamycin 100mg and Ketoconazole 400mg;   Drug: Tetracycline 100mg and Amphotericin B 50mg
Outcome Measures: Efficacy based on cure rate evaluated by clinical and laboratory criteria.;   Tolerability based on adverse events reports and patient's information;   Safety based on adverse events reports and laboratory criterion
11 Recruiting Assessing the Necessity of Prescribing Antibiotics (Clavulin or Clindamycin Versus Placebo) Post-peritonsillar Abscess Drainage
Condition: Peritonsillar Abscess
Interventions: Drug: Clavulin;   Drug: Randomization to Placebo;   Drug: Clindamycin
Outcome Measure: Re-accumulation of the patient's peri-tonsillar abscess
12 Unknown  Treatment of Chorioamnionitis After Delivery
Condition: Chorioamnionitis
Interventions: Drug: saline;   Drug: ampicillin gentamicin;   Drug: Ampicillin gentamicin Clindamycin;   Drug: ampicillin gentamicin Clindamycin
Outcome Measure: To determine the courses of antibiotics needed after vaginal delivery and after cesareans in pregnancies complicated by chorioamnionitis.
13 Recruiting Antibiotic Safety (SCAMP)
Condition: Complicated Intra Abdominal Infections
Interventions: Drug: ampicillin and metronidazole and gentamicin;   Drug: ampicillin and gentamicin and Clindamycin;   Drug: gentamicin and Piperacillin- tazobactam;   Drug: standard of care antibiotics and metronidazole
Outcome Measures: Death;   Number of participants with therapeutic success at Day 30 and Day 90
14 Unknown  Randomized Controlled Trial of Antibiotics in the Management of Children With Community-Acquired Skin and Soft Tissue Abscess Undergoing Incision and Drainage
Conditions: Skin and Soft Tissue Abscess;   Methicillin-resistant Staphylococcus Aureus (MRSA) Infection
Intervention: Drug: Oral Clindamycin
Outcome Measures: The primary objective is to measure clinical resolution of skin abscess at routine follow-up visit 10-14 days post operation.;   Secondary outcomes measured include incidence of additional skin and soft tissue infections in patient and in household contacts as determined by healthcare provider. Compliance to antibiotic regime will also be assessed at this time.
15 Not yet recruiting Orthognathic Surgery and Postoperative Antibiotic Use
Condition: Dentofacial Deformity
Intervention: Drug: Cefazolin, Cephalexin, Clindamycin
Outcome Measures: Rate of infection;   Side effect from antibiotic use
16 Not yet recruiting Prophylactic Antibiotics for Manual Removal of Retained Placenta in Vaginal Birth: a Randomized Controlled Trial
Condition: Endometritis
Interventions: Drug: Antibiotic prophylaxis;   Drug: Ampicillin;   Drug: Gentamycin;   Drug: Clindamycin
Outcome Measures: Endometritis rate;   Puerperal fever
17 Recruiting Uncomplicated Skin and Soft Tissue Infections Caused by Community-Associated Methicillin-Resistant Staphylococcus Aureus
Condition: Staphylococcal Infection
Interventions: Drug: Clindamycin;   Drug: Trimethoprim-sulfamethoxazole (TS);   Drug: Placebo
Outcome Measures: Clinical cure, defined as absence of clinical failure.;   Efficacy outcome: clinical cure of recurrences or relapses of SSTI.;   Safety outcomes: adverse events; and adverse events that are treatment limiting.
18 Recruiting PK of Antistaphylococcal Antibiotics in Infants (NICHD-2012-02-Staph Trio)
Condition: Systemic Infection
Intervention: Drug: Antibiotic
Outcome Measures: Pharmacokinetic concentrations in plasma will be measured at a central lab using a validated bioanalytical assay. Plasma samples will be drawn according to specific schedules for each drug;   Safety review will be performed through monitoring of adverse events each day that the infant is on study
19 Recruiting Skin Rash Study Before Chemotherapy in Colorectal & Head and Neck Cancer Patients
Conditions: Colorectal Cancer;   Head and Neck Cancer
Interventions: Drug: Doxycycline;   Drug: Hydrocortisone 1% cream;   Other: Sunscreen;   Other: Moisturizer;   Drug: Clindamycin;   Drug: Medrol-dose pack (Steroid)
Outcome Measures: Incidence of Rash;   Quality of Life (QOL);   Adherence to treatment regimen;   Progression Free Survival
20 Recruiting A Comparative Evaluation of the Safety and Efficacy of Daptomycin Versus Standard of Care in Pediatric Subjects Two - Seventeen Years of Age With Bacteremia Caused by Staphylococcus Aureus
Condition: Bacteremia
Interventions: Drug: Daptomycin;   Drug: Comparator (Vancomycin, Semi-synthetic penicillin, First-generation cephalosporins, Clindamycin)
Outcome Measures: Safety of daptomycin measured by the incidence of treatment-emergent adverse events, vital signs, echocardiogram (if performed) and clinical laboratory tests, use of concomitant medications,physical and neurological exam results.;   Efficacy of daptomycin will be based on Investigator's assessment of clinical response (cure, improved, failure or non-evaluable) at the Test of Cure (TOC) visit.