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DRUG WITHDRAWAL SYNDROME and Diazepam

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DRUG WITHDRAWAL SYNDROME Symptoms and Causes

Opioids, sometimes called narcotics, are a type of drug. They include strong prescription pain relievers, such as oxycodone, hydrocodone, fentanyl, and tramadol. The illegal drug heroin is also an opioid. Some opioids are made from the opium plant, and others are synthetic (man-made).

A doctor may give you a prescription opioid to reduce pain after you have had a major injury or surgery. You may get them if you have severe pain from health conditions like cancer. Some doctors prescribe them for chronic pain.

Opioids can cause side effects such as drowsiness, mental fog, nausea, and constipation. They may also cause slowed breathing, which can lead to overdose deaths. If someone has signs of an overdose, call 9-1-1:

  • The person's face is extremely pale and/or feels clammy to the touch
  • Their body goes limp
  • Their fingernails or lips have a purple or blue color
  • They start vomiting or making gurgling noises
  • They cannot be awakened or are unable to speak
  • Their breathing or heartbeat slows or stops

Other risks of using prescription opioids include dependence and addiction. Dependence means feeling withdrawal symptoms when not taking the drug. Addiction is a chronic brain disease that causes a person to compulsively seek out drugs, even though they cause harm. The risks of dependence and addiction are higher if you abuse the medicines. Abuse can include taking too much medicine, taking someone else's medicine, taking it in a different way than you are supposed to, or taking the medicine to get high.

Opioid abuse, addiction, and overdoses are serious public health problems in the United States. Another problem is that more women are abusing opioids during pregnancy. This can lead to babies being addicted and going through withdrawal, known as neonatal abstinence syndrome (NAS). Opioid abuse may sometimes also lead to heroin use, because some people switch from prescription opioids to heroin.

The main treatment for prescription opioid addiction is medication-assisted treatment (MAT). It includes medicines, counseling, and support from family and friends. MAT can help you stop using the drug, get through withdrawal, and cope with cravings. There is also a medicine called naloxone which can reverse the effects of an opioid overdose and prevent death, if it is given in time.

To prevent problems with prescription opioids, be sure to follow your doctor's instructions when taking them. Do not share your medicines with anyone else. Contact your doctor if you have any concerns about taking the medicines.

NIH: National Institute on Drug Abuse

Check out the latest treatments for DRUG WITHDRAWAL SYNDROME

DRUG WITHDRAWAL SYNDROME treatment research studies

Diazepam clinical trials, surveys and public health registries


Find Drug Side Effect reports



Diazepam Side Effects

Toxicity To Various Agents (570)
Completed Suicide (509)
Cardiac Arrest (440)
Respiratory Arrest (434)
Poisoning (391)
Death (378)
Overdose (157)
Cardio-respiratory Arrest (152)
Exposure Via Ingestion (127)
Anxiety (81)
Suicide Attempt (75)
Intentional Overdose (73)
Somnolence (72)
Hypotension (71)
Loss Of Consciousness (63)
Confusional State (61)
Dizziness (58)
Tachycardia (57)
Vomiting (53)
Headache (52)
Agitation (50)
Convulsion (50)
Respiratory Depression (48)
Fall (48)
Pyrexia (47)
Malaise (46)
Pulmonary Oedema (46)
Depression (45)
Coma (44)
Dyspnoea (43)
Insomnia (41)
Nausea (40)
Feeling Abnormal (38)
Therapeutic Agent Toxicity (37)
Sedation (37)
Poisoning Deliberate (37)
Pain (37)
Aggression (34)
Sopor (34)
Serotonin Syndrome (31)
Dysarthria (31)
Neuroleptic Malignant Syndrome (30)
Disorientation (30)
Fatigue (29)
Accidental Overdose (28)
Delirium (28)
Pneumonia (28)
Depressed Level Of Consciousness (28)
Hypertension (28)
Hallucination (27)

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Recent Reviews

Anon- I would say the weed would cause the MOST memory loss used over time also depending on how strong it is ie, (haze, kush....dro...regs from 60's with seeds) THE STONGER it is the faster the brain cells go! As far as the valium/dia

I find that taking diazepam 5mg twice a day i get totally relaxed and sleep well.My coordination would not be the bestso i do avoid driving.The only problem i seem to be having regarding it is that i needto take it every day or i become agi

I have had a very similar experience however I have terrifying and vivid nightmares the following night after a sound nights sleep has already been had. Most of the dreams end with me thinking that I have woken up and that I am having horrible halluc

I take 50 diazepam 5 m tab what is the side effect?

My daughter has taken diasepam25mg for many years.could this cause longterm memory loss?she also takes 85mg methedone also smokes weed.which of them would cause the memory loss most?

My doctor prescribed valium for stress and anxiety. I have had very strange and lucid dreams. I am also taking antibiotics, lovenox,and nadalol, for some serious medical conditions. *DONT_KNOW*

Chantix caused me to haveseizures I would not recommend anyone to take this drug find a different way to quit smoking that is safe.

I HAD 1 SHOT OF THIS AND WITHIN 12 HOURS I WENT FROM A VERY NORMAL BLOOD PRESSURE TO WAKING AT 5 A.M. NEXT DAY WITH 198/110 AND 104 PULSE RATE. IT HAS CONTINUED ALL WEEK AFTER AND I'M NOW ON A BLOOD PRESSURE DRUG TO TRY AND CONTROL IT. EVEN WITH DR

can advagraf makke you look like you are pregnant? Can this drug affect your eye site--blurry vision

Does anyone else have insomnia problems, with this drug, was fine before taking it, but now having major trouble getting to sleep and staying asleep.

I have experienced panic attacks, light headedness and pasty mouth taking this drug at 400mg's.

I have sjogren's syndrome. Can i use arcalion or is it not good for me?

Impact of this drug on blood pressure. Should I be worried?

My symptoms were tired, weak, unable to sleep. Was prescribed half of a 15 MG Mirtazapine nightly to help me sleep. Has this drug been successful used as a sleeping aid?

WHAT ARE SIDE EFFECT OF COTRIMOXAXOLE DRUG

<!--StartFragment--> I have advanced Rheumatoid Arthritis. My Left wrist swelled painfully. Had a negative X-ray so Dr (fully informed for current drug regimens and allergies--Aspirin, Penicillin, Thoradamides, Ornate, Iodine, Latex)

DRUG WITHDRAWAL SYNDROME Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting Comparison of Absorption of Vaginal Diazepam Using Different Delivery Systems
Condition: Metabolism, Drug
Interventions: Drug: Diazepam tablet, 5 mg, vaginal;   Drug: Diazepam Suppository, 5 mg, vaginal;   Drug: Diazepam Cream, 5 mg, Vaginal
Outcome Measures: Serum Diazepam levels measured over time;   Side effects observed with each of three types of vaginal Diazepam
2 Recruiting Vaginal Diazepam for the Treatment of Female Pelvic Pain
Conditions: Pelvic Floor Disorders;   Pelvic Pain
Interventions: Drug: Diazepam;   Drug: Placebo
Outcome Measures: Change from baseline in Visual Analog Pain Scale score at 4 weeks, 12 weeks, and 24 weeks.;   Change from baseline in Pelvic Floor Distress Inventory-20 Questionnaire score at 4 weeks, 12 weeks, and 24 weeks.;   Change from baseline in McGill Pain Questionnaire score at 4 weeks, 12 weeks, and 24 weeks.;   Change from baseline in Global Response Assessment score at 4 weeks, 12 weeks, and 24 weeks.
3 Recruiting Lofexidine for Inpatient Opiate Detox in Singapore
Condition: Opiate Dependent Patients Who Are Undergoing Inpatient Detoxification in Singapore
Interventions: Drug: Lofexidine;   Drug: Diazepam;   Drug: Placebo for Lofexidine;   Drug: Placebo for Diazepam
Outcome Measures: To evaluate differences in OOWS (Objective Opiate Withdrawal Scale);   To evaluate differences in SOWS (Short Opiate Withdrawal Scale);   To evaluate differences in pupil sizes;   To evaluate differences in craving on the Visual Analogue Scale;   To evaluate differences in time to drop-out (length of stay on the ward);   To evaluate differences in emotional/psychological symptoms
4 Unknown  Performance Study of the SOLO 2.0 Insulin Pump
Condition: Type 1 Diabetes
Intervention: Device: SOLO insulin pump
Outcome Measures: Device related safety issues;   SOLO use errors;   Device-related adverse outcome;   Diabetes-related adverse outcome;   Satisfaction iwth SOLO;   Product quality (MTBF)
5 Recruiting Safety and Feasibility Study of Enhanced Recovery in Pancreaticoduodenectomy
Condition: Pancreaticoduodenectomy (E04.210.760)
Interventions: Behavioral: Enhanced recovery after surgery protocol;   Procedure: Standard perioperative care;   Drug: PONV prophylaxis with Ondansetron + Dexamethasone;   Other: Postoperative mobilization program;   Drug: Epidural analgesia with naropin + sufentanil;   Drug: Pre-anesthetic medication with Diazepam;   Behavioral: Preadmission counselling;   Drug: Preoperative bowel preparation with sodium phosphate
Outcome Measures: Adherence to the pathway;   Postoperative outcome
6 Recruiting A Prospective Trial to Reduce Post-Operative Pain in Implant Based Breast Reconstruction
Condition: Post-operative Pain
Interventions: Drug: Bupivacaine;   Drug: Botulinum Toxins;   Drug: Analgesics
Outcome Measure: Pain Score Questionnaire
7 Recruiting Perioperative Δ9-THC for Postsurgical Pain
Condition: Pain
Interventions: Drug: Namisol;   Drug: Diazepam/placebo
Outcome Measures: Analgesic efficacy;   Incidence of persistent continuous or intermittent postsurgical abdominal pain
8 Unknown  The Effect of Prescription Medications in Marijuana Users
Condition: Marijuana Abuse
Intervention: Drug: bupropion, Diazepam, dronabinol, ramelteon (Investigational Drug)
Outcome Measures: marijuana withdrawal;   subjective effects of smoked marijuana;   cognitive performance
9 Recruiting The PROOF Study: The PICC Related Obstruction Of Flow Study
Condition: Patients Indicated for a PICC for Any Medical Condition
Interventions: Device: BioFlo™ Peripherally Inserted Central Catheter (PICC);   Device: Bard® Dual-Lumen PowerPICC SOLO2®
Outcome Measures: Incidence of catheter-related venous thrombosis as confirmed by diagnostic ultrasound;   Incidence of other catheter-related complications
10 Not yet recruiting Implementing Health Plan-Level Care Management for Solo & Small Practices
Conditions: Bipolar Disorder;   Depression
Interventions: Behavioral: Chronic Care Model for Mood Disorders;   Other: Educational Control
Outcome Measures: Quality of Life;   Reduced Mood Disorder Symptoms;   Improved Guideline-Concordant Care;   Reduced Hospitalizations;   Improved Work Productivity
11 Unknown  Positron Emission Mammography (PEM) Flex Solo II Positron Emission Tomography (PET) Scanner and Stereo Navigator Biopsy Accessory for the Diagnosis of Breast Cancer
Condition: Breast Cancer
Intervention: Procedure: PEM Breast Biopsy
Outcome Measures: Evidence that breast biopsy can be performed using PEM and Stereo Navigator software;   Evidence that breast biopsy can be performed in less clinical visits than if biopsy is performed using MRI, mammogram, and/or ultrasound
12 Unknown  Quality of Sleep in Patients With Rheumatoid Arthritis
Condition: Rheumatoid Arthritis
Intervention: Drug: Diazepam, melatonin
Outcome Measure:
13 Recruiting Optimization of Procedural Sedation Protocol Used for Dental Care Delivery in People With Mental Disability
Condition: Dental Care for Disabled
Interventions: Drug: Midazolam Mylan;   Drug: Lorazepam Mylan;   Drug: Valium + Akineton + Dehydrobenzperidol + Atropine sulfate
Outcome Measures: Level of cooperation of patient when receiving regular dental care;   Recording of vital parameters during regular dental care delivery;   Level of patient comfort and possible side-effects after dental treatment session
14 Recruiting Tolerance of PICC Line Versus Implanted Port for Adjuvant Chemotherapy in Early Breast Cancer
Condition: Early Stage Breast Carcinoma
Interventions: Device: implanted port for chemo administration (X-port isp);   Device: Use of a PICC line for chemo administration (PowerPICC SOLO²)
Outcome Measures: Probability of occurrence of a significant adverse event related to the central venous device;   Patients' satisfaction for the use of their central venous device
15 Unknown  Continuation Electroconvulsive Therapy (C-ECT) for Relapse Prevention in Major Depression
Condition: Depression
Interventions: Device: Thrymatron System IV device (CONSOLIDATION ELECTROCONVUsLIVE THERAPY) plus PHARMACOTHERAPY;   Drug: PHARMACOTHERAPY
Outcome Measures: Hamilton Depression Rating Scale 21 items (HDRS-21);   Mini-Mental State Examination (MMSE 35);   UKU - Adverse effects rating scales;   Demographical Data Memory (MEDABI-20);   Rey Figure;   Trail Making Test A;   Trail Making Test B;   Stroop Test;   Direct and inverse digits (WAIS, Weschler Adults Intelligence Sacle).;   Vocabulary WAIS (Weschler Adults Intelligence Scale);   Frequency Hospitalization Quotient;   Hospital Day Quotient (HDQ)
16 Recruiting RCT of Mesh Versus Jet Nebulizers on Clinical Outcomes During Mechanical Ventilation in the Intensive Care Unit
Condition: Respiratory Insufficiency
Interventions: Device: Vibrating Mesh Nebulizer Arm;   Device: Jet Nebulizer Arm
Outcome Measures: Venilator Associated Events;   Bacterial Count and type;   Length of Stay in Intensive Care Unit;   Days on Mechanical Ventilation;   Ventilator-Associated Tracheobronchitis
17 Recruiting Gabapentin Treatment of Benzodiazepine Dependence
Condition: Benzodiazepine Dependence
Interventions: Drug: gabapentin;   Drug: Placebo
Outcome Measure: Abstinence from Benzodiazepine use
18 Recruiting Electrical Status Epilepticus in Sleep: Response of Neuropsychological Deficits and Epileptiform Activity to Clobazam Treatment
Condition: Electrical Status Epilepticus in Sleep
Intervention: Drug: ESES treated with clobazam
Outcome Measures: Cognitive ability;   Language;   Executive function;   Adaptive/development skills;   Behavior;   Interictal epileptiform activity
19 Recruiting Carbon Dioxide (Carbogen) for the Treatment of Febrile Seizures
Condition: Febrile Seizure
Interventions: Drug: Carbogen;   Drug: Placebo
Outcome Measures: number of patients which need Diazepam;   number of severe adverse events;   manageability of the application assessed by the parents;   changes in quality of life of the parents and children after use of study medication;   contentment and anxiety of the parents
20 Unknown  Extended-release Epidural Morphine for Acute Post-operative Analgesia Following Selective Dorsal Rhizotomy in Children
Condition: Spastic Cerebral Palsy
Interventions: Drug: Extended-release Epidural morphine (EREM) 80;   Drug: Extended-release Epidural Morphine (EREM) 120;   Drug: Control: Saline
Outcome Measures: Quantity of fentanyl administered;   Adequacy of analgesia as judged by age-adjusted pain scales.;   Incidence of respiratory depression;   Hemodynamic instability;   Rate of CSF leak;   Rate of infection;   Urinary retention;   Nausea and/or vomiting;   Pruritis