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DRUG WITHDRAWAL SYNDROME and Genteal

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DRUG WITHDRAWAL SYNDROME Symptoms and Causes

Opioids, sometimes called narcotics, are a type of drug. They include strong prescription pain relievers, such as oxycodone, hydrocodone, fentanyl, and tramadol. The illegal drug heroin is also an opioid. Some opioids are made from the opium plant, and others are synthetic (man-made).

A doctor may give you a prescription opioid to reduce pain after you have had a major injury or surgery. You may get them if you have severe pain from health conditions like cancer. Some doctors prescribe them for chronic pain.

Opioids can cause side effects such as drowsiness, mental fog, nausea, and constipation. They may also cause slowed breathing, which can lead to overdose deaths. If someone has signs of an overdose, call 9-1-1:

  • The person's face is extremely pale and/or feels clammy to the touch
  • Their body goes limp
  • Their fingernails or lips have a purple or blue color
  • They start vomiting or making gurgling noises
  • They cannot be awakened or are unable to speak
  • Their breathing or heartbeat slows or stops

Other risks of using prescription opioids include dependence and addiction. Dependence means feeling withdrawal symptoms when not taking the drug. Addiction is a chronic brain disease that causes a person to compulsively seek out drugs, even though they cause harm. The risks of dependence and addiction are higher if you abuse the medicines. Abuse can include taking too much medicine, taking someone else's medicine, taking it in a different way than you are supposed to, or taking the medicine to get high.

Opioid abuse, addiction, and overdoses are serious public health problems in the United States. Another problem is that more women are abusing opioids during pregnancy. This can lead to babies being addicted and going through withdrawal, known as neonatal abstinence syndrome (NAS). Opioid abuse may sometimes also lead to heroin use, because some people switch from prescription opioids to heroin.

The main treatment for prescription opioid addiction is medication-assisted treatment (MAT). It includes medicines, counseling, and support from family and friends. MAT can help you stop using the drug, get through withdrawal, and cope with cravings. There is also a medicine called naloxone which can reverse the effects of an opioid overdose and prevent death, if it is given in time.

To prevent problems with prescription opioids, be sure to follow your doctor's instructions when taking them. Do not share your medicines with anyone else. Contact your doctor if you have any concerns about taking the medicines.

NIH: National Institute on Drug Abuse

Check out the latest treatments for DRUG WITHDRAWAL SYNDROME

DRUG WITHDRAWAL SYNDROME treatment research studies

Genteal clinical trials, surveys and public health registries


Find Drug Side Effect reports



Genteal Side Effects

Eye Irritation (30)
Eye Pain (25)
Vision Blurred (18)
Eye Pruritus (17)
Ocular Hyperaemia (16)
Pruritus (16)
Cataract (11)
Cataract Operation (9)
Dry Eye (8)
Eyelid Disorder (8)
Corneal Abrasion (7)
Eye Swelling (6)
Foreign Body Sensation In Eyes (6)
Lacrimation Increased (6)
Weight Decreased (4)
Fall (4)
Eye Infection (4)
Hypersensitivity (4)
Instillation Site Pain (3)
Corneal Disorder (3)
Keratitis (3)
Visual Acuity Reduced (3)
Superficial Injury Of Eye (3)
Ulcerative Keratitis (3)
Cerebrovascular Accident (2)
Cellulitis (2)
Anorexia (2)
Anaphylactic Shock (2)
Condition Aggravated (2)
Blepharospasm (2)
Death (2)
Pneumonia (2)
Dyspnoea (2)
Abnormal Sensation In Eye (2)
Diplopia (2)
Depression (2)
Conjunctival Ulcer (2)
Eye Inflammation (2)
Headache (2)
Intraocular Pressure Increased (2)
Hallucination, Visual (2)
Furuncle (2)
Eye Operation (2)
Large Intestinal Obstruction Reduction (2)
Lung Disorder (2)
Eye Discharge (2)
Plastic Surgery (2)
Memory Impairment (2)
Malaise (2)
Eye Burns (2)

➢ More


Common Meds

Abilify (10132)
Adderall (1304)
Amlodipine (6664)
Amoxicillin (4387)
Benadryl (1568)
Celebrex (12876 )
Celexa (1342)
Cialis (2975)
Cipro (8580)
Citalopram (7792)
Crestor (18839)
Cymbalta (14373)
Doxycycline (1757)
Effexor (7289)
Flexeril (435)
Flomax (2177)
Fluoxetine (4261)
Gabapentin (4593)
Hydrocodone (2469)
Ibuprofen (8222)
Lantus (10968)
Lexapro (3499)
Lipitor (17769)
Lisinopril (8919)
Lyrica (27148)
Medrol (650)
Mirena (41254)
Mobic (957)
Morphine (5356)
Naproxen (538)
Neurontin (6501)
Oxycodone (4438)
Pradaxa (13372)
Prednisone (5926)
Prilosec (2631)
Prozac (1954)
Seroquel (27216)
Simvastatin (8348)
Synthroid (4452)
Tamiflu (5585)
Topamax (3748)
Tramadol (5054)
Trazodone (1458)
Viagra (5394)
Vicodin (1153)
Wellbutrin (6324)
Xanax (2847)
Zocor (5718)
Zoloft(6792)
Zyrtec(1669)

Recent Reviews

After using Genteal, my face broke out in a rash

At 58, suffering from severe, chronic dry eye (age- & Lasik-related), my ophthalmologist inserted punctal 'plugs' and advised buying GenTeal eye drops, as they 'have no preservatives.' I've now spent a week with increasing eye irritation/burn

First time user of Genteal Lubricant eye gel. After using this gel about 3 times, the inner part of my eye lid next to the nose (both eyes) became very red and raw. Had to go to an optician and he said if it

My father (83 yrs old) underwent Glaucoma and cataract surgery (left eye only ; right eye had acute Glaucoma and was difficult to be improved) on 31st July 2009. As advised, He recently got checked up by another local doctor because of blurred vision

This product is bad in my opinion! I will never recommend this product to anyone!

Chantix caused me to haveseizures I would not recommend anyone to take this drug find a different way to quit smoking that is safe.

I HAD 1 SHOT OF THIS AND WITHIN 12 HOURS I WENT FROM A VERY NORMAL BLOOD PRESSURE TO WAKING AT 5 A.M. NEXT DAY WITH 198/110 AND 104 PULSE RATE. IT HAS CONTINUED ALL WEEK AFTER AND I'M NOW ON A BLOOD PRESSURE DRUG TO TRY AND CONTROL IT. EVEN WITH DR

can advagraf makke you look like you are pregnant? Can this drug affect your eye site--blurry vision

Does anyone else have insomnia problems, with this drug, was fine before taking it, but now having major trouble getting to sleep and staying asleep.

I have experienced panic attacks, light headedness and pasty mouth taking this drug at 400mg's.

I have sjogren's syndrome. Can i use arcalion or is it not good for me?

Impact of this drug on blood pressure. Should I be worried?

My symptoms were tired, weak, unable to sleep. Was prescribed half of a 15 MG Mirtazapine nightly to help me sleep. Has this drug been successful used as a sleeping aid?

WHAT ARE SIDE EFFECT OF COTRIMOXAXOLE DRUG

<!--StartFragment--> I have advanced Rheumatoid Arthritis. My Left wrist swelled painfully. Had a negative X-ray so Dr (fully informed for current drug regimens and allergies--Aspirin, Penicillin, Thoradamides, Ornate, Iodine, Latex)

DRUG WITHDRAWAL SYNDROME Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Unknown  A Placebo Controlled Comparison of Topical Zirgan Versus Genteal Gel for the Treatment of Adenovirus Conjunctivitis
Conditions: Keratoconjunctivitis Due to Adenovirus;   Viral Shedding
Interventions: Drug: Zirgan;   Drug: Genteal gel
Outcome Measures: Time to Viral Eradication;   Development of sub-epithelial infiltrates;   Degree of Bulbar conjunctival Injection;   Second eye involvment
2 Recruiting A Trial of Topical Dexamethasone Versus Artificial Tears for Treatment of Viral Conjunctivitis
Condition: Viral Conjunctivitis
Interventions: Drug: dexamethasone 0.1%/povidone-iodine 0.4%;   Drug: Artificial Tears
Outcome Measures: Conjunctival injection;   Conjunctival chemosis
3 Unknown  Hydroxypropylmethylcellulose 0.3% and Sodium Hyaluronate 0.18% for Ocular Surface Disease in Glaucoma
Conditions: Ocular Surface Disease;   Glaucoma
Interventions: Drug: hydroxypropylmethylcellulose;   Drug: sodium hyaluronate
Outcome Measures: Ocular surface index score;   Eye lid inflammation, corneal staining score, tear break up time and tear volume
4 Not yet recruiting Efficacy and Safety Study of Bimatoprost 0.01% Alone Compared With Travoprost 0.004% and Timolol 0.5% in Subjects With Glaucoma or Ocular Hypertension
Conditions: Glaucoma;   Ocular Hypertension
Interventions: Drug: bimatoprost 0.01%;   Drug: travoprost 0.004%;   Drug: timolol 0.5%;   Drug: hypromellose 0.3%
Outcome Measure: Intraocular Pressure (IOP) in the Study Eye
5 Recruiting An Efficacy and Safety Study of Bimatoprost 0.01% Alone Compared With Travoprost 0.004% and Timolol 0.5% in Subjects With Glaucoma or Ocular Hypertension
Conditions: Glaucoma;   Ocular Hypertension
Interventions: Drug: bimatoprost 0.01%;   Drug: travatan 0.004%;   Drug: timolol 0.5%;   Drug: hypromellose 0.3%
Outcome Measure: Intraocular Pressure (IOP) in the Study Eye
6 Recruiting Hydroxypropyl Beta Cyclodextrin for Niemann-Pick Type C1 Disease
Condition: Niemann-Pick Disease, Type C1
Intervention: Drug: 2-hydroxypropyl-beta-cyclodextrin
Outcome Measures: 24-hydroxycholesterol Area under the curve;   Hearing loss.
7 Recruiting The Utility of in Vivo Confocal Microscopy to Assess Cellular Response and Efficacy of Long-term Topical Steroid Treatment in Patients With Dry Eye Disease
Condition: Dry Eye Disease
Interventions: Drug: Lotemax;   Drug: Artificial Tears
Outcome Measures: In Vivo Confocal Microscopy (IVCM): Superficial corneal epithelial cells: Density, size, and hypereflectivity;   In Vivo Confocal Microscopy: Corneal subbasal immune dendritiform cells: Density, size, and cell field;   In Vivo Confocal Microscopy: Corneal subbasal nerves: Number and length of the main nerves and the branches;   Ocular Signs: Corneal epitheliopathy;   Ocular Signs: Conjunctival epitheliopathy;   Ocular Signs: Tear Break Up Time (TBUT);   Ocular Signs: Schirmer's Test with Anesthesia;   Ocular Signs: Intraocular pressure (IOP) by measure of applanation tonometry;   Ocular Symptoms: Ocular Surface Disease Index (OSDI) questionnaire;   Ocular Symptoms: • Symptom Assessment iN Dry Eye (SANDE) questionnaire
8 Unknown  Comparison of Combination Antibiotics Eyedrop to Artificial Tear in Hordeolum After Incision and Curettage
Condition: Hordeolum
Interventions: Drug: neomycin sulfate, polymyxin B sulfate and gramicidin;   Drug: Artificial tear
Outcome Measures: Pain scale;   Mass size and duration of cure
9 Recruiting Efficacy and Safety of Fluorometholone (FML) in Dry Eye Disease (Keratoconjunctivitis Sicca)
Condition: Dry Eye
Interventions: Drug: FML 0.1% eyedrops;   Drug: Liquifilm artificial tears eyedrops
Outcome Measures: Fluorescein corneal staining;   Symptom Assessment in Dry Eye (SANDE) I and II questionnaire;   Tear inflammatory molecule levels;   Best corrected visual acuity;   Biomicroscopy findings at slit lamp examination;   Adverse events during the trial;   Other Efficacy Measures;   Intraocular pressure (IOP) and fundus examination
10 Recruiting Effects of Conventional Dry Eye Treatments on the Ocular Surface Response to Low Humidity Environment in Patients With Keratoconjunctivitis Sicca
Conditions: Keratoconjunctivitis Sicca;   Dry Eye Syndrome
Intervention: Drug: dexamethasone, artificial tears
Outcome Measure: Changes in ocular surface measured by routine opthalmic dyes
11 Recruiting Effect of Topical Glaucoma Therapy on Tear Film Stability in Healthy Subjects
Condition: Healthy
Interventions: Drug: Timoptic® 0.5%;   Drug: Timophtal sine® 0.5%;   Device: Genteal HA®;   Device: Hylo-Comod®;   Device: Thealoz®
Outcome Measures: Tear film thickness;   Break up time (BUT)
12 Recruiting Fluorometholone as Ancillary Therapy for TT Surgery
Conditions: Trichiasis;   Trachoma;   Bilamellar Tarsal Rotation
Interventions: Drug: Fluorometholone 0.1% ophthalmic solution;   Other: Artificial tears (Placebo)
Outcome Measures: Safety assessments;   Recurrence of trichiasis in the study eye
13 Not yet recruiting Assessment of Tear Film Thickness by Optical Coherence Tomography in Healthy Subjects and Subjects With Dry Eye Disease
Condition: Dry Eye Syndrome
Interventions: Device: Genteal HA® Eye Drops (NOVARTIS, Switzerland);   Other: Physiological Sodium Chloride solution (0,9%)
Outcome Measures: Tear film thickness;   Schirmer I Test;   Tear Break Up Time;   Ocular Surface Disease Index
14 Recruiting A Phase IV, Randomized, Parallel Group, Investigator-Masked Evaluation of the Effect of Loteprednol Etabonate Ophthalmic Gel 0.5% on the Initiation of Dry Eye Treatment With Restasis®
Condition: Dry Eye Disease
Interventions: Drug: Loteprednol etabonate;   Drug: Artificial Tears;   Drug: Restasis
Outcome Measures: Fluorescein corneal staining scores;   Lissamine green conjunctival staining
15 Not yet recruiting Prostaglandin F2-alpha Eye Drops in Thyroid Eye Disease (Bima Study)
Condition: Graves' Ophthalmopathy
Interventions: Drug: Bimatoprost;   Drug: Eye drop solution
Outcome Measures: The primary endpoint of this study will be comparison of the change in ophthalmometry readings over the two 3 month treatment periods.;   Change in quality of life scores on the TED quality of life questionnaire (GO-QOL);   Intraocular pressures;   Side effects;   Health economic outcomes
16 Recruiting Treatment of Port-wine Mark in Sturge-Weber Syndrome Using Topical Timolol
Conditions: Sturge Weber Syndrome;   Port Wine Mark
Interventions: Drug: Timolol;   Drug: Preservative free artificial tear gel.
Outcome Measure: Appearance of Port-wine Mark at treatment site
17 Recruiting Steroids After Laser Trabeculoplasty for Glaucoma
Condition: Glaucoma
Interventions: Drug: Prednisolone 1%;   Drug: Diclofenac 0.1%;   Drug: Artificial Tears
Outcome Measures: Intraocular pressure (IOP) lowering;   Intraocular inflammation
18 Unknown  Aqueous Humor Dynamics and Brimonidine
Condition: Intraocular Pressure
Interventions: Drug: Brimonidine;   Drug: Artificial tears
Outcome Measure: Aqueous Humor Dynamics
19 Recruiting Postoperative Subtenons Anesthesia for Postoperative Pain in Pediatric Strabismus Surgery
Condition: Strabismus
Interventions: Drug: subtenons anesthetic - preservative-free bupivacaine 0.75%;   Drug: topical anesthetic - 0.5 cc of lidocaine 3.5% ophthalmic gel;   Drug: topical control - 0.5 cc of Hypromellose 0.3% gel;   Drug: subtenons control - 0.5 cc of Normal Saline
Outcome Measures: Average pain score over the first 30 post-operative minutes using the CHEOPS scale;   Peak pain score in the first 30 minutes;   Total narcotic and anti-emetic use during post-operative recovery;   Negative postoperative behavior score on the PHBQ (post hospitalization behavioral questionnaire);   Change in pain score
20 Unknown  Evaluation of Blood as a Submucosal Cushion During Endoscopic Polypectomy and Mucosal Resection
Condition: Large Polyps in the Gastrointestinal Tract
Interventions: Drug: Autologous blood injection;   Drug: Normal saline;   Drug: HPMC
Outcome Measures: Duration of the submucosal cushion Ease of injection Ability to complete lesion removal Post-procedure complications;   Ability to perform lesion removal Ability to visualize during the procedure