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DRUG WITHDRAWAL SYNDROME and Propranolol

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DRUG WITHDRAWAL SYNDROME Symptoms and Causes

Opioids, sometimes called narcotics, are a type of drug. They include strong prescription pain relievers, such as oxycodone, hydrocodone, fentanyl, and tramadol. The illegal drug heroin is also an opioid. Some opioids are made from the opium plant, and others are synthetic (man-made).

A doctor may give you a prescription opioid to reduce pain after you have had a major injury or surgery. You may get them if you have severe pain from health conditions like cancer. Some doctors prescribe them for chronic pain.

Opioids can cause side effects such as drowsiness, mental fog, nausea, and constipation. They may also cause slowed breathing, which can lead to overdose deaths. If someone has signs of an overdose, call 9-1-1:

  • The person's face is extremely pale and/or feels clammy to the touch
  • Their body goes limp
  • Their fingernails or lips have a purple or blue color
  • They start vomiting or making gurgling noises
  • They cannot be awakened or are unable to speak
  • Their breathing or heartbeat slows or stops

Other risks of using prescription opioids include dependence and addiction. Dependence means feeling withdrawal symptoms when not taking the drug. Addiction is a chronic brain disease that causes a person to compulsively seek out drugs, even though they cause harm. The risks of dependence and addiction are higher if you abuse the medicines. Abuse can include taking too much medicine, taking someone else's medicine, taking it in a different way than you are supposed to, or taking the medicine to get high.

Opioid abuse, addiction, and overdoses are serious public health problems in the United States. Another problem is that more women are abusing opioids during pregnancy. This can lead to babies being addicted and going through withdrawal, known as neonatal abstinence syndrome (NAS). Opioid abuse may sometimes also lead to heroin use, because some people switch from prescription opioids to heroin.

The main treatment for prescription opioid addiction is medication-assisted treatment (MAT). It includes medicines, counseling, and support from family and friends. MAT can help you stop using the drug, get through withdrawal, and cope with cravings. There is also a medicine called naloxone which can reverse the effects of an opioid overdose and prevent death, if it is given in time.

To prevent problems with prescription opioids, be sure to follow your doctor's instructions when taking them. Do not share your medicines with anyone else. Contact your doctor if you have any concerns about taking the medicines.

NIH: National Institute on Drug Abuse

Check out the latest treatments for DRUG WITHDRAWAL SYNDROME

DRUG WITHDRAWAL SYNDROME treatment research studies

Propranolol clinical trials, surveys and public health registries


Find Drug Side Effect reports



Propranolol Side Effects

Completed Suicide (157)
Cardiac Arrest (133)
Bradycardia (109)
Hypotension (104)
Overdose (76)
Dizziness (70)
Respiratory Arrest (69)
Dyspnoea (57)
Cardio-respiratory Arrest (57)
Sinus Bradycardia (51)
Toxicity To Various Agents (47)
Circulatory Collapse (45)
Hypoglycaemia (45)
Convulsion (43)
Nausea (41)
Hyperhidrosis (40)
Loss Of Consciousness (38)
Cardiogenic Shock (37)
Death (37)
Fall (37)
Intentional Overdose (37)
Headache (35)
Tachycardia (34)
Hypertension (34)
Fatigue (32)
Palpitations (32)
Heart Rate Decreased (32)
Poisoning (31)
Asthenia (31)
Chest Pain (31)
Blood Pressure Increased (30)
Condition Aggravated (29)
Diarrhoea (29)
Vomiting (29)
Metabolic Acidosis (28)
Suicide Attempt (28)
Malaise (28)
Anxiety (28)
Syncope (27)
Shock (26)
Coma (26)
Weight Increased (25)
Multi-organ Failure (24)
Grand Mal Convulsion (24)
Unresponsive To Stimuli (22)
Tremor (21)
Blood Pressure Decreased (21)
Hypokalaemia (20)
Somnolence (20)
Insomnia (20)

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Recent Reviews

Hi, i have been taken Deralin 40 for migraine i have been experimenting like a low blood pressure at night and also I'm worried of gain weigh because i have back problems what do you think about that

I have been taking 80mg per day for anxiety for two years with no side effects. Three weeks ago my doctor increased my dose to 120mg. After two weeks of being on the higher dose I started to experience head tremors. I went to my doctor who seemed to

I plan to ask my doctor if I can get off it. I am pesenly taking Plavix and baby aspirin as I had surgery for an aneurysm

It makes me feel tired, I have stomach aches and flatulance and diahreae and sometimes dizzy.

Tiredness, dizziness, ligtheaded, diahrea gas and stomach pain :'( >:o :'(

Chantix caused me to haveseizures I would not recommend anyone to take this drug find a different way to quit smoking that is safe.

I HAD 1 SHOT OF THIS AND WITHIN 12 HOURS I WENT FROM A VERY NORMAL BLOOD PRESSURE TO WAKING AT 5 A.M. NEXT DAY WITH 198/110 AND 104 PULSE RATE. IT HAS CONTINUED ALL WEEK AFTER AND I'M NOW ON A BLOOD PRESSURE DRUG TO TRY AND CONTROL IT. EVEN WITH DR

can advagraf makke you look like you are pregnant? Can this drug affect your eye site--blurry vision

Does anyone else have insomnia problems, with this drug, was fine before taking it, but now having major trouble getting to sleep and staying asleep.

I have experienced panic attacks, light headedness and pasty mouth taking this drug at 400mg's.

I have sjogren's syndrome. Can i use arcalion or is it not good for me?

Impact of this drug on blood pressure. Should I be worried?

My symptoms were tired, weak, unable to sleep. Was prescribed half of a 15 MG Mirtazapine nightly to help me sleep. Has this drug been successful used as a sleeping aid?

WHAT ARE SIDE EFFECT OF COTRIMOXAXOLE DRUG

<!--StartFragment--> I have advanced Rheumatoid Arthritis. My Left wrist swelled painfully. Had a negative X-ray so Dr (fully informed for current drug regimens and allergies--Aspirin, Penicillin, Thoradamides, Ornate, Iodine, Latex)

DRUG WITHDRAWAL SYNDROME Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting Safety and Efficacy of Propranolol Eye Drops in Treating Retinopathy of Premature
Condition: Retinopathy of Prematurity
Intervention: Drug: Propranolol eye drops
Outcome Measures: Incidence rate of progression from stage 2 ROP to more severe stage ROP (stage 2 or 3 with plus, stage 4 and stage 5);   Plasma concentrations of Propranolol at the steady state;   Number of newborns who progress to Stage 3 without plus ROP;   Number of newborns who progress to Stage 4 or 5 ROP with total or partial retinal detachment;   Number of newborns who need laser treatment;   Number of newborns who need rescue treatment with bevacizumab;   Number of newborns who need vitrectomy;   Collection of adverse events due to eye drop Propranolol treatment
2 Not yet recruiting Efficacy of Propranolol Treatment to Prevent Melanoma Progression
Conditions: Stages III Skin Melanoma;   Stages II Skin Melanoma;   Stage IB Skin Melanoma
Interventions: Drug: Propranolol hydrochloride;   Drug: Placebo pill
Outcome Measures: Efficacy of Propranolol on progression free survival for patients suffering from a primary melanoma with a high risk of recurrence;   Use of serum microRNA profile as a predictor for recurrence;   Overall survival
3 Recruiting Propanolol and Red Cell Adhesion Non-asthmatic Children Sickle Cell Disease
Condition: Sickle Cell Disease
Intervention: Drug: Propranolol
Outcome Measures: measurement of the sickle red cell response to epinephrine;   Safety data regarding the use of propanolol in children with sickle cell disease
4 Recruiting Study of Propranolol in Newly Diagnosed Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy
Condition: Locally Advanced Breast Cancer
Interventions: Drug: Propranolol;   Other: Breast imaging - Diffuse Optical Tomography (DOT)
Outcome Measures: Percentage of patients who are compliant with taking > 80% take the drug while on chemotherapy.;   Changes in angiogenesis;   Changes in stress levels;   Number of Patients with Adverse Events;   Change in DOT-derived parameters;   Changes in tumor proliferation
5 Unknown  Propranolol Treatment of Traumatic Memories (PTTM)
Conditions: Traumatic Memory;   Posttraumatic Stress Disorder
Interventions: Drug: Propranolol Hydrochloride;   Drug: Placebo
Outcome Measures: The primary endpoint will be changes between the pretreatment and posttreatment scores in the Clinician Assessment Posttraumatic Scale (CAPS), Impact of Event Scale (IES) and Traumatic Memory Description Measure (TMDM) instruments.;   The secondary endpoint will be changes between the treatment and posttreatment score in the other scales used - MINI, ZAS, ZDS and NIHS.
6 Recruiting Perioperative Propranolol in Patients With Post Traumatic Stress Disorder (PTSD)
Condition: Post-traumatic Stress Disorder
Interventions: Drug: Propranolol Hydrochloride;   Other: Placebo
Outcome Measures: ICU length of stay;   Hospital length of stay;   Postoperative delirium;   Postoperative renal dysfunction;   Perioperative complications;   Pain intensity;   Pain unpleasantness;   Analgesics use;   Length of intubation and mechanical ventilation;   Post Traumatic Stress Disorder symptomatology;   Quality of Life;   Functional status;   Sleep Quality;   Depression symptoms;   Postoperative Neurocognitive Dysfunction Score;   30-day, 3-month, and 1-year mortality;   Postoperative complications
7 Recruiting Efficacy of Clonidine and Propranolol in Dentistry (AAA)
Condition: Anxiety
Interventions: Drug: Clonidine;   Drug: Propranolol;   Drug: Placebo
Outcome Measures: Change from baseline in modified dental anxiety scale(MDAS)and vital signs (blood pressure, heart rate, respiratory rate, oxygen saturation) until four hours post treatment;   Changes in Verbal Numerical Rating Scale (VNRS) at three, six, and twenty-four hours post treatment
8 Unknown  Reducing Reconsolidation of Trauma Memories With Propranolol
Condition: Posttraumatic Stress Disorder
Interventions: Drug: Propranolol;   Drug: Short acting + long acting Propranolol + memory reactivation
Outcome Measures: Electromyogram;   Heart rate;   Skin conductance;   PTSD symptom levels;   Quality of life;   Memory Experience;   Psychophysiological assessments
9 Unknown  Endoscopic Band Ligation (EBL) Versus Propranolol for Primary Prophylaxis of Variceal Bleeding
Conditions: Variceal Bleeding;   Cirrhosis
Interventions: Procedure: Endoscopic band ligation;   Drug: Propranolol;   Procedure: endoscopic band ligation and Propranolol
Outcome Measures: First esophageal variceal bleeding;   Mortality; Significant esophageal variceal bleeding; Upper gastrointestinal bleeding except esophageal bleeding; Adverse events
10 Unknown  A Psychophysiologic Study of Weakening Traumatic Combat Memories With Post-Reactivation Propranolol
Condition: Post-Traumatic Stress Disorder
Intervention: Drug: Propranolol
Outcome Measure: Psychophysiologic responses during script-driven imagery of combat events
11 Unknown  A Novel Treatment For Chronic Posttraumatic Stress Disorder (PTSD) Using Post-Reactivation Propranolol
Condition: Stress Disorders, Post-Traumatic
Intervention: Drug: Propranolol is available in generic form as the Wyeth product under the trade name Inderal.
Outcome Measures: Clinician-Administered PTSD Scale (CAPS) for DSM-IV;   Mini International Neuropsychiatric Interview (MINI);   Peritraumatic Distress Inventory (PDI);   The Peritraumatic Dissociative Experiences Questionnaire;   PTSD Check List (PCL) civilian version;   Script-driven imagery psychophysiological measurement
12 Recruiting Propranolol in Severely Burned Children
Condition: Burn
Interventions: Drug: Propranolol;   Drug: Placebo
Outcome Measures: Resting heart rate multiplied by the systolic blood pressure measurement= rate pressure product;   Number of deaths
13 Recruiting Propranolol Versus Prednisolone for Treatment of Symptomatic Hemangiomas
Condition: Hemangioma of Infancy
Interventions: Drug: Propranolol;   Drug: Prednisolone
Outcome Measures: reduction in size of hemangioma;   Tolerability of medication
14 Recruiting The Safety and Efficiency of Propranolol as an Initial Treatment for Pediatric Hemangioma
Condition: Hemangioma
Interventions: Drug: Prednisolone;   Drug: Propranolol
Outcome Measures: Hemangioma volume measured by MRI or SONO;   Size changes from baseline;   Heart rate change from Baseline at 16 weeks;   Change from Baseline in color;   Changes in Size of Ulceration;   Whether or not Re-epithelized in 16weeks;   Stop time of proliferation;   Time of regression;   Drug compliance within 16 weeks;   Change from Baseline in systolic blood pressure at 16 weeks;   Changes from baseline in Glucose level at 16 weeks;   Whether the facial edema occurs within 16 weeks;   Whether growth retardation occurs within 16 weeks;   Whether the Gastroesophageal reflux occurs within 16 weeks;   Number of Participants with Adverse drug reaction
15 Recruiting Protective Effects of Propranolol in Adults
Condition: Burn
Interventions: Drug: Propranolol;   Drug: Placebo
Outcome Measures: Cardiac rate pressure product;   Mortality rates
16 Recruiting Rifaximin and Propranolol Combination Therapy Versus Propranolol Monotherapy in Cirrhotic Patients
Conditions: Liver Cirrhosis;   Portal Hypertension
Interventions: Drug: Rifaximin + Propranolol;   Drug: Propranolol + Placebo
Outcome Measures: Hepatic vein pressure gradient(HVPG);   occurence of gastrointestinal bleeding
17 Recruiting Efficacy and Safety of Propranolol Versus Acebutolol on the Proliferative Phase of Infantile Hemangioma
Condition: Hemangioma
Interventions: Drug: Acebutolol;   Drug: Propanolol
Outcome Measures: Hemangioma size;   Tolerance of treatment;   Proportion of patients requiring treatment with corticosteroids because of the evolution of a 'serious' hemangioma
18 Recruiting Early Propranolol After Traumatic Brain Injury: Phase II
Condition: Traumatic Brain Injury
Intervention: Drug: Propranolol
Outcome Measure: Determine in patients with traumatic brain injury (TBI) the safe dosing of early Propranolol.
19 Unknown  Propranolol for Diabetic Retinopathy
Condition: Proliferative Diabetic Retinopathy
Intervention: Drug: Propranolol
Outcome Measures: Area of retinal neovascularization on fundus photography;   Retinopathy level in contralateral eye;   Optical coherence tomography macular thickness of treated and fellow eye;   Amount of fluorescein leakage on angiography;   Early Treatment Diabetic Retinopathy Study visual acuity in study and fellow eye
20 Recruiting Treatment of PTSD by Reduction of Traumatic Memory Reconsolidation by Propranolol : a Multisite Trial
Condition: Post-traumatic Stress Disorder
Interventions: Drug: Propranolol;   Other: Trauma reactivation;   Drug: placebo
Outcome Measure: PTCD CheckList (PCL) total score.