DYSPHONIA and Nexium


DYSPHONIA Symptoms and Causes

Voice is the sound made by air passing from your lungs through your larynx, or voice box. In your larynx are your vocal cords, two bands of muscle that vibrate to make sound. For most of us, our voices play a big part in who we are, what we do, and how we communicate. Like fingerprints, each person's voice is unique.

Many things we do can injure our vocal cords. Talking too much, screaming, constantly clearing your throat, or smoking can make you hoarse. They can also lead to problems such as nodules, polyps, and sores on the vocal cords. Other causes of voice disorders include infections, upward movement of stomach acids into the throat, growths due to a virus, cancer, and diseases that paralyze the vocal cords.

Signs that your voice isn't healthy include

  • Your voice has become hoarse or raspy
  • You've lost the ability to hit some high notes when singing
  • Your voice suddenly sounds deeper
  • Your throat often feels raw, achy, or strained
  • It's become an effort to talk

Treatment for voice disorders varies depending on the cause. Most voice problems can be successfully treated when diagnosed early.

NIH: National Institute on Deafness and Other Communication Disorders

Check out the latest treatments for DYSPHONIA

DYSPHONIA treatment research studies

Nexium clinical trials, surveys and public health registries

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Nexium Side Effects

Gastrooesophageal Reflux Disease (3970)
Malaise (2729)
Dyspepsia (2294)
Pain (1309)
Vomiting (1209)
Osteoporosis (1201)
Abdominal Pain Upper (1180)
Abdominal Discomfort (946)
Off Label Use (840)
Fall (820)
Gastric Disorder (817)
Chest Pain (787)
Nausea (778)
Diarrhoea (704)
Aphagia (702)
Diabetes Mellitus (634)
Cerebrovascular Accident (610)
Headache (579)
Adverse Event (578)
Dyspnoea (575)
Arthritis (563)
Multiple Fractures (556)
Myocardial Infarction (551)
Hypertension (515)
Dysphagia (504)
Feeling Abnormal (495)
Insomnia (477)
Neoplasm Malignant (466)
Weight Decreased (456)
Throat Irritation (451)
Nasopharyngitis (441)
Hiatus Hernia (439)
Cough (436)
Pneumonia (430)
Bone Disorder (402)
Dizziness (378)
Back Pain (374)
Cardiac Disorder (360)
Depression (353)
Abdominal Pain (338)
Anxiety (334)
Regurgitation (327)
Road Traffic Accident (324)
Ulcer (313)
Pain In Extremity (309)
Fatigue (302)
Abdominal Distension (297)
Dysphonia (289)
Oropharyngeal Pain (286)
Chronic Obstructive Pulmonary Disease (280)

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DYSPHONIA Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting Examining the Spasmodic Dysphonia Diagnosis and Assessment Procedure (SD-DAP) for Measuring Symptom Change
Conditions: Spasmodic Dysphonia;   Laryngeal Dystonia
Outcome Measure: SD-DAP
2 Recruiting Controlled Study to Evaluate the Safety and Efficacy of Azficel-T for the Treatment of Vocal Fold Scarring and Age-Related Dysphonia
Conditions: Dysphonia Resulting From Vocal Fold Scarring;   Age-related Dysphonia
Interventions: Biological: Azficel-T (autologous fibroblasts);   Drug: Placebo
Outcome Measures: Videostroboscopy;   Voice Handicap Index Score;   Perceptual analysis using GRBAS scale;   Improvement in voice quality on visual analog scale;   Improvement in voice quality using questionnaire;   Change from baseline in auditory-perceptual ratings;   Change from baseline in the noise-to-harmonic ratio;   Change from baseline in maximum phonation time;   Proportion of subjects with "Normal" fundamental frequency;   Change from baseline in percentage jitter;   Change from baseline in shimmer
3 Recruiting Effect of Vocal Exercise After Botulinum Toxin Injection for Spasmodic Dysphonia
Conditions: Spasmodic Dysphonia;   Dystonia
Intervention: Behavioral: Vocal Exercise
Outcome Measures: Self-rating of vocal function;   Number of voice breaks during connected speech;   Duration of voice onset time in speech
4 Not yet recruiting Frequency of Dysphonia in Asthmatic Patients
Condition: Asthmatic Patients and Control Group
Intervention: Other: Phoniatric tests
Outcome Measure: Evidence of Dysphonia. The patient will be considered as having a Dysphonia if at least one of the tests (Voice Handicap Index, Rank Rough Breathy Asthenic Strained GRBAS, Quotien Phonatoire QP and Fundamental laryngeal F0) is abnormal
5 Recruiting Voice Tremor in Spasmodic Dysphonia: Central Mechanisms and Treatment Response
Conditions: Spasmodic Dysphonia;   Voice Tremor
Intervention: Drug: Sodium oxybate
Outcome Measure: Brain Activity
6 Not yet recruiting Effects of External Vibration on Voice Quality in Muscle Tension Dysphonia Patients and Classically Trained Singers
Conditions: Muscle Tension Dysphonia;   Classically Trained Singers
Interventions: Device: Lelo® Siri vibrator;   Device: Lelo® Siri vibrator with vibration component removed
Outcome Measures: jitter;   shimmer;   signal to noise ratio;   fundamental frequency;   singing power ratio (singer group only)
7 Not yet recruiting Treating Laryngeal Hyperfunction With Flow Phonation
Condition: Muscle Tension Dysphonia
Interventions: Behavioral: Vocal Hygiene Training;   Behavioral: Flow Phonation Exercises
Outcome Measures: Laryngeal Airway Resistance (Rlaw) Change Over Time;   Voice Handicap Index (VHI);   Consensus Auditory Perceptual Evaluation - Voice;   Noise-to-Harmonic Ratio
8 Recruiting Dystonia Coalition Projects
Conditions: Dystonia;   Voice Disorders
Outcome Measure: Observational
9 Recruiting Voice and Swallowing Outcomes Following Revision Anterior Cervical Spine Surgery
Conditions: Dysphagia;   Dysphonia
Intervention: Other: Voice and Swallowing evaluations
Outcome Measures: Vocal cord and swallowing function as measured by fiberoptic exam in the otolaryngology clinic pre-op and approximately 3 weeks post op.;   Quality of life as measured by a self-administered 10 point questionnaire.
10 Recruiting Effects of Octanoic Acid for Treatment of Essential Voice Tremor
Conditions: Essential Voice Tremor;   Vocal Tremor;   Voice Tremor;   Essential Tremor of Voice
Intervention: Drug: Octanoic acid
Outcome Measures: Pre- to post-treatment change in the acoustic characteristics of voice tremor;   Pre- to post-treatment change in the auditory-perceptual characteristics of voice tremor
11 Recruiting Botulinum Toxin for the Treatment of Involuntary Movement Disorders
Conditions: Chorea;   Drug Induced Dyskinesia;   Movement Disorder;   Muscular Disease;   Tic Disorder
Outcome Measure:
12 Recruiting Central Mechanisms in Speech Motor Control Studied With H215O PET
Conditions: Communication Disorder;   Healthy;   Stuttering;   Tourette Syndrome;   Voice Disorder
Outcome Measure:
13 Not yet recruiting Laryngeal Mask Airway Removal During Deep Anesthesia in Children
Condition: Post Operative Sore Throat After LMA Removal
Intervention: Other: LMA removal
Outcome Measures: Incidence of Postoperative Sorethroat;   Dysphagia;   Dysphonia;   Adverse event: teeth or mucosal trauma;   laryngospasm;   Bronchospasm;   Desaturation;   Nausea and vomiting;   cough
14 Recruiting A Study of Korean Society of Spine Surgery on the Outcomes of Anterior Cervical Discectomy and Fusion
Conditions: Radiculopathy, Cervical;   Myelopathy
Interventions: Procedure: anterior cervical discectomy and fusion;   Device: Cage and Plate;   Device: Cage alone
Outcome Measures: Cervical fusion status;   predisposing factor of non-union;   risk factors of dysphagia;   risk factors of Dysphonia;   factors for quality of life;   risk factors for adjacent segment degeneration;   correlation between osteoporosis and fusion;   relation between brace wearing and fusion;   surgical outcomes for combined uncinectomy;   change of neck motion after surgery;   neuropathy after anterior cervical discectomy and fusion surgery;   relation between the method of bone graft and fusion;   analysis of complication rates after anterior cervical discectomy and fusion surgery;   The correlation between existence of co-morbidity and surgical outcome;   The correlation analysis between smoking history and surgical outcome (fusion rates, improvement of pain and disability)
15 Unknown  Dysphagia in Oculopharyngeal Muscular Dystrophy (OPMD)- Evaluation, Endoscopic Examination of Swallowing, Treatment and Long Term Follow up
Condition: Dysphagia
Intervention: Procedure: Upper esophageal sphincter myotomy
Outcome Measure: Dysphagia, quality of life. Proper intervention timing in OPMD based on knowledge about the natural history of the feeding difficulty.
16 Recruiting Thyroid Gland Removal With or Without Central Lymph Node Dissection in Treating Patients With Node Negative Thyroid Cancer
Conditions: Stage I Papillary Thyroid Cancer;   Stage II Papillary Thyroid Cancer;   Stage III Papillary Thyroid Cancer
Interventions: Procedure: thyroidectomy;   Procedure: central lymph node dissection;   Procedure: quality-of-life assessment
Outcome Measures: Rate of transient hypoparathyroidism, as defined by a day 1 serum parathyroid hormone (PTH) level of < 10 pg/ml;   Post-operative serum calcium level (mg/dL);   Post-operative PTH (pg/ml);   Total calcium consumption in first 2 weeks (total gm);   Average episodes of hypocalcemia symptoms per day;   Hypocalcemia symptom severity, measured by the Hypocalcemia symptom severity scale (range of 1-5);   Requirement for calcium;   Requirement for calcitriol;   Phonation threshold pressure, in centimeters of water (dihydrogen monoxide [H2O]);   Dysphonia Severity Index (DSI) score;   Grade Roughness Breathiness Asthenia Strain (GRBAS) score;   Voice quality parameters, assessed using Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V);   Vocal fold vibratory and movement parameters, measured using stroboscopy assessment;   Glottal Function Index score;   Penetration-Aspiration Scale from videofluoroscopic swallow study;   Short Form Health Survey (SF-12) Mental Composite Scale (MCS) score;   SF-12 Physical Composite Scale (PCS) score;   European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ) Core-30 (C30) scores;   Thyroid Cancer Specific Quality of Life (ThyCA-QOL) score;   10-item Eating Assessment Tool (EAT-10) dysphagia inventory score;   Voice Handicap Index (VHI) score;   Themes and codes from interview transcripts, assessed using qualitative research methods;   Percent of patients with a recombinant thyroid-stimulating hormone (rTSH) stimulated thyroglobulin level < 1 ng/ml;   Unstimulated thyroglobulin level prior to beginning week 6 radioactive iodine treatment;   Incidence of stimulated thyroglobulin at the time of week 6 radioactive iodine treatment;   Incidence of unstimulated thyroglobulin > 1 ng/mL;   Incidence of stimulated thyroglobulin > 2 ng/mL;   Incidence of biopsy-proven disease identification on neck ultrasound or iodine-131 (I-131) uptake
17 Recruiting Comparison of a Single Use (Ambu aScope) and a Reusable Flexible Optical Scope for Intubation Through a Supraglottic Airway Device (Aura-i)
Condition: General Anesthesia
Intervention: Procedure: tracheal intubation
Outcome Measures: Duration of intubation. From the endoscope enters the supraglottic-airway-device to CO2-curve is seen;   Number of attempts at placing the supraglottic-airway-device (SAD);   number of attempts at placing the flexible endoscope in the trachea;   number of attempts at intubation;   Total time for placement of SAD and endoscopy and intubation;   The best glottic view obtained;   The ease of passage of the flexible endoscope via the SAD;   The anesthesiologists' satisfaction with the procedure;   The quality of the endoscopically obtained image;   Postoperative sore throat, Dysphonia or dysphagia one hour after extubation
18 Unknown  Comparison Study of Two Supraglottic Devices Used for Patients Under General Anesthesia
Condition: Patent Airway
Intervention: Device: Supraglottic airway device insertion
Outcome Measures: Measure of the airway leak pressure;   Measure of the peak airway pressure;   Time needed to secure the airway;   Number of attempts to introduce the devices;   Adverse effects after anesthesia (cough, sore throat, dysphagia, trauma, Dysphonia);   Airway manipulation
19 Recruiting A New Insertion Technique for Laryngeal Mask Airway
Condition: Airway Morbidity
Interventions: Other: Group 1 Classic;   Other: Group 2 pre-inflated;   Other: Group 3 ELLIA
Outcome Measure: Number of subjects who present with postoperative pharyngolaryngeal complications