Rank |
Status |
Study |
1 |
Recruiting
|
Improving Management of Breathlessness in Patients With Lung Cancer
Conditions: |
Breathlessness; Dyspnea; Lung Cancer |
Intervention: |
Behavioral: Cognitive Behavioral Intervention for Breathlessness |
Outcome Measures: |
Feasibility and acceptability of a nurse practitioner-delivered dyspnea management intervention in patients with advanced lung cancer; Effect of a nurse practitioner-delivered dyspnea management intervention on breathlessness in patients with advanced lung cancer; Effect of a nurse practitioner-delivered dyspnea management intervention on quality of life in patients with advanced lung cancer; Effect of a nurse practitioner-delivered dyspnea management intervention on mood symptoms in patients with advanced lung cancer |
|
2 |
Unknown †
|
Trial of a Breathlessness Intervention Service for Intractable Breathlessness
Condition: |
Dyspnea |
Interventions: |
Behavioral: Breathlessness Intervention Service; Behavioral: Best supportive care (Standard Care) |
Outcome Measures: |
Numerical rating Scale (NRS) for distress due to breathlessness; Modified BORG; NRS Breathlessness at best/worst; Dyspnoea descriptors; CRQ; EQ-5D; HADS; CSRI; Charlson Co-morbidity score; Social Functioning; Karnofsky; Experience of breathlessness and expectations/views of BIS; Burden interview and caregiver Appr scale |
|
3 |
Recruiting
|
Mechanisms of Exertional Dyspnea in Fibrotic Interstitial Lung Disease
Conditions: |
Lung; Disease, Interstitial, With Fibrosis; Healthy |
Interventions: |
Other: Room air (21% oxygen); Other: Hyperoxia (60% oxygen) |
Outcome Measures: |
To determine the physiological mechanisms of exertional dyspnea in patients with fibrotic ILD; To determine the mechanism by which hyperoxia improves exertional dyspnea and exercise time; To determine any physiological mechanistic differences of exertional dyspnea between participants with fibrotic ILD and healthy control participants. |
|
4 |
Recruiting
|
Evaluating Sensations of Breathlessness in Patients With Cystic Fibrosis
Conditions: |
Lung; Disease; Cystic Fibrosis; Healthy |
Intervention: |
|
Outcome Measures: |
To determine if dyspnea is qualitatively and quantitatively different in patients with cystic fibrosis compared with age and sex-matched healthy controls during exercise; To determine if the dyspnea responses can be explained by differences in the ventilatory response to exercise. |
|
5 |
Unknown †
|
Vibration Response Imaging (VRI) in Dyspnea Patients Presenting to the ED
Condition: |
Dyspnea |
Intervention: |
|
Outcome Measures: |
Assess the ability of the VRI to improve clinical outcomes via accurate, early classification of the cause of acute dyspnea as HF or other (i.e. COPD, PE etc).; Assess the agreement to aid in classifying the cause of acute dyspnea as HF or other of the VRI in comparison to BNP/NTproBNP assays.; Assess the ability of the VRI to aid in classifying the cause of acute dyspnea as HF or COPD; Evaluate the ability of the VRI to monitor changes in clinical status following treatment in comparison with other standard testing methods (e.g. ECG, serial chest x-rays, etc.) |
|
6 |
Recruiting
|
Prehospital Triage of Patients With Severe Shortness of Breath Using Biomarkers
Condition: |
Dyspnea |
Intervention: |
Other: Supplementary NT-proBNP measurement |
Outcome Measures: |
Proportion of patients with dyspnea caused by heart disease initially triaged to department of cardiology; Proportion of patients with dyspnea of other etiologies initially triaged to department of cardiology; Proportion of patients with dyspnea caused by heart disease that receives pulmonary medication; Length of hospital stay; Intensive care unit admission rate; All-cause re-admission; Proportion of patients not admitted to hospital; All-cause mortality; Proportion of patients with dyspnea caused by lung disease, that receives traditional heart failure medication; Proportion of patients with correct diagnosis of congestive heart failure in the prehospital setting; Proportion of patients where congestive heart failure is correctly disproved in the prehospital setting |
|
7 |
Recruiting
|
Self-Management Intervention for Breathlessness in Lung Cancer
Conditions: |
Lung Cancer; Breathlessness |
Intervention: |
Behavioral: Self-management Intervention |
Outcome Measures: |
Perceived severity of breathlessness; Affective distress of breathlessness; Dyspnea with activities of daily living and exercise; Self-efficacy and mastery for managing breathlessness; Beliefs about breathlessness; Adherence and Use of Self-Management Strategies; Exercise capacity; Psychological distress; Quality of life; Health care utilization |
|
8 |
Recruiting
|
Aerosol Inhalation Treatment for Dyspnea
Conditions: |
Healthy; Dyspnea |
Intervention: |
Drug: Furosemide |
Outcome Measures: |
Subject rating of Breathing Discomfort (dyspnea); Multidimensional Dyspnea Profile; Urine output |
|
9 |
Recruiting
|
Sensitivity of the Step Test to Detect Improvement in Dyspnea Following Bronchodilation in Patients With Chronic Obstructive Pulmonary Disease
Conditions: |
Moderate Chronic Obstructive Pulmonary Disease; Severe Chronic Obstructive Pulmonary Disease; Dyspnea |
Intervention: |
Drug: Combination ipratropium/salbutamol or placebo (nebulization) |
Outcome Measures: |
Symptom perception; Cardiac and ventilatory outcomes; Inspiratory capacity; Respiratory pressures and diaphragm EMG; Pulmonary function; Maximal oxygen consumption; Maximal inspiratory pressure (PImax) |
|
10 |
Not yet recruiting
|
Understanding the Importance of Plasticity in the Brain Mechanisms of Dyspnoea Perception
Condition: |
Chronic Obstructive Pulmonary Disease |
Interventions: |
Drug: d-cycloserine; Drug: placebo |
Outcome Measures: |
BOLD signal changes; Grey matter volume |
|
11 |
Unknown †
|
The Use of a Handheld Fan to Manage Breathlessness - A Feasibility Study
Condition: |
Dyspnea |
Intervention: |
Device: handheld fan directed to cheeks |
Outcome Measures: |
Primary outcome measure is time in minutes for which breathlessness is improved after 5 minutes use of the fan directed at the face; Relief from breathlessness noted on relief score after using the handheld fan; Correlation between VAS and NRS scales |
|
12 |
Recruiting
|
Acupuncture Feasibility Trial for Dyspnea in Lung Cancer
Conditions: |
Lung Cancer; Dyspnea |
Intervention: |
Procedure: Acupuncture |
Outcome Measure: |
Dyspnea |
|
13 |
Recruiting
|
Study of a Tiotropium Inhaler For Shortness of Breath in Advanced Non-Small Cell Lung Cancer
Conditions: |
NSCLC; Dyspnea |
Interventions: |
Drug: Tiotropium; Drug: Placebo |
Outcome Measures: |
12 question Cancer Dyspnea Scale; 10 point Dyspnea numeric scale; 10 point Cough scale; Forced Expiratory Volume 1 second (L/s) and Forced Vital Capacity (L) |
|
14 |
Recruiting
|
EUROpean Dyspnoea Survey in the EMergency Departments
Conditions: |
Dyspnea; Emergencies |
Intervention: |
|
Outcome Measures: |
All cause mortality; All cause rehospitalization |
|
15 |
Recruiting
|
Registry of Patients With Acute Dyspnea in the Emergency Department
Conditions: |
Dyspnea; Heart Failure; COPD |
Intervention: |
|
Outcome Measures: |
all cause mortality; demographics and baseline characteristics; medical care processes; subjective and objective risk assessment |
|
16 |
Recruiting
|
Basics in Acute Shortness of Breath EvaLuation (BASEL V) Study
Condition: |
Dyspnea |
Intervention: |
|
Outcome Measures: |
Diagnostic accuracy for the diagnosis of heart failure; Prognostic utility in patients with dyspnea |
|
17 |
Not yet recruiting
|
Dyspnea in COPD: Relationship With Exacerbations Frequency
Condition: |
Dyspnea |
Interventions: |
Procedure: Spirometry; Procedure: CO Exhaled breath; Procedure: P01; Procedure: FeNO |
Outcome Measures: |
The negative airway pressure generated during the first 100 ms of an occluded inspiration, which is an estimation of the neuromuscular drive to breathe. (P01 ); Borg scale; Fractional exhaled nitric oxide (FeNO); Inspiratory capacity (IC); Ventilation at rest; CO exhaled test |
|
18 |
Recruiting
|
Treatment of Dyspnea in Do-not-intubate Patients
Conditions: |
Acute Respiratory Failure; Acute on Chronic Respiratory Failure; Dyspnea |
Interventions: |
Device: NIV; Device: CPAP; Device: Standard oxygen; Device: HFNC |
Outcome Measures: |
Prevalence of use of Noninvasive ventilation in DNI patients; Subjects' comfort; Dyspnea score; Family members' impressions; Family member's impressions |
|
19 |
Not yet recruiting
|
Inhaled Furosemide & Dyspnea
Condition: |
Dyspnea |
Interventions: |
Other: CWS; Drug: Furosemide; Drug: Placebo |
Outcome Measure: |
Sensory intensity (Borg 0-10 scale) ratings of dyspnea at isotime |
|
20 |
Recruiting
|
Inhaled Ondansetron & Dyspnea
Condition: |
Dyspnea |
Interventions: |
Drug: Ondansetron; Other: CWS; Drug: Placebo |
Outcome Measure: |
Sensory Intensity (Borg 0-10 scale) ratings of dyspnea at isotime |
|