DYSTONIA and Clonazepam


DYSTONIA Symptoms and Causes

Dystonia is a movement disorder that causes involuntary contractions of your muscles. These contractions result in twisting and repetitive movements. Sometimes they are painful.

Dystonia can affect just one muscle, a group of muscles or all of your muscles. Symptoms can include tremors, voice problems or a dragging foot. Symptoms often start in childhood. They can also start in the late teens or early adulthood. Some cases worsen over time. Others are mild.

Some people inherit Dystonia. Others have it because of another disease. Researchers think that Dystonia may be due to a problem in the part of the brain that handles messages about muscle contractions. There is no cure. Doctors use medicines, Botox injections, surgery, physical therapy, and other treatments to reduce or eliminate muscle spasms and pain.

NIH: National Institute of Neurological Disorders and Stroke

Check out the latest treatments for DYSTONIA

DYSTONIA treatment research studies

Clonazepam clinical trials, surveys and public health registries

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Clonazepam Side Effects

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Balance Disorder (36)
Gait Disturbance (35)
Abdominal Pain (35)
Tachycardia (35)
Weight Decreased (33)
Sedation (33)
Pain In Extremity (33)
Abnormal Behaviour (33)
Irritability (32)
Rash (32)

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Recent Reviews

I have been on Clonazepam for about 3 or 4 months. It help a great deal with lack of sleep,and also helped the snxiety. Now I have been stressed at work. I think it is more about burn-out than my meds. How ever! I'm not sure what to do. I haven't bee

I have been on Clonazepam for several month up to 2-3mg a day. Went cold turkey 4 days ago and my psychiatrist agreed. Can't sleep on even a high dose of ambien. Blood pressure up to Hyperttension Stage 1 when I used to have normal BP. Wondering if I

I took celexa for one month and i blacked out as well as i have constant involuntary movement in my right arm and im still depressed

Initial symptoms were muscle cramps in neck & shoulders. As the reaction progressed, my arms began to cramp and contract until I could not lift my hands to my mouth. All symptoms were bilateral.

Patient was treated with seroxat up to 80mg per 24 hours in conjunction with Zopiclone up to 7.5 mg 24 hrs for 5 months.Patient developed severe long-term dystonia around face and limbs,seizures, blindness and dystonia storms resulting in unconscious

Stay on it, buddy

While being treated for a chronic pain syndrome (severe burning pain from spasms of the muscles of the pelvic floor), I was prescribed Suboxone (buprenophine/naloxone) sublingual for pain management. After 1 week of dosi

dystonia...on the right hand

Dystonia on a 15 year old male after only 3 doses

I had a massive reaction to the Zeldox medication I actually had a Dystonia which I nearly choked from not breathing and that was last Saturday, pretty bad shit, and I wish for you individuals to be a bit nicer, there's no need to be mean to anyone.

In December 2006 i had a mirena Iud and then was hospitialized and developed Dopa responsive Dystonia. I have lived with this for 5 years now. The IUD expelled itself in 2007 and i was told that this was rare and was the reason for the dystonia to p

Male 42 prescribed baclofen 30-60mg daily for the control of cervical dystonia, great for first week then started to get pain and discumfort in my bowels by week two i was being physicaly sick and unable to control the pain , had to stop taking the m

My husband is takingmadopar He has 2 125mg. capsules 3 times a day. He do0es not appear to be gaining any positive effects. His legs are very swollen and he is suffering badly with dystonia. This is severely compromising his mobility.

Patient was treated with seroxat up to 80mg per 24 hours in conjunction with Zopiclone up to 7.5 mg 24 hrs for 5 months.Patient developed severe long-term dystonia around face and limbs,seizures, blindness and dystonia storms resulting in unconscious

DYSTONIA Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting Neuroimaging of Dystonia
Conditions: Primary Cervical Dystonia;   DYT 1 Dystonia
Interventions: Drug: Primary Cervical Dystonia (Trihexyphenidyl);   Other: Controls Primary Cervical Dystonia (Trihexyphenidyl);   Other: DYT 1 Dystonia (Healthy Control);   Other: DYT 1 Dystonia
Outcome Measures: Change in cerebral blood flow based on blood-oxygen-level dependent (BOLD) contrast during a precision gripping task;   Change in cerebral blood flow based on blood-oxygen-level dependent (BOLD) contrast during a precision gripping task after administration of trihexyphenidyl compared to change in BOLD contrast during a precision gripping task
2 Recruiting Insights Into Deep Brain Stimulation (DBS) for Cervical Dystonia
Condition: Cervical Dystonia
Intervention: Procedure: Transcranial magnetic stimulation (TMS)
Outcome Measures: The body's response to transcranial magnetic stimulation (TMS);   Clinical assessment of Dystonia severity
3 Unknown  Somatosensory Processing in Focal Hand Dystonia
Conditions: Focal Hand Dystonia;   Musician's Dystonia;   Writer's Cramp;   Dystonic Cramp
Interventions: Other: Tactile training + sham rTMS;   Other: Tactile training + rTMS
Outcome Measures: Dystonia Rating Scale;   Neuroimaging maps of digit representation
4 Recruiting Dystonia Coalition Projects
Conditions: Dystonia;   Voice Disorders
Outcome Measure: Observational
5 Recruiting Ampicillin for DYT-1 Dystonia Motor Symptoms
Conditions: DYT-1;   Dystonia
Interventions: Drug: Ampicillin;   Drug: Sugar pill
Outcome Measures: Safety and tolerability of Ampicillin in treating DYT-1 Dystonia;   Burke-Fahn Marsden Dystonia Rating Scale (BFM-DRS)
6 Unknown  Cerebellum and Cortical Plasticity: the Case of Dystonia
Condition: Dystonia
Intervention: Other: Transcranial magnetic stimulation
Outcome Measures: Comparison of MEP0/MEP10 and MEP0/MEP30 values obtained after sham, cRTBS or iTBS of the cerebellum.;   Variation of the appropriate dystonic clinical score (depending on the type of Dystonia) after each rTMS session (cTBS, iTBS, sham).;   Measurement of number of errors, mean time to reach the target after each rTMS session (cTBS, iTBS, sham).;   Measurement of the variation of the motor threshold, intracortical inhibition and intracortical facilitation after each rTMS session (cTBS, iTBS, sham).
7 Unknown  Foot Dystonia Treatment by Botulinum Toxin Injections in Parkinson Disease : Efficiency of Injections Made in Extrinsic Muscle (Flexor Digitorum Longus Muscle) Compared to Intrinsic Muscle (Flexor Digitorum Brevis or Quadratus Plantae Muscles)
Conditions: Parkinson's Disease;   Foot Dystonia
Interventions: Drug: Botulinum Toxin: Xeomin;   Drug: Placebo
Outcome Measures: In a controlled double blind and randomized study, we want to show that intramuscular injections of botulinum toxin are beneficial to reduced Dystonia and associated pain in patient with foot Dystonia (compared to placebo injections).;   Efficiency comparison of injections made in leg muscle (Flexor digitorum longus) between injections made directly in foot muscle (Flexor digitorum brevis or quadratus plantae) - Effects of injections on pain and quality of life.
8 Recruiting Dysport for the Treatment of OMD
Conditions: Oral Dystonia;   Tardive Dystonia
Intervention: Drug: AbobotulinumtoxinA
Outcome Measures: Global Dystonia Rating Scale;   Analogue Pain Scale;   SCS-PD (Sialorrhea Clinical Scale for PD);   Estimated amount of tongue bites per day;   Swallowing Disturbance Questionnaire(SDQ);   Fahn-Marsden Part B "Speech" Question;   Oromandibular Dystonia Quality of Life Questionnaire (OMDQ-25);   Global Clinical Impression Scale (CGI) with Efficacy Index;   Unified Dystonia Rating Scale (UDRS)
9 Recruiting Functional Connectivity in Primary Focal Dystonia
Condition: Dystonia
Outcome Measures: A second level contrast between Primary Focal Dystonia (PFD) and Healthy Controls (HC) of the statistical parametric maps of correlation coefficients at rest and during a tapping motor task;   Strength of correlation between basal ganglia motor network functional connectivity measures and total PFD clinical assessment scale scores;   Lateralization;   Statistical dependence between symptoms and measures of basal ganglia functional connectivity
10 Unknown  Effects of Botulinum Toxin in Cervical Dystonia
Conditions: Torticollis;   Cervical Dystonia
Intervention: Drug: Botulinum Toxin A
Outcome Measures: Evidence of Cortical organizational changes with botulinum toxin treatment in patients with torticollis utilizing magnetoencephalography;   Tsui Torticollis Rating scale
11 Recruiting Effect of Increasing Motor Cortex Inhibition on Task Specific Dystonia
Condition: Dystonia
Intervention: Device: Transcranial Magnetic Stimulation
Outcome Measure: Efficacy of TMS on task-specific focal hand Dystonia
12 Recruiting Transcranial Magnetic Stimulation for Focal Hand Dystonia
Condition: Dystonia
Outcome Measure: Motor evoked potential following TMS conditioning versus the baseline MEP amplitude in Dystonia patients and healthy subjects.
13 Recruiting Analysis of Three-dimensional Movements of the Head in Cervical Dystonia
Condition: Cervical Dystonia
Outcome Measures: Range of motion of the voluntary mobility of the cervical spine in the three spatial planes;   movements disorders in cervical Dystonia;   head posture;   range of motion
14 Not yet recruiting ASIS for Botox in Cervical Dystonia
Conditions: Cervical Dystonia Adults ,;   Abnormal Head Position and Neck Pain for These 7 Muscle Groups: Splenius,Scalene,Sterno-cleido-mastoid,Levator Scapulae,Semispinalis,Trapezius,and Longissimus.
Interventions: Drug: Gadolinium;   Drug: Efficacy of Botox intramuscularly at Week 6;   Drug: Efficacy of Botox intramuscularly at Week 12;   Drug: Efficacy of Botox intramuscularly at Week 18;   Drug: Efficacy of Botox intramuscularly at Week 24;   Drug: Efficacy of Botox intramuscularly at Week 30;   Drug: Efficacy of Botox subdermally at Week 6;   Drug: Efficacy of Botox subdermally at Week 12;   Drug: Efficacy of Botox subdermally at Week 18;   Drug: Efficacy of Botox subdermally at Week 24;   Drug: Efficacy of Botox subdermally at Week 30;   Drug: Adverse Reactions of Botox intramuscularly;   Drug: Adverse Reactions of Botox subdermally
Outcome Measures: Relative Prolongation Ability Score for Gadolinium subdermally injected.;   Efficacy of Botox intramuscularly vs. subdermally in Cervical Dystonia.
15 Unknown  Alteration of Deep Brain Stimulation Parameters for Dystonia
Condition: Dystonia
Intervention: Procedure: Alteration of deep brain stimulator settings
Outcome Measures: To assess if the stimulation frequency of 60 Hz is superior to 130 Hz for patients with primary Dystonia who have responded poorly to standard 130 Hz pallidal stimulation;   Assess any potential changes in anxiety, mood, cognition
16 Unknown  Efficacy and Safety of Deep Brain Stimulation (DBS) of the Pallidal (GPi) in Patients With Tardive Dystonia
Conditions: Dystonia;   Movement Disorder
Intervention: Procedure: deep brain stimulation
Outcome Measures: Improvement of the motor scale of Burke-Fahn-Marsden-Dystonia Rating Scale via blinded video assessment 3 months after starting DBS in comparison to sham-stimulated patients;   AIMS;   Non-motor subscores of BMFDRS;   Visual analogue scales for both patients and treating physicians;   Quality of life (SF-36);   Psychiatric assessment (HADS-D and PANSS)
17 Recruiting Efficacy Trial of Zonisamide for Myoclonus Dystonia
Condition: Myoclonus Dystonia
Interventions: Drug: zonegran;   Drug: placebo
Outcome Measures: Measure of the evolution of the severity of myoclonus by a specific scale (UMRS);   Measure of the evolution of the severity of Dystonia by a specific scale (BFM);   measure of the evolution of the severity of myoclonus by electromyographic recording
18 Recruiting Brain Anatomy in Dystonia
Conditions: Dystonia;   Healthy
Outcome Measure:
19 Recruiting Can Short Latency Afferent Inhibition Give us Clues to Better DYT 1 Dystonia Treatments?
Conditions: DYT-1;   DYT1;   DYT 1;   Dystonia
Outcome Measures: Change in amplitude, at 3 and 6+ months, of motor evoked potentials (MEPs) with median nerve stimulation (SAI) and simultaneous median nerve and ulnar nerve stimulation (SAIdualstim);   Correlation of change in evoked potential amplitudes and clinical measures at 3 and 6+ months
20 Recruiting Incobotulinum Toxin A (Xeomin®) As A Treatment For Focal Task-Specific Dystonia Of The Musician's Hand
Condition: Dystonia
Intervention: Drug: incobotulinumtoxin A
Outcome Measures: Patient and Physician Global Perception of change;   Quantitative MIDI Analysis comparison;   Blinded high speed video analysis comparison;   Perceived Stress Scale;   Motor Strength comparison