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FATIGUE and Benadryl

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FATIGUE Symptoms and Causes

Everyone feels tired now and then. Sometimes you may just want to stay in bed. But, after a good night's sleep, most people feel refreshed and ready to face a new day. If you continue to feel tired for weeks, it's time to see your doctor. He or she may be able to help you find out what's causing your Fatigue and recommend ways to relieve it.

Fatigue itself is not a disease. Medical problems, treatments, and personal habits can add to Fatigue. These include

  • Taking certain medicines, such as antidepressants, antihistamines, and medicines for nausea and pain
  • Having medical treatments, like chemotherapy and radiation
  • Recovering from major surgery
  • Anxiety, stress, or depression
  • Staying up too late
  • Drinking too much alcohol or too many caffeinated drinks
  • Pregnancy

One disorder that causes extreme Fatigue is chronic Fatigue syndrome (CFS). This Fatigue is not the kind of tired feeling that goes away after you rest. Instead, it lasts a long time and limits your ability to do ordinary daily activities.

NIH: National Institute on Aging

Check out the latest treatments for FATIGUE

FATIGUE treatment research studies

Benadryl clinical trials, surveys and public health registries


Find Drug Side Effect reports



Benadryl Side Effects

Off Label Use (181)
Dyspnoea (162)
Nausea (141)
Hypersensitivity (139)
Urticaria (126)
Somnolence (119)
Vomiting (116)
Loss Of Consciousness (113)
Rash (109)
Pain (109)
Pruritus (108)
Headache (105)
Overdose (105)
Product Quality Issue (102)
Dizziness (98)
Insomnia (94)
Heart Rate Increased (86)
Hallucination (80)
Condition Aggravated (78)
Feeling Abnormal (78)
Anxiety (46)
Infusion Related Reaction (46)
Tremor (45)
Fatigue (45)
Diarrhoea (43)
Convulsion (42)
Erythema (38)
Malaise (38)
Pyrexia (38)
Asthenia (37)
Swelling Face (37)
Blood Pressure Increased (37)
Pharyngeal Oedema (35)
Throat Tightness (34)
Dehydration (32)
Chest Pain (31)
Swollen Tongue (30)
Pain In Extremity (30)
Cough (30)
Oedema Peripheral (29)
Hypoaesthesia (29)
Chest Discomfort (29)
Incorrect Dose Administered (28)
Abdominal Pain Upper (27)
Eye Swelling (27)
Flushing (26)
Fall (26)
Confusional State (25)
Lip Swelling (24)
Syncope (24)

➢ More


Common Meds

Abilify (10132)
Adderall (1304)
Amlodipine (6664)
Amoxicillin (4387)
Benadryl (1568)
Celebrex (12876 )
Celexa (1342)
Cialis (2975)
Cipro (8580)
Citalopram (7792)
Crestor (18839)
Cymbalta (14373)
Doxycycline (1757)
Effexor (7289)
Flexeril (435)
Flomax (2177)
Fluoxetine (4261)
Gabapentin (4593)
Hydrocodone (2469)
Ibuprofen (8222)
Lantus (10968)
Lexapro (3499)
Lipitor (17769)
Lisinopril (8919)
Lyrica (27148)
Medrol (650)
Mirena (41254)
Mobic (957)
Morphine (5356)
Naproxen (538)
Neurontin (6501)
Oxycodone (4438)
Pradaxa (13372)
Prednisone (5926)
Prilosec (2631)
Prozac (1954)
Seroquel (27216)
Simvastatin (8348)
Synthroid (4452)
Tamiflu (5585)
Topamax (3748)
Tramadol (5054)
Trazodone (1458)
Viagra (5394)
Vicodin (1153)
Wellbutrin (6324)
Xanax (2847)
Zocor (5718)
Zoloft(6792)
Zyrtec(1669)

Recent Reviews

Can I die from taking this many. Is it physicly addicting? Sorry about my spelling.

Convulsions and seizures sometimes for up to a week and a half at a time

Does taking too much benadryl cause a person to fall asleep and not wake up?

Hi i like know about heavy dosage of benadryl side effects can anybody please give feedback waiting for positive response regards vijay

I loved these strips. I have had allergic reactions to my own allergy shots. After waiting at the Dr.'s office for 15 minutes after my allergy shot, I leave to go shopping. Sometimes I can feel a little thickening in my throat, similar to when I'v

I take up to 50 Benadryl a day. How many should I take? I like how it makes me feel.

I was admitted to hospital with a suspected blood clot on my lung left side, i was getting bad pains there and dizzyness ,when i got to hospital they put me on oxygen coz it was reel low in a blood test then started injecting me in the stomac was kle

I've noticed that it when I am with my partner it makes me sensitive, but I am not able to be aroused. Is anyone else having the same issue. I've been taking it for alergies since I was a teenager. Its the only thing that has ever worked for me.

It was given to me in a hospital through emergency room, for nauseau. Nusrse said that they use it for that as well. Is true and can it be usedat home for the same?

Lately i have experienced fatigue, muscle soreness, headache and my breathing has shallowed. Whenever i get to doing something active, especially anything like running i feel like i cant breathe at all and i have to force myslef to take lon

My son was suffering from Head ache for the past one year. I have taken him to an ENT & he prescribed Sibelium 10 mg. & he was taking sibelium 3 months back for migraine and he was experiencing fatigue and drowsiness every day. Every t

The side effects from reactine were strange, dizziness, extreme fatigue, a cold sore (which may or may not have been caused by reactine on my lip). I only took it for two days (do not know the dosage, one pill each day). The day after taking it,

I have been Pradaxa for almost a month had severe outbreak of hives on my feet and my legs up to my knees. I also having swelling of legs and feet along with fatigue in joints and body limbs. Doctor changed my Med. but the side effects is still o

Is fatigue really so frequent?

I am taking Suboxone and have had constipation, fatigue and very bad chills and sweats at night. Even during the day, I sometimes feel like I am hot and cold at the same time. I am wondering though, if this is Menopause? The fatigue is so extrem

Unresponsive to 5mg/kg q 8wks; increased to 10mg/kg q6wks. After 3 doses at that strength noted fatigue, occasional night sweats, joint aches, sudden onset of chest pain and dyspnea (pleurisy, small pleuraleffusion) Had just taper

<b>Describe Your Ezetrol Experience Here:</b>Sleeplessness severe pain in muscles and joints nausea and abdominal pain headaches and pain behind eyes chronic fatigue and flat mood

Extreme fatigue, sleeplessness, short term memory and speech difficulties, Edema, weight gain, stumbling, shortness of breath, numbness in both legs, and completely kills ability to achieve orgasm.

Iama 41year old whitefemale After taking OTC delsym for a cough I developed pain in my back left side and severe fatigue, no energy. Thinking at first the illness just

Since starting champix i have experienced severral side effects including: -increased urination -lower back pain -extreme fatigue -mood swings -decrease in sex drive

FATIGUE Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting Pharmacogenetic Factors and Side Effects of Metoclopramide and Diphenhydramine
Condition: Drug Metabolism, Poor, CYP2D6-RELATED
Interventions: Drug: Diphenhydramine;   Drug: Metoclopramide
Outcome Measures: Area under curve of metoclopramide (MCP);   Area under curve of diphenhydramine(DPH);   Cmax of metoclopramide;   Tmax of metoclopramide;   Cmax of diphenhydramine;   Tmax of diphenhydramine
2 Recruiting Diphenhydramine for Acute Migraine
Condition: Migraine
Interventions: Drug: metoclopramide;   Drug: diphenhydramine;   Drug: placebo
Outcome Measure: Sustained headache relief
3 Not yet recruiting Study of Promethazine for Treatment of Diabetic Gastroparesis
Condition: Diabetic Gastroparesis
Interventions: Drug: Promethazine;   Drug: Sugar pill
Outcome Measures: Change in patient-reported symptoms as measured by the Gastroparesis Cardinal Symptom Index score (GCSI, 14) from week 0 to week 4.;   Occurrence of adverse events;   Use of rescue medication;   The impact on work activity as measured by the Work Productivity and Activity Impairment Questionnaire. (WPAI).
4 Unknown  Adjunct Sedatives in Procedures Involving Endoscopic Ultrasound (EUS) and Endoscopic Retrograde Cholangiopancreatography (ERCP)
Conditions: Endoscopic Ultrasound (EUS);   Endoscopic Retrograde Cholangiopancreatography (ERCP)
Interventions: Drug: Saline;   Drug: Diphenhydramine;   Drug: Promethazine
Outcome Measures: Sedation Level;   Time to achieve adequate level of sedation to begin procedure;   Time for Recovery;   Adverse Symptoms From Sedative Agents
5 Not yet recruiting Diphenhydramine as an Adjunctive Sedative in Patients on Chronic Opioids
Conditions: Colonoscopy;   Adjunct Anesthesia Medication
Interventions: Drug: Diphenhydramine;   Drug: Placebo
Outcome Measures: Dosage of Fentanyl and Midazolam;   Quality of sedation;   Duration of Procedure;   Adverse events;   24 hour follow up
6 Unknown  Morphine Versus Morphine-promethazine Combination for Acute Low Back Pain Relief in the Adult Emergency Department
Condition: Low Back Pain
Interventions: Drug: Morphine-Promethazine;   Drug: morphine
Outcome Measures: Pain relief;   Ambulatory status
7 Recruiting Antitussive Effect of a Naturally Flavored Syrup Containing Diphenhydramine, Compared With Dextromethorphan and Placebo
Condition: Cough Reflex Sensitivity
Interventions: Drug: Phenylephrine;   Drug: Diphenhydramine;   Drug: Dextromethorphan
Outcome Measure: change in cough reflex sensitivity to capsaicin
8 Not yet recruiting Randomized Trial of Diphenhydramine Versus Continued Midazolam in "Difficult-to-sedate" Patients Undergoing Colonoscopy
Conditions: Sedation;   Endoscopy
Interventions: Drug: Diphenhydramine;   Drug: Midazolam
Outcome Measure: Proportion of patients who achieve adequate sedation to allow colonoscopy (defined as MOAA/S ≤3)
9 Recruiting Ketamine as a Rapidly-Acting Antidepressant in Depressed Emergency Department Patients
Condition: Depression
Interventions: Drug: Ketamine;   Drug: Diphenhydramine
Outcome Measures: Evaluate the effects of ketamine on depressive symptomatology;   Evalaute the effects of ketamine on treatment alliance;   Evalaute the effects of ketamine on suicidal ideation
10 Unknown  Does Thiamine Help Vomiting and Nausea in Pregnancy?
Condition: Hyperemesis Gravidarum
Intervention: Drug: thiamine & promethazine
Outcome Measure: the improvement in nausea and/or vomiting after treatment
11 Not yet recruiting Histamine Glutamate Antagonism in Stroke
Conditions: Acute Cerebrovascular Accident;   Cerebral Edema
Interventions: Drug: Diphenhydramine;   Drug: Pantoprazole;   Drug: Famotidine;   Drug: Dextromethorphan
Outcome Measures: Modified Rankin Score;   National Institutes of Health Stroke Severity (NIHSS) Scale;   Neurological examination of the subject;   All cause mortality data
12 Recruiting Pazopanib Versus Temsirolimus in Poor-Risk Clear-Cell Renal Cell Carcinoma (RCC)
Condition: Kidney Cancer
Interventions: Drug: Pazopanib;   Drug: Temsirolimus;   Behavioral: Quality of Life Assessment;   Drug: Benadryl
Outcome Measure: Progression Free Survival (PFS)
13 Not yet recruiting Psilocybin-facilitated Treatment for Cocaine Use
Condition: Cocaine-Related Disorders
Interventions: Drug: Psilocybin;   Drug: Diphenhydramine
Outcome Measure: The difference between the treatment and placebo groups in the number of participants with biochemically verified cocaine abstinence.
14 Recruiting FUS1-nanoparticles and Erlotinib in Stage IV Lung Cancer
Condition: Lung Cancer
Interventions: Drug: DOTAP:Chol-fus1;   Drug: Erlotinib;   Drug: Dexamethasone;   Drug: Diphenhydramine
Outcome Measures: Maximum Tolerated Dose (MTD) Level for Drug Treatment Combination;   Response Rate
15 Recruiting The Role of Intravenous (IV) Lidocaine in the Management of Chronic Neuropathic Pain of Peripheral Nerve Origin
Condition: Neuropathic Pain
Interventions: Drug: Lidocaine;   Drug: Diphenhydramine
Outcome Measures: Changes from Baseline Pain scores on the Visual Analog Scale at 6 weeks;   Hospital Anxiety and Depression Scale;   Modified Brief Pain Inventory;   Leeds Sleep Evaluation Questionnaire;   Patient Global Satisfaction with Treatment and Impression of Change;   Side Effects;   Quality of Life Health Outcome Instrument
16 Not yet recruiting Countermeasures to Reduce Sensorimotor Impairment and Space Motion Sickness Resulting From Altered Gravity Levels
Condition: Vestibular
Interventions: Drug: Promethazine;   Behavioral: Hyper gravity training;   Drug: Placebo;   Behavioral: No hypergravity training
Outcome Measure: Rate of recovery of roll tilt perception errors after exposure to hypergravity
17 Not yet recruiting First-time-in-man, to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BP1.5375
Condition: Healthy Male Volunteers
Interventions: Drug: BP1.5375 suspension;   Drug: Diphenhydramine;   Drug: Placebo
Outcome Measures: Single Ascending Dose - safety and tolerability (Part 1);   Proof of Concept - effect on polysomnography (Part 2)
18 Not yet recruiting A Double-Blind Trial of Psilocybin-Assisted Treatment of Alcohol Dependence
Condition: Alcohol Dependence
Interventions: Drug: Psilocybin;   Drug: Diphenhydramine;   Behavioral: Motivational Enhancement and Taking Action (META)
Outcome Measures: percent heavy drinking days;   Changes in vital signs;   adverse events;   Percent days abstinent;   drinks per drinking day;   days to first drinking day;   Days to first heavy drinking day;   consequences of drinking;   craving;   self efficacy;   Motivation to change drinking behavior
19 Recruiting Study Looking at End Expiratory Pressure for Altitude Illness Decrease (SLEEP-AID)
Condition: Acute Mountain Sickness
Interventions: Device: Theravent;   Device: Control
Outcome Measures: Incidence of acute mountain sickness;   number of nocturnal desaturations;   acute mountain sickness severity;   nocturnal awakenings;   subjective quality of sleep
20 Recruiting Treatment of Orthostatic Hypotension in Autonomic Failure
Conditions: Autonomic Failure;   Orthostatic Hypotension
Interventions: Drug: Atomoxetine;   Drug: Acarbose;   Drug: Pyridostigmine Bromide;   Drug: Yohimbine;   Drug: Midodrine HCl;   Drug: placebo;   Drug: Modafinil;   Drug: Octreotide;   Other: water intake;   Drug: Diphenhydramine Hydrochloride;   Drug: Ranitidine HCL;   Drug: Tranylcypromine;   Drug: Ergotamine/ Caffeine;   Drug: Celecoxib;   Drug: Pseudoephedrine;   Drug: Methylphenidate;   Drug: Indomethacin;   Drug: Ibuprofen;   Drug: Oxymetazoline 0.05% nasal solution;   Dietary Supplement: Bovril;   Drug: Acetazolamide;   Drug: Rivastigmine tartrate;   Drug: Carbidopa/levodopa;   Device: Inflatable abdominal binder;   Device: inflatable abdominal binder (sham)
Outcome Measures: Increase in seated systolic blood pressure 1-hr post drug compared to baseline.;   Increase in standing time 1-hr post drug compared to baseline