FATIGUE Symptoms and Causes

Everyone feels tired now and then. Sometimes you may just want to stay in bed. But, after a good night's sleep, most people feel refreshed and ready to face a new day. If you continue to feel tired for weeks, it's time to see your doctor. He or she may be able to help you find out what's causing your Fatigue and recommend ways to relieve it.

Fatigue itself is not a disease. Medical problems, treatments, and personal habits can add to Fatigue. These include

  • Taking certain medicines, such as antidepressants, antihistamines, and medicines for nausea and pain
  • Having medical treatments, like chemotherapy and radiation
  • Recovering from major surgery
  • Anxiety, stress, or depression
  • Staying up too late
  • Drinking too much alcohol or too many caffeinated drinks
  • Pregnancy

One disorder that causes extreme Fatigue is chronic Fatigue syndrome (CFS). This Fatigue is not the kind of tired feeling that goes away after you rest. Instead, it lasts a long time and limits your ability to do ordinary daily activities.

NIH: National Institute on Aging

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Recent Reviews

I was admitted to hospital with a suspected blood clot on my lung left side, i was getting bad pains there and dizzyness ,when i got to hospital they put me on oxygen coz it was reel low in a blood test then started injecting me in the stomac was kle

Lately i have experienced fatigue, muscle soreness, headache and my breathing has shallowed. Whenever i get to doing something active, especially anything like running i feel like i cant breathe at all and i have to force myslef to take lon

The air i breath out through the nose smells very bad

My son was suffering from Head ache for the past one year. I have taken him to an ENT & he prescribed Sibelium 10 mg. & he was taking sibelium 3 months back for migraine and he was experiencing fatigue and drowsiness every day. Every t

The side effects from reactine were strange, dizziness, extreme fatigue, a cold sore (which may or may not have been caused by reactine on my lip). I only took it for two days (do not know the dosage, one pill each day). The day after taking it,

I have been Pradaxa for almost a month had severe outbreak of hives on my feet and my legs up to my knees. I also having swelling of legs and feet along with fatigue in joints and body limbs. Doctor changed my Med. but the side effects is still o

Is fatigue really so frequent?

I am taking Suboxone and have had constipation, fatigue and very bad chills and sweats at night. Even during the day, I sometimes feel like I am hot and cold at the same time. I am wondering though, if this is Menopause? The fatigue is so extrem

Unresponsive to 5mg/kg q 8wks; increased to 10mg/kg q6wks. After 3 doses at that strength noted fatigue, occasional night sweats, joint aches, sudden onset of chest pain and dyspnea (pleurisy, small pleuraleffusion) Had just taper

<b>Describe Your Ezetrol Experience Here:</b>Sleeplessness severe pain in muscles and joints nausea and abdominal pain headaches and pain behind eyes chronic fatigue and flat mood

Extreme fatigue, sleeplessness, short term memory and speech difficulties, Edema, weight gain, stumbling, shortness of breath, numbness in both legs, and completely kills ability to achieve orgasm.

Iama 41year old whitefemale After taking OTC delsym for a cough I developed pain in my back left side and severe fatigue, no energy. Thinking at first the illness just

Since starting champix i have experienced severral side effects including: -increased urination -lower back pain -extreme fatigue -mood swings -decrease in sex drive

FATIGUE Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting Acupuncture or MBSR for Patients With Fatigue and MS
Conditions: Fatigue;   Multiple Sclerosis
Interventions: Other: Usual care + acupuncture;   Other: usual care+mbsr;   Other: usual care
Outcome Measures: Fatigue severity scale;   modified Fatigue impact scale;   therapy response rates;   expanded disability status scale;   multipe sclerosis functional composite scale;   beck depression inventory II;   Body efficacy expectation;   SF-12;   HAQUAMS;   Costs;   overall treatment effect;   immune parameters;   number of serious adverse events;   number of suspected adverse reactions
2 Recruiting Fatigue and Cardiac Sympathetic Denervation in Parkinson Disease
Condition: Parkinson's Disease
Outcome Measure: Comparison of cardiac uptake with Fatigue severity score
3 Unknown  Development and Evaluation of a Cancer-Related Fatigue Patient Education Program
Condition: Cancer-Related Fatigue
Intervention: Behavioral: Fatigue Patient Education Program (FIBS)
Outcome Measures: Fatigue;   Quality of Life, Depression and anxiety, physical activity
4 Not yet recruiting Fatigue Management in HIV
Condition: Fatigue
Interventions: Behavioral: Sleep and Rhythm Intervention;   Behavioral: Dietary Modifications
Outcome Measures: Morning Fatigue severity;   Evening Fatigue severity;   Lack of energy - frequency;   Lack of energy - severity;   Lack of energy - distress;   Attrition;   Satisfaction with the intervention;   Adherence to intervention;   Objectively measured sleep duration;   Objectively measured sleep quality;   Objectively-measured activity;   Sleep medication use;   Self-reported sleep quality;   Depressed mood;   Anxious mood;   Physical function;   Cognitive function;   Medication adherence;   Daytime sleepiness;   Fatigue interference with daytime function;   Sleep behavior
5 Recruiting Cognitive Behavioral Therapy With or Without Armodafinil in Treating Cancer Survivors With Insomnia and Fatigue After Chemotherapy
Condition: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: Procedure: Quality-of-Life Assessment;   Other: Questionnaire Administration;   Other: Placebo;   Procedure: Fatigue Assessment and Management;   Procedure: Sleep Disorder Therapy;   Drug: Armodafinil;   Procedure: Quality-of-life assessment;   Procedure: Management of Therapy;   Procedure: Sleep disorder therapy;   Procedure: cognitive assessment;   Procedure: Quality of Life assessment;   Procedure: Fatigue assessment and management;   Procedure: Management of therapy and complications;   Procedure: Cognitive Assessment;   Procedure: Quality of Life Assessment;   Procedure: Fatifue assessment and management
Outcome Measures: Severity of insomnia as assessed by the insomnia severity index and daily sleeep diaries.;   Fatigue as assessed by the brief Fatigue index;   Adverse Events;   Fatigue as assessed by the functional assessment of chronic illness therapy-Fatigue;   Sleep latency, wake after sleep onset, and total sleep time
6 Recruiting Methylphenidate as Treatment Option of Fatigue in Multiple Sclerosis
Conditions: Multiple Sclerosis;   Fatigue
Interventions: Drug: Methylphenidate modified release;   Drug: Maltodextrin
Outcome Measures: Change of Fatigue as measured by Fatigue Severity Scale;   Change of Fatigue as measured by Modified Fatigue Impact Scale (MFIS)
7 Recruiting Treatment of Post-Traumatic Brain Injury (Post-TBI) Fatigue With Light Therapy
Conditions: Traumatic Brain Injury;   Fatigue
Interventions: Device: Bright White Light (BWL);   Device: Dim Red Light (DRL)
Outcome Measures: Multidimensional Assessment of Fatigue (MAF);   TBI-QOL Fatigue;   Neuro-QOL Depression and Sleep;   Epworth Sleepiness Scale (ESS);   CNS Vital Signs TBI Rehab Toolbox;   Cognitive Failures Questionnaire;   Neuro-QOL Anxiety;   Actiwatch Spectrum;   Satisfaction with Life Scale;   Treatment Satisfaction Questionnaire for Medication;   Credibility/Expectancy Questionnaire
8 Recruiting Biomarkers of Fatigue Related to Adjuvant Chemotherapy for Breast Cancer
Conditions: Fatigue;   Breast Cancer
Outcome Measure: Potential biomarkers related to chemotherapy induced Fatigue
9 Not yet recruiting Yoga Skills Training or Attention Control for Reducing Fatigue and Depressive Symptoms During Chemotherapy in Patients With Stage II-IV Colorectal Cancer
Conditions: Depressive Symptoms;   Fatigue;   Psychosocial Effects of Cancer and Its Treatment;   Stage IIA Colon Cancer;   Stage IIA Rectal Cancer;   Stage IIB Colon Cancer;   Stage IIB Rectal Cancer;   Stage IIC Colon Cancer;   Stage IIC Rectal Cancer;   Stage IIIA Colon Cancer;   Stage IIIA Rectal Cancer;   Stage IIIB Colon Cancer;   Stage IIIB Rectal Cancer;   Stage IIIC Colon Cancer;   Stage IIIC Rectal Cancer;   Stage IVA Colon Cancer;   Stage IVA Rectal Cancer;   Stage IVB Colon Cancer;   Stage IVB Rectal Cancer
Interventions: Behavioral: Yoga Skills Training (YST);   Other: questionnaire administration;   Other: Fatigue and depressive symptom assessment and management;   Other: psychological stress assessment;   Other: laboratory biomarker analysis;   Other: Attention Control
Outcome Measures: Changes in Fatigue (recalled);   Changes in depressive symptoms (recalled and daily);   Changes in daily Fatigue;   Changes in psychological stress (daily and recalled) as assessed by Perceived Stress Scale (PSS);   Regulation of psychological stress (daily and recalled) as assessed by Positive and Negative Affect Schedule-Expanded Form and Cancer Behavior Inventory
10 Recruiting Fire Fighter Fatigue Management Program: Operation Fight Fatigue
Conditions: Shift-Work Sleep Disorder;   Insomnia;   Restless Leg Syndrome;   Obstructive Sleep Apnea;   Impaired Driving
Interventions: Behavioral: Sleep health education provided via a web-based program;   Other: Sleep disorder detection and treatment;   Other: Optimization of Sleep in Fire Station
Outcome Measures: Sleep and health screening of firefighters using a composite of survey instruments;   Composite of firefighter information provided by the participating fire department;   Sleep and performance of firefighters measured by a composite of physiological monitoring;   Documentation of motor vehicle crashes (MVC), and reported injuries;   Employment verification as a firefighter of all participants;   Composite of firefighter health information
11 Recruiting Oral Testosterone for Fatigue in Male Multiple Sclerosis Patients
Conditions: Multiple Sclerosis;   Fatigue
Interventions: Drug: Testosterone undecanoate;   Drug: placebo
Outcome Measures: Change in Fatigue (measured with Modified Fatigue Impact Scale [M-FIS]);   Change in Fatigue as measured on a visual analog scale (VAS);   Quality of life as measured with the Aging Males' Symptoms (AMS) scale;   Neurological status as measured with the Expanded Disability Status Scale (EDSS);   Number of participants with , type and severity of adverse events
12 Unknown  Acupuncture for the Treatment of Chronic Post-Chemotherapy Fatigue
Condition: Fatigue
Interventions: Procedure: Acupuncture;   Procedure: Placebo Acupuncture
Outcome Measures: To determine whether acupuncture reduces chronic Fatigue after chemotherapy more effectively than placebo;   To examine the long term effects of acupuncture treatment on Fatigue;   To examine predictors of response to acupuncture treatment in terms of baseline symptoms, hemoglobin, age, sex, time since chemotherapy, and concurrent treatment;   To examine the effect of acupuncture on levels of physical activity and quality of life
13 Recruiting Exercise in Lessening Fatigue Caused by Cancer in Patients Undergoing Chemotherapy
Conditions: Fatigue;   Unspecified Adult Solid Tumor, Protocol Specific
Intervention: Behavioral: exercise
Outcome Measures: Improvement of cancer-related Fatigue as assessed by the Brief Fatigue Inventory total score at day 41 (after exercise intervention);   Improvement of aerobic capacity, strength, and quality of life as assessed by the 6-minute walk test, handgrip dynamometry, and Functional Assessment of Chronic Illness Therapy-Fatigue total score at day 41 (after exercise intervention)
14 Recruiting PG2 Treatment for Improving Fatigue Among Advanced Cancer Patients Under Standard Palliative Care
Condition: Cancer-related Fatigue
Interventions: Drug: Astragalus Polysaccharides 500 mg;   Drug: Astragalus Polysaccharides 250 mg
Outcome Measures: Fatigue Improvement Response Rate;   The Fatigue improvement response rate among patients within and between cycles (by BFI-T);   The Fatigue improvement by multiple BFI-T score percentage change levels among patients between two study arms;   The mean of patients' Fatigue score change from baseline within and between cycles (by BFI-T);   Symptoms and Quality of Life Assessments: SS11 from EORTC QLQ-C30 (including the evaluation of the quality of sleep, appetite, pain, Fatigue, nausea, vomiting and global quality of life);   Karnofsky performance score;   The correlation between Weight change and the related blood c-reactive protein level;   Physical Examination;   Labolatory Safety Examination;   Incidence of Adverse Events as a Measure of Safety and Tolerability;   Vital signs
15 Recruiting Treatment of Post Stroke Fatigue With a Wakefulness Promoting Agent
Conditions: Stroke;   Post Stroke Fatigue
Interventions: Drug: modafinil;   Drug: placebo
Outcome Measures: Multidimensional Fatigue Inventory (MFI- 20);   MFI-20;   Fatigue severity scale (FSS);   FSS
16 Not yet recruiting Sodium Oxybate in Patients With Chronic Fatigue Syndrome.
Condition: Chronic Fatigue Syndrome
Interventions: Drug: Sodium oxybate;   Drug: Placebo
Outcome Measures: Measurement of the effect of sodium oxybate on Fatigue with questionnaires.;   Effect of sodium oxybate on sleepiness.;   Effect of sodium oxybate on sleepiness;   Effect of sodium oxybate on sleep quality.;   Effect of sodium oxybate on general health.;   Effect of sodium oxybate on pain.
17 Recruiting Effects of Muscle Fatigue and a Taping Technique on Shoulder Motion of Athletes
Conditions: Shoulder Injury;   Muscle Fatigue
Interventions: Other: Elastic taping applied with tension;   Other: Elastic taping applied without tension;   Other: Fatigue protocol
Outcome Measures: Changes in scapular internal/external rotations, upward/downward rotations and anterior/posterior tilt movements;   Changes in the median frequency of electromyographic signal from upper and lower trapezius and serratus anterior muscles.
18 Recruiting American Ginseng to Improve HIV-Associated Fatigue: A Randomized, Placebo-Controlled, Parallel Design, Multiple-Dose Clinical Trial
Condition: HIV/AIDS-associated Fatigue
Interventions: Drug: American ginseng;   Dietary Supplement: Placebo for American ginseng
Outcome Measures: Change in Fatigue Severity Score;   Additional questionnaire will be used to quantify Fatigue, quality of life, symptoms of depression, sleep quality, virologic, immunologic, and inflammatory markers.;   Additional questionnaire will be used to quantify Fatigue, inflammatory, immunologic, and virologic markers, and side effects
19 Recruiting Investigating Molecular-Genetic Correlates of Fatigue Experienced by Cancer Patients Receiving Treatment
Conditions: Cancer;   Fatigue
Outcome Measures: The primary outcomes of this study are self-reported Fatigue, depression, and quality of life scores of patients before, at midpoint, and at completion of each cycle of their cancer treatment.;   White blood cell gene expression;   Fatigue, cognitive function, and HRQOL scores;   Physical activity levels;   Skeletal muscle strength
20 Recruiting Fatigue Before and After Exercise in Patients With Advanced Cancer Stage
Condition: Fatigue
Interventions: Other: 10 minute walk;   Other: 20 minute walk;   Other: 30 minute walk
Outcome Measures: Fatigue;   Quality of life;   Anxiety and Depression Evaluation;   Patient impression satisfaction