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HEPATIC FUNCTION ABNORMAL and Voltaren

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HEPATIC FUNCTION ABNORMAL Symptoms and Causes

What is fatty liver disease?

Your liver is the largest organ inside your body. It helps your body digest food, store energy, and remove poisons. Fatty liver disease is a condition in which fat builds up in your liver. There are two main types:

  • Nonalcoholic fatty liver disease (NAFLD)
  • Alcoholic fatty liver disease, also called alcoholic steatohepatitis
What is nonalcoholic fatty liver disease (NAFLD)?

NAFLD is a type of fatty liver disease that is not related to heavy alcohol use. There are two kinds:

  • Simple fatty liver, in which you have fat in your liver but little or no inflammation or liver cell damage. Simple fatty liver typically does not get bad enough to cause liver damage or complications.
  • Nonalcoholic steatohepatitis (NASH), in which you have inflammation and liver cell damage, as well as fat in your liver. Inflammation and liver cell damage can cause fibrosis, or scarring, of the liver. NASH may lead to cirrhosis or liver cancer.
What is alcoholic fatty liver disease?

Alcoholic fatty liver disease is due to heavy alcohol use. Your liver breaks down most of the alcohol you drink, so it can be removed from your body. But the process of breaking it down can generate harmful substances. These substances can damage liver cells, promote inflammation, and weaken your body's natural defenses. The more alcohol that you drink, the more you damage your liver. Alcoholic fatty liver disease is the earliest stage of alcohol-related liver disease. The next stages are alcoholic hepatitis and cirrhosis.

Who is at risk for fatty liver disease?

Researchers do not know the cause of nonalcoholic fatty liver (NAFLD). They do know that it is more common in people who

  • Have type 2 diabetes and prediabetes
  • Have obesity
  • Are middle aged or older (although children can also get it)
  • Are Hispanic, followed by non-Hispanic whites. It is less common in African Americans.
  • Have high levels of fats in the blood, such as cholesterol and triglycerides
  • Have high blood pressure
  • Take certain drugs, such as corticosteroids and some cancer drugs
  • Have certain metabolic disorders, including metabolic syndrome
  • Have rapid weight loss
  • Have certain infections, such as hepatitis C
  • Have been exposed to some toxins

NAFLD affects about 25 percent of people in the world. As the rates of obesity, type 2 diabetes, and high cholesterol are rising in the United States, so is the rate of NAFLD. NAFLD is the most common chronic liver disorder in the United States.

Alcoholic fatty liver disease only happens in people who are heavy drinkers, especially those who have been drinking for a long period of time. The risk is higher for heavy drinkers who are women, have obesity, or have certain genetic mutations.

What are the symptoms of fatty liver disease?

Both NAFLD and alcoholic fatty liver disease are usually silent diseases with few or no symptoms. If you do have symptoms, you may feel tired or have discomfort in the upper right side of your abdomen.

How is fatty liver disease diagnosed?

Because there are often no symptoms, it is not easy to find fatty liver disease. Your doctor may suspect that you have it if you get abnormal results on liver tests that you had for other reasons. To make a diagnosis, your doctor will use

  • Your medical history
  • A physical exam
  • Various tests, including blood and imaging tests, and sometimes a biopsy

As part of the medical history, your doctor will ask about your alcohol use, to find out whether fat in your liver is a sign of alcoholic fatty liver disease or nonalcoholic fatty liver (NAFLD). He or she will also ask which medicines you take, to try to determine whether a medicine is causing your NAFLD.

During the physical exam, your doctor will examine your body and check your weight and height. Your doctor will look for signs of fatty liver disease, such as

  • An enlarged liver
  • Signs of cirrhosis, such as jaundice, a condition that causes your skin and whites of your eyes to turn yellow

You will likely have blood tests, including liver function tests and blood count tests. In some cases you may also have imaging tests, like those that check for fat in the liver and the stiffness of your liver. Liver stiffness can mean fibrosis, which is scarring of the liver. In some cases you may also need a liver biopsy to confirm the diagnosis, and to check how bad the liver damage is.

What are the treatments for fatty liver disease?

Doctors recommend weight loss for nonalcoholic fatty liver. Weight loss can reduce fat in the liver, inflammation, and fibrosis. If your doctor thinks that a certain medicine is the cause of your NAFLD, you should stop taking that medicine. But check with your doctor before stopping the medicine. You may need to get off the medicine gradually, and you might need to switch to another medicine instead.

There are no medicines that have been approved to treat NAFLD. Studies are investigating whether a certain diabetes medicine or Vitamin E can help, but more studies are needed.

The most important part of treating alcohol-related fatty liver disease is to stop drinking alcohol. If you need help doing that, you may want to see a therapist or participate in an alcohol recovery program. There are also medicines that can help, either by reducing your cravings or making you feel sick if you drink alcohol.

Both alcoholic fatty liver disease and one type of nonalcoholic fatty liver disease (nonalcoholic steatohepatitis) can lead to cirrhosis. Doctors can treat the health problems caused by cirrhosis with medicines, operations, and other medical procedures. If the cirrhosis leads to liver failure, you may need a liver transplant.

What are some lifestyle changes that can help with fatty liver disease?

If you have any of the types of fatty liver disease, there are some lifestyle changes that can help:

  • Eat a healthy diet, limiting salt and sugar, plus eating lots of fruits, vegetables, and whole grains
  • Get vaccinations for hepatitis A and B, the flu and pneumococcal disease. If you get hepatitis A or B along with fatty liver, it is more likely to lead to liver failure. People with chronic liver disease are more likely to get infections, so the other two vaccinations are also important.
  • Get regular exercise, which can help you lose weight and reduce fat in the liver
  • Talk with your doctor before using dietary supplements, such as vitamins, or any complementary or alternative medicines or medical practices. Some herbal remedies can damage your liver.

Check out the latest treatments for HEPATIC FUNCTION ABNORMAL

HEPATIC FUNCTION ABNORMAL treatment research studies

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Voltaren Side Effects

Off Label Use (256)
Dyspnoea (171)
Therapeutic Response Unexpected (136)
Blood Creatinine Increased (129)
Aspartate Aminotransferase Increased (122)
Pain (115)
Alanine Aminotransferase Increased (114)
Nausea (114)
Pyrexia (112)
Erythema (108)
Blood Urea Increased (108)
Dizziness (107)
C-reactive Protein Increased (105)
Blood Pressure Decreased (105)
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Haemoglobin Decreased (85)
Blood Lactate Dehydrogenase Increased (84)
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Abdominal Pain Upper (81)
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Blood Bilirubin Increased (49)
Back Pain (49)
Disseminated Intravascular Coagulation (49)
Haematemesis (49)
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Blister (48)
Hypertension (47)

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Recent Reviews

It seems as though after I have applied the Voltaren to my hands and feet a couple of hours later or even the next day, I get a migrane headache and slowly but very surely all my joints, from my neck down to my elbows, knees, hips are especially pain

What is dyspnoae

after taking my medicine .i felt abnormal taste in mouth and my bilurubin level was increased.

I took centrum for almost one month.and I notice that my menstruation suddenly became abnormal in cycle..in short AMENNORHEA....until now iam almost 1 month and 3 days delayed and took pregnancy test but the result was

The St. Loree's Medi Shaver has made my life a lot easier to function at home since I left the hospital August 2008. I ask my wife how much it costs to replace it. I drop it one time and it is broken. Especial

<strong>I took 2 capsules at 7.20m after having breakfast and started feeling side effects at 8.25am. It started with increased temperature, abnormal levels of perspiration, dizziness and severe nausea. </strong

1100 sinus rhythm 2210 short pr intrval 9150 abnormal**ecg

24 year old son been on examphetamine 6 per day for 3 months. he is aggresive anxious, cant think straight, cant talk properly (hard to find the words) just cant function..ADD adult diagnosis...I am scared....could it be the pills.

61 years old male. Metformin 2,000 mg + Actos 15 mg/day After losing 20% body weight in one year, apparently began 14 month episode of hypoclycemia unawareness (bad crashes without warning, impaired cognitive function). Finally s

9150 **abnormal ecg

A friend of mine has cancer and the doctors are talking about having surgery and removing the sciatica nerve. My question is will he be a function with this removal.

A report-I had a suppression dose of Macrobid; after 8 months much worse and after a year in fulminant hepatic failure leading to a transplant. How can these changes be spotted for women like me.

HEPATIC FUNCTION ABNORMAL Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting Study Comparing a Generic Diclofenac Sodium Topical Gel, 1% to Voltaren in the Treatment of Subjects With Osteoarthritis of the Knee
Condition: Osteoarthritis
Interventions: Drug: Diclofenac Sodium Topical Gel, 1%;   Drug: Voltaren Topical Gel, 1%;   Drug: Vehicle Diclofenac Sodium Topical Gel
Outcome Measure: WOMAC Pain Score
2 Recruiting Safety Study of Flector Patch in Children With Minor Soft Tissue Injuries
Condition: Athletic Injuries
Intervention: Drug: Diclofenac hydroxyethylpyrrolidine
Outcome Measures: Dermatologic assessment at the patch application site;   Investigator assessment of the global response to therapy on a 5-point scale;   Patient assessment of pain on a 6-point scale;   Plasma concentration of diclofenac
3 Recruiting An Investigator Initiated, Within-Subject, Proof of Concept Study to Assess the Analgesic Efficacy and Safety of Voltaren Gel (1% Diclofenac Sodium) Compared to Placebo in Subjects Experiencing Delayed Onset Muscle Soreness
Condition: Delayed Onset Muscle Soreness
Interventions: Drug: 1% diclofenac sodium gel;   Drug: Placebo
Outcome Measure: To assess analgesic efficacy of Topical Voltaren® gel compared to placebo
4 Recruiting Treatment of Knee Pain With Topical Diclofenac Cream 8% or Diclofenac Gel 1%
Conditions: Knee Pain Chronic;   Knee Injuries
Interventions: Drug: Diclofenac Cream 8%;   Drug: Diclofenac Gel 1%
Outcome Measure: Descrete Response Scale Pain Scores
5 Unknown  Comparison of the Effect of Etoricoxib and Diclofenac on Early Morning Activity in Rheumatoid Arthritis (RA)
Condition: Rheumatoid Arthritis
Interventions: Drug: Etoricoxib;   Drug: Diclofenac
Outcome Measures: To explore the effect of Etoricoxib compared to Diclofenac on physical activity in RA subjects with Early morning pain and stiffness.;   To explore the effect of Etoricoxib compared to Diclofenac on average daily pain scores, fatigue scores, and quality of life.
6 Recruiting Efficacy of Diclofenac on Pain During Endometrial Sampling
Condition: Abnormal Uterine Bleeding Unrelated to Menstrual Cycle
Interventions: Drug: Diclofenac Potassium;   Drug: Folic Acid
Outcome Measure: Effectiveness of Diclofenac Potassium for additional acute pain control in patient undergoing fractional curettage under paracervical block due to abnormal uterine bleeding
7 Recruiting A Multicenter Efficacy Study of a Diclofenac+Menthol Gel in Subjects With Ankle Sprain
Condition: Ankle Sprain
Interventions: Drug: 1% diclofenac sodium plus 3% menthol;   Drug: 1% diclofenac sodium plus 0.09% menthol;   Drug: 3% menthol;   Drug: Placebo with 0.09% menthol gel
Outcome Measures: AUC (1-3 days);   Pain Intensity Difference (PID) on movement;   PID at rest;   Pain Relief Score (PRS);   Sum of Pain Intensity Difference (SPID);   Time of Onset of Pain Relief (TOPR);   Time of Onset of Meaningful Pain Relief (TOMR);   Time of Onset of Cooling Sensation (TOCS);   Total Pain Relief (TOTPAR);   Skin Temperature;   Ankle Swelling;   Time to complete Recovery;   Patient's Global Assessment in Response to Treatment (PGART);   Adverse events (AEs)
8 Recruiting Effects of Topical Diclofenac on Tumor Metabolism
Condition: Actinic Keratoses
Intervention: Drug: 3% diclofenac in 2.5% hyaluronic acid gel
Outcome Measures: Lactate level in skin biopsies of actinic keratoses;   Lactate level in skin biopsies of healthy skin in a subpopulation;   Glycolysis-relevant proteins evaluated using PCR and Westernblot techniques;   Metabolic changes (e.g. glucose, amino acids)
9 Not yet recruiting Supersaturation and Precipitation of Diclofenac in the Stomach of Healthy Volunteers
Condition: Supersaturation and Precipitation in the Stomach
Intervention: Drug: Diclofenac potassium 50 mg
Outcome Measure: Area under the Concentration - Time Curve
10 Unknown  Use of Etoricoxib Compared to Diclofenac in the Perioperative Treatment of Patients After Total Hip Arthroplasty
Conditions: Coxarthrosis;   Arthroplasties Hip Replacement;   Perioperative Blood Loss
Interventions: Drug: Etoricoxib;   Drug: Diclofenac
Outcome Measure:
11 Recruiting Diclofenac for Submassive PE
Condition: Pulmonary Embolism
Interventions: Drug: Diclofenac;   Drug: Placebo
Outcome Measure: Right ventricular dysfunction assessed by transthoracic echocardiography
12 Not yet recruiting In Vivo Inhibition Profile of CYP2C9 by Pineapple Juice
Condition: Healthy Volunteers
Intervention: Dietary Supplement: pineapple juice (Carrefour n°1) 500 ml/day 5 days
Outcome Measures: a) AUC 4-OH-diclofenac / AUC diclofenac quantified in plasma, on days 1 (without pineapple juice) and 11 (after pretreatment with pineapple juice);   (b) AUC 4-OH-diclofenac/ AUC diclofenac quantified in urine, on days 1 (without pineapple juice) and 11 (after pretreatment with pineapple juice)
13 Unknown  The Comparison Between the Therapeutic Affect of Intravitreal Diclophenac and Triamcinolone in Persistent Uveitic Cystoids Macular Edema
Conditions: Uveitis;   Cystoid Macular Edema
Interventions: Drug: Diclophenac;   Drug: Triamcinolone
Outcome Measure:
14 Recruiting Efficacy and Safety of Diclofenac DDEA 2.32 % in Patient Suffering From Knee Osteoarthritis (OA)
Condition: Osteoarthritis, Knee
Intervention: Drug: diclofenac diethylamine, DDEA 2.32% gel
Outcome Measures: Measure: Pain On Movement (POM);   Measure POM regarding onset of efficacy
15 Recruiting Intramuscular Diclofenac in the Prevention of Post-ERCP Pancreatitis
Condition: Post ERCP Pancreatitis
Interventions: Drug: Diclofenac;   Drug: normal saline
Outcome Measure: Incidence of post ERCP pancreatitis
16 Unknown  Efficacy of Diclofenac BCG Irrigations
Condition: Bladder Cancer
Interventions: Drug: Abitren;   Drug: Placebo
Outcome Measures: Change in weekly COOP Questionnaire 1;   Change in weekly COOP Questionnaire 2;   Change in weekly COOP Questionnaire 3;   Change in weekly Bladder symptoms Questionnaire;   Change in weekly time schedule questionnaire
17 Recruiting Post ERCP Pancreatitis Prevention in Average Risk Patients
Condition: Pancreatitis
Intervention: Procedure: Ceftazidime
Outcome Measure: Incidence of PEP in the group of patients receiving Ceftazidime versus incidence of PEP in the group of patients receiving Diclophenac potassium
18 Unknown  Intravitreal Diclofenac Versus Avastin as Primary Treatment of Diffuse Diabetic Macular Edema
Condition: Diffuse Diabetic Macular Edema
Interventions: Drug: Bevacizumab;   Drug: Diclofenac
Outcome Measure:
19 Not yet recruiting Diclofenac add-on to Treatment as Usual for Suicidal Patients
Condition: Depression Suicidal
Interventions: Drug: sugar pill;   Drug: Diclofenac
Outcome Measures: Suicide Assessment Scale (differences in scores before and after treatment);   Montgomery Asberg Rating Scale (differences in scores before and after treatment);   Barratt Impulsiveness Scale (differences in scores before and after treatment);   Montgomery Asberg depression Ratin scale (changes in suicidality item before and after treatment);   Montgomery Asberg Rating Scale (changes in concentration item before and after treatment);   Comprehensive Psychopathological Rating Scale (changes in aggressive feelings item before and after treatment);   Comprehensive Psychopthological Rating Scale (changes in fatigue item before and after treatment)
20 Recruiting OASIS: Osteoarthritis Sensitivity Integration Study
Conditions: Osteoarthritis;   Chronic Pain
Intervention: Drug: duloxetine, diclofenac
Outcome Measure: Pain