Rank |
Status |
Study |
1 |
Recruiting
|
ED50 Determination of Hydroxyethylstarch for Treatment of Hypotension During Cesarean Section Under Spinal Anesthesia
Conditions: |
Obstetric Anesthesia; Spinal Anesthesia; Hypotension; Fluid Therapy; Cesarean Section |
Intervention: |
Drug: Hydroxyethylstarch 130/0.4 |
Outcome Measures: |
Volume of HES which will prevent Hypotension if 50 % of the subjects.; Incidence of Hypotension episodes; Incidence of hypertensive episodes; cardiac output; Apgar score; umbilical artery pH; additional vasopressors administered |
|
2 |
Not yet recruiting
|
An Open Label Trial to Decrease Signs and Symptoms of Orthostatic Hypotension Using Midodrine or Intravenous Fluid Bolus in Patients Following Total Hip Arthroplasty
Condition: |
Orthostatic Hypotension |
Interventions: |
Drug: Midodrine; Other: Intravenous fluid bolus |
Outcome Measures: |
Change in Orthostatic Hypotension Questionnaire score; Length of stay; Orthostatic Hypotension/dizziness; Cardiac parameters (BP, AI, CO, HR, SVV, SVR); Number of attempts at physical therapy; Successful physical therapy sessions and milestones; Resolution of orthostatic Hypotension |
|
3 |
Recruiting
|
Post-prandial Hypotension and Sleepiness in Parkinson's Disease and Other Synucleinopathies
Conditions: |
Parkinsonian Patients; Post-prandial Sleepiness; Orthostatic Hypotension |
Interventions: |
Other: V1: HGPO + meal and V2: placebo + meal; Other: V1: placebo 75mg + meal and V2: HGPO 75mg + meal |
Outcome Measures: |
Rate of patients presenting a "sleep onset"; rate of patients without arterial Hypotension nor a sleep episode within 120 minutes after oral solution administration ;; rate of patients that show a sleep episode but without arterial Hypotension within 120 minutes after oral solution administration ;; rate of patients that show arterial Hypotension within 120 minutes after oral solution administration but not a sleep episode;; Occurrence of arterial Hypotension and a sleep episode within 120 minutes following a standardized meal; Changes in intestine-pancreatic neuropeptides including incretins (GLP-1 - GIP) following an oral glucose load, placebo fructose load, or standardized meal - correlation with the post-prandial BP drop. |
|
4 |
Recruiting
|
ET50 With Fentanyl for Post Caesarean Section Spinal Hypotension
Conditions: |
Hypotension; Pregnancy |
Intervention: |
Drug: Bupivacaine with 15 micrograms of fentanyl |
Outcome Measures: |
Sitting time to avoid Hypotension; Pain occurence |
|
5 |
Recruiting
|
Orthostatic Hypotension Among Veterans
Condition: |
Hypotension, Orthostatic Hypotension |
Intervention: |
|
Outcome Measure: |
Change in blood pressure from supine to standing. |
|
6 |
Recruiting
|
Compared Efficacy and Tolerance of Two Vasopressors Used to Treat Preoperative Hypotension During Carotid Surgery
Conditions: |
Endovascular Carotid Surgery;; Preoperative Hypotension; |
Intervention: |
Drug: ephedrine and phenylephrine |
Outcome Measures: |
Cerebral oxygen saturation (SctO2); Incidence of post-treatment Hypotension; Incidence of post-treatment bradycardia; Postoperative morbidity: cardiovascular, cerebral, renal, surgical; Postoperative recovery |
|
7 |
Recruiting
|
Phenylephrine in Spinal Anesthesia in Preeclamptic Patients
Conditions: |
Preeclampsia; Hypotension |
Interventions: |
Drug: Ephedrine; Drug: Phenylephrine |
Outcome Measures: |
The umbilical artery pH in the phenylephrine group will be higher than in the ephedrine group, although the overall incidence of absolute fetal acidosis is not anticipated to be different between groups.; Efficacy of study drug in preventing and treating Hypotension associated with spinal anesthesia in women with preeclampsia |
|
8 |
Recruiting
|
Preventing Hypotension in Parturients With an Elevated Body Mass Index (BMI)
Condition: |
Hypotension |
Interventions: |
Drug: Phenylephrine bolus; Drug: phenylephrine infusion |
Outcome Measures: |
incidence of nausea and vomiting; incidence of Hypotension; neonatal acidosis |
|
9 |
Recruiting
|
Blood Pressure Guided Biofeedback on Hemodialysis and the Reduction of IntraDialytic Hypotension
Condition: |
Hypotension |
Interventions: |
Other: BioLogic RR; Other: Hemodialysis without biofeedback |
Outcome Measures: |
intradialytic Hypotension episodes; urea clearance; Brain natriuretic peptide; intradialytic Hypotension (blood pressure criteria alone); Intradialytic symptoms |
|
10 |
Recruiting
|
Treatment of Hypotension of Prematurity (TOHOP)
Condition: |
Hypotension |
Intervention: |
Other: Anti-hypotensive treatment |
Outcome Measures: |
Neurodevelopmental outcome assessment using the Bayley Scales of Infant Development III; Incidence of peri-intraventricular haemorrhage; Incidence of white matter injury and gray matter injury; Difference in the ability to maintain cerebral blood flow autoregulation; Mortality |
|
11 |
Recruiting
|
Abdominal Binder to Treat Orthostatic Hypotension (OH) in Parkinson's Disease (PD)
Conditions: |
Parkinson's Disease; Neurogenic Orthostatic Hypotension in Parkinson's Disease |
Interventions: |
Device: Elastic abdominal binder; Device: Placebo binder |
Outcome Measures: |
Effect of an elastic abdominal binder versus a placebo binder on mean blood pressure (mmHg) after 3 minutes of orthostatic challenge (on passive tilting) with respect to baseline in Parkinson's disease patients with neurogenic orthostatic Hypotension; Effect of an elastic abdominal binder versus a placebo binder on systolic blood pressure (mmHg) after 3 minutes of orthostatic challenge with respect to baseline in Parkinson's disease patients with neurogenic orthostatic Hypotension; Effect of an elastic abdominal binder versus a placebo binder on diastolic blood pressure (mmHg) after 3 minutes of orthostatic challenge with respect to baseline in Parkinson's disease patients with neurogenic orthostatic Hypotension; Effect of an elastic abdominal binder with respect to a placebo binder on orthostatic symptoms after 3 minutes of orthostatic challenge in Parkinson's disease patients suffering from neurogenic orthostatic Hypotension; Effect of an elastic abdominal binder with respect to a placebo binder on mean supine blood pressure (mmHg) in Parkinson's disease patients suffering from neurogenic orthostatic Hypotension; Effects of an abdominal binder on orthostatic symptoms in daily living during 4-weeks open label trial; Effect of an elastic abdominal binder versus a placebo binder on mean blood pressure (mmHg) after 3 minutes of orthostatic challenge (on active standing) with respect to baseline in Parkinson's disease patients with neurogenic orthostatic Hypotension |
|
12 |
Recruiting
|
Acarbose and Older Adults With Postprandial Hypotension
Conditions: |
Other Specified Hypotension; Syncope |
Interventions: |
Drug: Acarbose; Drug: Placebo |
Outcome Measures: |
The postprandial cardiovascular response to a standardized meal compared between subjects with and without PPH; The postprandial glucagon-like peptide-1 (GLP-1) and gastric inhibitory peptide (GIP) response to a standardized meal compared between subjects with and without PPH; The postprandial cardiovascular response between the Acarbose group and the Placebo group will be compared. |
|
13 |
Recruiting
|
Transcutaneous Electrical Acupoint Stimulation(TEAS) for Hypotension After Spinal Anesthesia in Parturients
Condition: |
Hypotension |
Intervention: |
Other: TEAS |
Outcome Measures: |
Incidence of Hypotension; Average systemic blood pressure(SBP) and diastolic blood pressure(DBP); Lowest SBP and DBP; Dosage of ephedrine; postoperative nausea and vomiting(PONV) score; Incidence of dizzy and dyspnea; Change of concentration of serum adrenaline and noradrenaline |
|
14 |
Not yet recruiting
|
Insulin Therapy and Falls Due to Orthostatic Hypotension
Conditions: |
Orthostatic Hypotension; Diabetes; Syncope |
Intervention: |
Drug: Insulin ( Lantus) |
Outcome Measures: |
1. Presence or absence of orthostatic Hypotension; 1. The nadir of middle cerebral artery (MCA) velocity; 2. The presence or absence of a positive augmented tilt table test; 3. The nadir of systolic blood pressure (SBP) and diastolic blood pressure (DBP) during tilt table test. |
|
15 |
Unknown †
|
Fipamezole in Neurogenic Orthostatic Hypotension
Conditions: |
Symptomatic Neurogenic Orthostatic Hypotension (NOH); Parkinson's Disease; Multiple System Atrophy |
Interventions: |
Drug: Placebo; Drug: Fipamezole |
Outcome Measures: |
To compare the efficacy of fipamezole with that of placebo on orthostatic Hypotension as assessed by blood pressure response to orthostatism.; To compare the efficacy of fipamezole with that of placebo on heart rate (HR) response to orthostatism.; To compare the efficacy of fipamezole with that of placebo on clinical symptoms.; To explore the relationship between plasma levels of fipamezole and measures of efficacy and safety (pharmacokinetics).; To assess safety and tolerability of fipamezole. |
|
16 |
Unknown †
|
Prophylactic Phenylephrine Infusion for Preventing Hypotension During Spinal Anesthesia
Condition: |
Orthopedic Surgery of Lower Limb |
Interventions: |
Drug: phenylephrine infusion; Drug: patients receiving saline infusion |
Outcome Measures: |
number of Hypotension episodes; number of episodes of severe Hypotension; cardiovascular events; neurologic events |
|
17 |
Not yet recruiting
|
Management of Hypotension In the Preterm Infant
Conditions: |
Hypotension; Low Blood Pressure; Intraventricular Hemorrhage of Prematurity |
Interventions: |
Drug: Dopamine hydrochloride; Drug: Dextrose 5% |
Outcome Measures: |
First Co-Primary Outcome Measure: Survival to 36 weeks postmenstrual age free of severe brain injury; Second Co-Primary Outcome Measure: Survival without moderate or serious disability as defined using consensus criteria for neurodevelopmental impairment.; All cause mortality at 36 weeks gestational age |
|
18 |
Recruiting
|
NOX-100 for Preventing Hypotension During Hemodialysis
Condition: |
Hypotension |
Intervention: |
Drug: NOX-100 |
Outcome Measures: |
Number of Hypotension episode requiring intervention; systolic blood pressure (SBP); Onset of symptoms of Hypotension during HD; The need for treatment intervention to raise BP. |
|
19 |
Unknown †
|
Maternal and Neonatal Outcomes of the Use of Vasopressors to Treat Hypotension During Spinal Anesthesia for Cesarean
Conditions: |
Preeclampsia; Pregnancy Toxemias |
Interventions: |
Drug: Metaraminol; Drug: Ephedrine |
Outcome Measures: |
Incidence of maternal Hypotension; Maternal and Neonatal outcomes |
|
20 |
Unknown †
|
Predicting Hypotension During Dialysis in the ICU
Condition: |
Peridialytic Hypotension |
Intervention: |
Procedure: Transpulmonary Thermodilution |
Outcome Measures: |
hypotensive episode; fluid removal tolerance; predicted volume of fluid that can be removed without hypotensive events; mortality in the ICU; All cause mortality; Length of stay in ICU; Length of stay in hospital |
|