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INFLAMMATION and Methotrexate

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INFLAMMATION Symptoms and Causes

What are tonsils?

Tonsils are lumps of tissue at the back of the throat. There are two of them, one on each side. Along with the adenoids, tonsils are part of the lymphatic system. The lymphatic system clears away infection and keeps body fluids in balance. Tonsils and adenoids work by trapping the germs coming in through the mouth and nose.

What is tonsillitis?

Tonsillitis is an Inflammation (swelling) of the tonsils. Sometimes along with tonsillitis, the adenoids are also swollen.

What causes tonsillitis?

The cause of tonsillitis is usually a viral infection. Bacterial infections such as strep throat can also cause tonsillitis.

Who gets tonsillitis?

Tonsillitis is most common in children over age two. Almost every child in the United States gets it at least once. Tonsillitis caused by bacteria is more common in kids ages 5-15. Tonsillitis caused by a virus is more common in younger children.

Adults can get tonsillitis, but it is not very common.

Is tonsillitis contagious?

Although tonsillitis is not contagious, the viruses and bacteria that cause it are contagious. Frequent handwashing can help prevent spreading or catching the infections.

What are the symptoms of tonsillitis?

The symptoms of tonsillitis include

  • A sore throat, which may be severe
  • Red, swollen tonsils
  • Trouble swallowing
  • A white or yellow coating on the tonsils
  • Swollen glands in the neck
  • Fever
  • Bad breath
When should I get medical help for my child?

You should call your health care provider if your child

  • Has a sore throat for more than two days
  • Has trouble or pain when swallowing
  • Feels very sick or very weak

You should get emergency care right away if your child

  • Has trouble breathing
  • Starts drooling
  • Has a lot of trouble swallowing
How is tonsillitis diagnosed?

To diagnose tonsillitis, your child's health care provider will first ask you about your child's symptoms and medical history. The provider will look at your child's throat and neck, checking for things such as redness or white spots on the tonsils and swollen lymph nodes.

Your child will probably also have one or more tests to check for strep throat, since it can cause tonsillitis and it requires treatment. It could be a rapid strep test, a throat culture, or both. For both tests, the provider uses a cotton swab to collect a sample of fluids from your child's tonsils and the back of the throat. With the rapid strep test, testing is done in the office, and you get the results within minutes. The throat culture is done in a lab, and it usually takes a few days to get the results. The throat culture is a more reliable test. So sometimes if the rapid strep test is negative (meaning that it does not show any strep bacteria), the provider will also do a throat culture just to make sure that your child does not have strep.

What are the treatments for tonsillitis?

Treatment for tonsillitis depends on the cause. If the cause is a virus, there is no medicine to treat it. If the cause is a bacterial infection, such as strep throat, your child will need to take antibiotics. It is important for your child to finish the antibiotics even if he or she feels better. If treatment stops too soon, some bacteria may survive and re-infect your child.

No matter what is causing the tonsillitis, there are some things you can do to help your child feel better. Make sure that your child

  • Gets a lot of rest
  • Drinks plenty of fluids
  • Tries eating soft foods if it hurts to swallow
  • Tries eating warm liquids or cold foods like popsicles to soothe the throat
  • Isn't around cigarette smoke or do anything else that could irritate the throat
  • Sleeps in a room with a humidifier
  • Gargles with saltwater
  • Sucks on a lozenge (but do not give them to children under four; they can choke on them)
  • Takes an over-the-counter pain reliever such as acetaminophen. Children and teenagers should not take aspirin.

In some cases, your child may need a tonsillectomy.

What is a tonsillectomy and why might my child need one?

A tonsillectomy is surgery to remove the tonsils. Your child might need it if he or she

  • Keeps getting tonsillitis
  • Has bacterial tonsillitis that does not get better with antibiotics
  • Has tonsils are too big, and are causing trouble breathing or swallowing

Your child usually gets the surgery and goes home later that day. Very young children and people who have complications may need to stay in the hospital overnight. It can take a week or two before your child completely recovers from the surgery.

Check out the latest treatments for INFLAMMATION

INFLAMMATION treatment research studies

Methotrexate clinical trials, surveys and public health registries


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Methotrexate Side Effects

Pyrexia (411)
Pancytopenia (356)
Nausea (321)
Pneumonia (304)
Arthralgia (271)
Headache (269)
Injection Site Pain (265)
Rheumatoid Arthritis (260)
Dyspnoea (248)
Mucosal Inflammation (241)
Diarrhoea (238)
Vomiting (231)
Fatigue (223)
Asthenia (198)
Cough (196)
Sepsis (195)
Anaemia (195)
Pain (188)
Renal Failure Acute (177)
Malaise (156)
Febrile Neutropenia (152)
Abdominal Pain (152)
Injection Site Erythema (145)
Pain In Extremity (141)
Convulsion (139)
Rash (139)
Neurotoxicity (138)
Dizziness (131)
Neutropenia (129)
Condition Aggravated (129)
Thrombocytopenia (127)
Toxicity To Various Agents (125)
Oedema Peripheral (121)
Alanine Aminotransferase Increased (121)
Renal Failure (118)
Hypertension (115)
Weight Decreased (114)
Erythema (113)
Interstitial Lung Disease (113)
Stomatitis (108)
Respiratory Failure (108)
Bone Marrow Failure (108)
Leukopenia (104)
Fall (103)
Infection (103)
Aspartate Aminotransferase Increased (99)
Hypotension (95)
Nasopharyngitis (93)
Paraesthesia (93)
Septic Shock (91)

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Recent Reviews

Hi I haven't had any side effects for the past six years of Methotrexate. but recently I am having some stomach discomfort like as soon as i eat something i have the slight discomfort on my abdoman. I take a glass of green leaf juice and i am fine ag

I am 60 Years of age. 8 years ago i was falsely diagnosed with Rheumatoid Arthritis, i was started on Methoblastin 5Mg a week, Was not given Folic Acid and Ranitidine within the 5 months of taking the tablets i developed exposed blood vessels and spo

I have been on methotrexate for almost months and last two weeks have had severe pains at times lower back , It feel like the kidneys because one side hurts at times and in the mornings it is worse. I am 3 days shy of talking another blood test. Is

I have inflammation

I just started Methotrexate, I started itching in the same areas where I had experienced itching with the chicken pox 2 years ago. I am a 51 year old female who contracted chicken pox at 49 years old. This frightens me as I know this can cause diss

I only took it for 21 days but in that time, it put me into a full panic attack that lasted almost 8 days after I went off the medication. I had mental confusion, could not speak properly (I knew what I wanted to say but the words would not come out

I was diagnosed with Rheumatoid Arthritis about 4 years ago when I was 13 or 14, they looked at me and said I had it, they didn't do any blood tests and when they did, nothing showed. But they started me on about 5 mg of Methotrexate, Prednisone, and

Im a 44yrs old female who took methotrexate for 2yrs with excellent results and no side effects but had to stop taking it when it started lowering my white cells.

My 27 years of MTX therapy have prevented physical deformity but caused me to have damage to my lungs. I am short of breath on any activity. MTX helped the pain somewhat but at the cost of my lungs? I was never told about this possibility nor told it

Painful cough after 2 days of 1st dose lasting-- to date-- 6 days

25 YR OLD TRAPSPATIENT w/abdominal pain x 10 days. Stopped taking 100mg dail Kineret 3 days ago, now w/fever 100/102. Went to ER 5 days ago, w/no sign of inflammation in labs. Still have severe abdominal pain.&nbsp

A doctor prescribed Veramyst because he thinks I've had long term intrinsic inflammation in my nasal passages. He wanted to decrease that inflammation. Before I started taking it, I wasn't really having any symptoms, but the doctor was concerned abou

After being on Fosamax for approximately four and one half years suddenly I developed severe medial bilateral knee pain. Have pain when walking down and up stairs. I have NO history of arthritis, no inflammation or redness at the location of pain. I

Can it be a side effect of Solian if I had MASTYTIS (inflammation of breast) recently and rather much matter evacuated? I have been using Solian for about 8 - 9 months. My diagnosis is smth. schizotypical & depressive. Besides, I have been taking

Good evening Dr. I would like to consult you on the use of antibiotic Sbamox without consulting a doctor and that because I suffer from inflammation of the anus What do you think to use to dry the wound

Had a chest infection and lupus flare, felt so weak I imagined I would never be well again. I had inflammation in my lungs and wept in the pharmacy as I went for more pain meds. I agree drug from hell

Had RhoGAM after childirth in 1972 and 1975. In 1992 I was diagnosed with hepatitis C. I now have stage 3 liver fibrosis and inflammation. I went through interferon-ribavirin treatment for hepatitis C recently, but did n

Hi, I had an inflammation in my left shoulder and arm three years ago and got a 10 day treatment with 150 mg Voltaren and 60 mg Prednisolon per day. After three days my physician told me to start exercising with my arm, and I have done so since - gr

Hi, I took Avamys for a few days (sample bottle), ran out, then recommenced a week or so later when I got the script filled - on day ?5 or so now I think. My nasal congestion has cleared somewhat, and the ultimate goal is to improve the inflammation

I agree with all comments so far. I've developed Dupuytrin's syndrome in my left hand. Middle finger tendon inflammation. My Doctor said it wasn't related. BS! I KNOW my body. Don't know what else to do for my cholesterol. I've tried them all.

INFLAMMATION Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting Inflammation, Cardiac Sympathetic Innervation, and Arrhythmic Sudden Death
Conditions: Ischemic Cardiomyopathy;   Dilated Cardiomyopathy;   Inflammation;   Sudden Cardiac Death
Intervention:
Outcome Measures: Determine if Inflammation is associated with abnormal cardiac sympathetic innervation in patients enrolled in the PROSE-ICD study.;   Determine if Inflammation, measured by IL-6, is associated with abnormal cardiac sympathetic innervation, measured by MIBG imaging;   Examine the combination of CRP and MIBG to predict ICD therapies in PROSE-ICD;   Compare several MIBG imaging metrics of sympathetic innervation, in addition to the late H/M ratio, including the early H/M ratio and the MIBG washout rate, in regards to their association with biomarkers of Inflammation (CRP and IL-6).
2 Not yet recruiting Effect of Linagliptin on Vascular Inflammation in Patients With Type 2 Diabetes Mellitus
Conditions: Diabetes Mellitus Type 2 (T2DM),;   Vascular Inflammation,;   Plaque Morphology
Interventions: Drug: Linagliptin;   Drug: Placebo
Outcome Measures: Effect of linagliptin on vascular Inflammation of the carotic artery;   Effect of linagliptin on vessel wall volume of the carotid artery;   Effect of linagliptin on abdominal adipose tissue Inflammation;   Effect of linagliptin on biomarkers of vascular Inflammation
3 Recruiting Impact of EPA and DHA Supplementation on Plasma Biomarkers of Inflammation (n3)
Condition: Cardiovascular Disease, Inflammation
Interventions: Dietary Supplement: High DHA;   Dietary Supplement: High EPA;   Dietary Supplement: Placebo
Outcome Measures: Change in plasma biomarkers of Inflammation (CRP, IL-2, IL-6, IL-10, IL-18 and TNF-α);   Change in lipid concentrations (LDL-C, HDL-C, TG);   Change in blood pressure;   Change in endogenous production and clearance rate of CRP (in a subsample of the entire study population);   Change in expression of Inflammation genes in peripheral blood cells (in a subsample of the entire study population);   Change in anthropometric measures (waist and hip circumference)
4 Unknown  Inflammation and Oxidative Stress of Adipose Tissue in Sleep Apnea Syndrome
Conditions: Decrease of Inflammation of Adipose Tissue;   Sleep Apnea Syndrome
Intervention: Device: cPAP
Outcome Measures: Decrease of Inflammation in adipose tissue;   Decrease of oxidative stress;   measure of insulin sensitivity;   Decrease of systemic Inflammation;   Measure of local hypoxemia of adipose tissue;   Measure of structural and functional changes in skeletal muscle;   Measure of vascular adhesion factors modifications and protein synthesis signals modifications;   Decrease in endothelial dysfunction;   Decrease in arterial rigidity
5 Recruiting Prolensa (Bromfenac) 0.07% QD vs. Ilevro (Nepafenac) 0.3% QD for Treatment of Ocular Inflammation Post Cataract Surgery
Conditions: Cataract;   Retinal Edema;   Inflammation
Interventions: Drug: Prolensa (bromfenac 0.07%);   Drug: Ilevro (nepafenac 0.3%)
Outcome Measures: Treatment of Inflammation associated with cataract surgery;   Visual Acuity
6 Recruiting Effect of Inflammation on Voriconazole Concentration
Conditions: Inflammation;   Fungal Infection
Intervention:
Outcome Measure: Plamsa concentration of voriconazole and voriconazole N-oxide in patients during a severe Inflammation
7 Recruiting N-acetylcysteine in Intra-amniotic Infection/Inflammation
Conditions: Labor, Premature;   Preterm Premature Rupture of the Membranes;   Infection;   Inflammation;   Chorioamnionitis
Interventions: Procedure: amniocentesis;   Drug: N-acetylcysteine or placebo
Outcome Measures: early onset neonatal sepsis;   maternal and umbilical cord plasma N-acetylcysteine levels;   maternal and umbilical cord plasma antioxidant capacity;   maternal and umbilical cord blood glutathione concentration;   umbilical cord levels of inflammatory cytokine concentrations;   funisitis grades;   other neonatal outcomes (respiratory distress syndrome, necrotizing enterocolitis, intraventricular hemorrhage, retinopathy of prematurity, late-onset sepsis, bronchopulmonary dysplasia)
8 Unknown  Study Investigating the Levels and Effects of Low-grade Inflammation in Diabetic Retinopathy of Type 1 Diabetes
Conditions: Diabetic Retinopathy;   Inflammation
Interventions: Procedure: Blood sampling;   Procedure: Noninvasive measurement of systemic hemodynamics;   Procedure: Visual acuity assessment;   Device: Blue field entoptic technique (Blue field stimulator, BFS-2050);   Procedure: Ophthalmic examination and fundus photography;   Device: Retinal Vessel Analyzer (DVA);   Device: High resolution optical coherence tomography (OCT)
Outcome Measures: Plasma biomarkers for Inflammation (CRP, TNF-α, IL-6, vWF, e-Selektin);   Perifoveal white cell blood flow (Blue field entoptic technique);   Retinal vessel reactivity to flicker stimulation (Retinal Vessel Analyzer);   Arteriolar to venous ratio;   Capillary blood glucose;   Stage of diabetic retinopathy;   Visual acuity;   Intraocular pressure;   Systolic/diastolic arterial blood pressure, pulse rate
9 Recruiting Vitamin D Status Impacts Inflammation and Risk of Infections During Pregnancy
Conditions: Inflammation;   Infection
Intervention: Dietary Supplement: Vitamin D3 Supplementation
Outcome Measures: Change in Vitamin D status, infections and Inflammation across pregnancy after Vitamin D supplementation;   Change in maternal vitamin D status and inflammatory markers in serum
10 Unknown  Doxycycline and Airway Inflammation in Chronic Obstructive Pulmonary Disease (COPD)
Conditions: Chronic Obstructive Pulmonary Disease;   Inflammation;   Pulmonary Emphysema
Interventions: Drug: Doxycycline;   Drug: Placebo
Outcome Measures: myeloperoxidase in induced sputum;   MMP-8, MMP-9, IL-6 levels and differential cell counts in induced sputum.;   Lung function (FEV1);   Symptom scores
11 Recruiting Assessing NOS Uptake With PET Imaging in Lung Inflammation
Condition: Lung Inflammation
Interventions: Drug: Endotoxin (E. coli O:113, Reference Endotoxin);   Drug: [18F](+/-)NOS
Outcome Measures: Distribution volume ratio (DVR), determined by Logan plot analysis, in the right middle lobe;   Change in DVR in right middle lobe;   Mean Hounsfield units (HU), measure of density on CT images, in right middle lobe and lingula;   Change in HU in right middle lobe and lingula;   Bronchoalveolar lavage (BAL) cell counts (including total nucleated and neutrophil counts);   Number and percent of iNOS-stained BAL cells by flow cytometry;   Number and percent of 3-nitrotyrosine-stained cells on biopsy;   Change in exhaled nitric oxide (ENO) levels;   Regional PBF and EVLW in right middle lobe and lingula;   Number of iNOS positive cells from brushing cytospins
12 Unknown  Omega-3 Supplementation Decreases Inflammation and Fetal Obesity in Pregnancy
Conditions: Inflammation;   Obesity;   Pregnancy;   Fetal Growth
Intervention: Dietary Supplement: Omega-3 Fish Oil
Outcome Measures: Decreased Inflammation during human pregnancy;   Reduction of insulin resistance
13 Recruiting "Can Soluble-CD163 Discriminate Between Healthy and Unhealthy Obese Individuals?"
Conditions: Obesity;   Insulin Resistance;   Type 2-diabetes;   Inflammation
Intervention: Procedure: gastric bypass
Outcome Measures: Low grade Inflammation in adipose tissue after weight loss induced by gastric bypass;   Quantity of fat in the liver
14 Recruiting Anemia of Inflammation: Investigation on Impaired Iron Regulation in Acutely Ill Patients and Their Clinical Outcome
Condition: Anemia of Acute Inflammation
Intervention:
Outcome Measures: impact of acute inflammatory state on hemoglobin levels;   impact of acute inflammatory cytokines on hepcidin-driven iron balance and monocytes role in anemia of acute Inflammation
15 Recruiting Iron Homoeostasis in Inflammation
Conditions: Inflammation;   Bacterial Infections and Mycoses;   Anemia, Iron-Deficiency;   Iron Overload
Intervention:
Outcome Measures: Prevalence of different iron states (normal iron states, iron deficiency and iron overload) in the context of acute Inflammation;   Correlation between iron states and clinical course of acute Inflammation, mode of discharge and iron substitution
16 Recruiting Intestinal Inflammation in Ankylosing Spondylitis and the Effects of Adalimumab on Mucosal Healing
Conditions: Spondyloarthritis;   Intestinal Inflammation
Intervention: Drug: Adalimumab
Outcome Measures: Intestinal Inflammation measured by Lewis Score;   Intestinal Inflammation measured by faecal calprotectin;   Spondyloarthritis Consortium of Canada score;   Assessment Group in Ankylosing Spondylitis (ASAS) core set for clinical practice
17 Unknown  Obesity, Inflammation and Oxidative Stress
Conditions: C-reactive Protein;   Inflammation;   Obesity;   Oxidative Stress
Intervention: Dietary Supplement: Vitamin C (ascorbic acid)
Outcome Measures: high-sensitivity C-reactive protein;   CRP-related markers of Inflammation and oxidative stress, including cytokines and F2-isoprostanes.
18 Not yet recruiting Vascular Inflammation Imaging Using Somatostatin Receptor Positron Emission Tomography
Conditions: Atherosclerosis;   Stroke;   Transient Ischemic Attack;   Chronic Stable Angina;   Acute Coronary Syndrome
Intervention:
Outcome Measures: Correlation of 68Ga-DOTANOC PET signal to carotid plaque Inflammation;   Comparison of 68Ga-DOTANOC signal between symptomatic and asymptomatic carotid plaques;   Correlation of carotid artery and coronary artery 68Ga-DOTANOC uptake;   Correlation of Framingham Cardiovascular Risk Scores to arterial 68Ga-DOTANOC uptake;   Correlation between carotid artery 68Ga-DOTANOC autoradiographic signal and degree of carotid Inflammation, measured by CD68 immunohistochemistry;   Comparison of myocardial 68Ga-DOTANOC and 18F-FDG uptake
19 Recruiting Inflammation and Glycation in a General Adult Population
Condition: Inflammation
Intervention:
Outcome Measures: Glycation gap levels;   Interstitial glucose levels
20 Recruiting Effect of C1-esterase Inhibitor on Systemic Inflammation in Trauma Patients With a Femur or Pelvic Fracture
Conditions: Trauma;   Inflammation;   Sepsis;   Multiple Organ Dysfunction Syndrome
Interventions: Drug: C1-esterase inhibitor;   Other: Saline 0.9%
Outcome Measures: Delta Interleukine-6;   Cytokines and other markers of Inflammation;   Neutrophil redistribution and phenotype;   C1-inhibitor and complement concentration and activity;   Hemodynamic response