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INFLUENZA LIKE ILLNESS and Cymbalta

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INFLUENZA LIKE ILLNESS Symptoms and Causes

Mosquitoes are insects that live all over the world. There are thousands of different species of mosquitoes; about 200 of those live in the United States.

Female mosquitoes bite animals and humans and drink a very small amount of their blood. They need protein and iron from blood to produce eggs. After drinking blood, they find some standing water and lay their eggs in it. The eggs hatch into larvae, then pupae, and then they become adult mosquitos. The males live for about a week to ten days, and the females can live up to several weeks. Some female mosquitoes can hibernate in the winter, and they can live for months.

What health problems can mosquito bites cause?

Most mosquito bites are harmless, but there are times when they can be dangerous. The ways that mosquito bites can affect humans include

  • Causing itchy bumps, as an immune system response to the mosquito's saliva. This is the most common reaction. The bumps usually go away after a day or two.
  • Causing allergic reactions, including blisters, large hives, and in rare cases, anaphylaxis. Anaphylaxis is a severe allergic reaction that affects the whole body. It is a medical emergency.
  • Spreading diseases to humans. Some of these diseases can be serious. Many of them do not have any treatments, and only a few have vaccines to prevent them. These diseases are more of a problem in Africa and other tropical areas of the world, but more of them are spreading to the United States. One factor is climate change, which makes the conditions in some parts of the United States more favorable to certain types of mosquitoes. Other reasons include increased trade with, and travel to, tropical and subtropical areas.
Which diseases can mosquitoes spread?

Common diseases spread by mosquitoes include

  • Chikungunya, a viral infection that causes symptoms such as fever and severe joint pain. The symptoms usually last about a week, but for some, the joint pain may last for months. Most cases of chikungunya in the United States are in people who traveled to other countries. There have been a few cases where it has spread in the United States.
  • Dengue, a viral infection that causes a high fever, headaches, joint and muscle pain, vomiting, and a rash. Most people get better within a few weeks. In some cases, it can become very severe, even life-threatening. Dengue is rare in the United States.
  • Malaria, a parasitic disease that causes serious symptoms such as high fevers, shaking chills, and flu-like illness. It can be life-threatening, but there are drugs to treat it. Malaria is a major health problem in many tropical and subtropical areas of the world. Almost all cases of malaria in the United States are in people who traveled to other countries.
  • West Nile Virus (WNV), a viral infection that often has no symptoms. In those that do have symptoms, they are usually mild, and include fever, headache, and nausea. In rare cases, the virus can enter the brain, and it can be life-threatening. WNV has spread across the continental United States.
  • Zika Virus, a viral infection that often does not cause symptoms. One in five infected people do get symptoms, which are usually mild. They include a fever, rash, joint pain, and pinkeye. Besides being spread by mosquitoes, Zika can spread from mother to baby during pregnancy and cause serious birth defects. It can also spread from one partner to another during sex. There have been a few outbreaks of Zika in the southern United States.
How can I prevent mosquito bites?
  • Use an insect repellent when you go outdoors. Choose an Environmental Protection Agency (EPA)-registered insect repellent. They are evaluated to make sure they are safe and effective. Make sure that the repellant has one of these ingredients: DEET, picaridin, IR3535, oil of lemon eucalyptus, or para-menthane-diol. It is important to follow the instructions on the label.
  • Cover up. Wear long sleeves, long pants, and socks when outdoors. Mosquitoes may bite through thin fabric, so spray thin clothes with an EPA-registered repellent like permethrin. Don't apply permethrin directly to skin.
  • Mosquito-proof your home. Install or repair screens on windows and doors to keep mosquitoes out. Use air conditioning if you have it.
  • Get rid of mosquito breeding sites. Regularly empty standing water from your house and yard. The water could be in flowerpots, gutters, buckets, pool covers, pet water dishes, discarded tires, or birdbaths.
  • If you plan to travel, get information about the areas you will be going to. Find out whether there is a risk of diseases from mosquitoes, and if so, whether there is a vaccine or medicine to prevent those diseases. See a health care provider familiar with travel medicine, ideally 4 to 6 weeks before your trip.

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Cymbalta Side Effects

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Feeling Abnormal (918)
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Insomnia (782)
Anxiety (659)
Alanine Aminotransferase Increased (646)
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Recent Reviews

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INFLUENZA LIKE ILLNESS Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting The Cymbalta Pregnancy Registry
Condition: Pregnancy
Intervention: Drug: duloxetine
Outcome Measures: To estimate the risk of major congenital anomalies among pregnancies exposed to Cymbalta;   To estimate risk of recognized spontaneous abortions, stillbirths, elective terminations, minor congenital anomalies, and any serious adverse pregnancy outcomes among pregnancies exposed to Cymbalta and their live births during the first year of life;   To examine any potential impact of Cymbalta use while breastfeeding on the infant during the first year of life;   To compare the risk of major congenital anomalies among pregnancies exposed to Cymbalta to an appropriate comparator(s) such as the Centers for Disease Control and Prevention (CDC) Metropolitan Atlanta Congenital Defects Program (MACDP)
2 Unknown  Cymbalta for Fibromyalgia Pain
Condition: Fibromyalgia
Intervention: Drug: Duloxetine
Outcome Measures: Nerve Histology;   Improved Pain Ratings
3 Recruiting Crossover Trial of Duloxetine Versus Placebo in Breast Cancer Patients With Chronic Pain
Condition: Pain
Interventions: Drug: Duloxetine;   Drug: Placebo
Outcome Measures: Change in patient-reported pain between baseline and 6 weeks of treatment with duloxetine versus placebo;   Change in objectively assessed pain sensitivity between baseline and 6 weeks of treatment with duloxetine versus placebo
4 Unknown  Duloxetine for Major Depression in Peri-/Postmenopausal Women
Condition: Major Depressive Disorder
Intervention: Drug: Duloxetine
Outcome Measures: The effects of response to treatment with duloxetine on brain structure and activation in subjects (peri- and postmenopausal women with MDD).;   Changes in brain activation in remitters versus non-remitters after treatment with duloxetine (remission of depression defined MADRS total score <10 at study end).;   Correlations between changes in brain activation and changes from baseline to study end and menopausal symptoms, depressive symptoms, cognition, quality of life, and clinical global impression (improvement and severity).
5 Recruiting Comparison of the Efficacy of Duloxetine With Placebo in Patients With Chronic Low Back Pain With a Radicular Component
Condition: Chronic Low Back Pain
Intervention: Drug: Duloxetine
Outcome Measures: Weekly mean pain intensity in study phase I (Visual analogue score, units 1-10);   Weekly mean pain intensity in study phase II (Visual analogue score, units 1-10);   Use of rescue medication in study phase I;   Beck Depression Inventory score in phase I of study period;   Health related Quality of Life SF-36 score in phase I of study period;   painDetect score in phase I of study period;   Use of rescue medication in phase II of study period;   Beck Depression Inventory score in phase II of study period;   Health related Quality of Life SF-36 score in phase II of study period.;   painDetect score in phase II of study period
6 Unknown  Study to Assess Mechanisms in Peripheral Tissue Innervation for Fibromyalgia
Condition: Fibromyalgia
Interventions: Drug: Duloxetine;   Procedure: Skin biopsy
Outcome Measure: Efficacy of duloxetine will be determined by neurological and pain assessments.
7 Unknown  Open-Label Duloxetine Monotherapy in the Treatment of Posttraumatic Stress Disorder
Condition: Posttraumatic Stress Disorders
Intervention: Drug: Duloxetine hydrochloride
Outcome Measures: PTSD Symptoms will be assessed by the Clinician-Administered PTSD Scale for DSM-IV (CAPS);   Visual Analog Scale for Pain (VAS)
8 Recruiting Does Duloxetine Reduce Sub-Acute Pain After Knee Arthroplasty?
Condition: Total Knee Arthroplasty
Interventions: Drug: Placebo;   Drug: Duloxetine 60mg
Outcome Measures: NRS Pain with ambulation at 2 weeks;   Numeric Rating Scale (NRS) Pain Scores at Rest, during Ambulation and while Bending Knee
9 Recruiting An Open Label Extension Study of Duloxetine (LY248686) in Participants With Chronic Low Back Pain
Condition: Back Pain Lower Back Chronic
Intervention: Drug: Duloxetine
Outcome Measures: Number of Participants with Drug Related Adverse Events (AEs) or any Serious AE's;   Change from Baseline in Brief Pain Inventory (BPI) Pain Severity Item and Interference Item to Week 50;   Patient Global Impression of Improvement (PGI-Improvement) to Week 50;   Change from Baseline in Clinical Global Impression of Severity (CGI-Severity) to Week 50;   Change from Baseline in Roland Morris Disability Questionnaire (RMDQ-24) to Week 50;   Change from Baseline in 36-Item Short-Form Health Survey (SF-36) to Week 50;   Change from Baseline in European Quality of Life Questionnaire-5 Dimension (EQ-5D) to Week 50;   Change from Baseline in Beck Depression Inventory-II (BDI-II) to Week 50;   Change from Baseline in Columbia Suicide Severity Rating Scale (C-SSRS) to Week 52;   Number of Participants with Fall Events from Fall Questionnaire
10 Recruiting Duloxetine for the Treatment of Obsessive Compulsive Disorder (OCD)
Condition: Obsessive Compulsive Disorder
Intervention: Drug: Duloxetine
Outcome Measures: Y-BOCS scores at 1st and last visit (17 weeks later);   BDI - first and last visit (Given week 0, 1, 5, 9, 13, & 17);   BAI - first and last visit (Given week 0, 1, 5, 9, 13, & 17);   QLESQ - first and last visit (Given week 0 and 17);   Clinical Global Impressions Scale at 2nd visit (2 weeks after 1st visit) and 6th visit (17 weeks post first visit)
11 Recruiting Open Trial of Duloxetine in Outpatients With Irritable Bowel Syndrome Symptoms and Co-Morbid Major Depression
Conditions: Major Depression;   Irritable Bowel Syndrome Symptoms
Intervention: Drug: Duloxetine
Outcome Measures: Montgomery-Asberg Depression Rating Scale (MADRS);   Gastrointestinal Symptoms Rating Scale (GSRS);   Clinician-Rated Global Impression Scales;   Visual Analogue Scales (VAS);   Somatization module of the Patient's Health Questionnaire (PHQ-15)
12 Recruiting A Study of Duloxetine in Participants With Chronic Pain Due to Osteoarthritis in China
Condition: Osteoarthritis
Interventions: Drug: Duloxetine;   Drug: Placebo
Outcome Measures: Change from Baseline to 13 Weeks in the Brief Pain Inventory (BPI) 24-hour Average Pain Rating;   Patient Global Impressions of Improvement (PGI-I) at 13 Weeks;   Change from Baseline to 13 Weeks in Western Ontario and McMaster Universities Arthritis Index (WOMAC) Total and Subscale Scores;   Change from Baseline to 13 Weeks in Clinical Global Impression of Severity (CGI-S);   Change from Baseline to 13 Weeks in BPI Severity;   Change from Baseline to 13 Weeks in Hospital Anxiety and Depression Scale-Depression (HADS-D) or HADS-Anxiety (HADS-A) Subscale Scores
13 Recruiting A Study of Duloxetine in Adolescents With Juvenile Primary Fibromyalgia Syndrome
Condition: Fibromyalgia
Interventions: Drug: Duloxetine;   Drug: Placebo
Outcome Measures: Change from baseline to 13 week endpoint in Brief Pain Inventory (BPI) modified short form-adolescent version 24 hour average pain severity item;   Change from baseline to 13 week endpoint in Brief Pain Inventory (BPI) modified short form-adolescent version severity and interference items;   Maintenance effect in acute phase responders on the Brief Pain Inventory (BPI) modified short form-adolescent version 24 hour average pain severity item;   Proportion of patients with greater than or equal to 30% and 50% reduction in BPI 24 hour average pain severity score at 13 weeks;   Change from baseline in Pediatric Pain Questionnaire (PPQ) item scores;   Change from baseline in Clinical Global Impression (CGI) Severity: overall score and mental illness score;   Change from baseline in Functional Disability Inventory (FDI) child scale and rent scale;   Change from baseline in Children's Depression Inventory (CDI);   Change from baseline in Multidimensional Anxiety Scale for Children (MASC)
14 Recruiting Duloxetine Versus Pregabalin for Alcohol Dependence
Condition: Alcohol Dependence
Interventions: Drug: Pregabalin;   Drug: Duloxetine;   Behavioral: Standardized behavioral therapy;   Drug: Placebo
Outcome Measure: Drinking Quantity and Frequency
15 Recruiting Duloxetine for the Treatment of Chronic Pelvic Pain
Condition: Pelvis Pain Chronic
Interventions: Drug: Duloxetine;   Drug: Sugar Pill
Outcome Measures: The primary clinical efficacy measure is reduction in spontaneous (non-evoked) pelvic pain. This will be assessed by using the 0-10 numerical pain ratings to derive the primary outcome variable of clinical pain intensity difference due to treatment.;   Functional limitations due to pain
16 Unknown  Pretreatment Identification of Duloxetine Success in Neuropathic Pain Patients
Conditions: Diabetes;   Painful Neuropathy
Intervention: Drug: Duloxetine
Outcome Measures: Prediction of duloxetine pain relief efficacy by pre-treatment extent of the CPM response;   Treatment-related increase in CPM response
17 Unknown  Effects of Duloxetine on Fear Conditioning in Posttraumatic Stress Disorder (PTSD)
Condition: Posttraumatic Stress Disorder
Intervention: Drug: Duloxetine
Outcome Measure: Anxiolytic and antidepressant effects of duloxetine in patients with chronic PTSD
18 Not yet recruiting Research Examining Gulf War Illness in Our Nations Service Members
Condition: Gulf War Illness
Interventions: Drug: Duloxetine;   Drug: Pregabalin;   Drug: Placebo
Outcome Measures: Pain , Safety, tolerability;   Side Effects
19 Not yet recruiting Study of Placebo Without Deception Versus Standard Antidepressant for Major Depressive Disorder
Condition: Major Depressive Disorder
Interventions: Drug: Duloxetine;   Drug: placebo;   Other: Study visits only
Outcome Measures: >= 50% improvement in Montgomery-Asberg Depression Rating Scale (MADRS) Scores (MADRS Response);   MADRS remission;   Credibility and Expectancy Scale (CES)
20 Recruiting S1202: Duloxetine Hydrochloride to Treat Muscle, Bone, and Joint Pain in Pts W/Early-Stage Breast Cancer Receiving Hormone Therapy
Conditions: Breast Cancer;   Musculoskeletal Complications;   Pain
Interventions: Drug: duloxetine hydrochloride;   Other: placebo
Outcome Measures: Reduction in average joint pain according to BPI-SF assessed up to 12 weeks;   Reduction in worst joint pain according to the BPI-SF worst pain score assessed up to 12 weeks;   Reduction in pain interference according to the BPI-SF worst pain score assessed up to 12 weeks