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INFLUENZA LIKE ILLNESS and Prozac

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INFLUENZA LIKE ILLNESS Symptoms and Causes

Mosquitoes are insects that live all over the world. There are thousands of different species of mosquitoes; about 200 of those live in the United States.

Female mosquitoes bite animals and humans and drink a very small amount of their blood. They need protein and iron from blood to produce eggs. After drinking blood, they find some standing water and lay their eggs in it. The eggs hatch into larvae, then pupae, and then they become adult mosquitos. The males live for about a week to ten days, and the females can live up to several weeks. Some female mosquitoes can hibernate in the winter, and they can live for months.

What health problems can mosquito bites cause?

Most mosquito bites are harmless, but there are times when they can be dangerous. The ways that mosquito bites can affect humans include

  • Causing itchy bumps, as an immune system response to the mosquito's saliva. This is the most common reaction. The bumps usually go away after a day or two.
  • Causing allergic reactions, including blisters, large hives, and in rare cases, anaphylaxis. Anaphylaxis is a severe allergic reaction that affects the whole body. It is a medical emergency.
  • Spreading diseases to humans. Some of these diseases can be serious. Many of them do not have any treatments, and only a few have vaccines to prevent them. These diseases are more of a problem in Africa and other tropical areas of the world, but more of them are spreading to the United States. One factor is climate change, which makes the conditions in some parts of the United States more favorable to certain types of mosquitoes. Other reasons include increased trade with, and travel to, tropical and subtropical areas.
Which diseases can mosquitoes spread?

Common diseases spread by mosquitoes include

  • Chikungunya, a viral infection that causes symptoms such as fever and severe joint pain. The symptoms usually last about a week, but for some, the joint pain may last for months. Most cases of chikungunya in the United States are in people who traveled to other countries. There have been a few cases where it has spread in the United States.
  • Dengue, a viral infection that causes a high fever, headaches, joint and muscle pain, vomiting, and a rash. Most people get better within a few weeks. In some cases, it can become very severe, even life-threatening. Dengue is rare in the United States.
  • Malaria, a parasitic disease that causes serious symptoms such as high fevers, shaking chills, and flu-like illness. It can be life-threatening, but there are drugs to treat it. Malaria is a major health problem in many tropical and subtropical areas of the world. Almost all cases of malaria in the United States are in people who traveled to other countries.
  • West Nile Virus (WNV), a viral infection that often has no symptoms. In those that do have symptoms, they are usually mild, and include fever, headache, and nausea. In rare cases, the virus can enter the brain, and it can be life-threatening. WNV has spread across the continental United States.
  • Zika Virus, a viral infection that often does not cause symptoms. One in five infected people do get symptoms, which are usually mild. They include a fever, rash, joint pain, and pinkeye. Besides being spread by mosquitoes, Zika can spread from mother to baby during pregnancy and cause serious birth defects. It can also spread from one partner to another during sex. There have been a few outbreaks of Zika in the southern United States.
How can I prevent mosquito bites?
  • Use an insect repellent when you go outdoors. Choose an Environmental Protection Agency (EPA)-registered insect repellent. They are evaluated to make sure they are safe and effective. Make sure that the repellant has one of these ingredients: DEET, picaridin, IR3535, oil of lemon eucalyptus, or para-menthane-diol. It is important to follow the instructions on the label.
  • Cover up. Wear long sleeves, long pants, and socks when outdoors. Mosquitoes may bite through thin fabric, so spray thin clothes with an EPA-registered repellent like permethrin. Don't apply permethrin directly to skin.
  • Mosquito-proof your home. Install or repair screens on windows and doors to keep mosquitoes out. Use air conditioning if you have it.
  • Get rid of mosquito breeding sites. Regularly empty standing water from your house and yard. The water could be in flowerpots, gutters, buckets, pool covers, pet water dishes, discarded tires, or birdbaths.
  • If you plan to travel, get information about the areas you will be going to. Find out whether there is a risk of diseases from mosquitoes, and if so, whether there is a vaccine or medicine to prevent those diseases. See a health care provider familiar with travel medicine, ideally 4 to 6 weeks before your trip.

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INFLUENZA LIKE ILLNESS Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Not yet recruiting Fluoxetine Prevention Trial
Condition: Cognitive Dysfunction
Interventions: Drug: Fluoxetine;   Drug: Placebo
Outcome Measures: Change from baseline in regional cerebral metabolism;   Durability of the protective effect of fluoxetine;   Change from baseline in neuropsychological (cognitive, functional) test results;   Correlation between cognitive functioning and cerebral metabolism by correlating neuropsychological testing results with PET imaging;   Correlation between inflammatory cytokines and cerebral metabolism by correlating blood cytokine marker levels with PET imaging
2 Not yet recruiting "Evaluation by Transcranial Magnetic Stimulation of the Benefit of Fluoxetine on Motor Recovery After Stroke"
Condition: Cerebral Infarction
Interventions: Drug: Fluoxetine;   Drug: Placebo of fluoxetine
Outcome Measures: Slope of the curve of recruitment of the PEMs;   Slope of recruitment of the PEMs;   Index finger force control in paretic hand under time-course of treatment of Fluoxetine;   in index finger force control in non-paretic hand under time-course of treatment of Fluoxetine
3 Unknown  Predictors of Treatment Response to Fluoxetine in PTSD Following a Recent History of War Zone Stress Exposure
Condition: Posttraumatic Stress Disorder, Combat-related
Interventions: Drug: Fluoxetine;   Drug: Placebo
Outcome Measures: Clinician Administered PTSD Scale;   PTSD Symptom Checklist
4 Recruiting A Study of Olanzapine and Fluoxetine for Treatment-resistant Depression
Condition: Treatment Resistant Depression
Interventions: Drug: Olanzapine;   Drug: Fluoxetine;   Drug: Placebo
Outcome Measures: Mean Change from Baseline to 8 Week Endpoint in Montgomery-Äsberg Depression Rating Scale (MADRS);   Mean Change from Baseline to 8 Week Endpoint in Clinical Global Impressions-Severity of Depression (CGI-S) Scale;   Mean Change from Baseline to 8 Week Endpoint in the Simpson-Angus Scale (SAS);   Mean Change from Baseline to 8 Week Endpoint in the Short-Form 36 Health Survey (SF-36);   Mean Change from Baseline to 8 Week Endpoint in the Sheehan Disability Scale (SDS);   Percentage of Participants who Achieve a Response Based on a ≥50% Reduction from Baseline in MADRS Total Score;   Percentage of Participants who Achieve Remission Based on MADRS Total Score ≤10 at 8 Weeks;   Mean Change from Baseline to 8 Week Endpoint in the Barnes Akathisia Scale (BAS);   Mean Change from Baseline to 8 Week Endpoint in the Abnormal Involuntary Movement Scale (AIMS)
5 Recruiting Role of Inflammation Factors and Insulin Resistance in Major Depressive Disorder
Condition: Major Depressive Disorder
Interventions: Drug: Fluoxetine + Valsartan;   Drug: Fluoxetine + Placebo
Outcome Measures: Hamilton Depression Rating Scale (HDRS);   fasting plasma glucose;   fasting serum insulin;   C-reactive Protein, and IL-6
6 Recruiting Effectiveness Study to Compare Venlafaxine With Fluoxetine in the Treatment of Postmenopausal Women With Major Depression
Condition: Major Depression
Intervention: Drug: venlafaxine,fluoxetine
Outcome Measures: change of 24-item Hamilton Rating Scale for Depression total score;   the mean change of HAMD-24 subscale score in items 10, 11, 12, 13 (anxiety and somatizations) at endpoint
7 Recruiting Fluoxetine for Motor, Aphasia, and Neglect Recovery After Ischemic Stroke
Condition: Stroke
Interventions: Drug: fluoxetine;   Drug: placebo
Outcome Measures: Fugl-Meyer Motor Scale (FMMS);   Western Aphasia Battery;   Behavioral Inattention Test (BIT);   Functional Independence Measure
8 Recruiting Fluoxetine for Motor Recovery After Acute Intracerebral Hemorrhage
Conditions: Intracerebral Hemorrhage;   Motor Impairment
Interventions: Drug: Fluoxetine;   Drug: Placebo
Outcome Measures: Fugl Meyer Motor Scale score;   Barthel Index;   modified Rankin Scale;   NIH Stroke Scale
9 Unknown  Safety and Efficacy of Fluoxetine in Pulmonary Arterial Hypertension
Condition: Pulmonary Arterial Hypertension
Intervention: Drug: Fluoxetine
Outcome Measures: The primary endpoint will be change in pulmonary vascular resistance (PVR) measured by right heart catheterization after three months of therapy.;   Efficacy, Safety and tolerability endpoints will include change between baseline and three month QIDS-SR depression scale, systolic and diastolic blood pressure (systemic) and tabulation of adverse events
10 Recruiting Hypoglycemia Associated Autonomic Failure in Type 1 Diabetes Mellitus (DM)
Conditions: Type 1 Diabetes;   Hypoglycemia Associated Autonomic Failure
Interventions: Drug: Fluoxetine;   Drug: Placebo control
Outcome Measure: Change in Catecholamines
11 Unknown  Pharmacogenomics Studies of Antidepressants
Conditions: Major Depressive Disorder;   Antidepressive Agents;   Pharmacogenetics;   Venlafaxine;   Fluoxetine
Interventions: Drug: Venlafaxine;   Drug: Fluoxetine
Outcome Measures: Hamilton Depression Rating Scale (HDRS);   C-reactive Protein and IL-6;   fasting blood glucose, lipid profiles
12 Recruiting Developing Adaptive Treatment Strategies for Children and Adolescents With Obsessive-compulsive Disorder.
Condition: Obsessive-Compulsive Disorder
Interventions: Drug: fluoxetine;   Behavioral: Group cognitive-behavioral therapy
Outcome Measures: Treatment response status at week 28;   Treatment response status at week 14;   Predictors of treatment response at week 28
13 Not yet recruiting RCT of a Neuroplasticity Agent and CI Therapy for Severe Arm Paresis After Stroke
Condition: Severe Stroke With Affected Arm Motor Function
Interventions: Drug: Fluoxetine;   Drug: Placebo;   Procedure: eCMIT;   Procedure: Usual Care
Outcome Measures: Grade 4/5 Motor Activity Log (MAL) Arm Use Scale;   Grade 4/5 MAL Arm Use scale;   Grade 4/5 Wolf Motor Function Test Performance Rate score
14 Recruiting A Positron Emission Topographic (PET) Study on Depression Patient With Electroacupuncture
Conditions: Major Depressive Disorder;   Depression
Interventions: Drug: Fluoxetine;   Procedure: DCEAS (Hwato®/ Dongbang®);   Procedure: n-CEA (Strietberger®)
Outcome Measures: HAMD-17;   SDS;   PET scanning;   Clinical response;   Remission;   Latency;   Adverse events
15 Recruiting Characterization and Sequential Pharmacotherapy of Severe Mood Dysregulation
Condition: Severe Mood Dysregulation
Interventions: Drug: lisdexamfetamine;   Drug: Placebo;   Drug: fluoxetine
Outcome Measures: Clinical Global Impression-Improvement-Severe Mood Dysregulation;   Pediatric Anxiety Rating Scale (PARS);   Children's Depression Rating Scale;   ADHD-IV Rating Scale;   ADHD IV Rating Scale;   Columbia Suicide Severity Scales;   Barnes Akathisia Scale;   Children's Affective Lability Scale;   Physical Symptom Checklist;   Revised Modified Overt Aggression Scale;   Screen for Children's Affective Reactivity;   Affective Reactivity Index
16 Recruiting Efficacy of Exposure and Response Prevention(ERP) and SSRIs in Chinese OCD Patients
Conditions: Obsessive-Compulsive Disorder;   Anxiety Disorders;   Mental Disorders
Interventions: Drug: Fluoxetine;   Drug: Sertraline;   Drug: Paroxetine;   Drug: Citalopram;   Drug: Fluvoxamine;   Behavioral: Exposure and Response Prevention
Outcome Measures: The change of Yale-Brown Obsessive-Compulsive Scale score;   The change of Beck Depression Inventory(BDI-II) score;   The change of Beck Anxiety Inventory(BAI) score;   The change of Stress Perceived Questionnaire (PSS-10) score;   The change of Behavioral Inhibition/Behavioral Activation System Scales score;   The change of Barratt Impulsiveness Scale 11 (BIS-11) score;   The change of Obsessive Beliefs Questionnaire-44(OBQ-44) score;   The NEO-Five Factor Inventory-Revised (NEO-FFI-R);   The Early Trauma Inventory Self Report-Short Form(ETISR-SF)
17 Recruiting Clinical Trial of Fluoxetine in Anxiety and Depression in Children, and Associated Brain Changes
Conditions: Depression;   Mood Disorder;   Anxiety Disorder;   Healthy
Intervention:
Outcome Measure:
18 Recruiting Comparing Treatments for Self-Injury and Suicidal Behavior in People With Borderline Personality Disorder
Conditions: Borderline Personality Disorder;   Suicide
Interventions: Drug: Fluoxetine;   Behavioral: DBT;   Drug: Citalopram
Outcome Measure: Suicidal and self-injurious behavior
19 Recruiting An Adaptive Treatment Strategy for Adolescent Depression-Continuation
Condition: Adolescent Depression
Interventions: Drug: Fluoxetine;   Behavioral: Interpersonal Psychotherapy
Outcome Measures: K-SADS-PL - baseline; change from baseline in KSADS at week 16 and 32;   BDI-II-baseline; change from baseline in BDI at weeks 4/8/12/16/24/32;   HRSD-baseline; change from baseline in HRSD at weeks 4/8/12/16/24/32;   CSSR-S-baseline; change from baseline in CSSR-S at weeks 4/8/12/16/24/32
20 Recruiting An Adaptive Treatment Strategy for Adolescent Depression
Condition: Adolescent Depression
Interventions: Drug: Fluoxetine;   Behavioral: Interpersonal Psychotherapy
Outcome Measures: K-SADS-PL - baseline; change from baseline in KSADS at week 16 and 32;   BDI-II-baseline; change from baseline in BDI at weeks 4/8/12/16/32;   HRSD-baseline; change from baseline in HRSD at weeks 4/8/12/16/32;   CSSR-S-baseline; change from baseline in CSSR-S at weeks 4/8/12/16/32