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INJURY and Methotrexate

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INJURY Symptoms and Causes

Your shoulder joint is composed of three bones: the clavicle (collarbone), the scapula (shoulder blade), and the humerus (upper arm bone). Your shoulders are the most movable joints in your body. They can also be unstable because the ball of the upper arm is larger than the shoulder socket that holds it. To remain in a stable or normal position, the shoulder must be anchored by muscles, tendons, and ligaments.

Because your shoulder can be unstable, it can be easily injured. Common problems include

  • Sprains and strains
  • Dislocations
  • Separations
  • Tendinitis
  • Bursitis
  • Torn rotator cuffs
  • Frozen shoulder
  • Fractures
  • Arthritis

Health care providers diagnose shoulder problems by using your medical history, a physical exam, and imaging tests.

Often, the first treatment for shoulder problems is RICE. This stands for Rest, Ice, Compression, and Elevation. Other treatments include exercise and medicines to reduce pain and swelling. If those don't work, you may need surgery.

NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

Check out the latest treatments for INJURY

INJURY treatment research studies

Methotrexate clinical trials, surveys and public health registries


Find Drug Side Effect reports



Methotrexate Side Effects

Pyrexia (411)
Pancytopenia (356)
Nausea (321)
Pneumonia (304)
Arthralgia (271)
Headache (269)
Injection Site Pain (265)
Rheumatoid Arthritis (260)
Dyspnoea (248)
Mucosal Inflammation (241)
Diarrhoea (238)
Vomiting (231)
Fatigue (223)
Asthenia (198)
Cough (196)
Sepsis (195)
Anaemia (195)
Pain (188)
Renal Failure Acute (177)
Malaise (156)
Febrile Neutropenia (152)
Abdominal Pain (152)
Injection Site Erythema (145)
Pain In Extremity (141)
Convulsion (139)
Rash (139)
Neurotoxicity (138)
Dizziness (131)
Neutropenia (129)
Condition Aggravated (129)
Thrombocytopenia (127)
Toxicity To Various Agents (125)
Oedema Peripheral (121)
Alanine Aminotransferase Increased (121)
Renal Failure (118)
Hypertension (115)
Weight Decreased (114)
Erythema (113)
Interstitial Lung Disease (113)
Stomatitis (108)
Respiratory Failure (108)
Bone Marrow Failure (108)
Leukopenia (104)
Fall (103)
Infection (103)
Aspartate Aminotransferase Increased (99)
Hypotension (95)
Nasopharyngitis (93)
Paraesthesia (93)
Septic Shock (91)

➢ More


Common Meds

Abilify (10132)
Adderall (1304)
Amlodipine (6664)
Amoxicillin (4387)
Benadryl (1568)
Celebrex (12876 )
Celexa (1342)
Cialis (2975)
Cipro (8580)
Citalopram (7792)
Crestor (18839)
Cymbalta (14373)
Doxycycline (1757)
Effexor (7289)
Flexeril (435)
Flomax (2177)
Fluoxetine (4261)
Gabapentin (4593)
Hydrocodone (2469)
Ibuprofen (8222)
Lantus (10968)
Lexapro (3499)
Lipitor (17769)
Lisinopril (8919)
Lyrica (27148)
Medrol (650)
Mirena (41254)
Mobic (957)
Morphine (5356)
Naproxen (538)
Neurontin (6501)
Oxycodone (4438)
Pradaxa (13372)
Prednisone (5926)
Prilosec (2631)
Prozac (1954)
Seroquel (27216)
Simvastatin (8348)
Synthroid (4452)
Tamiflu (5585)
Topamax (3748)
Tramadol (5054)
Trazodone (1458)
Viagra (5394)
Vicodin (1153)
Wellbutrin (6324)
Xanax (2847)
Zocor (5718)
Zoloft(6792)
Zyrtec(1669)

Recent Reviews

Hi I haven't had any side effects for the past six years of Methotrexate. but recently I am having some stomach discomfort like as soon as i eat something i have the slight discomfort on my abdoman. I take a glass of green leaf juice and i am fine ag

I am 60 Years of age. 8 years ago i was falsely diagnosed with Rheumatoid Arthritis, i was started on Methoblastin 5Mg a week, Was not given Folic Acid and Ranitidine within the 5 months of taking the tablets i developed exposed blood vessels and spo

I have been on methotrexate for almost months and last two weeks have had severe pains at times lower back , It feel like the kidneys because one side hurts at times and in the mornings it is worse. I am 3 days shy of talking another blood test. Is

I just started Methotrexate, I started itching in the same areas where I had experienced itching with the chicken pox 2 years ago. I am a 51 year old female who contracted chicken pox at 49 years old. This frightens me as I know this can cause diss

I only took it for 21 days but in that time, it put me into a full panic attack that lasted almost 8 days after I went off the medication. I had mental confusion, could not speak properly (I knew what I wanted to say but the words would not come out

I was diagnosed with Rheumatoid Arthritis about 4 years ago when I was 13 or 14, they looked at me and said I had it, they didn't do any blood tests and when they did, nothing showed. But they started me on about 5 mg of Methotrexate, Prednisone, and

Im a 44yrs old female who took methotrexate for 2yrs with excellent results and no side effects but had to stop taking it when it started lowering my white cells.

My 27 years of MTX therapy have prevented physical deformity but caused me to have damage to my lungs. I am short of breath on any activity. MTX helped the pain somewhat but at the cost of my lungs? I was never told about this possibility nor told it

Painful cough after 2 days of 1st dose lasting-- to date-- 6 days

Quadriplegic secondary to spinal cord injury, impaired skin integrity, pressure ulcers, ileostomy and colostomy, diabetes mellitus.

Age 39 UK - Misprescribed Cipro and given with nsaid. Had sports injury, was athlete. 8 months on still in pain - peripheral neruopathies, joint and muslce pain, continuous head pain/pressure. Inability to exercise, couldnt work for 5 months. Ne

Are u still on epanutin if i may ask, i had a head injury after accident and have been taking it for the last 2 years did u stop taking it??

BEWARE!!! I had an extremely adverse reaction to this drug while receiving some prolotherapy for an injury. I had the max dose and became paralyzed for about 15 minutes or so, passed out and honestly...it felt as if I were dying a

Citracal Calcium + Dwith Genistein 1200mg per day, 3 days in and excessive abdominal gas. Acid reflux also flaired back up. Since previous back injury did not associate back painwith Citracal, just assumed I had done something

Does endone cause pain in teeth after prolonged use. In the past couple of weeks the back of my teeth are aching. I have been taking endone for Rhuematoid Arthritis and low back injury for past two years.

During posterior fossa craniectomy, while my head was stablilized in cranial tongs, the lower half of the Skytron OR table collasped to the floor.As my legs were strapped to the fallen end of the table I sustained nerve injury 'overstretch'

Have had a back injury for over 4 yrs, had surgery and awaiting another. They say it's the only strong pain killer they can give, but hasn't helped the pain at all. Dizzyness, sleepy and spaced out is how this affects me. Even after being rushed to h

Having herniated my L4 5 disc and effected my s1 nerve root endone pain releif and mobic anti inflamatory have been a really great help at giving me a close as possible to normal life again.but as with all back injury's the more active you become&

Hello, I've been taking a cocktail of meds for 9 years to help treat acute nerve pain from a severe Brachial Plexus nerve avulsion C 7, 8, T1 and Spinal cord injury. Medications: Gabapentin 3600 mg., Methadone 100 mg. , Baclofen 20 mg. every 8 hour

I HAD A TBI TRAMATIC BRAIN INJURY AND I AM BI-POLAR AND WAS PLACED ON CYMBALTA WHICH CAUSED WORD FINDING DIFFICULT ACCORDING TO MY PSYCH DR. AM I NOW TO UNDERSTAND THIS MEDICATION SHOULD NOT HAVE BEEN DISPENSED TO ME?

INJURY Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting Cincinnati Home Injury Prevention Study
Condition: Injury in the Home
Intervention: Other: Injury Intervention Group
Outcome Measures: Any modifiable and medically-attended Injury in enrolled children;   Correlation of self-reports of non-emergent but medically attended residential injuries in enrolled children.
2 Recruiting Healthy Homes Healthy Children (H3C)
Condition: Injury in the Home
Intervention: Other: Injury Prevention Measures
Outcome Measures: Any modifiable and medically-attended Injury in enrolled children sustained in the home;   Presenteeism / Absenteeism at work due to child's Injury
3 Recruiting Canadian Eye Injury Registry
Condition: Eye Injuries
Intervention: Behavioral: Public Health strategies
Outcome Measures: Number and type of eye injuries occurring in Canada;   Ocular Trauma Score
4 Recruiting Helping Children's Centres to Enhance Home Safety
Conditions: Burns;   Smoke Inhalation Injury
Interventions: Behavioral: Injury Prevention Briefing Plus facilitation;   Behavioral: Injury Prevention Briefing
Outcome Measures: The proportion of families who have a fire escape plan (ascertained from self-completion questionnaire).;   The proportion of Childrens Centres providing information and advice on the prevention of fire-related Injury including
5 Recruiting Traumatic Brain Injury - Knowledge Translation
Condition: Traumatic Brain Injury
Intervention: Other: Computerized clinical decision support
Outcome Measure: Change in proportion of cranial CT use in children with minor blunt head trauma at very low risk of clinically important traumatic brain injuries
6 Not yet recruiting Treatment of Splenic Trauma: a Retrospective Cohort Study
Condition: Splenic Injury
Intervention: Procedure: Treatment of splenic Injury
Outcome Measures: type of splenic trauma treatment;   Mortality;   Length of hospital stay;   Length of stay in the intensive care unit;   Emergency procedures
7 Recruiting Mission Connect Mild Traumatic Brain Injury (TBI) Integrated Clinical Protocol
Conditions: Mild Traumatic Brain Injury;   Post-traumatic Stress Disorder
Interventions: Drug: Atorvastatin;   Drug: Placebo
Outcome Measures: Subjects with mild traumatic brain Injury (MTBI) treated with atorvastatin for 7 days after MTBI will show a significant improvement in outcome, as measured by the Rivermead Post-Concussion Symptoms Questionnaire, administered at 3 months after Injury.;   MTBI subjects treated with atorvastatin for 7 days after mild TBI will show fewer symptoms of PCS and PTSD at 3 months post Injury than those receiving placebo.;   MTBI subjects treated with atorvastatin for 7 days after mild TBI will show greater cognitive recovery and higher functional outcome than those receiving placebo.;   MTBI subjects treated with atorvastatin for 7 days after mild TBI will show better preservation of whole brain volumes and reduced white matter abnormalities at 3 months post-Injury than placebo treated subjects.;   There will be no significant difference in liver function tests between the subjects treated with atorvastatin for 7 days and those receiving placebo.;   There will be no significant difference in clinical findings of liver dysfunction (jaundice, discolored urine, fatigue, or unexplained fever) or in other reported symptoms between subjects treated with atorvastatin for 7 days and those receiving placebo.
8 Recruiting Laparoscopy Versus Clinical Follow up to Detect Diaphragm Injury
Condition: Diaphragm Injury
Interventions: Procedure: Laparoscopy;   Other: Clinical follow up
Outcome Measure: To assess the clinical outcome of potential occult diaphragm injuries in patients presenting at the Groote Schuur trauma centre with left sided thoracoabdominal stab wounds, if an expectant non operative management course is taken.
9 Not yet recruiting Influence of Cognitive Rest on Minor Traumatic Brain Injury
Condition: Minor Head Injury
Interventions: Other: Cognitive rest;   Other: Usual care
Outcome Measures: Minor traumatic brain Injury symptoms;   Days of work or school missed;   Visits to the emergency department or other health care professionals
10 Unknown  Effect of Passive Gait Training on the Cortical Activity in Patients With Severe Brain Injury.
Conditions: Craniocerebral Trauma;   Traumatic Brain Injury;   Subarachnoid Hemorrhage;   Anoxic Brain Injury
Intervention: Behavioral: Tilt Table With Integrated Stepping System
Outcome Measures: EEG:frequency ratios: Alpha versus delta; alpha and beta versus delta and theta; ERP: latency of P300-component.;   EEG: absolute and relative power in every frequency band; median frequency;
11 Recruiting TBI Project Amsterdam
Condition: Traumatic Brain Injury
Intervention:
Outcome Measures: The white-matter integrity of children with TBI will be compared to children with traumatic control injuries;   Performance on tests of attention will be compared between children with TBI and children with traumatic control injuries;   Parental reports of behavioural regulation will be compared between children with TBI and children with traumatic control injuries;   Academic achievement will be compared between children with TBI and children with traumatic control injuries;   Performance on test of reinforced learning will be compared between children with TBI and children with traumatic control injuries
12 Recruiting Treatment of Acute, Unstable Chest Wall Injuries
Conditions: Blunt Injury of Thorax;   Flail Chest;   Chest Wall Injury Trauma;   Rib Fracture
Intervention: Procedure: Surgical fixation
Outcome Measures: Ventilator-free days (VFD);   Number of days in the Intensive Care Unit (ICU);   Amount of pain medication administration, converted to oral morphine equivalence;   Rate of Pneumonia;   Pulmonary function assessment;   Rate of return to work;   assessment of functional health and well being
13 Not yet recruiting Hormone Deficiency After Brain Injury During Combat
Conditions: Traumatic Brain Injury;   Hypopituitarism
Intervention: Other: Blast Traumatic Brain Injury
Outcome Measures: Prevalence of anterior pituitary dysfunction;   Prevalence of posterior pituitary dysfunction
14 Unknown  Dissemination of Injury Interventions
Conditions: Fall Injury;   Elderly
Interventions: Other: facilitative system;   Other: Standard Program
Outcome Measure: Emergency department and in-patient hospitalization for fall Injury
15 Recruiting North American Clinical Trials Network (NACTN) for Treatment of Spinal Cord Injury
Condition: Spinal Cord Injury
Intervention:
Outcome Measure: American Spinal Injury Association Impairment Scale
16 Recruiting Timing and Intensity of the Exposures and Attributable Burden of Acute Lung Injury
Conditions: Acute Lung Injury;   Acute Respiratory Distress Syndrome
Intervention:
Outcome Measures: Development of ALI;   Quality adjusted survival
17 Recruiting Study of Sand Versus Wood Chip Surfaces on School Playgrounds to Minimize Injury in School Children
Conditions: Wounds and Injuries;   Closed Head Injury
Intervention: Behavioral: school playgrounds
Outcome Measures: Upper extremity fracture rates;   Fracture rates, upper extremity;   Head Injury rates;   All Injury rates
18 Recruiting Hormonal Deficiency in the Quality of Life of Patients With Traumatic Brain Injury
Condition: Traumatic Brain Injury (TBI)
Intervention: Other: MRI scan and endocrinology analysis
Outcome Measures: Evolution of the SF-36(Short-Form health survey)score up to 18 months post-trauma;   QOLIBRI (Quality of Life after Brain Injury) measure #1;   Questions on Life Satisfaction-Hypopituitarism (QLS-H) measure #2;   Tests of Attentional, mnesic and executive performances #3;   Functional outcomes (#4):The Glasgow Outcome Scale (GOS)-Score;   Functional outcome #5 :the Functional Independence Measure (FIM)
19 Recruiting The EPIC Project: Impact of Implementing the EMS Traumatic Brain Injury Treatment Guidelines
Conditions: Brain Injuries, Traumatic;   Injuries, Acute Brain;   TBI (Traumatic Brain Injury)
Intervention: Other: The National Prehospital TBI Management Guidelines
Outcome Measures: Survival;   hospital length of stay;   Intensive care unit length of stay;   ventilator days;   Patient disposition
20 Recruiting Vestibular Rehabilitation and Balance Training After Traumatic Brain Injury
Conditions: Traumatic Brain Injury;   Brain Concussion;   Head Injury;   Dizziness
Interventions: Other: Multidisciplinary evaluation and VR;   Other: Multidisciplinary evaluation
Outcome Measures: Dizziness Handicap Inventory (DHI);   High level mobility assessment tool for traumatic brain Injury (HiMAT)