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IRRITABILITY and Clindamycin

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IRRITABILITY Symptoms and Causes

For most adults, moderate alcohol use is probably not harmful. However, about 18 million adult Americans have an alcohol use disorder (AUD). This means that their drinking causes distress and harm. It includes alcoholism and alcohol abuse.

Alcoholism, or alcohol dependence, is a disease that causes

  • Craving - a strong need to drink
  • Loss of control - not being able to stop drinking once you've started
  • Physical dependence - withdrawal symptoms
  • Tolerance - the need to drink more alcohol to feel the same effect

With alcohol abuse, you are not physically dependent, but you still have a serious problem. The drinking may cause problems at home, work, or school. It may cause you to put yourself in dangerous situations, or lead to legal or social problems.

Another common problem is binge drinking. It is drinking about five or more drinks in two hours for men. For women, it is about four or more drinks in two hours.

Too much alcohol is dangerous. Heavy drinking can increase the risk of certain cancers. It can cause damage to the liver, brain, and other organs. Drinking during pregnancy can harm your baby. Alcohol also increases the risk of death from car crashes, injuries, homicide, and suicide.

You may have an AUD if you can answer yes to two or more of these questions:

In the past year, have you

  • Ended up drinking more or for a longer time than you had planned to?
  • Wanted to cut down or stop drinking, or tried to, but couldn't?
  • Spent a lot of your time drinking, or recovering from drinking?
  • Felt a strong need to drink?
  • Found that drinking - or being sick from drinking - often interfered with your family life, job, or school?
  • Kept drinking even though it was causing trouble with your family or friends?
  • Given up or cut back on activities that you enjoyed just so you could drink?
  • Gotten into dangerous situations while drinking or after drinking? Some examples are driving drunk and having unsafe sex.
  • Kept drinking even though it was making you feel depressed or anxious? Or when it was adding to another health problem?
  • Had to drink more and more to feel the effects of the alcohol?
  • Had withdrawal symptoms when the alcohol was wearing off? They include trouble sleeping, shakiness, Irritability, anxiety, depression, restlessness, nausea, and sweating. In severe cases, you could have a fever, seizures, or hallucinations.

If you have any of these symptoms, your drinking may already be a cause for concern. The more symptoms you have, the more serious the problem is. If you think you might have an AUD, see your health care provider for an evaluation. Your provider can help make a treatment plan, prescribe medicines, and if needed, give you treatment referrals.

NIH: National Institute on Alcohol Abuse and Alcoholism

Check out the latest treatments for IRRITABILITY

IRRITABILITY treatment research studies

Clindamycin clinical trials, surveys and public health registries


Find Drug Side Effect reports



Clindamycin Side Effects

Diarrhoea (245)
Rash (142)
Nausea (108)
Pruritus (101)
Vomiting (79)
Pyrexia (77)
Clostridium Difficile Colitis (68)
Dyspnoea (67)
Urticaria (61)
Erythema (59)
Abdominal Pain Upper (58)
Clostridial Infection (55)
Renal Failure Acute (50)
Dizziness (49)
Abdominal Pain (47)
Pain (46)
Dysphagia (43)
Headache (41)
Dyspepsia (41)
Hypersensitivity (39)
Asthenia (38)
Chest Pain (38)
Weight Decreased (35)
Rash Pruritic (35)
Fatigue (34)
Malaise (33)
Rash Erythematous (33)
Swelling Face (32)
Pseudomembranous Colitis (30)
Angioedema (30)
International Normalised Ratio Increased (29)
Dysgeusia (29)
Dehydration (28)
Oedema Peripheral (28)
Hypotension (27)
Chills (27)
Pancytopenia (26)
Rash Maculo-papular (25)
Stevens-johnson Syndrome (25)
Skin Exfoliation (25)
Colitis (24)
Arthralgia (23)
Abdominal Discomfort (23)
Abdominal Distension (22)
Alanine Aminotransferase Increased (22)
Pharyngeal Oedema (20)
Haematochezia (20)
Blister (20)
Gastrointestinal Disorder (19)
Renal Failure (19)

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Common Meds

Abilify (10132)
Adderall (1304)
Amlodipine (6664)
Amoxicillin (4387)
Benadryl (1568)
Celebrex (12876 )
Celexa (1342)
Cialis (2975)
Cipro (8580)
Citalopram (7792)
Crestor (18839)
Cymbalta (14373)
Doxycycline (1757)
Effexor (7289)
Flexeril (435)
Flomax (2177)
Fluoxetine (4261)
Gabapentin (4593)
Hydrocodone (2469)
Ibuprofen (8222)
Lantus (10968)
Lexapro (3499)
Lipitor (17769)
Lisinopril (8919)
Lyrica (27148)
Medrol (650)
Mirena (41254)
Mobic (957)
Morphine (5356)
Naproxen (538)
Neurontin (6501)
Oxycodone (4438)
Pradaxa (13372)
Prednisone (5926)
Prilosec (2631)
Prozac (1954)
Seroquel (27216)
Simvastatin (8348)
Synthroid (4452)
Tamiflu (5585)
Topamax (3748)
Tramadol (5054)
Trazodone (1458)
Viagra (5394)
Vicodin (1153)
Wellbutrin (6324)
Xanax (2847)
Zocor (5718)
Zoloft(6792)
Zyrtec(1669)

Recent Reviews

I was given Clindamycin (150 MG Capsule) to take for 10 days 4 times daily for tooth extractions aftercare. It gives me splitting headaches and acid reflux . Evdokia

After taking Clindamycin 4 days for my tooth infection, I started heart burn pain, cough, difficult swollen food. Now I have stoped the drug 4 days, but I only can drink fluid. Any solid food cause me severe chest pain.

After taking the Clindamycin Capsules, I have nausea then it feels as if my chest is about to burst open, like i am about to choke which lasts at least 3 hours. I never felt like this in my life. Help!

Clindamycin has caused me such horrible heartburn. It effects everything I drink or eat. I have burning in my throat and tightness in my chest tonight as well. My ears itch and burn deep inside them and they are red and hot to the touch. Horrible fee

Clindamycin is a safe medicine. If you have an abcess or tooth infection it can be VERY dangerous to NOT take the antibiotic. You can alleviate a lot of the stomach discomfort by taking high quality PRO-BIOTICS and consuming a LOT of unsweetened yo

Does clindamycin interact with Fentanyl or "industrial-strength" diuretics? Is it possible for clindamycin by itself, or with one of the other 2, or both, to cause a sleep that is almost like unconciousness? My Dad had this happen recently

Have been taking clindamycin for 10 days now, I am usually very sensitive to antibiotics, have been loading myself up with pro-biotics which has helped, I do have quite a sore throat from it though bu it is bearable

Headaches, red rash on legs, fatigue

Hello. I went to a Dentist for "Tooth Infection". I was prescribed Clindamycin. It has been 9 days since I stopped taking the medication. About every 3 days I get stomach pain, then diarhea. I have also had flatulance. My only

How many days should we take it? I have an ear infection and my doctor wanted me to take it for 3 days. Antibiotics should be taken 7 days right?

<span style='font-family: Calibri; '>I am experiencing severe irritability and moderate depression since I started taking Fenofibrate 160 mg 3 weeks ago, which is not at all normal for me.

16, ADHD, hate my dependency on adderall, depression, random euphoria, aggression, slight tics, restlessness, irritability, antisocial, anger, all day the only thing i'm able to think about is the list of shit that needs to get done and if it's a lon

After taking crestor for several months I experienced major hip, leg and foot pain. I also seem to haveexperiencedirritability and anxiety which I now can associate with crestor. I have stopped taking it and no

Day 3 on the daily patch and have had the weird dreams and waking up more at night, but I was expecting that as is is not my first time using the patches. I was even expecting a bit of Irritability as you would expect to, but I was not expecting dep

Have been on it for 1 year now, plus Tamoxifen, as treatment for positive hormone receptor breast cancer. Side effects are extreme fatigue, mood swings (irritability being the worst), depression (only a couple of days a month), insomnia, and very int

Horrible irritability, not sleeping, depression, overall this medicine is not worth the side effects.

HOT FLUSHES COUGH IRRITABILITY TIRED

I have been taking 10mg Bystolic for over a year and have had some uncontrollable coughing, shortness of breath, tightness in chest and irritability. At first I thought the coughing occurred mainly during hay fever season and the other side effects o

I have been taking Elequine for almost 15 days I have experience a lot of headaches! and lots of acid as well. I cant stand the headaches it is too much all day long, irritability and I want to know if it is normal I just need to take it 2 more days

I have been taking Eutirox for about 2 months....having nausea after eating, headache over right eye, depression, irritability. Not sure if these symptoms are related to Eutirox? Maybe my dose is too high...I take Eutirox 50.

IRRITABILITY Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting Adjunctive Clindamycin for Cellulitis: Clinical Trial Comparing Flucloxacillin With or Without Clindamycin for the Treatment of Limb Cellulitis (C4C Trial).
Condition: Cellulitis
Interventions: Drug: Flucloxacillin and Clindamycin;   Drug: Flucloxacillin and placebo
Outcome Measures: Improvement based on a composite of systemic and local features;   Decrease in pain;   Quality of life;   Physiological recovery
2 Recruiting Comparison Between Oral Clindamycin Vs Metronidazole for the Treatment of Abnormal Vaginal Flora in High Risk Pregnancies
Conditions: Abnormal Vaginal Flora;   Clindamycin Vs Metronidazole;   High Risk Pregnancies for Preterm Labor
Interventions: Drug: Clindamycin;   Drug: Metronidazole
Outcome Measures: To compare the efficacy between oral Clindamycin Vs Metronidazole in the eradication of abnormal vaginal flora;   The prevalence of adverse effects;   The prevalence of late abortions and preterm deliveries;   Assessing the correlation between Nugent score , physical examination and Ph indicators
3 Recruiting Safety and Pharmacokinetics of Clindamycin in Pediatric Subjects With BMI ≥ 85th Percentile
Conditions: Bacterial Infections;   Obesity
Intervention: Drug: Clindamycin
Outcome Measures: Clearance (Cl);   Volume of distribution (Vd);   Area under the curve (AUCtau);   Oral apparent clearance (Cl/F);   Oral apparent volume of distribution (V/F);   Number of Adverse Events
4 Unknown  A Study Comparing Combination Clindamycin Phosphate/Tretinoin Gel Alone Versus With Benzoyl Peroxide Foaming Cloths for Facial Acne
Condition: Acne Vulgaris
Interventions: Drug: Clindamycin phosphate 1.2%/tretinoin 0.025% gel alone;   Drug: Clindamycin phosphate 1.2%/tretinoin 0.025% gel plus benzoyl peroxide 6% foaming cloths
Outcome Measures: Change in PGA scores of patients using combination Clindamycin phosphate 1.2%/tretinoin 0.025% gel with or without benzoyl peroxide 6% foaming cloths for facial acne;   Change in Postinflammatory hyperpigmentation score at each study visit and from baseline to final visit.;   Total number of adverse events.;   Change in Subject Self Assessment Scoring Scale;   Change in Acne-Specific Quality of Life Questionnaire (Acne-QoL)
5 Recruiting Clindamycin to Reduce Preterm Birth in a Low Resource Setting
Conditions: Pregnancy;   Prematurity;   Preterm Birth;   Bacterial Vaginosis
Interventions: Drug: Clindamycin;   Drug: Placebo
Outcome Measures: Preterm birth prior to 37 weeks;   Preterm birth prior to 34 weeks;   Late Miscarriage;   Low Birth weight;   Very Low birth Weight;   Neonatal complications through 42 days after delivery;   Maternal complications through 42 days postpartum;   The utility of vaginal pH tests for identification of women at elevated risk for preterm delivery
6 Recruiting Asymptomatic Colonization With S. Aureus After Therapy With Linezolid or Clindamycin for Acute Skin Infections
Conditions: Skin Diseases, Bacterial;   Abscess
Interventions: Biological: Linezolid;   Biological: Clindamycin
Outcome Measures: The presence of Staphylococcus aureus after treatment with linezolid versus Clindamycin;   Clinical response of skin infections to treatment;   The type of of Staphylococcus aureus present at the diagnosis will be compared to the type of Staphylococcus aureus present after treatment
7 Recruiting Comparison of the Efficacy and Safety of Clindamycin + Benzoyl Peroxide Formulation With Azelaic Acid Formulation in the Treatment of Acne Vulgaris
Condition: Acne Vulgaris
Interventions: Drug: Clindamycin + BPO;   Drug: Azelaic acid
Outcome Measures: Change from Baseline of inflammatory lesion counts at Week 4;   Change from Baseline of lesion counts;   Change from Baseline of lesions by Investigator's Static Global Assessment (ISGA);   Time to 50% reduction in total lesion count;   Change from Baseline of local tolerability as assessed by investigator;   Subject's global change assessment (SGCA) of skin;   Change from Baseline of local tolerability as assessed by subject;   Subject satisfaction score at Week 12;   Measured adherence to study medication at Week 12;   Quality of Life Assessments;   Number of treatment related adverse events (AEs) and serious adverse events (SAEs)
8 Unknown  Evaluation of Fosmidomycin and Clindamycin in the Treatment of Acute Uncomplicated Plasmodium Falciparum Malaria
Condition: Malaria
Intervention: Drug: Fosmidomycin and Clindamycin
Outcome Measures: Cure rate;   cure rate
9 Recruiting To Compare the Efficacy and Safety of Clindamycin Phosphate 1.2% / Benzoyl Peroxide 5% Gel of CHL Versus DUAC® Gel
Condition: Acne Vulgaris
Interventions: Drug: Clindamycin Phosphate 1.2% / Benzoyl Peroxide 5% Gel;   Drug: DUAC® Gel;   Drug: Placebo
Outcome Measures: Mean percent change from baseline to week 11 (study Day 77) for inflammatory (papules and pustules) lesions.;   Mean percent change from baseline to week 11 in the non-inflammatory lesion count;   Proportion of subjects with a clinical response of "success" at week 11
10 Unknown  Evaluate Efficacy, Tolerability & Safety of Combination of Clindamycin and Ketoconazole for the Treatment of Mixed-Type Vaginosis, Bacterial Vaginosis and Candidiasis
Conditions: Candidiasis;   Bacterial Vaginosis
Interventions: Drug: Clindamycin 100mg and Ketoconazole 400mg;   Drug: Tetracycline 100mg and Amphotericin B 50mg
Outcome Measures: Efficacy based on cure rate evaluated by clinical and laboratory criteria.;   Tolerability based on adverse events reports and patient's information;   Safety based on adverse events reports and laboratory criterion
11 Recruiting Assessing the Necessity of Prescribing Antibiotics (Clavulin or Clindamycin Versus Placebo) Post-peritonsillar Abscess Drainage
Condition: Peritonsillar Abscess
Interventions: Drug: Clavulin;   Drug: Randomization to Placebo;   Drug: Clindamycin
Outcome Measure: Re-accumulation of the patient's peri-tonsillar abscess
12 Unknown  Treatment of Chorioamnionitis After Delivery
Condition: Chorioamnionitis
Interventions: Drug: saline;   Drug: ampicillin gentamicin;   Drug: Ampicillin gentamicin Clindamycin;   Drug: ampicillin gentamicin Clindamycin
Outcome Measure: To determine the courses of antibiotics needed after vaginal delivery and after cesareans in pregnancies complicated by chorioamnionitis.
13 Recruiting Antibiotic Safety (SCAMP)
Condition: Complicated Intra Abdominal Infections
Interventions: Drug: ampicillin and metronidazole and gentamicin;   Drug: ampicillin and gentamicin and Clindamycin;   Drug: gentamicin and Piperacillin- tazobactam;   Drug: standard of care antibiotics and metronidazole
Outcome Measures: Death;   Number of participants with therapeutic success at Day 30 and Day 90
14 Unknown  Randomized Controlled Trial of Antibiotics in the Management of Children With Community-Acquired Skin and Soft Tissue Abscess Undergoing Incision and Drainage
Conditions: Skin and Soft Tissue Abscess;   Methicillin-resistant Staphylococcus Aureus (MRSA) Infection
Intervention: Drug: Oral Clindamycin
Outcome Measures: The primary objective is to measure clinical resolution of skin abscess at routine follow-up visit 10-14 days post operation.;   Secondary outcomes measured include incidence of additional skin and soft tissue infections in patient and in household contacts as determined by healthcare provider. Compliance to antibiotic regime will also be assessed at this time.
15 Not yet recruiting Orthognathic Surgery and Postoperative Antibiotic Use
Condition: Dentofacial Deformity
Intervention: Drug: Cefazolin, Cephalexin, Clindamycin
Outcome Measures: Rate of infection;   Side effect from antibiotic use
16 Not yet recruiting Prophylactic Antibiotics for Manual Removal of Retained Placenta in Vaginal Birth: a Randomized Controlled Trial
Condition: Endometritis
Interventions: Drug: Antibiotic prophylaxis;   Drug: Ampicillin;   Drug: Gentamycin;   Drug: Clindamycin
Outcome Measures: Endometritis rate;   Puerperal fever
17 Recruiting Uncomplicated Skin and Soft Tissue Infections Caused by Community-Associated Methicillin-Resistant Staphylococcus Aureus
Condition: Staphylococcal Infection
Interventions: Drug: Clindamycin;   Drug: Trimethoprim-sulfamethoxazole (TS);   Drug: Placebo
Outcome Measures: Clinical cure, defined as absence of clinical failure.;   Efficacy outcome: clinical cure of recurrences or relapses of SSTI.;   Safety outcomes: adverse events; and adverse events that are treatment limiting.
18 Recruiting PK of Antistaphylococcal Antibiotics in Infants (NICHD-2012-02-Staph Trio)
Condition: Systemic Infection
Intervention: Drug: Antibiotic
Outcome Measures: Pharmacokinetic concentrations in plasma will be measured at a central lab using a validated bioanalytical assay. Plasma samples will be drawn according to specific schedules for each drug;   Safety review will be performed through monitoring of adverse events each day that the infant is on study
19 Recruiting Skin Rash Study Before Chemotherapy in Colorectal & Head and Neck Cancer Patients
Conditions: Colorectal Cancer;   Head and Neck Cancer
Interventions: Drug: Doxycycline;   Drug: Hydrocortisone 1% cream;   Other: Sunscreen;   Other: Moisturizer;   Drug: Clindamycin;   Drug: Medrol-dose pack (Steroid)
Outcome Measures: Incidence of Rash;   Quality of Life (QOL);   Adherence to treatment regimen;   Progression Free Survival
20 Recruiting A Comparative Evaluation of the Safety and Efficacy of Daptomycin Versus Standard of Care in Pediatric Subjects Two - Seventeen Years of Age With Bacteremia Caused by Staphylococcus Aureus
Condition: Bacteremia
Interventions: Drug: Daptomycin;   Drug: Comparator (Vancomycin, Semi-synthetic penicillin, First-generation cephalosporins, Clindamycin)
Outcome Measures: Safety of daptomycin measured by the incidence of treatment-emergent adverse events, vital signs, echocardiogram (if performed) and clinical laboratory tests, use of concomitant medications,physical and neurological exam results.;   Efficacy of daptomycin will be based on Investigator's assessment of clinical response (cure, improved, failure or non-evaluable) at the Test of Cure (TOC) visit.