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IRRITABILITY and Gabapentin

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IRRITABILITY Symptoms and Causes

What is caffeine?

Caffeine is a bitter substance that occurs naturally in more than 60 plants including

  • Coffee beans
  • Tea leaves
  • Kola nuts, which are used to flavor soft drink colas
  • Cacao pods, which are used to make chocolate products

There is also synthetic (man-made) caffeine, which is added to some medicines, foods, and drinks. For example, some pain relievers, cold medicines, and over-the-counter medicines for alertness contain synthetic caffeine. So do energy drinks and "energy-boosting" gums and snacks.

Most people consume caffeine from drinks. The amounts of caffeine in different drinks can vary a lot, but it is generally

  • An 8-ounce cup of coffee: 95-200 mg
  • A 12-ounce can of cola: 35-45 mg
  • An 8-ounce energy drink: 70-100 mg
  • An 8-ounce cup of tea: 14-60 mg
What are caffeine's effects on the body?

Caffeine has many effects on your body's metabolism. It

  • Stimulates your central nervous system, which can make you feel more awake and give you a boost of energy
  • Is a diuretic, meaning that it helps your body get rid of extra salt and water by urinating more
  • Increases the release of acid in your stomach, sometimes leading to an upset stomach or heartburn
  • May interfere with the absorption of calcium in the body
  • Increases your blood pressure

Within one hour of eating or drinking caffeine, it reaches its peak level in your blood. You may continue to feel the effects of caffeine for four to six hours.

What are the side effects from too much caffeine?

For most people, it is not harmful to consume up to 400mg of caffeine a day. If you do eat or drink too much caffeine, it can cause health problems, such as

  • Restlessness and shakiness
  • Insomnia
  • Headaches
  • Dizziness
  • Rapid or abnormal heart rhythm
  • Dehydration
  • Anxiety
  • Dependency, so you need to take more of it to get the same results

Some people are more sensitive to the effects of caffeine than others.

What are energy drinks, and why can they be a problem?

Energy drinks are beverages that have added caffeine. The amount of caffeine in energy drinks can vary widely, and sometimes the labels on the drinks do not give you the actual amount of caffeine in them. Energy drinks may also contain sugars, vitamins, herbs, and supplements.

Companies that make energy drinks claim that the drinks can increase alertness and improve physical and mental performance. This has helped make the drinks popular with American teens and young adults. There's limited data showing that energy drinks might temporarily improve alertness and physical endurance. There is not enough evidence to show that they enhance strength or power. But what we do know is that energy drinks can be dangerous because they have large amounts of caffeine. And since they have lots of sugar, they can contribute to weight gain and worsen diabetes.

Sometimes young people mix their energy drinks with alcohol. It is dangerous to combine alcohol and caffeine. Caffeine can interfere with your ability to recognize how drunk you are, which can lead you to drink more. This also makes you more likely to make bad decisions.

Who should avoid or limit caffeine?

You should check with your health care provider about whether you should limit or avoid caffeine if you

  • Are pregnant, since caffeine passes through the placenta to your baby
  • Are breastfeeding, since a small amount of caffeine that you consume is passed along to your baby
  • Have sleep disorders, including insomnia
  • Have migraines or other chronic headaches
  • Have anxiety
  • Have GERD or ulcers
  • Have fast or irregular heart rhythms
  • Have high blood pressure
  • Take certain medicines or supplements, including stimulants, certain antibiotics, asthma medicines, and heart medicines. Check with your health care provider about whether there might be interactions between caffeine and any medicines and supplements that you take.
  • Are a child or teen. Neither should have as much caffeine as adults. Children can be especially sensitive to the effects of caffeine.
What is caffeine withdrawal?

If you have been consuming caffeine on a regular basis and then suddenly stop, you may have caffeine withdrawal. Symptoms can include

  • Headaches
  • Drowsiness
  • Irritability
  • Nausea
  • Difficulty concentrating

These symptoms usually go away after a couple of days.

Check out the latest treatments for IRRITABILITY

IRRITABILITY treatment research studies

Gabapentin clinical trials, surveys and public health registries


Find Drug Side Effect reports



Gabapentin Side Effects

Completed Suicide (332)
Dizziness (329)
Somnolence (304)
Pain (286)
Headache (273)
Confusional State (257)
Nausea (248)
Off Label Use (227)
Tremor (214)
Depression (214)
Fatigue (212)
Fall (194)
Convulsion (183)
Feeling Abnormal (181)
Toxicity To Various Agents (173)
Suicidal Ideation (166)
Malaise (165)
Respiratory Arrest (163)
Cardiac Arrest (145)
Condition Aggravated (144)
Dyspnoea (113)
Pain In Extremity (112)
Myoclonus (108)
Anxiety (108)
Asthenia (107)
Amnesia (104)
Diarrhoea (102)
Insomnia (97)
Vision Blurred (90)
Gait Disturbance (85)
Vomiting (84)
Death (84)
Oedema Peripheral (83)
Disorientation (82)
Back Pain (80)
Rash (80)
Weight Increased (79)
Agitation (78)
Paraesthesia (74)
Memory Impairment (73)
Dyskinesia (73)
Abdominal Pain (73)
Hallucination (72)
Muscular Weakness (71)
Sedation (71)
Myalgia (70)
Loss Of Consciousness (70)
Renal Failure Acute (69)
Hypoaesthesia (66)
Muscle Spasms (66)

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Viagra (5394)
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Wellbutrin (6324)
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Zocor (5718)
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Zyrtec(1669)

Recent Reviews

Be careful! Avoid Gabapentin at all costs! My mother's doctor ordered a 900 mg/day dose. In the 2 years she was under this dose, she fell 5 times! No doctor 'suspected' this drug! Then, he increased the dose to...1800 mg/day! I almost lost her! I am

Dose Gabapantin have any ting to do with the nearves in your body

For the last two weeks I have been taking a lowish dose of Gabapentin for night-time nerve pain (100gm three times a day and then 200mg at night.) It has worked brilliantly for the pain and I was ecstatic BUT I have now wet the bed two nights in a r

GABAPENTIN noticed that medication got worsen n Nurgloist n don't listin. My problem n even rash n stomach ach n was getting stress out n decided go different doctor n was. Going take that chance with my n stop going to Nurgloist n been two.n bo

Great so far for my anxiety... just side effects has ... sexually saticfied,nausea little bit.. dizzynezz! lolz.. but great medication/ i think..

Having racing thoughts and unmotivated *DONT_KNOW*

Hear voices

Hello, I've been taking a cocktail of meds for 9 years to help treat acute nerve pain from a severe Brachial Plexus nerve avulsion C 7, 8, T1 and Spinal cord injury. Medications: Gabapentin 3600 mg., Methadone 100 mg. , Baclofen 20 mg. every 8 hour

I am having trouble falling to sleep, and I feel like I' having anxiety attacks I stopped the 400 Mg and I am taking 2 100 MGS now. I am doing this on my own , until I see my Dr next week. .

I am just starting Gabapentin to help with phantom pain from a BKA (below-knee-amputation). I am taking 600 mg and am scheduled to increase to 900 mg, then review results with my doctors. One of the side effects I seem to have is

<span style='font-family: Calibri; '>I am experiencing severe irritability and moderate depression since I started taking Fenofibrate 160 mg 3 weeks ago, which is not at all normal for me.

16, ADHD, hate my dependency on adderall, depression, random euphoria, aggression, slight tics, restlessness, irritability, antisocial, anger, all day the only thing i'm able to think about is the list of shit that needs to get done and if it's a lon

After taking crestor for several months I experienced major hip, leg and foot pain. I also seem to haveexperiencedirritability and anxiety which I now can associate with crestor. I have stopped taking it and no

Day 3 on the daily patch and have had the weird dreams and waking up more at night, but I was expecting that as is is not my first time using the patches. I was even expecting a bit of Irritability as you would expect to, but I was not expecting dep

Have been on it for 1 year now, plus Tamoxifen, as treatment for positive hormone receptor breast cancer. Side effects are extreme fatigue, mood swings (irritability being the worst), depression (only a couple of days a month), insomnia, and very int

Horrible irritability, not sleeping, depression, overall this medicine is not worth the side effects.

HOT FLUSHES COUGH IRRITABILITY TIRED

I have been taking 10mg Bystolic for over a year and have had some uncontrollable coughing, shortness of breath, tightness in chest and irritability. At first I thought the coughing occurred mainly during hay fever season and the other side effects o

I have been taking Elequine for almost 15 days I have experience a lot of headaches! and lots of acid as well. I cant stand the headaches it is too much all day long, irritability and I want to know if it is normal I just need to take it 2 more days

I have been taking Eutirox for about 2 months....having nausea after eating, headache over right eye, depression, irritability. Not sure if these symptoms are related to Eutirox? Maybe my dose is too high...I take Eutirox 50.

IRRITABILITY Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting Effectiveness of Gabapentin on Chronic Irritability in Neurologically Impaired Children
Conditions: Neurologically Impaired;   Irritable Mood;   Signs and Symptoms, Digestive;   Sleeplessness;   Chronic Pain
Interventions: Drug: Gabapentin;   Drug: placebo
Outcome Measures: Symptom relief for chronic Irritability in neurologically impaired children using gabapentin.;   Prevalence of associated gastrointestinal and sleep problems in neurologically impaired children and improvement using gabapentin.
2 Recruiting Cognitive-Behavioral Therapy for Irritability in Adolescents With High Functioning Autism Spectrum Disorder
Conditions: Autism;   Autism Spectrum Disorder (ASD;   Asperger's Disorder;   Pervasive Developmental Disorder (PDD-NOS)
Intervention: Behavioral: Cognitive-Behavioral Therapy (CBT) for Irritability
Outcome Measure: ABC Irritability Scale
3 Recruiting Buspirone for the Treatment of Traumatic Brain Injury (TBI) Irritability and Aggression
Condition: Traumatic Brain Injury
Interventions: Drug: Buspirone;   Drug: Placebo
Outcome Measures: Neuropsychiatric Inventory-Irritability Domain;   Neuropsychiatric Inventory-Aggression Domain;   Neuropsychiatric Inventory-Distress Irritability Domain;   Neuropsychiatric Inventory-Distress Aggression Domain;   St. Andrews-Swansea Neurobehavioural Outcome Scale;   Personal Health Questionnaire;   Traumatic Brain Injury-Quality of Life Anger;   Global Impressions of Change;   Clinical Global Impressions;   Aggression and Irritability Impact Measure;   Generalized Anxiety Disorder
4 Unknown  The Effects of Soy Dietary Fiber in Adults With Diarrhea Predominant Irritable Bowel Syndrome
Condition: Diarrhea Predominant Irritable Bowel Syndrome
Interventions: Dietary Supplement: Soy Dietary Fiber;   Dietary Supplement: Rice powder
Outcome Measures: sum of irritable bowel syndrome symptom score;   irritable bowel syndrome symptom score;   Stool frequency and form;   Symptom control of irritable bowel syndrome;   Improvement of overall symptom in patient with irritable bowel syndrome;   Severity of overall symptom in patient with irritable bowel syndrome;   Severity of diarrhea;   Assessment for quality of life related with irritable bowel syndrome;   Assessment for patient satisfaction after administration completion
5 Recruiting The Effects of Multi-strain Probiotics in Adults With Diarrhea Predominant Irritable Bowel Syndrome
Condition: Diarrhea Predominant Irritable Bowel Syndrome
Interventions: Drug: Multi-strain probiotics;   Drug: Placebo powder
Outcome Measures: change of Irritable bowel syndrome symptom severity score (IBS-SSS);   Stool frequency and form;   Symptom control of irritable bowel syndrome;   Improvement of overall symptom in patient with irritable bowel syndrome;   Assessment for quality of life related with irritable bowel syndrome;   Assessment for patient satisfaction after administration completion
6 Unknown  Assessment of Small Intestinal Bowel Epithelial Gaps in Irritable Bowel Syndrome
Conditions: Irritable Bowel Syndrome;   Inflammatory Bowel Disease
Intervention:
Outcome Measure:
7 Unknown  Iyengar Yoga for Young People With Irritable Bowel Syndrome
Condition: Irritable Bowel Syndrome
Intervention: Behavioral: Iyengar yoga
Outcome Measures: Irritable bowel symptoms;   Quality of Life
8 Recruiting A Placebo-Controlled Trial of Pregabalin (Lyrica) for Irritable Bowel Syndrome
Condition: Irritable Bowel Syndrome
Interventions: Drug: Pregabalin (Lyrica);   Drug: Placebo
Outcome Measures: Primary aim: Collect preliminary data comparing effects of Pregabalin and placebo on abdominal pain/discomfort on bowel symptom score (BSS), overall BSS score, and adequate relief of irritable bowel syndrome (IBS) symptoms in patients with IBS;   To compare the effect of Pregabalin and placebo on self-reported overall and individual BSS scores;   compare effect of Pregabalin and placebo on adequate relief of IBS pain or discomfort at least 50% of the time;   To compare effect of Pregabalin and placebo on overall and individual BSS scores;   To compare the effect of Pregabalin and placebo on the proportion of patients with at least 3 point changes in 11 point pain and IBS scores
9 Recruiting Subsensory Sacral Nerve Stimulation for Irritable Bowel Syndrome
Condition: Irritable Bowel Syndrome
Interventions: Device: subsensory;   Device: External pacemaker, OFF;   Drug: Suprasensory
Outcome Measures: The Gastrointestinal Symptom Rating Scale - Irritable Bowel Syndrome version questionnaire;   Irritable Bowel Syndrome - Impact Scale questionnaire
10 Recruiting Open Trial of Duloxetine in Outpatients With Irritable Bowel Syndrome Symptoms and Co-Morbid Major Depression
Conditions: Major Depression;   Irritable Bowel Syndrome Symptoms
Intervention: Drug: Duloxetine
Outcome Measures: Montgomery-Asberg Depression Rating Scale (MADRS);   Gastrointestinal Symptoms Rating Scale (GSRS);   Clinician-Rated Global Impression Scales;   Visual Analogue Scales (VAS);   Somatization module of the Patient's Health Questionnaire (PHQ-15)
11 Recruiting Study of Brexpiprazole as Adjunctive Treatment of Irritability in Patients With Major Depressive Disorder and an Inadequate Response to Antidepressant Therapy
Conditions: Major Depressive Disorder;   Irritability
Intervention: Drug: Brexpiprazole
Outcome Measures: Change from baseline to Week 6 in KSQ total score;   Change from baseline to Week 6 in KSQ anger-hostility subscore;   Change from baseline to Week 6 in BIS-11 total score;   Change from baseline to Week 6 in AAQ score;   Change from baseline to Week 6 in SIS total score;   Change from baseline to Week 6 in delay discounting - MCQ scores;   Change from baseline to Week 6 in delay discounting - EDT scores;   Change from baseline to Week 6 in IDS-C30 total score;   Change from baseline to Week 6 in MADRS total score;   Change from baseline to Week 6 in MADRS total score in patients with a pre-defined baseline BIS-11 total score;   Change from baseline to Week 6 in CPFQ total score;   Change from baseline to Week 6 in KSQ depression subscore;   Change from baseline to Week 6 in CGI-S score;   Change from baseline to Week 6 in CGI-S score in patients with a pre-defined baseline BIS-11 total score;   CGI-I score at Week 6;   CGI-I score at Week 6 in patients with a pre-defined baseline BIS-11 total score;   Change from Week 6 to Week 10 in KSQ anger-hostility subscore;   Change from Week 6 to Week 10 in BIS-11 total score;   Change from Week 6 to Week 10 in SIS total score;   Change from Week 6 to Week 10 in CGI-S score;   Change from Week 6 to Week 10 in delay discounting - MCQ scores;   Safety;   Tolerability;   Risk of suicidality
12 Unknown  Saccharomyces Boulardii in Diarrhea Dominant Irritable Bowel Syndrome
Condition: Irritable Bowel Syndrome
Interventions: Drug: Saccharomyces boulardii;   Drug: Methyl cellulose powder (low viscosity)
Outcome Measures: Any Improvement in symptoms of number of bowel habits, urgency, straining,sense of incomplete evacuation, stool form (evaluated by Bristol stool form scale, abdominal pain and bloating/flatulence;   Improvement in quality of life in diarrhea dominant IBS by validated IBS-QOL questionnaire.
13 Recruiting 12-Week Efficacy and Safety Study of Ibodutant in Women With Irritable Bowel Syndrome With Diarrhea (IBS-D)
Condition: Irritable Bowel Syndrome With Diarrhea
Interventions: Drug: Ibodutant 10 mg;   Drug: Placebo
Outcome Measures: Weekly response for abdominal pain intensity AND stool consistency over 12 weeks of treatment in at least 50% of the weeks of treatment (6 out of 12 weeks).;   Weekly response for abdominal pain intensity over 12 weeks of treatment in at least 50% of the weeks of treatment (6 out of 12 weeks).;   Weekly response for stool consistency over 12 weeks of treatment in at least 50% of the weeks of treatment (6 out of 12 weeks).;   Weekly Response for relief of overall IBS signs and symptoms over 12 weeks of treatment in at least 50% of the weeks of treatment (6 out of 12 weeks).;   Evaluation of rebound effects
14 Recruiting 52-Week Efficacy and Safety Study of Ibodutant in Women With Irritable Bowel Syndrome With Diarrhea (IBS-D)
Condition: Irritable Bowel Syndrome With Diarrhea
Interventions: Drug: Ibodutant 10 mg;   Drug: Placebo
Outcome Measures: Weekly response for abdominal pain intensity AND stool consistency over the first 24 weeks of treatment in at least 50% of the weeks of treatment (12 out of 24 weeks).;   Weekly response for abdominal pain intensity over the first 24 weeks of treatment in at least 50% of the weeks of treatment (12 out of 24 weeks).;   Weekly response for stool consistency over the first 24 weeks of treatment in at least 50% of the weeks of treatment (12 out of 24 weeks).;   Weekly response for relief of overall IBS signs and symptoms over the first 24 weeks of treatment in at least 50% of the weeks (12 out of 24);   Sustained efficacy
15 Recruiting Study to Investigate the Irritation Potential of GSK1940029 Gel
Condition: Acne Vulgaris
Interventions: Drug: 0.3% GSK1940029 gel;   Drug: 1% GSK1940029 gel;   Drug: 0.3%/1% vehicle gel only;   Other: Sterile distilled water;   Other: 0.5% SLS in sterile distilled water;   Other: 0.1% SLS in sterile distilled water;   Other: Patch only
Outcome Measures: Primary cutaneous irritation scores;   Cumulative cutaneous irritation scores;   Facial irritation scores;   Lanman-Maibach irritation classifications;   Tolerability of GSK1940029 as assessed by Clinical monitoring/observation;   Tolerability of GSK1940029 as assessed by adverse events (AEs);   Safety and tolerability of GSK1940029 as assessed by clinical laboratory tests;   Safety and tolerability of GSK1940029 as assessed by vital signs measurements;   Safety and tolerability of GSK1940029 as assessed by clinical monitoring/observation;   Ocular tolerability of topical applications of GSK1940029;   Plasma GSK1940029 pharmacokinetics (PK)
16 Unknown  Irritable Bowel Syndrome and Lactibiane Tolerance
Condition: Irritable Bowel Syndrome
Interventions: Dietary Supplement: Lactibiane Tolerance;   Dietary Supplement: Placebo
Outcome Measures: Severity of bowel symptoms according to the Francis Score;   Quality of life;   Severity of Anxiety/Depression;   Impact of the complementation on fatigue;   Impact of the intervention on immunological parameters in stools;   Impact of the intervention on immunological parameters in blood;   severity of the anxiety/depression
17 Recruiting Pilot Study of Riluzole for Drug-Refractory Irritability in Autism Spectrum Disorders
Condition: Autism Spectrum Disorders
Interventions: Drug: Riluzole;   Drug: placebo
Outcome Measures: Clinical Global Impression-Improvement;   Aberrant Behavior Checklist- Irritability
18 Recruiting Delivered Dietary Intervention for Children With Irritable Bowel Syndrome
Conditions: Irritable Bowel Syndrome;   Abdominal Pain
Interventions: Other: Low fermentable substrate diet;   Other: High fermentable substrate diet
Outcome Measures: Average daily abdominal pain frequency;   Abdominal pain severity;   Hydrogen gas production
19 Unknown  Efficacy of Hair Transplantation Compared With Hypodermic Needle Irritation in Alopecia Areata
Conditions: Alopecia Areata;   Alopecia;   Balding
Interventions: Procedure: Hair transplantation;   Procedure: Hypodermic needle irritation
Outcome Measure: Change in follicular growth
20 Recruiting Fecal Microbiota Transplantation in Patients With Irritable Bowel Syndrome
Condition: Irritable Bowel Syndrome (IBS)
Intervention: Other: Fecal transplantation
Outcome Measures: Effect of fecal microbiota transplantation on the symptoms of IBS patients using the IBS version of the gastrointestinal symptom rating scale (GSRS-IBS);   Effect of fecal transplantation on IBS patients' visceral perception (Pain scores on the visual analogue scale during barostat procedure);   Effect of fecal transplantation on IBS patients' composition of mucosal microbiota (HITChip analysis);   Effect of fecal transplantation on IBS patients' composition of fecal microbiota (HITChip analysis);   Effect of fecal transplantation on IBS patients' mucosal immune cell composition (lymphocyte fingerprinting using flow cytometry);   Effect of fecal microbiota transplantation on the symptoms of IBS patients using the IBS - severity scoring system (IBS-SSS);   Effect of fecal microbiota transplantation on the symptoms of IBS patients using the health-related quality of life questionnaire for IBS patients (IBS-QOL);   Effect of fecal microbiota transplantation on the symptoms of IBS patients using the hospital and anxiety depression scale (HADS);   Effect of fecal microbiota transplantation on the general health of IBS patients using the SF-36 survey