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Liver and Diaformin

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Liver Symptoms and Causes

Your Liver is the largest organ inside your body. It helps your body digest food, store energy, and remove poisons.

There are many kinds of Liver diseases:

  • Diseases caused by viruses, such as hepatitis A, hepatitis B, and hepatitis C
  • Diseases caused by drugs, poisons, or too much alcohol. Examples include fatty Liver disease and cirrhosis.
  • Liver cancer
  • Inherited diseases, such as hemochromatosis and Wilson disease

Symptoms of Liver disease can vary, but they often include swelling of the abdomen and legs, bruising easily, changes in the color of your stool and urine, and jaundice, or yellowing of the skin and eyes. Sometimes there are no symptoms. Tests such as imaging tests and Liver function tests can check for Liver damage and help to diagnose Liver diseases.

Check out the latest treatments for Liver

Liver treatment research studies

Diaformin clinical trials, surveys and public health registries


Find Drug Side Effect reports



Diaformin Side Effects

Fatigue (67)
Arterial Disorder (52)
Hunger (46)
Dyspnoea (45)
Blood Glucose Increased (34)
Angioneurotic Oedema (24)
Weight Decreased (21)
Dehydration (18)
Vomiting (18)
Renal Failure Acute (15)
Pernicious Anaemia (15)
Hypoglycaemia (14)

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Common Meds

Abilify (10132)
Adderall (1304)
Amlodipine (6664)
Amoxicillin (4387)
Benadryl (1568)
Celebrex (12876 )
Celexa (1342)
Cialis (2975)
Cipro (8580)
Citalopram (7792)
Crestor (18839)
Cymbalta (14373)
Doxycycline (1757)
Effexor (7289)
Flexeril (435)
Flomax (2177)
Fluoxetine (4261)
Gabapentin (4593)
Hydrocodone (2469)
Ibuprofen (8222)
Lantus (10968)
Lexapro (3499)
Lipitor (17769)
Lisinopril (8919)
Lyrica (27148)
Medrol (650)
Mirena (41254)
Mobic (957)
Morphine (5356)
Naproxen (538)
Neurontin (6501)
Oxycodone (4438)
Pradaxa (13372)
Prednisone (5926)
Prilosec (2631)
Prozac (1954)
Seroquel (27216)
Simvastatin (8348)
Synthroid (4452)
Tamiflu (5585)
Topamax (3748)
Tramadol (5054)
Trazodone (1458)
Viagra (5394)
Vicodin (1153)
Wellbutrin (6324)
Xanax (2847)
Zocor (5718)
Zoloft(6792)
Zyrtec(1669)

Recent Reviews

<b>i feel sick all the time im on diaformin 850</b>

Been overdosed over nine months on 5700mg of Diaformin per dayby my GP. Had lost weight, loss of appetite anaemia B12 deficiency vitamin D deficiency lethagy pains in back on exertion etc. Rushed to hospital, no recordable blood sugar, acut

Dosage 3x500mg daily. Nausea, loss of appetite, Possibly also constipation.On Thyroxine,Tritace,Cardizem,Natrilix,Lipitor,Cartia. Because of the nausea myDiet therefore not well balanced any more which affects

Fatty liver. hypoechogenic areas may represent focal fat sparing left mid pole nephrolithiasis

Had to increase dosage to 1000mg twice a day. Immediately began to find it difficult to summon any energy to do any normal day to day acttivities eg washing, cooking. Diarhoea, lethargy, increase in thirst ( nothing quen

I am a type 2 diabetic 62 years of age, female,and recently my doctor has increased my Diafomin 1000g from two a day to three times a day...she has also stated me on a new Blood Presssure tablet called Avapro HCT 300/25 since I started them I have

I am diaform 500mg 3 times a day each time two tablets I have running stomach and I am very tired and very stress My diabetic is type 2

I BEGAN LOSING MY HAIR, AND AFTER FOUR VISITS BACK TOO THE DOC THAT HE REALLY TOOK NOTICE OF WHAT I WAS SAYING. EVERY TIME I HAD SHOWER OR WASHED MY HAIR, THERE WAS HAIR EVERY WHERE IN THE BOTTOM OF SHOWER. HE NOW HAS CHANGED ME FROM DIAFORIN TOO DIA

I first started with diaformin early August, I now have very bad diarohhea which has now strated for the last 4 days as a very dark green that flows like water. This happins after each meal.

I have been on diaformin for 3 months, I have type 2 diabettes and have an ongoing heart condition. Iam 51, i have noticed excessive sweating and feeling hot continually, also fatigue and the runs. i am on 3 tablets of 500mgs per day. my sugar leve

why is my doctor checking my liver functions before he represcribes my synthoid that I have been on for over 20 years now?

<b>After taking this drug I suffered abdominal pain with diarrhea after eating even small amounts, pain developed with the urge to get to a toilet at once. I had a full blood and liver test and a stool test and all was normal.&nbs

<strong></strong>after duoloton intake i was diagonosed with fatty liver with s.g.p.t.746u/l &amp; jaundice alongwith cystic fimbrae which i had to operate out

1 week after my liver biopsy, I developed a beefy red, hot, inflamed, tense, swollen, painful, itchy rash on the area where the chloraprep was used on over 80% of my abdomen. 3 weeks later, the rash is still red, but dry and peeling. Some areas look

4 years old boy ,liver cancer ,liver transplant . Is going to start Sorafenib . Is there any kids that got this treatment ?

A recent problem with a gall stone blocking the bile duct left my liver compromised. Jaundice and antibiotics left me feeling exhausted. I have a sebaceous cyst on my back which has become inflamed and in infected after I bumped against a

A YOUNG doctor said TAVEGYL is liver-damaging

Afr takingit stops my mild tremors 3x a dayas prescrribed but afr self medications for more than 3 years i was diagnosed to have high ck-mm and spgt..now i am taking another drug for liver....

After 10 days of taking Aclasta serum 5mg i had all the side effects and after 10 days i still have chills and bone pain, what should i do? By the way im having a blood test tomorrow to know about the kidney,liver and glucose. so what should i do??

After only taking 3 tablets i had difficulty breathing and a similar sharp stabbing pain as gallstones. Ended up in hospital - tests showed that my liver levels were almost 15 times normal levels.

Liver Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Unknown  Detection Rate of Liver Metastases With Contrast Enhanced Intraoperative Ultrasound Compared to Regular Imaging
Conditions: Colorectal Liver Metastasis;   Contrast Enhances Intraoperative Ultrasound;   Imaging for Liver Cancer;   Imaging for Liver Metastasis
Interventions: Procedure: Liver Surgery;   Device: Contrast Enhanced Ultrasound;   Radiation: CT Scan (standard);   Radiation: Primovist MRI (3 Tesla)
Outcome Measures: Detection of Liver Metastasis during Operation;   Comparison of Detection Rate for Liver Metastases of all imaging modalities;   Comparison of Sensitivity of all imaging modalities;   Comparison of Specicivity of all imaging modalities
2 Unknown  Human Fetal Liver Cell Transplantation in Chronic Liver Failure
Condition: Liver Cirrhosis
Intervention: Other: Human Fetal Liver Cell Transplantation
Outcome Measures: Assess the therapeutic efficacy of human fetal Liver progenitor cell transplantation by monitoring standard and specific Liver function parameters;   Assess the safety of human fetal Liver progenitor cell transplantation on the clinical course of chronic Liver failure patients Assess the development of ectopic Liver tissue in the spleen by means of serial imaging studies.
3 Recruiting Oslo Randomized Laparoscopic Versus Open Liver Resection for Colorectal Metastases Study
Conditions: Secondary Malignant Neoplasm of Liver;   Colorectal Neoplasms
Interventions: Procedure: Open Liver resection;   Procedure: Laparoscopic Liver resection
Outcome Measures: Perioperative morbidity;   5 year survival;   Recurrence pattern;   Immediate oncologic outcome;   Postoperative quality of life;   Surgical trauma and activation of the immune system;   Health economy;   Postoperative pain;   Molecular biology;   Anti-tumor immunology;   Imaging
4 Recruiting Liver Fibrosis in Alpha-1 Antitrypsin Deficiency (AATD)
Conditions: Liver Fibrosis;   Alpha-1 Antitrypsin Deficiency;   AAT Deficiency;   AATD
Interventions: Device: Abdominal ultrasound;   Procedure: History and physical;   Procedure: Intravenous catheter;   Procedure: Blood draw;   Other: Liver questionnaire;   Procedure: Liver Biopsy;   Drug: Midazolam;   Drug: Fentanyl;   Drug: Lidocaine;   Drug: Acetaminophen;   Drug: Lorazepam;   Drug: Oxycodone/Acetaminophen;   Drug: Ondansetron
Outcome Measures: To estimate the prevalence and histologic spectrum of Liver injury in an adult with Alpha-1 Antitrypsin deficiency and a genotype of ZZ.;   To identify environmental and host risk factors for clinically significant Liver fibrosis.;   To define the diagnostic accuracy of non-invasive markers of fibrosis in AAT Liver disease.;   To explore epigenetic markers for the development of Liver fibrosis.;   To quantify Liver fibrosis progression.
5 Recruiting Liver-PILP First-in-Man
Condition: Liver Metastases
Intervention: Device: Liver-PILP kit
Outcome Measure: To demonstrate the feasibility of the Liver PILP intervention.
6 Not yet recruiting Study of Peripheral Tissue Oxygenation in End-stage Liver Disease Patients During Liver Transplantation
Condition: End Stage Liver Disease
Intervention:
Outcome Measures: the significant changes in StO2 between anhepatic and reperfusion phase of the end-stage Liver disease patient undergoing Liver transplantation;   dynamic changes in StO2 during Liver transplantation with possible correlation with hemodynamic or chemical parameters in different time points
7 Recruiting Acoustic Radiation Force Impulse Imaging (ARFI) : a New Technique to Assess Liver Elasticity
Conditions: Liver Fibrosis;   Liver Cirrhosis;   Viral Hepatitis;   Liver Tumour;   Cardiac Failure;   Biliary Cholestasis.
Intervention: Device: ARFI measurement
Outcome Measures: The elasticity parameter will be for each patient the median of ten ARFI values (m/s) in the right Liver.;   Inter and intra observer reproducibility;   Median (m/s) of ARFI values between before and after effective treatment for Liver reversible disease
8 Not yet recruiting Observational Study of Biomarker During Liver Surgery
Conditions: Liver Cancer;   Hepatobiliary Tract Adenomas and Carcinomas
Intervention: Procedure: Hepatocellular carcinoma
Outcome Measure: Biochemical analysis of sirtuin1 from Liver tissues during Liver surgery
9 Recruiting Portal Vein Thrombosis Relevance on Liver Cirrhosis: Italian Venous Thrombotic Events Registry
Conditions: Liver Cirrhosis;   Portal Vein Thrombosis
Intervention:
Outcome Measures: PVT prevalence;   Thrombotic Events;   Mortality;   Cirrhosis Complications
10 Recruiting Hepar-P Study to Evaluate the Safety and Efficacy of a Standardised Extract of Phyllanthus Niruri for the Treatment of Non-alcoholic Fatty Liver Disease
Condition: Non-alcoholic Fatty Liver Disease
Interventions: Drug: Hepar-P;   Drug: Placebo for Hepar-P
Outcome Measures: Improvement in serum aspartate aminotransferase and alanine aminotransferase levels;   Histologic findings including degree of steatosis, lobular inflammation, hepatocellular ballooning and fibrosis and overall disease activity score
11 Recruiting Fatty Acids Lipidome and Oxidative Stress in Liver Transplantation
Condition: Liver Cirrhosis
Intervention:
Outcome Measures: Post operative graft function after Liver transplantation;   Early gene expression in the Liver graft
12 Unknown  Multiparametric MR for Rapid Imaging Assessment of the Liver
Conditions: Liver Cirrhosis;   Fatty Liver
Intervention:
Outcome Measures: Liver fat content;   Liver fibrosis
13 Recruiting Pre-recovery Bedside Liver Biopsy in Brain Death Organ Donors
Conditions: Neurological Death;   Organ Donation;   Liver Disease
Interventions: Procedure: Percutaneous Liver Biopsy;   Procedure: Wedge and Core Liver Biopsy
Outcome Measures: Safety;   Reliability;   Feasibility
14 Recruiting Non Invasive Assessment of Liver Fibrosis in Children: Comparison of ShearWave Elastography, Fibrotest and Liver Biopsy
Conditions: Liver Fibrosis;   Children
Intervention: Procedure: Shearwave electrography
Outcome Measures: Liver fibrosis evaluated by the ISHAK score and morphometric evaluation;   Liver fibrosis evaluation : stiffness using SHEARWAVE elastography;   Liver fibrosis evaluation using Fibrotest (Fibromax)
15 Not yet recruiting Stratification of Patients With Chronic Liver Disease Using Multi Spectral CT
Conditions: Chronic Liver Disease.;   Hepatocellular Carcinoma.;   Liver Fibrosis.
Intervention: Device: Multispectral CT of the Liver
Outcome Measure: Detection of hepatocellular carcinoma on Multi Spectral CT
16 Recruiting Safety, Efficacy, and Dosing of Stereotactic Radiosurgery for Hepato-cellular Carc/Colo-rectal Liver Metastases
Conditions: Liver Neoplasms;   Colonic Neoplasms;   Metastatic Cancer to Liver
Intervention: Radiation: Stereotactic Radiosurgery using the CyberKnife System.
Outcome Measures: Tolerable Doses of Radiation in Patients with Liver Cancer or Metastases to the Liver in Patients with Good vs. Compromised Liver Function.;   Tumor Response to Doses of Radiation in Patients with Liver Cancer or Metastases to the Liver, in Patients with Good vs. Compromised Liver Function.
17 Recruiting The Effects of Local Infiltration Versus Epidural Following Liver Resection 2
Condition: Open Liver Resection
Interventions: Device: Wound catheter;   Device: Epidural
Outcome Measures: Length of stay;   Pain Scores;   Molecular response to surgery;   Central Venous Pressure;   Estimated Blood Loss;   Operative field asessment;   Pringle time
18 Recruiting Sonoelastography: Ultrasound Method to Measure Liver Fibrosis
Conditions: Chronic Liver Disease;   Non-Alcoholic Fatty Liver Disease;   HCV Coinfection;   HBV;   Drug-Induced Liver Injury
Intervention: Device: Shear Wave sonoelastography
Outcome Measure: The ROC curve of the capacity of the continuous measure of Liver elasticity (measured in kilopascals) to differentiate cirrhosis from lesser degree of Liver fibrosis.
19 Unknown  Comparison of Analgesic Methods, and Their Effects on Patient Recovery, Following Liver Surgery
Condition: Postoperative Pain
Interventions: Other: Standard optimised recovery protocol.;   Other: Wound catheter plus patient-controlled analgesia.
Outcome Measures: Length of time to reach criteria for discharge from hospital.;   Pain scores, assessed using numerical rating score (0 to 10).;   Nausea and sedation scores, assessed using numerical rating score (0 to 3).;   Sleep disturbance, assessed using numerical rating score (0 to 10).;   Volume of intravenous fluids received in the first 48 hours following operation (ml).;   Mobility (percentage of time spent lying / sitting, standing or walking, as measured by ActivPAL meter).;   Time to return of bowel function (days).;   Length of time to meet criteria for discharge from the High Dependency Unit.;   Complications (General and Technical).
20 Recruiting Liver Fibrosis in Sickle Cell Disease
Condition: Sickle Cell Disease
Interventions: Other: Liver transient elastography;   Other: magnetic resonance imaging R2*
Outcome Measures: Liver transient elastography (FibroScan) of Liver iron content and stiffness;   magnetic resonance imaging (MRI) measure of Liver iron content and stiffness;   Liver function tests (ALT, AST, serum alkaline phosphate, GGTP, total bilirubin, direct bilirubin), complete blood count, platelets, reticulocyte count, serum ferritin to assess Liver function and evaluate overall health