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MALAISE and Norco

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MALAISE Symptoms and Causes

What is chronic fatigue syndrome?

Chronic fatigue syndrome (CFS) is a serious, long-term illness that affects many body systems. Another name for it is myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). CFS can often make you unable to do your usual activities. Sometimes you may not even be able to get out of bed.

What are the symptoms of chronic fatigue syndrome?

CFS symptoms can include

  • Severe fatigue that is not improved by rest
  • Sleep problems
  • Post-exertional Malaise (PEM), where your symptoms get worse after any physical or mental activity
  • Problems with thinking and concentrating
  • Pain
  • Dizziness

CFS can be unpredictable. Your symptoms may come and go. They may change over time - sometimes they might get better, and other times they may get worse.

Who gets chronic fatigue syndrome?

Anyone can get CFS, but it is most common in people between 40 and 60 years old. Adult women have it more often that adult men. Whites are more likely than other races to get a diagnosis of CFS, but many people with CFS have not been diagnosed with it.

What causes chronic fatigue syndrome?

Scientists don't know what causes CFS. There may be more than one thing that causes it. It is possible that two or more triggers might work together to cause the illness.

How is chronic fatigue syndrome diagnosed?

CFS can be difficult to diagnose. There are no tests for it, and other illnesses can cause similar symptoms. Your health care provider has to rule out other diseases before making a diagnosis of CFS. He or she will do a thorough medical exam, including

  • Asking about your health history and your family's medical history
  • Asking about your current illness, including your symptoms. Your doctor will want to know how often you have symptoms, how bad they are, how long they have lasted, and how they affect your life.
  • A thorough physical and mental status exam
  • Blood, urine or other tests
What are the treatments for chronic fatigue syndrome?

There is no cure or approved treatment for CFS, but you may be able to treat or manage some of your symptoms. You, your family, and your health care provider should work together to decide on a plan. You should figure out which symptom causes the most problems, and try to treat that first. For example, if sleep problems affect you the most, you might first try using good sleep habits. If those do not help, you may need to take medicines or see a sleep specialist.

Strategies such as learning new ways to manage activity can also be helpful. You need to make sure that you do not "push and crash." This can happen when you feel better, do too much, and then get worse again.

Since the process of developing a treatment plan and attending to self-care can be hard if you have CFS, it is important to have support from family members and friends.

Don't try any new treatments without talking to your health care provider. Some treatments that are promoted as cures for CFS are unproven, often costly, and could be dangerous.

Centers for Disease Control and Prevention

Check out the latest treatments for MALAISE

MALAISE treatment research studies

Norco clinical trials, surveys and public health registries


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Norco Side Effects

Pain (25)
Nausea (20)
Headache (14)
Anxiety (14)
Dyspnoea (14)
Insomnia (13)
Vomiting (12)
Depression (11)
Diarrhoea (11)
Injury (11)
Pain In Extremity (11)
Fatigue (10)
Emotional Distress (10)
Product Quality Issue (9)
Dehydration (9)
Cholecystitis Chronic (8)
Back Pain (8)
Deep Vein Thrombosis (8)
Arthralgia (8)
Fall (8)
Pulmonary Embolism (8)
Oedema Peripheral (8)
Feeling Abnormal (8)
Decreased Appetite (7)
Abdominal Pain (7)
Dizziness (7)
Malaise (7)
Musculoskeletal Pain (7)
Loss Of Consciousness (7)
Blister (6)
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Confusional State (6)
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Pyrexia (5)
Neoplasm Malignant (4)
Weight Increased (4)
Suicidal Ideation (4)

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Recent Reviews

I was taking Norco for 1.5 months after a shoulder surgery. It worked well for pain. The side effect I had was when I stopped taking them. I could not sleep. I was tired and just could not sleep. I felt as though I had restless leg syndrome. I would

After taking Cialis I experienced nause and chest discomfort for two days so far, along with a pronounced feeling of general malaise and fatigue.

Bad gastritis or abdominal pain; had to get into tub with hot shower on my belly;never had a worse experience or pain; thought I was going to die; malaise; moderate ear pain

Hi. yes i have the same symptoms. I feel terrible when I wake up in the can. I have lots of back pain, leg pain, general pain and muscle stiffness: a general feeling of malaise and fatigue. After I'm up for little while, I usually feel bett

I have been on Flomaxtra forover a year. During this time I have been experiencing fatigue, low energy and malaise. Has anyone stopped this drug for any alternative methods/drug ?

I have been taking the new, smaller pill for a few weeks now, and finally realized that it's the reason that I've been having this constant nausea, sometimes coupled with headaches, and general feeling of malaise. Haven't taken it for a few days and

I haven't felt generally good since starting Humira 9months ago. Previous to that I had a four month hiatus while the insurance got straightened out. While I'm on it, along with general malaise, I have an acid stomach and nausea a

I'm 31. Only day 2 for me. General feeling of malaise, slightly achy and restless legs and itching all over, developed a rash on right side of torso. Noticed the nausea on taking my tablets (mornings only for now), in spite of full stomach and sudden

Inadequate control of blood sugar, have to starve myself to get lower blood sugar even on two types of insulin, diarrhoea, dizziness, syncope, dyspnoea, severe malaise, nausea, tremors.

My husband experienced nausea, vomiting, malaise, raised creatinine levels, 2.1-2.3, extreme thirst and urination. He filled 5 urinals in the hospital in 12 hours. Diabetes insipidus neph. He also had an elevated eosin l

RECLAST SIDE EFFECTS: I investigated the new drug, Reclast, in advance of my one and only injection in November 2008. After the injection, I became extremely fatigued and developed an overall sense of malaise and misery. I am normally energetic and u

MALAISE Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting Phase III Study of the Safety and Efficacy of Cl-108 in the Treatment of Moderate to Severe Pain
Conditions: Pain;   Nausea;   Vomiting
Interventions: Drug: CL-108;   Drug: Placebo
Outcome Measures: To compare the occurrence and severity of opioid-induced nausea and vomiting (OINV) associated with CL-108 to Norco.;   To demonstrate the efficacy of CL-108 when compared to placebo for the relief of pain following surgical removal of impacted third molar teeth.;   Reduction of the severity of nausea in patients treated with an opioid-containing pain reliever.;   Reduction of vomiting in patients treated with an opioid-containing pain reliever.
2 Not yet recruiting Efficacy and Safety of Amantadine HCl Extended Release Tablets in Parkinson's Disease Subjects With Levodopa-Induced Dyskinesias
Conditions: Parkinson's Disease;   Levodopa Induced Dyskinesia (LID)
Interventions: Drug: Amantadine HCl ER (ALLAY-LID II);   Drug: Placebo
Outcome Measures: Unified Dyskinesia Rating Scale;   Mobility State Self Assessment (Subject Diary Cards);   Mobility State Self-Assessment (Subject Diary Cards);   MDS-Unified Parkinson's Disease Rating Scale;   Fatigue Severity Scale
3 Not yet recruiting Efficacy and Safety of Amantadine ER Tablets to Treat Parkinson's Disease Patients With Levodopa Induced Dyskinesia.
Conditions: Parkinson's Disease;   Levodopa Induced Dyskinesia (LID)
Interventions: Drug: Amantadine ER Tablets;   Drug: Placebo Tablets for Amantadine ER Tablets
Outcome Measures: Unified Dyskinesia Rating Scale (UDysRS);   Mobility State Self-Assessment (Subject Diary Cards);   MDS-UPDRS;   Fatigue Severity Scale
4 Recruiting Edible Plant Exosome Ability to Prevent Oral Mucositis Associated With Chemoradiation Treatment of Head and Neck Cancer
Conditions: Head and Neck Cancer;   Oral Mucositis
Interventions: Dietary Supplement: Grape extract;   Drug: Lortab, Fentanyl patch, mouthwash
Outcome Measures: Pain caused by oral mucositis;   Level of immune biomarkers in blood;   Level of immune biomarkers in mucosal tissue
5 Not yet recruiting Ureteral Stent-related Pain and Mirabegron (SPAM) Trial
Condition: Nephrolithiasis
Interventions: Drug: Mirabegron;   Drug: Tamsulosin;   Drug: Percocet
Outcome Measures: Ureteral stent related pain and lower urinary tract symptoms (LUTS) as measured by the Ureteral Stent Symptom Questionnaire.;   Quality of life impact of mirabegron for stent symptoms as measured with the Ureteral Stent Symptoms Questionnaire.
6 Unknown  Fentanyl Administered Intraorally for Rapid Treatment of Orthopedic Pain
Condition: Pain, Fracture, Sprain
Interventions: Drug: Fentanyl rapid dissolving tablet 100mcg;   Drug: lansoprazole 15mg rapidly dissolving tablet + Percocet PO
Outcome Measures: Time to analgesia;   Occurrence of untoward opioid side effects
7 Not yet recruiting An Open Label, Prospective Study of the Analgesic Efficacy of Oral Xartemis Compared to Generic Oxycodone/APAP( Acetaminophen) in the Treatment of Moderate to Severe Post Operative Pain.
Condition: Post Operative Pain
Interventions: Drug: Percocet;   Drug: Xartemis
Outcome Measures: Non Inferiority;   Patient Global Assessment
8 Recruiting Adductor Canal Nerve Block Following Total Knee Arthroplasty
Condition: Post-op Pain
Interventions: Drug: Morphine PCA started at the end of surgery, 1 Percocet 1/325mg every 4 hours; may receive a second Percocet if needed.;   Drug: For the 30ml ropivacaine the intervention would be the subject can request extra pain medication which would be Percocet and/or morphine PCA.
Outcome Measures: Total Opiate pain medication;   Patient satisfaction with pain control
9 Not yet recruiting The Effect of NSAIDs After a Rotator Cuff Repair Surgery.
Condition: Rotator Cuff Tear
Interventions: Procedure: Rotator cuff repair;   Drug: Ibuprofen, Hydrocodone/Acetaminophen, Omeprazole;   Drug: Hydrocodone/Acetaminophen
Outcome Measures: American Shoulder and Elbow Surgeons (ASES) Shoulder Score;   Ultrasound evaluation of retear rate
10 Recruiting Liver Fibrosis in Alpha-1 Antitrypsin Deficiency (AATD)
Conditions: Liver Fibrosis;   Alpha-1 Antitrypsin Deficiency;   AAT Deficiency;   AATD
Interventions: Device: Abdominal ultrasound;   Procedure: History and physical;   Procedure: Intravenous catheter;   Procedure: Blood draw;   Other: Liver questionnaire;   Procedure: Liver Biopsy;   Drug: Midazolam;   Drug: Fentanyl;   Drug: Lidocaine;   Drug: Acetaminophen;   Drug: Lorazepam;   Drug: Oxycodone/Acetaminophen;   Drug: Ondansetron
Outcome Measures: To estimate the prevalence and histologic spectrum of liver injury in an adult with Alpha-1 Antitrypsin deficiency and a genotype of ZZ.;   To identify environmental and host risk factors for clinically significant liver fibrosis.;   To define the diagnostic accuracy of non-invasive markers of fibrosis in AAT liver disease.;   To explore epigenetic markers for the development of liver fibrosis.;   To quantify liver fibrosis progression.
11 Recruiting Safety and Efficacy Study of Fentanyl Buccal Tablet Use in the Emergency Department for Isolated Extremity Injury
Condition: Pain
Interventions: Drug: Fentanyl;   Drug: Oxycodone/acetaminophen;   Drug: oxycodone/acetaminophen
Outcome Measures: Pain Level;   Nausea level;   Occurrence of adverse events
12 Recruiting Comparing the Efficacy of Oral Opioids for Outpatient Acute Pain Management After ED Discharge Discharge
Condition: Analgesia After ED Discharge for Extremity Injuries
Intervention: Drug: Oral Opioid Pain Medicine
Outcome Measures: Difference in pain score before and after last dose.;   Overall Satisfaction with the pain medicine;   Side Effects
13 Recruiting Safety and Efficacy of Gabapentin for Neuropathic Pain in Fabry Disease
Conditions: Fabry Disease;   Neuropathic Pain
Interventions: Drug: Gabapentin;   Drug: placebo
Outcome Measures: average reduction in hydrocodone-acetaminophen use;   Number and type of adverse events;   Pain levels;   Define therapeutic level for gabapentin
14 Not yet recruiting Equality Study of Ofirmev vs Oral Acetaminophen
Condition: Pain, Postoperative
Interventions: Drug: IV acetaminophen;   Drug: oral acetaminophen
Outcome Measures: Primary outcome will measure total opioid consumption while the patient is in the PACU;   time from PACU admission to request for first opioid dose
15 Not yet recruiting Local Anesthesia and Analgesics in Endodontic Pain
Condition: Odontalgia
Interventions: Drug: Oral placebo;   Drug: Oral ibuprofen;   Drug: oral naproxen;   Drug: oral acetaminophen/hydrocodone + ibuprofen
Outcome Measures: Effect of long acting anesthesia and analgesics on endodontic pain;   Effect of gender and age on post-operative endodontic pain treatment
16 Not yet recruiting Post-operative Analgesia in Elective, Soft-tissue Hand Surgery
Conditions: Carpal Tunnel;   Ganglion Cyst;   Trigger Finger
Interventions: Drug: Acetaminophen/Hydrocodone;   Drug: Acetaminophen/Ibuprofen
Outcome Measures: Efficacy comparison utilizing Visual Analog Scale (VAS), Likert Pain Score and Mean daily pain values;   Incidence of adverse effects
17 Recruiting Clinical Research of the Prognostic Influence of NSAIDS's Anti-inflammatory Effect on Senior Patients With Hip Fracture
Condition: Hip Fracture
Interventions: Drug: celecoxib;   Drug: Acetaminophen oxycodone
Outcome Measure:
18 Recruiting Tracking & Feedback Registry to Reduce Breast Cancer Treatment Disparities
Condition: Breast Cancer
Intervention: Other: Tracking & Feedback
Outcome Measures: Change in intervention effect of adjuvant treatment;   Organizational Characteristics
19 Recruiting Narcotic vs. Non-narcotic Pain Study Protocol
Condition: Carpal Tunnel
Interventions: Drug: Narcotic;   Drug: non-narcotic
Outcome Measure: Pain relief
20 Not yet recruiting Comprehensive Opioid Management
Condition: Chronic Pain
Interventions: Behavioral: IVR self-management;   Behavioral: Opioid monitoring;   Other: Enhanced usual care
Outcome Measures: Brief Pain Inventory;   Concordance with opioid treatment practice guidelines