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MIGRAINE and Seroquel

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MIGRAINE Symptoms and Causes

What are Migraines?

Migraines are a recurring type of headache. They cause moderate to severe pain that is throbbing or pulsing. The pain is often on one side of your head. You may also have other symptoms, such as nausea and weakness. You may be sensitive to light and sound.

Who gets Migraines?

About 12 percent of Americans get Migraines. They can affect anyone, but you are more likely to have them if you

  • Are a woman. Women are three times more likely than men to get Migraines.
  • Have a family history of Migraines. Most people with Migraines have family members who have Migraines.
  • Have other medical conditions, such as depression, anxiety, bipolar disorder, sleep disorders, and epilepsy.
What causes Migraines?

Researchers believe that Migraine has a genetic cause. There are also a number of factors that can trigger a Migraine, including

  • Stress
  • Anxiety
  • Hormonal changes in women
  • Bright or flashing lights
  • Loud noises
  • Strong smells
  • Medicines
  • Too much or not enough sleep
  • Sudden changes in weather or environment
  • Overexertion (too much physical activity)
  • Tobacco
  • Caffeine or caffeine withdrawal
  • Skipped meals
  • Medication overuse (taking medicine for Migraines too often)
  • Certain foods and food additives such as
    • Alcohol
    • Chocolate
    • Aged cheeses
    • Monosodium glutamate (MSG)
    • Some fruits and nuts
    • Fermented or pickled goods
    • Yeast
    • Cured or processed meats
What are the symptoms of Migraines?

There are four different phases of Migraines. You may not always go through every phase each time you have a Migraine.

  • Prodome. This phase starts up to 24 hours before you get the Migraine. You have early signs and symptoms, such as food cravings, unexplained mood changes, uncontrollable yawning, fluid retention, and increased urination.
  • Aura. If you have this phase, you might see flashing or bright lights or zig-zag lines. You may have muscle weakness or feel like you are being touched or grabbed. An aura can happen just before or during a Migraine.
  • Headache. A Migraine usually starts gradually and then becomes more severe. It typically causes throbbing or pulsing pain, which is often on one side of your head. But sometimes you can have a Migraine without a headache. Other Migraine symptoms may include
    • Increased sensitivity to light, noise, and odors
    • Nausea and vomiting
    • Worsened pain when you move, cough, or sneeze
  • Postdrome (following the headache). You may feel exhausted, weak, and confused after a Migraine. This can last up to a day.

Migraines are more common in the morning; people often wake up with them. Some people have Migraines at predictable times, such as before menstruation or on weekends following a stressful week of work.

How are Migraines diagnosed?

To make a diagnosis, your health care provider will

  • Take your medical history
  • Ask about your symptoms
  • Do a physical and neurological exam

An important part of diagnosing Migraines is to rule out other medical conditions which could be causing the symptoms. So you may also have blood tests, an MRI or CT scan, or other tests.

How are Migraines treated?

There is no cure for Migraines. Treatment focuses on relieving symptoms and preventing additional attacks.

There are different types of medicines to relieve symptoms. They include triptan drugs, ergotamine drugs, and pain relievers. The sooner you take the medicine, the more effective it is.

There are also other things you can do to feel better:

  • Resting with your eyes closed in a quiet, darkened room
  • Placing a cool cloth or ice pack on your forehead
  • Drinking fluids

There are some lifestyle changes you can make to prevent Migraines:

  • Stress management strategies, such as exercise, relaxation techniques, and biofeedback, may reduce the number and severity of Migraines. Biofeedback uses electronic devices to teach you to control certain body functions, such as your heartbeat, blood pressure, and muscle tension.
  • Make a log of what seems to trigger your Migraines. You can learn what you need to avoid, such as certain foods and medicines. It also help you figure out what you should do, such as establishing a consistent sleep schedule and eating regular meals.
  • Hormone therapy may help some women whose Migraines seem to be linked to their menstrual cycle
  • If you have obesity, losing weight may also be helpful

If you have frequent or severe Migraines, you may need to take medicines to prevent further attacks. Talk with your health care provider about which drug would be right for you.

Certain natural treatments, such as riboflavin (vitamin B2) and coenzyme Q10, may help prevent Migraines. If your magnesium level is low, you can try taking magnesium. There is also an herb, butterbur, which some people take to prevent Migraines. But butterbur may not be safe for long-term use. Always check with your health care provider before taking any supplements.

NIH: National Institute of Neurological Disorders and Stroke

Check out the latest treatments for MIGRAINE

MIGRAINE treatment research studies

Seroquel clinical trials, surveys and public health registries


Find Drug Side Effect reports



Seroquel Side Effects

Diabetes Mellitus (6103)
Type 2 Diabetes Mellitus (3575)
Insomnia (2241)
Pancreatitis (1939)
Blood Cholesterol Increased (1705)
Weight Increased (1696)
Obesity (1197)
Diabetes Mellitus Inadequate Control (1084)
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Depression (1046)
Hyperglycaemia (1037)
Diabetic Neuropathy (1010)
Somnolence (997)
Anxiety (972)
Malaise (971)
Off Label Use (948)
Feeling Abnormal (830)
Blood Triglycerides Increased (806)
Suicidal Ideation (805)
Diabetic Coma (803)
Convulsion (757)
Death (753)
Neuropathy Peripheral (744)
Tardive Dyskinesia (696)
Dizziness (683)
Type 1 Diabetes Mellitus (667)
Hyperlipidaemia (662)
Chest Pain (641)
Hypertension (632)
Fall (631)
Fatigue (612)
Headache (611)
Overdose (594)
Suicide Attempt (564)
Back Pain (547)
Bipolar Disorder (519)
Nausea (492)
Agitation (488)
Tremor (449)
Dyspnoea (437)
Confusional State (432)
Loss Of Consciousness (403)
Vomiting (395)
Mental Disorder (383)
Blood Glucose Increased (382)
Abdominal Pain (378)
Cardiac Disorder (373)
Cerebrovascular Accident (370)
Asthenia (368)
Aggression (359)

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Recent Reviews

After taking 300 mgm a day of seroquel, I gained 30 lbs over a period of 3 months with all the symptoms of metabolic syndrome. Now I am unable to lose that weight even though I no longer take the medicati9on

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Doing range of motion exercises on the neck with the head is an excellent way of treating cronic insomonia. >:o O:-)

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I also had to increase the weight for my pendulum exercises to make easier to adjust my shoulder. :)

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Is it effective for cases of migraine

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MIGRAINE Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Not yet recruiting Pharmacokinetic Study Comparing Topical, Rectal, and Oral Quetiapine
Conditions: Dementia;   Delirium
Interventions: Drug: Quetiapine 25 mg gel applied topically;   Drug: Quetiapine 25 mg tablet by mouth;   Drug: Quetiapine 25 mg rectal suppository
Outcome Measures: Serum quetiapine levels after topical application (Visit 1);   Serum quetiapine levels after oral administration (Visit 2);   Serum quetiapine levels after rectal administration (Visit 3)
2 Unknown  A Study to Evaluate the Efficacy and Safety of Flexible Dose of Quetiapine Fumarate (Seroquel) Switching From Other Drugs in the Treatment of Acute Manic Patients With Bipolar Disorder
Condition: Bipolar Disorder
Intervention: Drug: quetiapine fumarate tablet (Seroquel)
Outcome Measures: The primary efficacy variable for this study is the YMRS total score change from baseline to Day 28 (LOCF).;   To evaluate the effectiveness of quetiapine fumarate;   To evaluate the relationship between the serum brain-derived neurotrophic factor and quetiapine fumarate;   To evaluate the safety and tolerability of quetiapine fumarate
3 Unknown  Effects of 'Seroquel-XR' on the Improvement of Neurocognitive Function in People At-risk Mental States(ARMS)
Conditions: Abnormal Mental State;   Schizophrenia
Intervention: Drug: Quetiapine(Seroquel-XR) 50~800mg a day
Outcome Measures: California Verbal Learning Test;   verbal & spatial 2-back test, Digit Span, 3-7 CPT, WCST, Rey-CFT, TMT A & B, COWAT, SOPS, PANSS, SAS, PAS, AIHQ, BIS
4 Unknown  Efficacy and Safety of Utapine vs. Seroquel in Patients With Bipolar Mania
Conditions: Bipolar, Mania;   Utapine;   Seroquel
Interventions: Drug: Utapine;   Drug: Seroquel
Outcome Measure:
5 Recruiting The Effect of Quetiapine XR in Depressive Patients Showing Aberrant N100 Amplitude Slope
Condition: Major Depressive Disorder
Interventions: Drug: SSRI monotherapy;   Drug: Seroquel XR adjunctive
Outcome Measures: Change from baseline in HDRS scale;   Change from baseline in CGI, BDI, and YMRS scales
6 Unknown  Pilot Study to Evaluate the Efficacy and Safety of Quetiapine Fumarate Instant-Release (Seroquel IR) in Controlling Agitation and Aggressive Symptoms in the Acute Treatment of Patients With Schizophrenia
Condition: Acute Schizophrenia
Interventions: Drug: Quetiapine fumarate;   Drug: Haloperidol
Outcome Measures: The primary objective of this study is to evaluate the efficacy of quetiapine fumarate in improving agitation and aggression symptoms for the schizophrenic patients;   The response rate of quetiapine in improving agitation and aggression symptoms - the efficacy of quetiapine - the safety and tolerability of quetiapine - differences between quetiapine and haloperidol
7 Unknown  Quetiapine Extended Release (XR) for the Management of Psychotic Aggression or Agitation in Adult Acute Psychiatry
Conditions: Schizophrenia;   Psychosis
Intervention: Drug: Quetiapine XR
Outcome Measures: The primary efficacy variable is the change in aggression between admission and day 8 of treatment with Quetiapine XR as measured by the OAS.;   Measuring psychotic symptomatology change from baseline in BPRS-Total Score in aggressive, psychotic patients managed with Quetiapine XR;   Measuring the incidence of adverse events (including Extrapyramidal symptoms) by the change from baseline in SAS and BAS and subjective reports;   Measuring the incidence of concomitant benzodiazepine and other permitted medication use
8 Unknown  Trial of Quetiapine in Anorexia Nervosa
Condition: Anorexia Nervosa
Intervention: Drug: Quetiapine
Outcome Measures: Primarily we will seek to show that Quetiapine is superior to placebo in terms of reducing core eating disorder symptoms on the Yale-Brown-Cornell Eating Disorder Scale (YBC-EDS) and the Eating Disorders Inventory-2.;   We seek to show that Quetiapine is superior to placebo in reducing anxiety, depression, obsessionality, or weight gain in patients with AN. We also will seek to show that Quetiapine is superior to placebo at reducing positive and negative symptoms.
9 Recruiting Quetiapine Pharmacotherapy for Cannabis Dependence
Condition: Cannabis Dependence
Interventions: Drug: Quetiapine;   Drug: Placebo
Outcome Measures: Marijuana Use;   Marijuana Abstinence;   Urine toxicology;   Marijuana withdrawal symptoms;   Marijuana craving;   Sleep disturbance
10 Unknown  Brain Derived Neurotrophic Factor as a Predictor of Response to Treatment in Bipolar Depression and Mania: 16-weeks Follow-up With Quetiapine XR
Condition: BIPOLAR DISORDER
Intervention: Drug: quetiapine
Outcome Measures: Efficacy of quetiapine as a treatment for acute mania and depression, and of as a manutence treatment.;   Assess the pharmacodynamics of quetiapine by neurotrophins in blood samples.
11 Recruiting Gao Bipolar Spectrum Lithium/Quetiapine Study
Condition: Bipolar Disorder
Interventions: Drug: Lithium;   Drug: Quetiapine
Outcome Measures: Time to study discontinuation;   Lithium vs. Quetiapine effects on general cardiovascular disease risk and role effects on general cardiovascular disease risk and role impairment
12 Not yet recruiting Safety and Tolerability of Quetiapine in Multiple Sclerosis
Condition: Multiple Sclerosis
Intervention: Drug: Extended-release quetiapine fumarate
Outcome Measures: Dose-limiting toxicity;   Adverse events
13 Recruiting Post-Traumatic Stress Disorder (PTSD) and Seroquel
Condition: Post-Traumatic Stress Disorder
Intervention: Drug: Seroquel
Outcome Measures: The primary outcome will be the change from baseline in PTSD symptomatology at the week 8 timepoint.;   The secondary outcome will be the change from baseline in PTSD symptomatology at the Week 8 timepoint.
14 Recruiting European Drug Utilization Study
Condition: Major Depressive Disorder (MDD)
Intervention:
Outcome Measures: Patient age (mean and range);   Patient gender (%);   Diagnosis for which Seroquel XR was prescribed (% of Major Depressive Disorder- MDD);   Patients hospitalized for any psychiatric condition (n, %);   Daily dose of Seroquel XR (mode and range);   Patient referral pathway (%);   Participating psychiatrist practice setting (%);   Percent of patients experiencing psychotic symptoms at initiation of Seroquel XR (n, %)
15 Unknown  Effects of Seroquel XR on Sleep Architecture in Patients With Major Depressive Disorder
Condition: Major Depressive Disorder
Interventions: Drug: Quetiapine Fumarate Extended Release;   Other: healthy control
Outcome Measures: change from baseline Pittsburgh Quality Index total scores at 4 weeks;   change from baseline Pittsburgh Quality Index total scores at 2 weeks;   change from baseline Pittsburgh Quality Index total scores at 4 days;   change from baseline in sleep architecture measured using polysomnography at 4 weeks;   number of participants with adverse events
16 Recruiting Efficacy of Quetiapine for Pediatric Delirium
Condition: Delirium
Interventions: Drug: quetiapine;   Other: Placebo
Outcome Measures: Time to first resolution of delirium;   Total ICU days with delirium
17 Unknown  Heart Rate Changes in Schizophrenic and Bipolar Patients Under the Medication of Aripiprazole and Quetiapine
Conditions: Schizophrenia;   Bipolar
Intervention: Drug: Aripiprazole; Quetiapine
Outcome Measure:
18 Recruiting Trial Comparing Haloperidol, Quetiapine and Placebo in the Pharmacological Treatment of Delirium
Condition: Delirium
Interventions: Drug: Quetiapine;   Drug: Haloperidol;   Drug: Placebo
Outcome Measures: Time to first resolution of delirium;   Days in delirium during the study;   Duration of delirium;   Severity of delirium (highest Nu-DESC score, mean episode Nu-DESC score);   ICU and hospital mortality;   ICU and hospital length of stay;   Length of mechanical ventilation;   Time spent deeply sedated (RASS <3);   Episodes of subject-initiated device removal;   Use of haloperidol therapy (including total dose in haloperidol equivalents during the study, number of doses, number of days of therapy, use of rescue IV haloperidol);   Average daily and maximum total antipsychotic drug dose in haloperidol equivalents;   Duration of study drug administration;   Use of benzodiazepines;   Use of opioids;   QTc prolongation;   Extrapyramidal symptoms;   Neuroleptic malignant syndrome
19 Recruiting Comparative Efficacy and Acceptability of Antimanic Drugs in Acute Mania
Condition: Bipolar Disorder
Interventions: Drug: Lithium;   Drug: Valproate;   Drug: Oxcarbazepine;   Drug: Quetiapine;   Drug: Olanzapine;   Drug: Ziprasidone
Outcome Measures: Change from baseline in Young Mania Rating Scale at 2 weeks and 6 weeks;   rate of dropout (treatment discontinuation);   Clinical Global Impressions (CGI) Scale;   Brief Psychiatric Rating Scale;   Global Assessment Scale;   Treatment Emergent Symptom Scale;   Hamilton Anxiety Rating Scale;   Hamilton Depression Rating Scale
20 Unknown  Quetiapine for the Treatment of Insomnia in Alzheimer's Disease
Conditions: Alzheimer's Disease;   Insomnia
Intervention: Drug: quetiapine
Outcome Measures: The primary objective is to determine whether quetiapine can increase total sleep time and reduce time awake in patients with AD and sleep disturbance.;   Dose-response relationship of quetiapine and sleep in AD patients?;   Are there sleep architecture changes from quetiapine?;   Do the primary sleep variables change relative to placebo at any weekly time or dose point?;   Are caregivers, blind to treatment status, able to detect changes in sleep quality in the patients for quetiapine relative to placebo?;   Does quetiapine used at single bedtime dosing for potential nighttime soporific effect have a measurable impact on neuropsychiatric symptoms other than insomnia?