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MIGRAINE and Simvastatin

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MIGRAINE Symptoms and Causes

What are Migraines?

Migraines are a recurring type of headache. They cause moderate to severe pain that is throbbing or pulsing. The pain is often on one side of your head. You may also have other symptoms, such as nausea and weakness. You may be sensitive to light and sound.

Who gets Migraines?

About 12 percent of Americans get Migraines. They can affect anyone, but you are more likely to have them if you

  • Are a woman. Women are three times more likely than men to get Migraines.
  • Have a family history of Migraines. Most people with Migraines have family members who have Migraines.
  • Have other medical conditions, such as depression, anxiety, bipolar disorder, sleep disorders, and epilepsy.
What causes Migraines?

Researchers believe that Migraine has a genetic cause. There are also a number of factors that can trigger a Migraine, including

  • Stress
  • Anxiety
  • Hormonal changes in women
  • Bright or flashing lights
  • Loud noises
  • Strong smells
  • Medicines
  • Too much or not enough sleep
  • Sudden changes in weather or environment
  • Overexertion (too much physical activity)
  • Tobacco
  • Caffeine or caffeine withdrawal
  • Skipped meals
  • Medication overuse (taking medicine for Migraines too often)
  • Certain foods and food additives such as
    • Alcohol
    • Chocolate
    • Aged cheeses
    • Monosodium glutamate (MSG)
    • Some fruits and nuts
    • Fermented or pickled goods
    • Yeast
    • Cured or processed meats
What are the symptoms of Migraines?

There are four different phases of Migraines. You may not always go through every phase each time you have a Migraine.

  • Prodome. This phase starts up to 24 hours before you get the Migraine. You have early signs and symptoms, such as food cravings, unexplained mood changes, uncontrollable yawning, fluid retention, and increased urination.
  • Aura. If you have this phase, you might see flashing or bright lights or zig-zag lines. You may have muscle weakness or feel like you are being touched or grabbed. An aura can happen just before or during a Migraine.
  • Headache. A Migraine usually starts gradually and then becomes more severe. It typically causes throbbing or pulsing pain, which is often on one side of your head. But sometimes you can have a Migraine without a headache. Other Migraine symptoms may include
    • Increased sensitivity to light, noise, and odors
    • Nausea and vomiting
    • Worsened pain when you move, cough, or sneeze
  • Postdrome (following the headache). You may feel exhausted, weak, and confused after a Migraine. This can last up to a day.

Migraines are more common in the morning; people often wake up with them. Some people have Migraines at predictable times, such as before menstruation or on weekends following a stressful week of work.

How are Migraines diagnosed?

To make a diagnosis, your health care provider will

  • Take your medical history
  • Ask about your symptoms
  • Do a physical and neurological exam

An important part of diagnosing Migraines is to rule out other medical conditions which could be causing the symptoms. So you may also have blood tests, an MRI or CT scan, or other tests.

How are Migraines treated?

There is no cure for Migraines. Treatment focuses on relieving symptoms and preventing additional attacks.

There are different types of medicines to relieve symptoms. They include triptan drugs, ergotamine drugs, and pain relievers. The sooner you take the medicine, the more effective it is.

There are also other things you can do to feel better:

  • Resting with your eyes closed in a quiet, darkened room
  • Placing a cool cloth or ice pack on your forehead
  • Drinking fluids

There are some lifestyle changes you can make to prevent Migraines:

  • Stress management strategies, such as exercise, relaxation techniques, and biofeedback, may reduce the number and severity of Migraines. Biofeedback uses electronic devices to teach you to control certain body functions, such as your heartbeat, blood pressure, and muscle tension.
  • Make a log of what seems to trigger your Migraines. You can learn what you need to avoid, such as certain foods and medicines. It also help you figure out what you should do, such as establishing a consistent sleep schedule and eating regular meals.
  • Hormone therapy may help some women whose Migraines seem to be linked to their menstrual cycle
  • If you have obesity, losing weight may also be helpful

If you have frequent or severe Migraines, you may need to take medicines to prevent further attacks. Talk with your health care provider about which drug would be right for you.

Certain natural treatments, such as riboflavin (vitamin B2) and coenzyme Q10, may help prevent Migraines. If your magnesium level is low, you can try taking magnesium. There is also an herb, butterbur, which some people take to prevent Migraines. But butterbur may not be safe for long-term use. Always check with your health care provider before taking any supplements.

NIH: National Institute of Neurological Disorders and Stroke

Check out the latest treatments for MIGRAINE

MIGRAINE treatment research studies

Simvastatin clinical trials, surveys and public health registries


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Simvastatin Side Effects

Rhabdomyolysis (1169)
Myalgia (1039)
Renal Failure Acute (504)
Fatigue (491)
Blood Creatine Phosphokinase Increased (489)
Pain In Extremity (449)
Muscular Weakness (445)
Asthenia (394)
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Muscle Spasms (346)
Pain (328)
Dyspnoea (311)
Dizziness (304)
Nausea (281)
Fall (261)
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Gait Disturbance (243)
Alanine Aminotransferase Increased (241)
Headache (240)
Myositis (238)
Malaise (187)
Myopathy (180)
Back Pain (166)
Amnesia (163)
Vomiting (160)
Insomnia (157)
Depression (156)
Rash (154)
Aspartate Aminotransferase Increased (152)
Renal Failure (143)
Liver Function Test Abnormal (141)
Abdominal Pain (140)
Chest Pain (134)
Blood Creatinine Increased (133)
Confusional State (130)
Paraesthesia (126)
Hypoaesthesia (126)
Feeling Abnormal (123)
Memory Impairment (122)
Anxiety (117)
Myocardial Infarction (112)
Weight Decreased (111)
Pruritus (107)
Cough (107)
Condition Aggravated (106)
Cerebrovascular Accident (104)
Tendon Rupture (103)
Hepatic Enzyme Increased (101)
Mobility Decreased (98)
Abasia (98)

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Recent Reviews

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:(vvery dissy imsoniac light headness.................. =-O

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Blurred vision, like I was looking through water around the outside of my eyes, then very dizz, faint but not fainting--this has happened twice, I was shaky and weak after--it was frightening.....

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Hair loss

Has anyone taking this medication after a year,expierenced headaches?

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I am taking 40 mg of simvaststin and my hair is really falling out bad. it stated this after i've been on the drug for awhile. should i stop taking it to see will my hair stop coming out from the root?

My son was suffering from Head ache for the past one year. I have taken him to an ENT & he prescribed Sibelium 10 mg. & he was taking sibelium 3 months back for migraine and he was experiencing fatigue and drowsiness every day. Every t

<i>it was really painfull in my stomach after 5mins of taking ponstan,but i cant stop, to relieve pain for my terrible migraine!!! suggest please any medicine to replace PONSTAN,thanks!</i>

Is it effective for cases of migraine

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After receiving daily shots of Kenalog for 1 month for allergies and stopping, about a week later my blood pressure went from the usual 120/80 to an average 145/105 with migraine headaches. I had also gotten tiny bumps on my forehead. It lasted abou

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Aside from being on my 8th day of a migraine...I also have terrible aches in my legs and wozziness in my head at times. Almost like tunnel vision. Trouble sleeping, dreaming constantly. Shortness of breath and abnormally tired.

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Been on symbicort for three weeks, experiencing headaches and today have migraine, also leg (calf) cramps. for last two days have been having what feels like bronchospasms. Interestingly symptoms have worsened since increasing dose frequency under Dr

Did panandeine can use for migraine??? can get it at pharmacy??

MIGRAINE Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting MIBRAIN - Migraine and the Brain: Consequences, Causes, and Vascular Interaction
Condition: Migraine
Interventions: Device: MRI;   Device: EndoPAT;   Other: Neuropsychological battery
Outcome Measures: Differences in magnetic resonance imaging (MRI) between Migraine without aura and Migraine with aura patients (frequency of hyperintensities, white matter lesions....);   Differences in the Total Score of the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) between Migraine without aura and Migraine with aura patients.;   Differences in the Reactive Hyperemia Index (RHI) and the Augmentation Index (AI) between Migraine without aura and Migraine with aura patients;   Correlation between MRI and Total Score of RBANS with RHI / AI (endothelial function) between Migraine groups.
2 Recruiting Behavioral Weight Loss as a Treatment for Migraine in Obese Women
Conditions: Migraine;   Obesity
Interventions: Behavioral: Behavioral Weight Loss Intervention;   Other: Migraine Education
Outcome Measures: Change in the number of Migraine headache days;   Change in body weight;   Changes in serum inflammatory markers (C-reactive protein, Interleukin-6);   Changes in depression;   Changes in physical activity;   Changes in fat intake and other diet/eating behavior components
3 Recruiting One-Day Intervention for Depression and Impairment in Migraine Patients
Conditions: Migraine;   Depression
Interventions: Behavioral: ACT-ME;   Behavioral: Migraine Education Only
Outcome Measures: HRSD;   SCID-IV;   WHO-DAS-II;   WHO-QOL;   HDI
4 Unknown  Identification of Inflammatory Markers in Migraine Patients
Conditions: Inflammation;   Migraine;   Headache
Intervention:
Outcome Measures: To evaluate if the levels of inflammatory markers in patients with Migraine is higher compared to the levels of these markers in the control groups.;   To evaluate the levels of inflammatory markers in-between Migraine and other forms of headaches.
5 Recruiting Migraine and Body Composition
Conditions: Migraine With and Without Aura;   Chronic Migraine;   Healthy Controls
Intervention:
Outcome Measures: association between Migraine and obesity - evaluate serum adipokine levels;   association between Migraine and obesity -evaluate subcutaneous adipose tissue (SAT) and its ratio to visceral adipose tissue (VAT)
6 Unknown  Influence of a Dietary Supplement as Treatment of Migraine in Children and Adolescents
Condition: Migraine
Intervention: Dietary Supplement: Migra 3
Outcome Measures: number of days with headache before and after 12 weeks of daily treatment with a Migraine specific dietary supplement;   frequency, duration and intensity of the Migraine
7 Unknown  Treximet in Acute Migraine Headache: Assessing Cognitive Function
Conditions: Migraine Headache;   Cognitive Impairment
Interventions: Drug: Treximet;   Drug: Migraine rescue medication of choice
Outcome Measures: To evaluate the effectiveness of treatment with Treximet versus placebo in patients with acute Migraine headache on the neuropsychological function before treatment and at one and two hours after treatment of a Migraine.;   To assess incidence and types of neuropsychological deficits by MEWT in patients with acute Migraine headache before treatment.
8 Recruiting The Childhood and Adolescent Migraine Prevention Study
Conditions: Migraine;   Migraine Disorders;   Headache
Interventions: Drug: Amitriptyline;   Drug: Topiramate;   Drug: Placebo
Outcome Measures: Reduction in Migraine Frequency (amitriptyline and topiramate);   Reduction in absolute Migraine disability score on PedMIDAS;   Safety and tolerability of amitriptyline and topiramate;   Occurrence of treatment-emergent serious adverse events;   Reduction in absolute Migraine frequency days
9 Recruiting Acupuncture for Migraine Prophylaxis
Conditions: Migraine Without Aura;   Unilateral Headache
Intervention: Other: acupuncture
Outcome Measures: frequency of Migraine attacks;   headache severity
10 Recruiting A Non-Invasive Neuromodulation Device for Treatment of Migraine Headache
Condition: Migraine Headache, Episodic
Intervention: Device: neuromodulation for episodic Migraine headache
Outcome Measures: Number of monthly Migraine headache days;   Number of monthly Migraine headache days (reduction by by 50% or more);   Total monthly pain score;   Mood and cognition measures - Change in mood scores;   Verify the absence of material dizziness;   Mood and cognition measures - Change in cognitive speed scores;   Mood and cognition measures - Change in memory scores
11 Not yet recruiting Prediction of Migraine Prevention Efficacy: Individualization of Treatment by Coupling Drug's Mode of Action With Patient's Mechanism of Pain Modulation
Conditions: Migraine;   Preventive Treatment
Interventions: Drug: Amitriptyline;   Drug: placebo
Outcome Measures: the association between pre-treatment assessment parameter(s) and the reduction in frequency of Migraine attacks by amitriptyline;   the association between pain-related psychological parameters and the reduction in Migraine attacks by amitriptyline
12 Recruiting A Randomized, Parallel, Double-blind, Placebo-controlled Study of Vitamin D as Prophylactic Treatment for Migraine
Condition: Migraine According to International Headache Society (IHS) Criteria (ICHD-II)
Interventions: Drug: D3 Vitamin ®;   Drug: Placebo
Outcome Measures: The number of Migraine attacks;   Evaluation of pain during Migraine attacks;   Hypersensitivity;   Migraine Symptoms;   Quantitative Sensory Testing;   Measuring levels of a biomarker. Changes in the levels of these biomarkers.
13 Recruiting Does Treximet Improve Productivity and Patient Satisfaction Due to Sustained Response and Consistency of Response?
Condition: Workplace Migraine Treatment
Interventions: Drug: Usual prescribed triptan;   Drug: Treximet for Migraine treatment
Outcome Measures: workplace productivity compared between Migraines treated with usual triptan versus Migraines treated with Treximet;   comparison of patient completeness of response to Migraine treatments across 6 treated workplace Migraines
14 Recruiting TI-001 (Intranasal Oxytocin) for Treatment of Chronic Migraine
Condition: Chronic Migraine
Interventions: Drug: TI-001;   Drug: Placebo
Outcome Measures: Mean reduction in Migraine headache days;   Change in Migraine pain scores measured with a 4-point verbal rating scale;   Frequency of nausea;   Frequency of photophobia;   Frequency of phonophobia;   Frequency of Migraine episodes;   Time to study discontinuation due to any cause;   Frequency and severity of adverse events
15 Recruiting Pathway M-1: Sphenopalatine Ganglion Stimulation for the Treatment of Chronic or High Frequency, High Disability Migraine Headache
Conditions: Chronic Migraine;   High Frequency, High Disability Migraine
Intervention: Device: ATI Neurostimulation System
Outcome Measures: Major Device- and Surgical-Related Complications;   Effective Therapy;   Headache Frequency;   Pain Relief at 1 Hour;   Pain Freedom at 1 Hour;   Migraine Associated Symptom Relief at 1 Hour;   Disability and Quality of Life;   Global Evaluation of SPG Stimulation Therapy;   Prophylactic Medication Use;   Acute Medication Use
16 Unknown  Inflammatory Markers Identification in Migraine Patients
Conditions: Inflammation;   Migraine;   Headache
Intervention:
Outcome Measure:
17 Unknown  The Efficacy and Safety of Intra-oral Topical Ketoprofen for the Treatment of Acute Migraine
Conditions: Migraine Disorders;   Migraine Headache;   Migraine;   Acute Migraine
Interventions: Drug: Topical, intra-oral ketoprofen gel;   Other: Placebo gel
Outcome Measures: Pain relief (defined as at least 2 graded reduction in a 5-grade scale) at 120 minutes post-treatment;   Pain free status at 30, 60, 120, and 240 minutes post-treatment based on headache severities reported in patient's journals;   Pain relief at 30, 60, and 240 minutes post-treatment based on headache severities reported in patient's journals;   Relief of Photophobia at 30, 60, 120, and 240 minutes post-treatment;   Relief of Phonophobia at 30, 60, 120, and 240 minutes post-treatment;   Relief of Nausea at 30, 60, 120 and 240 minutes post-treatment;   Relief of Vomiting 30, 60, 120 and 240 minutes post-treatment;   Need for Rescue Medication between the time of dosing to 240 minutes
18 Recruiting PACAP Induced Migraine Attacks in Patients With High and Low Genetic Load
Condition: Migraine Without Aura
Intervention: Drug: PACAP
Outcome Measures: PACAP induced Migraine attacks in patients with high and low genetic load.;   PACAP induced Migraine attacks in patients with high and low genetic load
19 Recruiting Clopidogrel For the Prevention of New Onset Migraine Headache Following Transcatheter Closure of Atrial Septal Defects
Condition: Migraine
Intervention: Drug: Clopidogrel
Outcome Measures: Mean number of monthly Migraine days per patient within the 3 months following transcatheter ASD closure.;   Severity of Migraine attacks following ASD closure as evaluated by the intensity of Migraine episodes and the Migraine Disability Assessment (MIDAS) questionnaire at 3-month follow-up after ASD closure.;   Incidence of bleeding complications at 3-month follow-up.;   Percentage of patients with new-onset Migraine attacks.;   Time to first Migraine episode.;   Percentage of patients with Migraine headaches at 6-month and 1-year follow-up (exploratory only according to local feasibility).
20 Recruiting A Randomized, Placebo-Controlled, Double-blind Study of Tianshu Capsule in the Treatment of Migraine.
Condition: Migraine
Interventions: Drug: Tianshu capsule;   Drug: Sugar pill
Outcome Measures: Change in the frequency of attack of Migraine Per 4 weeks at Week 16 from baseline;   Change in seizure duration of Migraine Per 4 weeks at Week 16 from baseline.;   Change in degree of pain of Migraine Per 4 weeks at Week 16 from baseline.;   Change in the days using acute therapy of Migraine Per 4 weeks at Week 16 from baseline.;   Proportion of subjects whose number or days of Migraine attacks reduce at least 50%.;   Change in number of concomitant migrainous symptoms attacks Per 4 weeks at Week 16 from baseline.;   Safety assessments will be based on adverse event reports and the results of vital sign measurements, electrocardiogram, and clinical laboratory tests.