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MIGRAINE and Tylenol

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MIGRAINE Symptoms and Causes

What are Migraines?

Migraines are a recurring type of headache. They cause moderate to severe pain that is throbbing or pulsing. The pain is often on one side of your head. You may also have other symptoms, such as nausea and weakness. You may be sensitive to light and sound.

Who gets Migraines?

About 12 percent of Americans get Migraines. They can affect anyone, but you are more likely to have them if you

  • Are a woman. Women are three times more likely than men to get Migraines.
  • Have a family history of Migraines. Most people with Migraines have family members who have Migraines.
  • Have other medical conditions, such as depression, anxiety, bipolar disorder, sleep disorders, and epilepsy.
What causes Migraines?

Researchers believe that Migraine has a genetic cause. There are also a number of factors that can trigger a Migraine, including

  • Stress
  • Anxiety
  • Hormonal changes in women
  • Bright or flashing lights
  • Loud noises
  • Strong smells
  • Medicines
  • Too much or not enough sleep
  • Sudden changes in weather or environment
  • Overexertion (too much physical activity)
  • Tobacco
  • Caffeine or caffeine withdrawal
  • Skipped meals
  • Medication overuse (taking medicine for Migraines too often)
  • Certain foods and food additives such as
    • Alcohol
    • Chocolate
    • Aged cheeses
    • Monosodium glutamate (MSG)
    • Some fruits and nuts
    • Fermented or pickled goods
    • Yeast
    • Cured or processed meats
What are the symptoms of Migraines?

There are four different phases of Migraines. You may not always go through every phase each time you have a Migraine.

  • Prodome. This phase starts up to 24 hours before you get the Migraine. You have early signs and symptoms, such as food cravings, unexplained mood changes, uncontrollable yawning, fluid retention, and increased urination.
  • Aura. If you have this phase, you might see flashing or bright lights or zig-zag lines. You may have muscle weakness or feel like you are being touched or grabbed. An aura can happen just before or during a Migraine.
  • Headache. A Migraine usually starts gradually and then becomes more severe. It typically causes throbbing or pulsing pain, which is often on one side of your head. But sometimes you can have a Migraine without a headache. Other Migraine symptoms may include
    • Increased sensitivity to light, noise, and odors
    • Nausea and vomiting
    • Worsened pain when you move, cough, or sneeze
  • Postdrome (following the headache). You may feel exhausted, weak, and confused after a Migraine. This can last up to a day.

Migraines are more common in the morning; people often wake up with them. Some people have Migraines at predictable times, such as before menstruation or on weekends following a stressful week of work.

How are Migraines diagnosed?

To make a diagnosis, your health care provider will

  • Take your medical history
  • Ask about your symptoms
  • Do a physical and neurological exam

An important part of diagnosing Migraines is to rule out other medical conditions which could be causing the symptoms. So you may also have blood tests, an MRI or CT scan, or other tests.

How are Migraines treated?

There is no cure for Migraines. Treatment focuses on relieving symptoms and preventing additional attacks.

There are different types of medicines to relieve symptoms. They include triptan drugs, ergotamine drugs, and pain relievers. The sooner you take the medicine, the more effective it is.

There are also other things you can do to feel better:

  • Resting with your eyes closed in a quiet, darkened room
  • Placing a cool cloth or ice pack on your forehead
  • Drinking fluids

There are some lifestyle changes you can make to prevent Migraines:

  • Stress management strategies, such as exercise, relaxation techniques, and biofeedback, may reduce the number and severity of Migraines. Biofeedback uses electronic devices to teach you to control certain body functions, such as your heartbeat, blood pressure, and muscle tension.
  • Make a log of what seems to trigger your Migraines. You can learn what you need to avoid, such as certain foods and medicines. It also help you figure out what you should do, such as establishing a consistent sleep schedule and eating regular meals.
  • Hormone therapy may help some women whose Migraines seem to be linked to their menstrual cycle
  • If you have obesity, losing weight may also be helpful

If you have frequent or severe Migraines, you may need to take medicines to prevent further attacks. Talk with your health care provider about which drug would be right for you.

Certain natural treatments, such as riboflavin (vitamin B2) and coenzyme Q10, may help prevent Migraines. If your magnesium level is low, you can try taking magnesium. There is also an herb, butterbur, which some people take to prevent Migraines. But butterbur may not be safe for long-term use. Always check with your health care provider before taking any supplements.

NIH: National Institute of Neurological Disorders and Stroke

Check out the latest treatments for MIGRAINE

MIGRAINE treatment research studies

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Recent Reviews

Broke out in hives and itching for hours even benadryl wouldn't help

Hello, over the past one or two years i have been suffering from VERY bad miagrains. I have been to my docter about it however he says quote ' its like finding a needle in a hay stack to narrow it down to what could be wrong' therefore i would real

I am told I have miagraines I feel my ead is going to explode feel very sick but am not light sensitive can it still be miagraine. I can not walk as in to much pain and noise really affects me!! this is the first time its happened and am a fit 20 ye

I get chronic headaches and migraines (yes, I have been advised to see a neurologist). I became ill with a headache saturday (may 14, 2011) afternoon and went to bed early hoping I could sleep it off. I kept waking up through the evening with little

Since starting levothyroxine (11 days) I have had two migraines and three occular migraines. I'm thinking I should get off the medication and suffer with being cold.

When i used to cry i got migrain aatack nd this is often takes place is dis normal ?

My son was suffering from Head ache for the past one year. I have taken him to an ENT & he prescribed Sibelium 10 mg. & he was taking sibelium 3 months back for migraine and he was experiencing fatigue and drowsiness every day. Every t

<i>it was really painfull in my stomach after 5mins of taking ponstan,but i cant stop, to relieve pain for my terrible migraine!!! suggest please any medicine to replace PONSTAN,thanks!</i>

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Been on symbicort for three weeks, experiencing headaches and today have migraine, also leg (calf) cramps. for last two days have been having what feels like bronchospasms. Interestingly symptoms have worsened since increasing dose frequency under Dr

Did panandeine can use for migraine??? can get it at pharmacy??

MIGRAINE Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Unknown  Analgesic Effect of Paracetamol, Paracetamol + Codeine, Ibuprofen and Their Combination
Condition: Pain, Postoperative
Interventions: Drug: Ibuprofen + Paracetamol;   Drug: Ibuprofen + Paracetamol + Codeine;   Drug: Paracetamol + Codeine;   Drug: Placebo
Outcome Measures: Sum pain intensity SPI (0-10 Numerical Rating Scale);   Sum pain intensity difference score (PID);   Overall assessment of efficacy (4-point Verbal Rating Scale);   Adverse effects AE (Specific reporting of AE - type, duration and severity)
2 Not yet recruiting Equality Study of Ofirmev vs Oral Acetaminophen
Condition: Pain, Postoperative
Interventions: Drug: IV acetaminophen;   Drug: oral acetaminophen
Outcome Measures: Primary outcome will measure total opioid consumption while the patient is in the PACU;   time from PACU admission to request for first opioid dose
3 Unknown  Acetaminophen for Cancer Pain
Conditions: Cancer;   Pain
Interventions: Drug: Acetaminophen;   Drug: acetaminophen;   Drug: placebo, sugar pill
Outcome Measures: Patient preference for the acetaminophen or the placebo arm as assessed by asking the patient whether he/she preferred treatment period 1 or treatment period 2;   Differences in the mean pain intensity score as assessed by the daily average Numeric Rating Scale (NRS) pain score during the week given acetaminophen compared with the daily average NRS pain score during the week given placebo;   Symptoms possibly associated with acetaminophen use for each period using an NRS: feeling sick (nausea and vomiting);   drowsiness;   constipation;   cold sweats;   overall sense of well being;   Total analgesic consumption in each treatment period;   Best and worst pain scores for each treatment period;   Pain relief obtained in each treatment period;   Effect of pain on functional ability;   Strength of preference for acetaminophen versus placebo on a 5-point scale;   Proportion of patients who had a preference for acetaminophen who perceived the improvement warranted taking the additional tablets;   Proportion of patients having a clinically significant improvement in pain (defined as an improvement in mean NRS of at least 33% during the week taking acetaminophen)
4 Recruiting Intraoperative and Post-operative Analgesic Effect of IV Acetaminophen for Sinus Surgery
Condition: Chronic Sinusitis
Interventions: Drug: IV Acetaminophen;   Drug: Placebo
Outcome Measures: Assess the efficacy of IV acetaminophen in controlling postoperative pain;   Investigate the effect of IV acetaminophen on the use of postoperative opioid analgesics;   Analyze effects of IV acetaminophen on intraoperative analgesic use;   Identify potential correlation between vital signs and postoperative pain intensity;   Examine the effect of IV acetaminophen on post-operative quality of recovery
5 Recruiting Paracetamol (Acetaminophen) for Closure of PDA in Preterm Infants
Condition: PDA
Interventions: Drug: Paracetamol;   Drug: Ibuprofen;   Procedure: Closure of PDA
Outcome Measures: Closure of arterial duct - yes / No;   Need for surgical closure of arterial duct
6 Recruiting Paracetamol Effect on Oxidative Stress and Renal Function in Severe Malaria
Condition: Malaria
Interventions: Drug: Paracetamol;   Drug: No Paracetamol
Outcome Measures: Effect of paracetamol concentrations;   Compare treatment arm with control arm with respect to duration of Acute Kidney Injury (AKI) and development of AKI.;   Oxidative stress assessed by measuring F2-isoprostanes (F2-IsoPs);   Assessment of Blackwater fever;   Mortality trends;   Intravascular Haemolysis;   Fever clearance time;   Parasite clearance time;   Parasite sequestration;   Assessment of Acute Kidney Injury;   Creatinine clearance;   Safety assessment
7 Recruiting Slow Initial β-lactam Infusion With High-dose Paracetamol to Improve the Outcomes of Childhood Bacterial Meningitis
Condition: Bacterial Meningitis
Interventions: Drug: Infusion with paracetamol;   Drug: Bolus without paracetamol
Outcome Measures: Mortality;   Status on the modified Glasgow Outcome Scale;   Death or any sequelae;   A change in hearing threshold compared to the first test result;   Death or severe neurological sequelae;   Deafness
8 Unknown  Paracetamol for Cancer Pain
Conditions: Advanced Cancer;   Opioid Use, Unspecified
Interventions: Drug: paracetamol;   Drug: placebo tablets
Outcome Measures: Pain reduction caused by paracetamol 4g/d;   Overall satisfaction with the pain treatment
9 Recruiting Clinical Study Comparing the Efficacy of Transbuccal Paracetamol 125 mg Versus Paracetamol Injection 1g in Slow Infusion IV in Patients With Acute Pain
Condition: Acute Pain
Interventions: Drug: paracetamol;   Drug: Placebo
Outcome Measure: Pain score measured by visual analogue scale
10 Unknown  The Effect of Single Dose Paracetamol on the Lower Airways of Asthmatic and Healthy Children
Condition: Asthma
Intervention: Drug: paracetamol
Outcome Measure: A measurable change in lung functions in response to paracetamol exposure.
11 Recruiting Prospective, Randomized, Double Blind Study Comparing IV vs PO Acetaminophen in Patients Undergoing Lumbar Discectomy
Condition: Pain
Interventions: Drug: oral acetaminophen;   Drug: intravenous acetaminophen
Outcome Measures: Postoperative pain scores;   Quantity of intraoperative and postoperative opioids administered.
12 Recruiting Can Acetaminophen Given 1-2 Hours to Children Before Ear Tube Surgery Reduce Agitation After Anesthesia?
Conditions: Emergence Agitation;   Pain
Intervention: Drug: Acetaminophen
Outcome Measures: Emergence Agitation;   Pain
13 Recruiting Analgesic Efficacy of Intravenous Acetaminophen After Video-assisted Thoracic Surgery
Condition: Video-assisted Thoracic Surgery
Interventions: Drug: IV Acetaminophen;   Drug: Saline Placebo
Outcome Measures: Total morphine consumption;   Number of PCA morphine bolus requests;   Pain Scores;   Vital signs
14 Recruiting A Prospective, Randomized, Double Blind, Comparative-effectiveness Study Comparing Perioperative Administration of Oral Versus Intravenous Acetaminophen for Laparoscopic Cholecystectomy
Condition: Laparoscopic Cholecystectomy
Interventions: Drug: 2 capsules Oral Tylenol 2000 mg and IV "salt water";   Drug: IV Tylenol 1000mg and 2 oral capsule "sugar pills"
Outcome Measures: Pain;   Opioid Use
15 Not yet recruiting Adding Paracetamol to Ibuprofen for Treatment of Patent Ductus Arteriosus in Preterm Infants
Condition: Hemodynamically Significant Patent Ductus Arteriosus in Preterm Infants
Interventions: Drug: Paracetamol;   Drug: Placebo
Outcome Measures: The incidence of patent ductus arteriosus closure;   The need for surgical ligation for PDA;   Adverse effects
16 Recruiting Intravenous Acetaminophen for Non-Narcotic Postoperative Pain Management Following Knee Arthroscopy
Condition: Pain, Postoperative
Intervention: Drug: Intravenous Acetaminophen
Outcome Measures: Postoperative pain levels;   Postoperative opioid consumption
17 Recruiting Intravenous Acetaminophen in Craniotomy
Condition: Postoperative Pain
Interventions: Drug: Acetaminophen;   Drug: Placebo
Outcome Measures: Post-Operative Opioid Requirement;   Intra-Operative Opioid Requirement;   Post-Operative Pain;   Post-Operative Side Effects
18 Recruiting Efficacy of IV Acetaminophen for Pain Management
Condition: Post-operative Pain
Interventions: Drug: Placebo (normal saline);   Drug: IV acetaminophen
Outcome Measures: Amount of opioid rescue needed;   Time to return of bowel function (passage of flatus);   Patient Satisfaction;   Cost Effectiveness
19 Recruiting Acetaminophen Versus Ibuprofen in Children With Asthma
Conditions: Asthma;   Wheezing
Interventions: Drug: Acetaminophen;   Drug: Ibuprofen
Outcome Measure: exacerbation frequency
20 Recruiting The Efficacy of Intravenous Acetaminophen During The Perioperative Period Of Neurosurgical Patients Undergoing Craniotomies
Conditions: Craniotomy;   Brain Surgery
Interventions: Drug: Acetaminophen;   Drug: Placebo
Outcome Measures: Opioid requirement after surgery;   Time to rescue medication in both groups;   Amount of rescue medication in PACU in both groups;   Median difference in ICU length of stay/hospital length of stay between both groups;   Number of successful neurologic exams between intervention and placebo group as determined by a neurosurgical provider by answering either Yes or No;   Median difference in temperature between intervention and placebo groups;   Sedation scores measured by RASS every 8 hours for 24 hours in both groups;   Pain VAS scores (1-10) every 8 hours for 24 hours in both groups;   Delirium measured by CAM-ICU every 8 hours for 24 hours in both groups