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MUSCLE SPASMS and Clonidine

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MUSCLE SPASMS Symptoms and Causes

Angina is chest pain or discomfort you feel when there is not enough blood flow to your heart muscle. Your heart muscle needs the oxygen that the blood carries. Angina may feel like pressure or a squeezing pain in your chest. It may feel like indigestion. You may also feel pain in your shoulders, arms, neck, jaw, or back.

Angina is a symptom of coronary artery disease (CAD), the most common heart disease. CAD happens when a sticky substance called plaque builds up in the arteries that supply blood to the heart, reducing blood flow.

There are three types of angina:

  • Stable angina is the most common type. It happens when the heart is working harder than usual. Stable angina has a regular pattern. Rest and medicines usually help.
  • Unstable angina is the most dangerous. It does not follow a pattern and can happen without physical exertion. It does not go away with rest or medicine. It is a sign that you could have a heart attack soon.
  • Variant angina is rare. It happens when you are resting. Medicines can help.

Not all chest pain or discomfort is angina. If you have chest pain, you should see your health care provider.

NIH: National Heart, Lung, and Blood Institute

Check out the latest treatments for MUSCLE SPASMS

MUSCLE SPASMS treatment research studies

Clonidine clinical trials, surveys and public health registries


Find Drug Side Effect reports



Clonidine Side Effects

Blood Pressure Increased (136)
Completed Suicide (121)
Hypotension (117)
Hypertension (95)
Product Adhesion Issue (72)
Headache (68)
Product Substitution Issue (64)
Dizziness (62)
Dyspnoea (55)
Product Quality Issue (54)
Poisoning (53)
Bradycardia (52)
Death (49)
Cardiac Arrest (47)
Nausea (45)
Somnolence (43)
Dry Mouth (42)
Fatigue (41)
Anxiety (40)
Asthenia (39)
Overdose (38)
Pain (35)
Agitation (34)
Feeling Abnormal (32)
Suicide Attempt (31)
Lethargy (31)
Depression (30)
Heart Rate Increased (30)
Sinus Bradycardia (30)
Loss Of Consciousness (29)
Hypertensive Crisis (29)
Vomiting (28)
Respiratory Arrest (28)
Chest Pain (26)
Blood Pressure Decreased (25)
Syncope (25)
Convulsion (24)
Cardio-respiratory Arrest (24)
Rash (23)
Application Site Rash (23)
Blood Pressure Inadequately Controlled (22)
Insomnia (22)
Cerebrovascular Accident (22)
Hyperhidrosis (21)
Accidental Overdose (20)
Tachycardia (20)
Application Site Pruritus (20)
Hypersensitivity (19)
Tremor (19)
Sedation (19)

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Common Meds

Abilify (10132)
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Wellbutrin (6324)
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Zocor (5718)
Zoloft(6792)
Zyrtec(1669)

Recent Reviews

After taking clonidine 0.1mg cut 9in half, for two dauys, twicw a day: it felt like a I had a terrible gastric ulcer. i TOOK IYT WITH A MEAL AND DRANK 10 OUNCES OF WATER. i took it again the next day with the same result. Do they

Anxiety and waking dreams about mouth. The dryness of mouth so annoying tha the reason for taking med not worth discomfort.

Calf twitches

Calfs constly twitching

Head, ears, throat, too tired, hate to take it.....Dr. said it is a nasty pill but still prescribed it. also, constipation/ loose stools. stomach discomfort....leg / foot spasms at night

I am feeling drowsy,weak, and my heart is racing. is that suppose to happen?

I find this medication terrible. I dont know aboutanyone else but I have found that my body has become addictived to this drug. I have only been on this drug since June 18, 2010. I am on the patch 2mg plusone 1 mg tablet 2x per da

I have been taking Metoprolol tar 25mg for the past six year my muscles have been hurting. If I set for a while its hard for me to get up and get moving. But Im in constant pain daily. It's been eight month since I stop taking them and im s

I just had my first shots of xolair 2wks ago. within the first few days I had some spasms in the right side of my back. i also exoerienced spasms in my left hand within those same few days. since then my left eye has been twitching every day.

I just started on Clonidine for excessive sweating of the scalp and face, but also for insomnia. I had to take .3 mg to get sleepy. I woke up this morning with several canker like sores on the inside of my lips. Anyone else had this happen? I als

<b><span style='font-weight: normal;'><b>After 6 weeks of oral lamisil I experienced</b>eczema, muscle weakness, asthma, bloody bowels, lower abdominal pain, dizziness, extreme f

muscle cramping when in a dead sleep

I just had the infusion two days ago (1/19/10) and was surprised with the intensity of muscle pain the day after the treatment. My pain was localized to my rib cage, neck, shoulders and upper back. In addition I was very fatiqued...slept most of

I started taking this medicine geodon 40 mg once a day. Then i notice i was blinking a lot. Then i started having eye muscle spasms several times a day.Now i have to go to the eye dr.I stop taking the medicine. Til I see what the dr.says.

I was having frequent leg cramps. They worked their way from my foot up to my thigh. I just thought it was from stopping the use of muscle relaxers ( for a serious back and neck problem). I had forgotten about them and never mentioned it to either

I am having cramps, muscle pain, memory loss, I have been on Revlmid for about 1 year. Does anybody else my age have this disease, I am only 46 yr woman.

one 10 mg pill cuased presure in thechest bad muslespasms in the back think past doses has sent me skizzo

<b>Describe Your Pravastatin Experience Here:</b> I have been on 20 mg since Jan. And have been having muscle pain in the back of the thighs? Has anyone felt muscle pain in that area. Don't know if it is from medication or exercise

I received an injection close to my shoulder blade June 16, 2010. Three months later, I have an indentation and my health care provider has indicated that perhaps the muscle has scare tissue and the indentation and disc

<span style='color: #808080;'><b>I experienced severe neck spasms the day after receiving my second shot of Gardasil. It's been 2 days with no releif. The doctor did not inform me of the side effects in fact she said '

MUSCLE SPASMS Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Not yet recruiting Safety of Clonidine in Infants With Hypoxic Ischemic Encephalopathy During Therapeutic Hypothermia
Condition: Encephalopathy, Hypoxic-Ischemic
Intervention: Drug: Clonidine (Duraclon®)
Outcome Measures: Maximum-tolerated dose of Clonidine;   Clonidine Plasma levels;   Time to onset of shivering after Clonidine;   shivering
2 Not yet recruiting The Effect of Clonidine-enhanced Sedation on Delirium in Ventilated Critically Ill Patients
Condition: Delirium
Interventions: Drug: Clonidine;   Drug: SodiumChloride
Outcome Measures: CAM-ICU (Confusion Assessment Method for the Intesive Care Unit);   Signs of agitation;   Opiate use;   Sedative use;   Anti-psychotic use;   Ventilation free days;   Sedation free days
3 Not yet recruiting Comparison of Epidural Fentanyl and Clonidine for Breakthrough Pain
Condition: Labor Pain
Interventions: Drug: Clonidine or Fentanyl;   Drug: Clonidine or fentanyl
Outcome Measures: Pain Score on a VAS scale;   Maternal blood pressure;   Maternal heart rate;   Neonatal Apgar score;   Number of spontaneous vaginal deliveries
4 Recruiting A Comparison of Ropivacaine Alone Versus Combination of Dexamethasone and Clonidine for Block
Condition: Upper Extremity Fracture
Interventions: Drug: Ropivacaine;   Drug: Ropivacaine and dexamethasone;   Drug: Ropivacaine, dexamethasone, Clonidine;   Drug: Ropivacaine and Clonidine
Outcome Measures: Duration of the supraclavicular block;   Postoperative analgesia
5 Recruiting Combination of Dronabinol and Clonidine for Cannabis Dependence in Patients With Schizophrenia
Conditions: Cannabis Dependence;   Marijuana Dependence
Interventions: Drug: Dronabinol;   Drug: Clonidine;   Drug: Placebo
Outcome Measures: Change from baseline in cannabis use at 10 weeks;   Change in withdrawal symptoms from baseline at 10 weeks;   Change from baseline in cannabis use at 14 weeks;   Change in withdrawal symptoms from baseline at 14 weeks
6 Unknown  Use of Transdermal Clonidine in Trauma Patients
Condition: Delirium
Interventions: Drug: Clonidine;   Drug: Placebo
Outcome Measures: Duration of mechanical ventilation following administration of the first dose of Clonidine or placebo;   Incidence and duration in hours of delirium currently used;   Time to pass first SBT following administration of the first dose of Clonidine or placebo;   Mean incidence and duration of delirium
7 Recruiting Effectiveness of Perineural Clonidine as an Adjuvant With Ropivacaine for Popliteal Nerve Block in Patients Undergoing Foot and Ankle Surgery
Condition: Pain
Interventions: Drug: Clonidine;   Drug: ropivacaine
Outcome Measures: Compare the onset of sensory and motor block between the control group and the control group;   Compare the duration of sensory and motor block between the control group and the control group;   Compare the mean VAS scores at 24 hours post procecure to determine the effectiveness of perineural Clonidine on duration of postoperative analgesia;   Compare the number of subjects taking postoperative opioids to determine the effect of perineural Clonidine versus placebo;   Compare the subjects mean blood pressure effect of perineural Clonidine versus placebo;   number of subjects in each group requiring sedation;   Determine the effect of perineural Clonidine versus placebo on time to discharge;   Determine the effect of perineural Clonidine versus placebo on postoperative time to first analgesic intake;   Compare the mean VAS scores at 24 hours post procedure to determine the patient satisfaction of perineural Clonidine on duration of postoperative analgesia
8 Recruiting Solifenacin Compared to Clonidine for Reducing Hot Flashes Among Breast Cancer Patients
Conditions: Hot Flashes;   Breast Cancer
Interventions: Drug: solifenacin;   Drug: Clonidine
Outcome Measures: hot flash composite and frequency scores (daily diary);   number of clinician-rated adverse events;   daily functioning (Hot Flash-Related Daily Interference score);   sleep (Insomnia Severity Index);   quality of life (Illness Cognition Questionnaire, SF-12)
9 Recruiting Efficacy of Clonidine and Propranolol in Dentistry (AAA)
Condition: Anxiety
Interventions: Drug: Clonidine;   Drug: Propranolol;   Drug: Placebo
Outcome Measures: Change from baseline in modified dental anxiety scale(MDAS)and vital signs (blood pressure, heart rate, respiratory rate, oxygen saturation) until four hours post treatment;   Changes in Verbal Numerical Rating Scale (VNRS) at three, six, and twenty-four hours post treatment
10 Unknown  Neonatal Spinal Anesthesia: Effects of the Addition of Clonidine
Conditions: Spinal Anesthesia;   Neonates
Intervention: Drug: Clonidine
Outcome Measures: number of "rescue" general anesthesia;   apnea and desaturation occurrence;   duration of spinal anesthesia
11 Recruiting The Addition of Clonidine to 0.2% Ropivacaine for Wound Instillation After Minor Lower Abdominal Surgery in Children
Conditions: Hernia, Inguinal;   Hydrocele
Intervention: Drug: Clonidine
Outcome Measures: Time to first analgesia after procedure;   continuous pain scores (modified Children's Hospital of Eastern Ontario Pain Score [mCHEOPS], modified Wong-Baker Faces);   sedation scores;   emergence delirium score (Pediatric Anesthesia Emergence Delirium [PAED]);   total analgesics consumed;   total sedation consumed
12 Recruiting Assessment of the Effect of Clonidine for Cataract Surgery
Conditions: Pain;   Arrythmia
Interventions: Drug: Clonidine;   Drug: placebo
Outcome Measures: intensity of pain;   intraocular pressure
13 Recruiting Added Value of Local Clonidine for Spine Postoperative Pain Control, in Addition to Bupivacaine
Condition: Post-operative Pain
Interventions: Drug: Bupivacaine;   Drug: Clonidine
Outcome Measures: Mean Area under curve;   Area under Curve (AUC) of pain;   Daily rescue opiates consumption;   Global subjective patient satisfaction of post-operative wound pain control
14 Not yet recruiting Oral Clonidine & Gabapentin: Improving Recovery and Pain Management After Outpatient With Major Orthopedic Surgery
Conditions: Shoulder Arthroscopy;   Knee Arthroscopy
Interventions: Drug: Sugar pill;   Drug: Gabapentin;   Drug: Clonidine
Outcome Measures: Postoperative Pain using a Verbal Rating Scale (VRS);   Opioid consumption obtained from the recorded data;   postoperative nausea and vomiting using a Verbal Rating Scale;   return to normal activities of daily living using follow up questionnaires;   Patient satisfaction using a verbal rating scale from 0 to 100
15 Recruiting Clonidine for Relapse Prevention in Buprenorphine-Maintenance Patients
Condition: Opioid-Related Disorders
Interventions: Drug: Clonidine;   Drug: Placebo
Outcome Measures: Opiate-negative urine screens;   HIV risk behaviors;   Craving
16 Unknown  Clonidine in Femoral Nerve Block Surgery in Children
Condition: Other Reconstructive Surgery
Interventions: Drug: Ropivacaine;   Drug: Clonidine
Outcome Measures: Pain;   Heart rate;   Blood pressure;   Oxygen saturation
17 Recruiting The Oslo Study of Clonidine in Elderly Patients With Delirium
Condition: Delirium
Interventions: Drug: Clonidine;   Drug: Placebo
Outcome Measures: MDAS (Memorial delirium assessment scale);   Time-to-first delirium;   Incidence of "full-scale" delirium;   Severity of delirium;   Delirium subtype;   The use of "rescue medication";   Length of hospital stay;   Patient distress;   Side effects of Clonidine;   Pharmacokinetic response to Clonidine;   Pharmacodynamic response to Clonidine;   Biomarkers;   Institutionalization;   Survival;   Cognitive function/ independence
18 Recruiting The Value of Adding Either Meperdine or Fentanyl to Clonidine-bupivacaine
Condition: Amputation Stumps
Interventions: Drug: Meperdine;   Drug: Fentanyl
Outcome Measures: the hemodynamic effects .;   the analgesic efficacy.
19 Recruiting Efficacy and Safety Study of Clonidine Lauriad® to Treat Oral Mucositis
Condition: Oral Mucositis
Interventions: Drug: Clonidine Lauriad® 50µg;   Drug: Clonidine Lauriad® 100µg;   Drug: Placebo Lauriad®
Outcome Measures: Percentage of patients with an oral mucositis score≥ 3 using the WHO scale at cumulative radiation dose of 50 Gy;   Percentage of patients with an oral mucositis score≥ 3 using the WHO scale at cumulative radiation doses of 40 Gy and 60 Gy
20 Recruiting Safety and Efficacy Study of Clonidine Hydrochloride Topical Gel, 0.1% in the Treatment of Pain Associated With Diabetic Neuropathy
Conditions: Painful Diabetic Neuropathy;   Diabetic Neuropathy;   Neuropathy
Intervention: Drug: Clonidine Gel 0.1%
Outcome Measures: Change in average pain score over time.;   Mean daily average pain intensity Numeric Pain Rating Scale scores over time.;   Mean daily worst pain intensity Numeric Pain Rating Scale scores