PatientsVille.com Logo

MUSCULAR WEAKNESS and Methadone

PatientsVille

MUSCULAR WEAKNESS Symptoms and Causes

Myasthenia gravis is a disease that causes weakness in your voluntary muscles. These are the muscles that you control. For example, you may have weakness in the muscles for eye movement, facial expressions, and swallowing. You can also have weakness in other muscles. This weakness gets worse with activity, and better with rest.

Myasthenia gravis is an autoimmune disease. Your body's immune system makes antibodies that block or change some of the nerve signals to your muscles. This makes your muscles weaker.

Other conditions can cause muscle weakness, so myasthenia gravis can be hard to diagnose. Tests used to make a diagnosis include blood, nerve, muscle, and imaging tests.

With treatment, the muscle weakness often gets much better. Medicines can help improve nerve-to-muscle messages and make muscles stronger. Other drugs keep your body from making so many abnormal antibodies. These medicines can have major side effects, so they should be used carefully. There are also treatments which filter abnormal antibodies from the blood or add healthy antibodies from donated blood. Sometimes, surgery to take out the thymus gland helps.

Some people with myasthenia gravis go into remission. This means that they do not have symptoms. The remission is usually temporary, but sometimes it can be permanent.

NIH: National Institute of Neurological Disorders and Stroke

Check out the latest treatments for MUSCULAR WEAKNESS

MUSCULAR WEAKNESS treatment research studies

Methadone clinical trials, surveys and public health registries


Find Drug Side Effect reports



Methadone Side Effects

Toxicity To Various Agents (601)
Cardiac Arrest (334)
Respiratory Arrest (316)
Completed Suicide (256)
Overdose (197)
Death (147)
Electrocardiogram Qt Prolonged (142)
Torsade De Pointes (97)
Respiratory Depression (82)
Cardio-respiratory Arrest (73)
Somnolence (65)
Accidental Overdose (59)
Nausea (57)
Pulmonary Oedema (57)
Loss Of Consciousness (54)
Vomiting (51)
Confusional State (47)
Pneumonia (40)
Dyspnoea (39)
Syncope (39)
Mental Status Changes (38)
Pain (37)
Fall (37)
Sedation (36)
Bronchopneumonia (36)
Dizziness (35)
Hypotension (31)
Convulsion (31)
Hyperhidrosis (31)
Malaise (30)
Depressed Level Of Consciousness (30)
Coma (29)
Unresponsive To Stimuli (27)
Intentional Overdose (27)
Constipation (27)
Feeling Abnormal (26)
Hypokalaemia (26)
Pulmonary Congestion (26)
Renal Failure Acute (26)
Ventricular Tachycardia (25)
Headache (25)
Fatigue (25)
Brain Oedema (25)
Lethargy (24)
Rhabdomyolysis (24)
Respiratory Failure (24)
Incorrect Dose Administered (23)
Bradycardia (23)
Accidental Poisoning (23)
Miosis (22)

➢ More


Common Meds

Abilify (10132)
Adderall (1304)
Amlodipine (6664)
Amoxicillin (4387)
Benadryl (1568)
Celebrex (12876 )
Celexa (1342)
Cialis (2975)
Cipro (8580)
Citalopram (7792)
Crestor (18839)
Cymbalta (14373)
Doxycycline (1757)
Effexor (7289)
Flexeril (435)
Flomax (2177)
Fluoxetine (4261)
Gabapentin (4593)
Hydrocodone (2469)
Ibuprofen (8222)
Lantus (10968)
Lexapro (3499)
Lipitor (17769)
Lisinopril (8919)
Lyrica (27148)
Medrol (650)
Mirena (41254)
Mobic (957)
Morphine (5356)
Naproxen (538)
Neurontin (6501)
Oxycodone (4438)
Pradaxa (13372)
Prednisone (5926)
Prilosec (2631)
Prozac (1954)
Seroquel (27216)
Simvastatin (8348)
Synthroid (4452)
Tamiflu (5585)
Topamax (3748)
Tramadol (5054)
Trazodone (1458)
Viagra (5394)
Vicodin (1153)
Wellbutrin (6324)
Xanax (2847)
Zocor (5718)
Zoloft(6792)
Zyrtec(1669)

Recent Reviews

Good afternoon doc,my name dimasautisme,i comefrom indonesia ? im methadoners with 120 mg,im drink ARV to?please private my status? i just want quesstion i want to detox,where i must go to hospital doc? please help me :-D :)

I have been on methadone for two years. Went fro 70 mgs a day to 20. I do for pain and I have been prescribed klonipin also recently for severe panic attacks and I read online that it's a deadly combo. I take my methadone at 9 am. And have panic

Ive been takeing 90mls of methadone for approxamitley 2 years on and off but properly this time for a total off 7 months i get servere sweating from taking my methadone and feel very hot like im burning up and dripping with sweat why is this happenin

Methodone Side Effects, I have had many trips to Emergency Unit at my Town, having tight painful heart problems. But when they do the Tests for Heart attacks, I jave always been told I have no problem my heart is fine. I have had ECG Tests, all fine.

<b><span style='font-weight: normal;'><b>After 6 weeks of oral lamisil I experienced</b>eczema, muscle weakness, asthma, bloody bowels, lower abdominal pain, dizziness, extreme f

<strong></strong><span style='color: #ffa500;'>I am experiencing severe muscular <span style='color: #0000ff;'>pain/muscle tighteningin the diaphragm and sometimes &

<strong>I am on Cipralex now for about 2-3 months -10mg in the morning for depression, and now am experiencing chronic muscle weakness, chronic pain in both wrists and left hip, chronic fatigue, nausea, constant dizziness, tremors/shaky, restle

2 patients given thiocolchicoside reported of muscular stiffness,uneasiness,insomnia,breathlessness and feeling of restlessness, 2 out of 5 patients have reported such experiences after consuming thiocolchicoside.i strongly recommend to withdraw this

Afeccion cardiaca,pues a pesar de hacer ejercicio se me bloquearon las arterias,por mucho colesterol y tuvieron que hacerme un cateterismo, tengo once aos de que me detectaron la enfermedad. He perdido masa muscular pero nado ycamino dos o tres ve

After 18 months, great fatigue and muscular pain. Is this due to Intragam? consultant thinks I'm being fussy

After a 1 week course of Trimethoprim 200mg. I developed mild thrush on day3, muscle weakness for 1 day on the day after completion of the course and, 3 days after completion generalised urticaria. Not sure if this is delayed sensitivity but I assu

After finnishing the dose for Artequin I started feeling, body twitching, weakness,dizzness, body cramps, headache, neck pain, sore joints and now am at my sixth day after the dose and still experiencing the side effects..

After my first injection on Friday three weeks ago I experienced numbness and weakness Sunday night after injection along with a fever and night sweats. Went back to doctor on Tuesday and had an ultrasound to see if blockages or blood clots everythin

After takin tablets, i am feelimg somewhat uneasyness, feeling weakness, food intake is reduced

MUSCULAR WEAKNESS Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting The Use of Methadone in Newborn Infants
Conditions: Premature Birth of Newborn;   Critically Ill
Intervention: Drug: Methadone
Outcome Measures: Methadone PK and EDDP;   DNA
2 Recruiting Methadone in Pediatric Anesthesiology II
Condition: Pain
Interventions: Drug: Group 1- 0.4mg/kg IV Methadone HCl;   Drug: Group 2 - 0.5mg/kg IV methadon HCI;   Other: Group 3 - control no Methadone
Outcome Measures: Morphine consumption;   Pain scores;   Methadone clearance
3 Recruiting CYP2B6 Polymorphisms in Methadone
Condition: Healthy Volunteers
Interventions: Drug: racemic Methadone HC1;   Drug: Oral deuterated racemic Methadone HCl,
Outcome Measures: The effects of Methadone on healthy volunteers;   Methadone and bupropion concentration;   Methadone and bupropion clearance from the body;   Oral Methadone and bupropion absorption;   Influence of CYP2B6*6 hetero or homozyge genotype on the above primary and secondary outcomes
4 Unknown  Compare Methadone Combined With N-Acetyl-Cysteine (NAC) and Methadone Alone for Opioids Astaining
Condition: Opioids Use
Interventions: Drug: Methadone; NAC;   Drug: Methadone
Outcome Measure:
5 Recruiting Treatment of Pain in Head-and-Neck Cancer Patients: is Methadone More Effective?
Conditions: Pain;   Cancer of Head and Neck
Interventions: Drug: fentanyl;   Drug: Methadone
Outcome Measures: significant pain relief (reduction of Numeric Rating Scale (NRS) of 50%);   time to achieve significant pain relief;   side-effect profile
6 Recruiting Methadone vs Magnesium in Spinal Fusion
Condition: Idiopathic Scoliosis
Interventions: Drug: Methadone hydrochloride;   Drug: Magnesium Sulfate;   Drug: Remifentanil
Outcome Measures: Intra- and Post-operative Pain Relief;   Intra-operative parameters
7 Not yet recruiting Drug Interaction & Methadone & Buprenorphine
Condition: Hepatitis C
Interventions: Drug: Methadone;   Drug: DCV 3DAA FDC;   Drug: BMS-791325;   Drug: Buprenorphine;   Drug: Naloxone
Outcome Measures: Maximum observed concentration (Cmax) of R-Methadone for Part 1;   Area under the concentration-time curve in one dosing interval (AUC(TAU)) of R-Methadone for Part 1;   Cmax of Buprenorphine and Norbuprenorphine for Part 2;   AUC(TAU) of Buprenorphine and Norbuprenorphine for Part 2;   Cmax of S-Methadone and Total Methadone for Part 1;   AUC(TAU) of S-Methadone and Total Methadone for Part 1;   Concentration at 24 hours (C24) of S-Methadone, Total Methadone and R-Methadone for Part 1;   Time of maximum observed concentration (Tmax) of S-Methadone, Total Methadone and R-Methadone for Part 1;   C24 of Buprenorphine and Norbuprenorphine for Part 2;   Tmax of Buprenorphine and Norbuprenorphine for Part 2;   Ratio of metabolite AUC(TAU) to parent AUC(TAU) (MR_AUC(TAU)) of Norbuprenorphine to Buprenorphine;   Cmax of of Daclatasvir (DCV) , Asunaprevir (ASV) , BMS-791325, and BMS-794712;   AUC(TAU) of DCV, ASV, BMS-791325, and BMS-794712;   Concentration at 12 hours (C12) of DCV, ASV, BMS-791325, and BMS-794712;   Tmax of DCV, ASV, BMS-791325, and BMS-794712;   MR_AUC(TAU) for BMS-794712 to BMS-791325;   Incidence of Adverse Events (AEs), Serious Adverse Events (SAEs), death and AEs leading to discontinuation;   Results of vital signs, Electrocardiograms (ECGs), Physical Examinations (PEs) and clinical labs;   Scores of Clinical Opiate Withdrawal Scale (COWS), Subjective Opiate Withdrawal Scale (SOWS), Objective Opiate Withdrawal Scale (OOWS), and Opiate Overdose Assessment (OOA)
8 Recruiting Pharmacokinetics of Multiple Dose Methadone in Children Treated for Opiate Withdrawal
Condition: Opiate Withdrawal Syndrome
Intervention: Drug: Methadone
Outcome Measures: PK Parameters after multiple doses of enteral Methadone;   PK of Methadone's primary metabolite EDDP;   PK of R- and S-enantiomers of Methadone;   Correlation between plasma and DBS samples;   Correlation between plasma and scavenge samples;   Influence of CYP3A4 and CYP3B6 genetic polymorphisms on Methadone PK;   Methadone pharmacodynamics using the WAT-1;   Adverse events
9 Unknown  Perioperative Opioid-induced Hyperalgesia and Its Prevention With Ketamine and Methadone
Conditions: Post Operative Pain;   Hyperalgesia
Interventions: Drug: ketamine infusion;   Drug: Methadone PCA
Outcome Measures: the extent of hyperalgesia area proximal to surgical wound;   pain intensity;   opioids related adverse events
10 Unknown  Methadone Versus Morphine for Orthopedic Surgery Patients
Conditions: Fracture;   Pain, Postoperative
Interventions: Drug: Methadone;   Drug: Morphine
Outcome Measures: Opioid consumption during the 48 hours after surgery;   Time to initial dose of rescue analgesic;   Overall rescue analgesic;   Side effects with special attention paid to respiratory rate and possible respiratory depression, and PONV;   Overall satisfaction of the patient with the analgesic graded on a scale of 1-5
11 Recruiting Evaluation of the Efficacy and Safety of Two Methadone Titration Methods for the Treatment of Cancer-related Pain With Inadequate Pain Relief or Intolerable Side Effects When Treated With Level 3 Opioids.
Condition: Pain Related to Cancer
Intervention: Drug: Methadone
Outcome Measure: Binary main criterion based on success/failure rate related to Methadone switch on Day 4.
12 Unknown  Efficacy of Drug and Risk Counseling Among Methadone Patients in Jakarta, Indonesia
Conditions: HIV Risk Behaviors;   Heroin Injection;   Retention in Methadone Treatment
Interventions: Behavioral: Behavioral Drug and Risk Counseling (BDRC);   Behavioral: Methadone maintenance treatment
Outcome Measures: Injection drug use;   retention in Methadone treatment
13 Unknown  Role of CYP2B6, CYP3A4, and MDR1 in the Metabolic Clearance of Methadone
Condition: Substance-Related Disorders
Interventions: Drug: midazolam(drug), digoxin (drug);   Drug: Bupropion (drug);   Drug: Methadone (drug)
Outcome Measures: Explore if there is a correlation between the areas of the concentration curves of probe substrates for CYP3A4 and/or CYP2B6 and Pgp and the area of the concentration curve of Methadone.;   LC-MS assays will be developed to analyze the plasma content of the probe substrates, Methadone and their metabolites. Specifically, midazolam, 1-OH midazolam, bupropion, t-butyl-hydroxy bupropion, digoxin, Methadone, and EDDP (a Methadone metabolite).;   Isolate and bank the DNA of the subjects for future genotyping of variant alleles that will be identified in this study to be important in Methadone pharmacokinetics.
14 Recruiting Efficacy Methadone for Management Postoperative Pain After the Use of Anesthesia Intravenous in Laparoscopic Cholecystectomy
Condition: Pain, Postoperative
Interventions: Drug: Morphine;   Drug: Methadone;   Drug: TIVA
Outcome Measures: Difference in milligrams of morphine used as rescue analgesia;   Difference in pain scores, using the Numeric Rating Scale
15 Not yet recruiting Pilot Study of Nicotine Nasal Spray and Varenicline on Smoking in Methadone-Maintained Patients
Conditions: Cigarette Smoking;   Methadone Maintenance
Interventions: Drug: Nicotine Nasal Spray;   Drug: Varenicline;   Drug: Placebo Nasal Spray;   Drug: Placebo Varenicline
Outcome Measures: Proportion of daily cigarettes smoked in the 4 hours after receiving Methadone dose;   Cigarettes per day;   Carbon monoxide level
16 Recruiting Pupillometry and Pain Thresholds Patients Substituted by Methadone and Buprenorphine
Conditions: Opiate Dependent;   Previous Illicit Drug Use
Intervention: Drug: Buprenorphine and Methadone Hydrochloride
Outcome Measures: Measurement of the pupil diameter;   - The mechanical punctuate pain threshold as measured by Electronical Von Frey;   - The mechanical pressure pain threshold measured by Algometer on the tibial bone;   - The pupil diameter measured in scotopic .conditions (via infrared camera) at the hypothetical peak effect of either Methadone or buprenorphine.;   - The pupil diameter measured in photopic conditions (via infrared camera) at the hypothetical residual effect of either Methadone or buprenorphine
17 Recruiting Buprenorphine and Methadone for Opioid-dependent Chronic Back Pain Patients
Condition: Low Back Pain
Interventions: Drug: Methadone;   Drug: Buprenorphine/naloxone
Outcome Measures: Analgesia;   Illicit drug use;   Cravings;   Functioning;   Depression;   Treatment retention
18 Recruiting Conversion From Parenteral to Oral Methadone.
Condition: Pain
Interventions: Drug: Parenteral /oral Methadone ratio 1:2;   Drug: Parenteral /oral Methadone ratio 1:1.2
Outcome Measures: Proportion of intoxicated patients in each groups;   Parenteral/oral MTD final ratio in patients considered as "failure"
19 Recruiting Methadone in Pediatric and Adult Sickle Cell Patients
Condition: Sickle Cell Disease
Interventions: Drug: Morphine;   Drug: Methadone
Outcome Measures: To determine the pharmacokinetics of Methadone in children and adults with Sickle Cell disease experiencing a VOE.;   Pain
20 Unknown  Switching From Morphine to Oral Methadone Plus Acetaminophen in the Treatment of Cancer Pain
Conditions: Cancer;   Pain;   Palliative Care
Intervention: Drug: Methadone plus Acetaminophen or Placebo
Outcome Measures: Pain intensity and time to equianalgesic effect;   Degree of nausea, vomiting, obstipation, xerostomia and drowsiness