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MYOCARDIAL INFARCTION and Furosemide

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MYOCARDIAL INFARCTION Symptoms and Causes

Each year almost 800,000 Americans have a heart attack. A heart attack happens when blood flow to the heart suddenly becomes blocked. Without the blood coming in, the heart can't get oxygen. If not treated quickly, the heart muscle begins to die. But if you do get quick treatment, you may be able to prevent or limit damage to the heart muscle. That's why it's important to know the symptoms of a heart attack and call 911 if you or someone else is having them. You should call, even if you are not sure that it is a heart attack.

The most common symptoms in men and women are

  • Chest discomfort. It is often in center or left side of the chest. It usually lasts more than a few minutes. It may go away and come back. It can feel like pressure, squeezing, fullness, or pain. It also can feel like heartburn or indigestion.
  • Shortness of breath. Sometimes this is your only symptom. You may get it before or during the chest discomfort. It can happen when you are resting or doing a little bit of physical activity.
  • Discomfort in the upper body. You may feel pain or discomfort in one or both arms, the back, shoulders, neck, jaw, or upper part of the stomach.

You may also have other symptoms, such as nausea, vomiting, dizziness, and lightheadedness. You may break out in a cold sweat. Sometimes women will have different symptoms then men. For example, they are more likely to feel tired for no reason.

The most common cause of heart attacks is coronary artery disease (CAD). With CAD, there is a buildup of cholesterol and other material, called plaque, on their inner walls or the arteries. This is atherosclerosis. It can build up for years. Eventually an area of plaque can rupture (break open). A blood clot can form around the plaque and block the artery.

A less common cause of heart attack is a severe spasm (tightening) of a coronary artery. The spasm cuts off blood flow through the artery.

At the hospital, health care providers make a diagnosis based on your symptoms, blood tests, and different heart health tests. Treatments may include medicines and medical procedures such as coronary angioplasty. After a heart attack, cardiac rehabilitation and lifestyle changes can help you recover.

NIH: National Heart, Lung, and Blood Institute

Check out the latest treatments for MYOCARDIAL INFARCTION

MYOCARDIAL INFARCTION treatment research studies

Furosemide clinical trials, surveys and public health registries


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Furosemide Side Effects

Renal Failure Acute (363)
Hypokalaemia (211)
Dyspnoea (208)
Hypotension (178)
Dehydration (168)
Somnolence (152)
Dizziness (145)
Cardiac Failure (139)
Renal Failure (129)
Syncope (122)
Fall (116)
Asthenia (116)
Hyperkalaemia (109)
Fatigue (108)
Hyponatraemia (108)
Oedema Peripheral (103)
Blood Creatinine Increased (93)
Death (92)
Diarrhoea (88)
Confusional State (85)
Nausea (78)
Vomiting (76)
Renal Impairment (74)
Cardiac Arrest (64)
Cardiac Failure Congestive (63)
Condition Aggravated (63)
Pulmonary Oedema (63)
Malaise (63)
Pain (59)
Atrial Fibrillation (58)
Pneumonia (57)
Respiratory Failure (55)
Hypovolaemia (53)
Oedema (50)
Anaemia (49)
Metabolic Alkalosis (44)
Cough (44)
Electrocardiogram Qt Prolonged (42)
Blood Urea Increased (41)
Pyrexia (40)
Weight Decreased (39)
Toxicity To Various Agents (37)
Gait Disturbance (37)
Loss Of Consciousness (35)
Chest Pain (35)
Pemphigoid (35)
Polyuria (35)
Fluid Retention (34)
Rash (34)
Hypertension (34)

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MYOCARDIAL INFARCTION Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Unknown  Investigation of Gender Specificity of the Effects of Furosemide in Healthy Female and Male Volunteers
Condition: Healthy Male and Female Volunteers
Interventions: Drug: Furosemide;   Drug: aminohippurate sodium
Outcome Measures: pharmacokinetic parameter of Furosemide (AUC-24);   pharmacodynamic parameter of Furosemide (Sodium excretion in the urine);   pharmacogenetic parameters;   pharmacokinetic of aminohippuric acid;   other pharmacokinetic parameter of Furosemide;   other pharmacodynamic parameter of Furosemide
2 Not yet recruiting The Use of Furosemide in Patients on Dialysis
Condition: End Stage Renal Disease
Interventions: Drug: Withdrawal of Furosemide;   Drug: Furosemide administration
Outcome Measures: 24 hour urine sodium and water excretion;   Interdialytic weight gain
3 Recruiting Oral Metolazone and Intermittent Intravenous Furosemide Versus Continuous Infusion Furosemide in Acute Heart Failure
Condition: Acute Decompensated Heart Failure
Interventions: Drug: Intravenous Bolus Furosemide and Oral Metolazone;   Drug: Intravenous Continuous Infusion Furosemide
Outcome Measures: Daily net fluid output;   Patient Global Assessment Scale;   Daily urine output (mL urine out per mg Furosemide received);   Need for additional or alternative diuretic (crossover) or IV vasoactive therapy (study failure);   Death, rehospitalization, and unscheduled visit for HF to an emergency department or outpatient clinic;   Critically low potassium (< 3.5 mmol/L) and magnesium (< 1.6 mg/dL) concentrations;   Change in blood urea nitrogen or creatinine;   Number of hypotensive episodes defined as systolic blood pressure below 85 mmHg or greater than 10 mmHg below baseline (whichever is greater);   Total number of times antihypertensive doses are held due to low blood pressure
4 Unknown  Dopamine in Acute Decompensated Heart Failure (DAD-HF) Trial
Condition: Acute Heart Failure
Interventions: Drug: Furosemide;   Drug: low-dose dopamine + low-dose Furosemide
Outcome Measures: 1-year mortality or rehospitalization (all-cause, cardiovascular, non-cardiovascular, and due to worsening heart failure).;   60-day mortality or rehospitalization (all-cause, cardiovascular, non-cardiovascular, and due to worsening heart failure).
5 Unknown  The Influence of Furosemide on Fluid Balance and Intra-abdominal Pressure in Critically Ill Patients
Condition: Intra-Abdominal Hypertension
Intervention: Drug: Furosemide
Outcome Measures: intra-abdominal pressure;   serum creatinine;   need for renal replacement therapy;   ICU mortality;   acid-base status;   hospital and 28d mortality;   duration of mechanical ventilation;   ICU length of stay;   vasopressor dose;   fluid balance;   SOFA score
6 Not yet recruiting Inhaled Furosemide & Dyspnea
Condition: Dyspnea
Interventions: Other: CWS;   Drug: Furosemide;   Drug: Placebo
Outcome Measure: Sensory intensity (Borg 0-10 scale) ratings of dyspnea at isotime
7 Recruiting Peritoneal Dialysis vs Furosemide for Acute Kidney Injury After Cardiopulmonary Bypass
Condition: Acute Kidney Injury
Interventions: Drug: Furosemide;   Procedure: Peritoneal Dialysis
Outcome Measures: Fluid Balance;   Respiratory Support Administered;   NGAL Concentration;   Duration of cardiac ICU stay;   Duration of hospital stay;   All cause mortality;   Renal/electrolyte abnormalities;   Doses of Potassium Chloride or Arginine Chloride required;   B-Natriuretic Peptide
8 Recruiting Furosemide in Early Acute Kidney Injury
Condition: Acute Renal Failure
Interventions: Drug: Furosemide;   Drug: Normal Saline
Outcome Measures: Worsening AKI;   Fluid balance;   Renal replacement therapy (RRT);   Renal Recovery;   Survival
9 Unknown  Effect of Acetazolamide and Furosemide on Obesity-induced Glomerular Hyperfiltration
Condition: Obesity-induced Hyperfiltration
Intervention: Drug: Furosemide, acetazolamide
Outcome Measure: change in GFR and RPF
10 Recruiting Trial on Treatment With Inhaled Furosemide of Preterm and Term Neonates With Transient Tachypnoea
Condition: Transient Tachypnoea of the Newborn
Interventions: Drug: Furosemide;   Drug: Saline 0,9%
Outcome Measures: Reduction of the Silverman-Score;   Oxygen supplementation;   A need for secondary intubation and mechanical ventilation;   body weight;   CPAP-time;   blood electrolytes (Na+, K+, Ca++, HCO3-, Cl-);   blood gas (pH, pCO2,pO2)
11 Recruiting Furosemide Versus Ethacrynic Acid in Children With Congenital Heart Disease
Condition: Fluid Overload
Interventions: Drug: Furosemide;   Drug: ethacrynic acid
Outcome Measures: Mean total urine output production in the first post-operative day;   Mean creatinine and NGAL values
12 Unknown  Using Furosemide to Prevent Fluid Overload During Red Blood Cell Transfusion in Neonates
Condition: Lung Disease
Interventions: Drug: Furosemide;   Drug: Saline
Outcome Measures: Cardiac chamber volume loading.;   Clinical cardio-respiratory stability (heart rate, blood pressure, respiratory rate, oxygen saturation, and oxygen requirement).;   Myocardial performance, cardiac input and output and pulmonary hemodynamics (echocardiograph exam).;   Changes in electrolyte balance, body weight and urine output.
13 Not yet recruiting Furosemide Treatment Before Blood Transfusion in Patients With Systolic Dysfunction
Condition: Anemia Treatment Among Patients Suffering From Left Ventricular Systolic Dysfunction
Interventions: Drug: Furosemide;   Drug: placebo normal saline
Outcome Measures: Diastolic echocardiographic changes following blood transfusion, with or without Furosemide treatment;   clinical outcome following blood transfusion, with or without Furosemide treatment
14 Unknown  Stop Hypernatremia, Use Metolazone, for Aggressive, Controlled, Effective Diuresis
Conditions: Respiratory Failure;   Volume Overload;   Hypernatremia
Interventions: Drug: Supplemental metolazone diuresis;   Drug: Placebo Comparator: Control-- Furosemide (lasix) only
Outcome Measures: Fluid balance;   Serum sodium;   Hyponatremia;   Time to extubation;   Acute Kidney Injury
15 Recruiting Clinical Trial to Compare Effectiveness of Diuretics in Hemodialysis Patients With Residual Renal Function
Conditions: Chronic Kidney Insufficiency;   Hemodialysis Treatment;   Diuresis Preserved
Intervention: Drug: Hydrochlorothiazide and Furosemide
Outcome Measures: To asses the effect of combined hydrochlorothiazide-Furosemide therapy on weight gain between haemodialysis sessions in patients with RRF;   To asses the effect of combined hydrochlorothiazide-Furosemide therapy on dialytic, clinical and analytical variables and use of the antihypertensive treatment
16 Not yet recruiting The Impact of TORasemide oN hemodynAmic and Neurohormonal Stress, and carDiac remOdeling in Heart Failure
Condition: Heart Failure
Interventions: Drug: Furosemide;   Drug: Torasemide
Outcome Measures: The influence of therapy on cardiovascular events associated with heart failure (deaths, hospitalisations);   The change of dosing of diuretic due to worsening of condition of patient.;   The change of NYHA (New York Heart Association) class - worsening or improvement
17 Unknown  Comparing the Effects of Conivaptan and Diuretics on Plasma Neurohormones and Renal Blood Flow in Patients With Chronic Congestive Heart Failure
Condition: Heart Failure
Interventions: Drug: Conivaptan;   Drug: Furosemide;   Drug: Conivaptan and Furosemide
Outcome Measures: renal hemodynamics renal blood flow and glomerular filtration rate;   measure plasma neurohormone levels
18 Unknown  The Effect of Continuous, Various Doses of Furosemide Drip on Hearing as Measured by Acoustic Emission
Condition: Hearing Status
Intervention:
Outcome Measure:
19 Recruiting Aerosol Inhalation Treatment for Dyspnea
Conditions: Healthy;   Dyspnea
Intervention: Drug: Furosemide
Outcome Measures: Subject rating of Breathing Discomfort (dyspnea);   Multidimensional Dyspnea Profile;   Urine output
20 Not yet recruiting A Study of MK-7145 in Participants With Renal Insufficiency (Part I) and Heart Failure With Renal Insufficiency (Part II) (MK-7145-011)
Conditions: Renal Impairment;   Heart Failure
Interventions: Drug: MK-7145 2 mg;   Drug: MK-7145 8 mg;   Drug: Furosemide;   Drug: Torsemide
Outcome Measures: Change from baseline in first 24hr UNa (Part I);   NT-proBNP values at 24 hours post last dose (Part II);   Fold change from baseline for serum creatinine (Part I);   Area under the concentration-time curve from time zero to 24 hours after dosing (AUC0-24hr) for MK-7145 (Part I);   Maximum plasma concentration (Cmax) for MK-7145 (Part I);   Trough plasma concentration (Ctrough) for MK-7145 (Part I);   Time to Cmax (Tmax) for MK-7145 (Part I);   Apparent terminal half-life (t1/2) for MK-7145 (Part I);   Serum creatinine measured at 24 hours post last dose (Part II);   Area under the concentration-time curve from time zero to 24 hours after dosing (AUC0-24hr) for MK-7145 (Part II);   Maximum plasma concentration (Cmax) for MK-7145 (Part II);   Trough plasma concentration (Ctrough) for MK-7145 (Part II);   Time to Cmax (Tmax) for MK-7145 (Part II);   Apparent terminal half-life (t1/2) for MK-7145 (Part II)