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MYOCARDIAL INFARCTION and Loratadine

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MYOCARDIAL INFARCTION Symptoms and Causes

Each year almost 800,000 Americans have a heart attack. A heart attack happens when blood flow to the heart suddenly becomes blocked. Without the blood coming in, the heart can't get oxygen. If not treated quickly, the heart muscle begins to die. But if you do get quick treatment, you may be able prevent or limit damage to the heart muscle. That's why it's important to know the symptoms of a heart attack and call 9-1-1 if you or someone else is having them. You should call, even if you are not sure that it is a heart attack.

The most common symptoms in men and women are

  • Chest discomfort. It is often in center or left side of the chest. It usually lasts more than a few minutes. It may go away and come back. It can feel like pressure, squeezing, fullness, or pain. It also can feel like heartburn or indigestion.
  • Shortness of breath. Sometimes this is your only symptom. You may get it before or during the chest discomfort. It can happen when you are resting or doing a little bit of physical activity.
  • Discomfort in the upper body. You may feel pain or discomfort in one or both arms, the back, shoulders, neck, jaw, or upper part of the stomach.

You may also have other symptoms, such as nausea, vomiting, dizziness, and lightheadedness. You may break out in a cold sweat. Sometimes women will have different symptoms then men. For example, they are more likely to feel tired for no reason.

The most common cause of heart attacks is coronary artery disease (CAD). With CAD, there is a buildup of cholesterol and other material, called plaque, on their inner walls or the arteries. This is atherosclerosis. It can build up for years. Eventually an area of plaque can rupture (break open). A blood clot can form around the plaque and block the artery.

A less common cause of heart attack is a severe spasm (tightening) of a coronary artery. The spasm cuts off blood flow through the artery.

At the hospital, health care providers make a diagnosis based on your symptoms, blood tests, and different heart health tests. Treatments may include medicines and medical procedures such as coronary angioplasty. After a heart attack, cardiac rehabilitation and lifestyle changes can help you recover.

NIH: National Heart, Lung, and Blood Institute

Check out the latest treatments for MYOCARDIAL INFARCTION

MYOCARDIAL INFARCTION treatment research studies

Loratadine clinical trials, surveys and public health registries


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MYOCARDIAL INFARCTION Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting Evaluation of Loratadine for Prevention of Pegfilgrastim-Induced Pain
Condition: Pegfilgrastim-induced Back and Leg Pain
Interventions: Drug: Loratadine;   Drug: placebo
Outcome Measures: Prevention of pegfilgrastim-induced back and leg pain by administration of the antihistamine Loratadine;   Identification of adverse events when Loratadine is given to prevent pegfilgrastim-induced back and leg pain;   Incidence of pegfilgrastim-induced back and leg pain
2 Recruiting NOLAN: Naproxen or Loratadine and Neulasta
Condition: Bone Pain in Stage I - III Breast Cancer
Interventions: Drug: Naproxen;   Drug: Loratadine
Outcome Measures: Bone pain (all grade) in cycle 1;   Bone pain (all grade) by cycle (2-4) and across cycles;   Severe (grade 3/4) bone pain by cycle and across cycles;   Subject reported bone pain;   Maximum Subject Reported bone pain;   Area under the Curve for subject-reported bone pain;   Adverse Event and Serious Adverse Events;   Severity of Adverse Events
3 Recruiting Long-Term Efficacy and Safety Study of SCH 900237/MK-8237 in Children and Adults With House Dust Mite-Induced Allergic Rhinitis/Rhinoconjunctivitis (P05607)
Conditions: Rhinitis, Allergic, Perennial;   Rhinitis, Allergic, Nonseasonal
Interventions: Biological: MK-8237 tablets;   Biological: Placebo tablets;   Drug: Rescue Medication: Self-Injectable Epinephrine;   Drug: Rescue Medication: Loratadine tablets;   Drug: Rescue Medication: Olopatadine ophthalmic drops;   Drug: Rescue Medication: Mometasone furoate nasal spray
Outcome Measures: Average Total Combined Rhinitis Score (TCRS);   Number of Participants Who Experience At Least One Adverse Event;   Number of Participants Who Discontinue Study Drug Due to an Adverse Event;   Average Rhinitis Daily Symptom Score (Rhinitis DSS);   Average Total Combined Rhinoconjunctivitis Score (TCS);   Average Rhinitis Daily Medication Score (Rhinitis DMS);   Average Allergic Rhinitis/Rhinoconjunctivitis Symptoms Assessed by Visual Analogue Scale (VAS)
4 Unknown  Combination of Peripheral Nerve Block and DepoDur in Total Knee Joint Replacement
Condition: Arthroplasty, Replacement, Knee
Interventions: Drug: Depodur;   Procedure: sciatic nerve block
Outcome Measures: Postoperative Pain;   Time Required for Placement of Block;   Time to first use of rescue analgesia and PCA;   Total opioid consumption;   Degree of knee flexion (Range of motion);   Day of first ambulation;   Number of days required to achieve a 110° knee flexion;   Number of days of hospitalization;   Need for manipulation of knee joint under general anesthesia;   Secondary effects: nausea and vomiting, pruritus, supplemental oxygen, urinary catheterization;   Satisfaction score