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MYOCARDIAL INFARCTION and Methadone

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MYOCARDIAL INFARCTION Symptoms and Causes

Each year almost 800,000 Americans have a heart attack. A heart attack happens when blood flow to the heart suddenly becomes blocked. Without the blood coming in, the heart can't get oxygen. If not treated quickly, the heart muscle begins to die. But if you do get quick treatment, you may be able prevent or limit damage to the heart muscle. That's why it's important to know the symptoms of a heart attack and call 9-1-1 if you or someone else is having them. You should call, even if you are not sure that it is a heart attack.

The most common symptoms in men and women are

  • Chest discomfort. It is often in center or left side of the chest. It usually lasts more than a few minutes. It may go away and come back. It can feel like pressure, squeezing, fullness, or pain. It also can feel like heartburn or indigestion.
  • Shortness of breath. Sometimes this is your only symptom. You may get it before or during the chest discomfort. It can happen when you are resting or doing a little bit of physical activity.
  • Discomfort in the upper body. You may feel pain or discomfort in one or both arms, the back, shoulders, neck, jaw, or upper part of the stomach.

You may also have other symptoms, such as nausea, vomiting, dizziness, and lightheadedness. You may break out in a cold sweat. Sometimes women will have different symptoms then men. For example, they are more likely to feel tired for no reason.

The most common cause of heart attacks is coronary artery disease (CAD). With CAD, there is a buildup of cholesterol and other material, called plaque, on their inner walls or the arteries. This is atherosclerosis. It can build up for years. Eventually an area of plaque can rupture (break open). A blood clot can form around the plaque and block the artery.

A less common cause of heart attack is a severe spasm (tightening) of a coronary artery. The spasm cuts off blood flow through the artery.

At the hospital, health care providers make a diagnosis based on your symptoms, blood tests, and different heart health tests. Treatments may include medicines and medical procedures such as coronary angioplasty. After a heart attack, cardiac rehabilitation and lifestyle changes can help you recover.

NIH: National Heart, Lung, and Blood Institute

Check out the latest treatments for MYOCARDIAL INFARCTION

MYOCARDIAL INFARCTION treatment research studies

Methadone clinical trials, surveys and public health registries


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MYOCARDIAL INFARCTION Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting The Use of Methadone in Newborn Infants
Conditions: Premature Birth of Newborn;   Critically Ill
Intervention: Drug: Methadone
Outcome Measures: Methadone PK and EDDP;   DNA
2 Recruiting Methadone in Pediatric Anesthesiology II
Condition: Pain
Interventions: Drug: Group 1- 0.4mg/kg IV Methadone HCl;   Drug: Group 2 - 0.5mg/kg IV methadon HCI;   Other: Group 3 - control no Methadone
Outcome Measures: Morphine consumption;   Pain scores;   Methadone clearance
3 Recruiting CYP2B6 Polymorphisms in Methadone
Condition: Healthy Volunteers
Interventions: Drug: racemic Methadone HC1;   Drug: Oral deuterated racemic Methadone HCl,
Outcome Measures: The effects of Methadone on healthy volunteers;   Methadone and bupropion concentration;   Methadone and bupropion clearance from the body;   Oral Methadone and bupropion absorption;   Influence of CYP2B6*6 hetero or homozyge genotype on the above primary and secondary outcomes
4 Unknown  Compare Methadone Combined With N-Acetyl-Cysteine (NAC) and Methadone Alone for Opioids Astaining
Condition: Opioids Use
Interventions: Drug: Methadone; NAC;   Drug: Methadone
Outcome Measure:
5 Recruiting Treatment of Pain in Head-and-Neck Cancer Patients: is Methadone More Effective?
Conditions: Pain;   Cancer of Head and Neck
Interventions: Drug: fentanyl;   Drug: Methadone
Outcome Measures: significant pain relief (reduction of Numeric Rating Scale (NRS) of 50%);   time to achieve significant pain relief;   side-effect profile
6 Recruiting Methadone vs Magnesium in Spinal Fusion
Condition: Idiopathic Scoliosis
Interventions: Drug: Methadone hydrochloride;   Drug: Magnesium Sulfate;   Drug: Remifentanil
Outcome Measures: Intra- and Post-operative Pain Relief;   Intra-operative parameters
7 Not yet recruiting Drug Interaction & Methadone & Buprenorphine
Condition: Hepatitis C
Interventions: Drug: Methadone;   Drug: DCV 3DAA FDC;   Drug: BMS-791325;   Drug: Buprenorphine;   Drug: Naloxone
Outcome Measures: Maximum observed concentration (Cmax) of R-Methadone for Part 1;   Area under the concentration-time curve in one dosing interval (AUC(TAU)) of R-Methadone for Part 1;   Cmax of Buprenorphine and Norbuprenorphine for Part 2;   AUC(TAU) of Buprenorphine and Norbuprenorphine for Part 2;   Cmax of S-Methadone and Total Methadone for Part 1;   AUC(TAU) of S-Methadone and Total Methadone for Part 1;   Concentration at 24 hours (C24) of S-Methadone, Total Methadone and R-Methadone for Part 1;   Time of maximum observed concentration (Tmax) of S-Methadone, Total Methadone and R-Methadone for Part 1;   C24 of Buprenorphine and Norbuprenorphine for Part 2;   Tmax of Buprenorphine and Norbuprenorphine for Part 2;   Ratio of metabolite AUC(TAU) to parent AUC(TAU) (MR_AUC(TAU)) of Norbuprenorphine to Buprenorphine;   Cmax of of Daclatasvir (DCV) , Asunaprevir (ASV) , BMS-791325, and BMS-794712;   AUC(TAU) of DCV, ASV, BMS-791325, and BMS-794712;   Concentration at 12 hours (C12) of DCV, ASV, BMS-791325, and BMS-794712;   Tmax of DCV, ASV, BMS-791325, and BMS-794712;   MR_AUC(TAU) for BMS-794712 to BMS-791325;   Incidence of Adverse Events (AEs), Serious Adverse Events (SAEs), death and AEs leading to discontinuation;   Results of vital signs, Electrocardiograms (ECGs), Physical Examinations (PEs) and clinical labs;   Scores of Clinical Opiate Withdrawal Scale (COWS), Subjective Opiate Withdrawal Scale (SOWS), Objective Opiate Withdrawal Scale (OOWS), and Opiate Overdose Assessment (OOA)
8 Recruiting Pharmacokinetics of Multiple Dose Methadone in Children Treated for Opiate Withdrawal
Condition: Opiate Withdrawal Syndrome
Intervention: Drug: Methadone
Outcome Measures: PK Parameters after multiple doses of enteral Methadone;   PK of Methadone's primary metabolite EDDP;   PK of R- and S-enantiomers of Methadone;   Correlation between plasma and DBS samples;   Correlation between plasma and scavenge samples;   Influence of CYP3A4 and CYP3B6 genetic polymorphisms on Methadone PK;   Methadone pharmacodynamics using the WAT-1;   Adverse events
9 Unknown  Perioperative Opioid-induced Hyperalgesia and Its Prevention With Ketamine and Methadone
Conditions: Post Operative Pain;   Hyperalgesia
Interventions: Drug: ketamine infusion;   Drug: Methadone PCA
Outcome Measures: the extent of hyperalgesia area proximal to surgical wound;   pain intensity;   opioids related adverse events
10 Unknown  Methadone Versus Morphine for Orthopedic Surgery Patients
Conditions: Fracture;   Pain, Postoperative
Interventions: Drug: Methadone;   Drug: Morphine
Outcome Measures: Opioid consumption during the 48 hours after surgery;   Time to initial dose of rescue analgesic;   Overall rescue analgesic;   Side effects with special attention paid to respiratory rate and possible respiratory depression, and PONV;   Overall satisfaction of the patient with the analgesic graded on a scale of 1-5
11 Recruiting Evaluation of the Efficacy and Safety of Two Methadone Titration Methods for the Treatment of Cancer-related Pain With Inadequate Pain Relief or Intolerable Side Effects When Treated With Level 3 Opioids.
Condition: Pain Related to Cancer
Intervention: Drug: Methadone
Outcome Measure: Binary main criterion based on success/failure rate related to Methadone switch on Day 4.
12 Unknown  Efficacy of Drug and Risk Counseling Among Methadone Patients in Jakarta, Indonesia
Conditions: HIV Risk Behaviors;   Heroin Injection;   Retention in Methadone Treatment
Interventions: Behavioral: Behavioral Drug and Risk Counseling (BDRC);   Behavioral: Methadone maintenance treatment
Outcome Measures: Injection drug use;   retention in Methadone treatment
13 Unknown  Role of CYP2B6, CYP3A4, and MDR1 in the Metabolic Clearance of Methadone
Condition: Substance-Related Disorders
Interventions: Drug: midazolam(drug), digoxin (drug);   Drug: Bupropion (drug);   Drug: Methadone (drug)
Outcome Measures: Explore if there is a correlation between the areas of the concentration curves of probe substrates for CYP3A4 and/or CYP2B6 and Pgp and the area of the concentration curve of Methadone.;   LC-MS assays will be developed to analyze the plasma content of the probe substrates, Methadone and their metabolites. Specifically, midazolam, 1-OH midazolam, bupropion, t-butyl-hydroxy bupropion, digoxin, Methadone, and EDDP (a Methadone metabolite).;   Isolate and bank the DNA of the subjects for future genotyping of variant alleles that will be identified in this study to be important in Methadone pharmacokinetics.
14 Recruiting Efficacy Methadone for Management Postoperative Pain After the Use of Anesthesia Intravenous in Laparoscopic Cholecystectomy
Condition: Pain, Postoperative
Interventions: Drug: Morphine;   Drug: Methadone;   Drug: TIVA
Outcome Measures: Difference in milligrams of morphine used as rescue analgesia;   Difference in pain scores, using the Numeric Rating Scale
15 Not yet recruiting Pilot Study of Nicotine Nasal Spray and Varenicline on Smoking in Methadone-Maintained Patients
Conditions: Cigarette Smoking;   Methadone Maintenance
Interventions: Drug: Nicotine Nasal Spray;   Drug: Varenicline;   Drug: Placebo Nasal Spray;   Drug: Placebo Varenicline
Outcome Measures: Proportion of daily cigarettes smoked in the 4 hours after receiving Methadone dose;   Cigarettes per day;   Carbon monoxide level
16 Recruiting Pupillometry and Pain Thresholds Patients Substituted by Methadone and Buprenorphine
Conditions: Opiate Dependent;   Previous Illicit Drug Use
Intervention: Drug: Buprenorphine and Methadone Hydrochloride
Outcome Measures: Measurement of the pupil diameter;   - The mechanical punctuate pain threshold as measured by Electronical Von Frey;   - The mechanical pressure pain threshold measured by Algometer on the tibial bone;   - The pupil diameter measured in scotopic .conditions (via infrared camera) at the hypothetical peak effect of either Methadone or buprenorphine.;   - The pupil diameter measured in photopic conditions (via infrared camera) at the hypothetical residual effect of either Methadone or buprenorphine
17 Recruiting Buprenorphine and Methadone for Opioid-dependent Chronic Back Pain Patients
Condition: Low Back Pain
Interventions: Drug: Methadone;   Drug: Buprenorphine/naloxone
Outcome Measures: Analgesia;   Illicit drug use;   Cravings;   Functioning;   Depression;   Treatment retention
18 Recruiting Conversion From Parenteral to Oral Methadone.
Condition: Pain
Interventions: Drug: Parenteral /oral Methadone ratio 1:2;   Drug: Parenteral /oral Methadone ratio 1:1.2
Outcome Measures: Proportion of intoxicated patients in each groups;   Parenteral/oral MTD final ratio in patients considered as "failure"
19 Recruiting Methadone in Pediatric and Adult Sickle Cell Patients
Condition: Sickle Cell Disease
Interventions: Drug: Morphine;   Drug: Methadone
Outcome Measures: To determine the pharmacokinetics of Methadone in children and adults with Sickle Cell disease experiencing a VOE.;   Pain
20 Unknown  Switching From Morphine to Oral Methadone Plus Acetaminophen in the Treatment of Cancer Pain
Conditions: Cancer;   Pain;   Palliative Care
Intervention: Drug: Methadone plus Acetaminophen or Placebo
Outcome Measures: Pain intensity and time to equianalgesic effect;   Degree of nausea, vomiting, obstipation, xerostomia and drowsiness