| Rank |
Status |
Study |
| 1 |
Recruiting
|
Evaluation of Laryngeal Ultrasonography Performance in Predicting Major Post Extubation Laryngeal Edema in Intensive Care Patients
| Conditions: |
Laryngeal Edema; Acute Respiratory Failure Requiring Reintubation |
| Intervention: |
|
| Outcome Measures: |
Performance of laryngeal ultrasonography in predicting major post extubation laryngeal edema in intensive care patients.; Performance of laryngeal ultrasonography in predicting post-extubation stridor in intensive care patients.; Frequency of major post-extubation laryngeal edema and post-extubation stridor; Risk factors of major post-extubation laryngeal edema in intensive care unit; Evolution of ultrasonic parameters with corticotherapy after reintubation for a major post-extubation laryngeal edema; Evaluation of impact of major post-extubation laryngeal edema occurence on mechanical ventilation duration, hospitalization duration and mortality in intensive care unit; Inter-observer reproductibility of ultrasound scanning and ultrasonic air-leak volume measurement |
|
| 2 |
Not yet recruiting
|
Dexamethasone Intravitreal Implant for Treatment of Macular Edema After Plaque Radiotherapy of Uveal Melanoma
| Conditions: |
Macular Edema; Cystoid Macular Edema; Uveal Melanoma; Radiation Maculopathy; Radiation Retinopathy |
| Interventions: |
Drug: Ozurdex; Drug: Bevacizumab |
| Outcome Measures: |
Proportion of eyes showing >=2 lines of improvement in best-corrected visual acuity; Change in central subfield retinal thickness; Development of glaucoma; Development of cataract; Development of retinal detachment; Development of vitreous hemorrhage |
|
| 3 |
Recruiting
|
Intraocular Bevacizumab Compared With Intraocular Triamcinolone in Patients With Diabetic Macular Edema
| Condition: |
Diabetic Macular Edema |
| Interventions: |
Drug: Bevacizumab (Avastin); Drug: Triamcinolone; Drug: Sham; Procedure: Lucentis |
| Outcome Measures: |
Efficacy of the treatment assessed with visual acuity measured by ETDRS charts and central retinal thickness as measured by standard Optical Coherence Tomography (OCT); To explore the structural mechanisms of the effect on diabetic macular edema as assessed by fluorescein angiography and ultra high-resolution optical coherence tomography. To observe the changes in retinal function a microperimetry is assessed. |
|
| 4 |
Recruiting
|
Does NMES Help Relieve Lower Limb Oedema and Improve Joint Mobility and Skin Tissue Oxygenation Levels?
| Condition: |
Oedema |
| Intervention: |
Device: Duo-STIM neuromuscular electrical stimulator |
| Outcome Measures: |
Oedema Reduction; Joint Mobility; Skin Oxygenation |
|
| 5 |
Recruiting
|
Trial of Switching Between Intravitreal Bevacizumab (Avastin®)& Intravitreal Dexamethasone (Ozurdex™) for Persistent Diabetic Macular Oedema
| Conditions: |
Diabetes; Diabetic Macular Oedema; Diabetic Macular Edema; Diabetic Retinopathy |
| Interventions: |
Drug: Avastin (Bevacizumab); Drug: Ozurdex (dexamethasone) |
| Outcome Measures: |
Proportion of eyes that have central macular thickness <300 microns 6 months after switching; Mean change in central macular thickness (CMT) as measured by OCT. |
|
| 6 |
Unknown †
|
Effect of Topical Brimonidine on Post Cataract Surgery Corneal Edema
| Conditions: |
Corneal Edema; Visual Acuity |
| Interventions: |
Drug: Brimonidine Tartrate 0.2%; Drug: Timolol maleate 0.5% |
| Outcome Measures: |
central corneal thickness in micrometer; grading of corneal edema (1-3) |
|
| 7 |
Not yet recruiting
|
OCT Screening for Diabetic Macular Edema at Primary Diabetes Care Visits
| Conditions: |
Diabetes; Diabetic Macular Edema; Diabetic Retinopathy |
| Intervention: |
Device: OCT imaging |
| Outcome Measures: |
Rates of retina care for patients with diabetic macular edema; Retinal referral rates for patients with DME; Rates of retinal treatment for patients with DME; Rates of retinal treatment over 1 year for patients with DME |
|
| 8 |
Recruiting
|
Randomized Trial of Exercise on Lower Extremity Edema After Lymphadenectomy in Gynecologic Cancer
| Condition: |
Gynecologic Cancer |
| Intervention: |
Other: Pelvic and lower extremity exercise |
| Outcome Measures: |
Change in lower extremity edema-related symptoms after pelvic and lower extremities exercise; the compliance rate of management guidelines for lower extremity edema, the performance rate for pelvic and lower extremity exercise |
|
| 9 |
Unknown †
|
Power Spectral Analysis of Breath Sound in Pulmonary Edema
| Condition: |
Pulmonary Edema |
| Intervention: |
|
| Outcome Measure: |
|
|
| 10 |
Unknown †
|
Triple Therapy for Diffuse Diabetic Macular Edema
| Condition: |
Diffuse Diabetic Macular Edema |
| Intervention: |
Procedure: Triple therapy for diffuse diabetic macular edema |
| Outcome Measures: |
Best-corrected visual acuity (BCVA) and central macular thickness (CMT); Presence of vitreomacular traction or epimacular membrane, grade of DR, patients age, HbA1c level, BMI, systemic hypertension |
|
| 11 |
Not yet recruiting
|
A Phase 1, Open-Label Study of Teprotumumab in Patients With Diabetic Macular Edema (DME)
| Condition: |
Diabetic Macular Edema |
| Intervention: |
Drug: Teprotumumab |
| Outcome Measure: |
Safety of RV001in subjects with Diabetic Macular Edema |
|
| 12 |
Recruiting
|
Characterization of Eyes With Diabetic Macular Edema That Show Different Treatment Response to Intravitreal Anti-VEGF (CHARTRES)
| Condition: |
Diabetic Macular Edema |
| Intervention: |
|
| Outcome Measures: |
Central Retinal Thickness (Change from screening); Presence (and location) of cysts in the retinal layers (change from screening); Presence of OCT diffuse macular edema (without cyst formation) (change from screening); Presence of neurosensorial retinal detachment. (change from screening); Degree of integrity of the photoreceptors in the inner/outer segments layer in the 1 mm centered in the fovea (change from screening); Presence and extension of capillary occlusion (change from screening); Area of macular leakage (intraretinal fluid volume and retinal thickness) (change frmo screening); Best Corrected Visual Acuity (BCVA) (Change from screening); Central Retinal Thickness (change from screening); Area of macular leakage (intraretinal fluid volume and retinal thickness) (change from screening); Best Corrected Visual Acuity (change from screening) |
|
| 13 |
Recruiting
|
A Phase 2, Multi-Center Study To Compare The Efficacy And Safety Of A Chemokine CCR2/5 Receptor Antagonist With Ranibizumab In Adults With Diabetic Macular Edema
| Condition: |
Macular Edema, Diabetic |
| Interventions: |
Drug: Ranibizumab; Drug: Placebo; Drug: PF-04634817; Drug: Masked Sham Therapy |
| Outcome Measures: |
Mean Change from Baseline in the Best Corrected Visual Acuity Score; Proportion of participants gaining 15 ETDRS letters in BCVA from baseline; Mean changes in central subfield retinal thickness from baseline as assessed by optical coherence tomography (OCT); Mean changes in the area of fluorescein leakage from baseline by scheduled study visit as assessed by fluorescein angiography (FA); Mean change in steps of diabetic retinopathy (ETDRS severity scale) from baseline as assessed by digital fundus photography (FP); The systemic exposure of PF-04634817 in participants with diabetes and macular edema |
|
| 14 |
Unknown †
|
Assessment of Efficacy of Zoledronic Acid in the Treatment of Bone Marrow Edema Syndrome
| Condition: |
Bone Marrow Edema |
| Interventions: |
Drug: Aclasta; Drug: Placebo |
| Outcome Measures: |
Reduction of the Edema area; Reduction of pain (VAS); Quality of life (Qualeffo-41 questionnaire - Quality of life questionnaire of the European Foundation for Osteoporosis); Subjective estimation of medical condition (PDI); Number of additional medicinal visits; Number of days of illness; Number of Participants with Adverse Events as a Measure of Safety and Tolerability |
|
| 15 |
Recruiting
|
Impact of Fluid Resuscitation Therapy on Pulmonary Edema as Measured by Alveolar Fluid Clearance in Patients With Acute Respiratory Distress Syndrome (ARDS)
| Conditions: |
Acute Respiratory Distress Syndrome (ARDS); Hypovolemia; Pulmonary Edema |
| Intervention: |
Drug: hydroxyethyl starch |
| Outcome Measures: |
Rate of alveolar fluid clearance; Extra-vascular lung water; Pulmonary vascular permeability index; Global enddiastolic volume index; mean arterial pressure; cardiac output; pulse pressure variation; stroke volume variation; central venous venous oxygenation; central venous pressure; PaO2; lung compliance; airways resistance; lung injury score; Plasma levels of sRAGE; Alveolar levels of sRAGE; Brain natriuretic peptide levels; Plasma osmolarity; Oncotic pressure; Electrical impedance tomography; Mortality |
|
| 16 |
Unknown †
|
Dosing Study of Ranibizumab for Diabetic Retinal and Macular Edema
| Conditions: |
Diabetic Retinopathy; Macular Edema |
| Intervention: |
Drug: Ranibizumab |
| Outcome Measures: |
Mean change in Early Treatment for Diabetic Retinopathy Study (ETDRS) eye chart vision.; Mean number of injections.; Mean change in spectral domain optical coherence tomography (SD-OCT) central foveal thickness (CFT).; Percentage of patients with best corrected visual acuity (BCVA) Snellen-equivalent of 20/40 or better.; Percentage of patients anatomically "dry."; Number of participants with adverse events as a measure of safety and tolerability. |
|
| 17 |
Recruiting
|
Prevention and Treatment of Immersion Pulmonary Edema
| Conditions: |
Immersion Pulmonary Edema (IPE); Swimming Induced Pulmonary Edema (SIPE) |
| Intervention: |
Drug: Sildenafil |
| Outcome Measure: |
Pulmonary artery pressure during cold water immersion |
|
| 18 |
Not yet recruiting
|
Cold Magnesium Sulfate Solution for Perineal Swelling Following Vaginal Delivery
| Conditions: |
Vaginal Delivery; Perineal Swelling; Perineal Pain |
| Interventions: |
Other: Cold pads soaked in Magnesium sulfate solution; Other: Cold pads soaked in water |
| Outcome Measures: |
Reduction in the level of perineal pain; Reduction in perineal swelling; Reduction in hemorrhoids pain and swelling |
|
| 19 |
Recruiting
|
The Intraocular Pressure Measured by Different Tonometers in Corneal Edema
| Conditions: |
Intraocular Pressure; Corneal Edema |
| Intervention: |
Other: Intraocular pressure measurement |
| Outcome Measures: |
Intraocular pressure; Relationship between the central corneal thickness and intraocular pressure measured by each tonometer |
|
| 20 |
Recruiting
|
Intraoperative Dexamethasone Implant Improves Outcome of Cataract Surgery With Diabetic Macular Edema
| Conditions: |
Macular Edema, Cystoid; Vision Disorders; Diabetic Macular Edema; Cystoid Macular Edema Following Cataract Surgery; Cataract |
| Interventions: |
Drug: Dexamethasone Drug delivery system (Ozurdex); Procedure: Cataract surgery |
| Outcome Measures: |
change in the central macular thickness; Change in the visual acuity |
|
