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OFF LABEL USE and Dilaudid

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OFF LABEL USE Symptoms and Causes

Normally, your cells grow and die in a controlled way. Cancer cells keep growing without control. Chemotherapy is drug therapy for cancer. It works by killing the cancer cells, stopping them from spreading, or slowing their growth. However, it can also harm healthy cells, which causes side effects.

You may have a lot of side effects, some, or none at all. It depends on the type and amount of chemotherapy you get and how your body reacts. Some common side effects are fatigue, nausea, vomiting, pain, and hair loss. There are ways to prevent or control some side effects. Talk with your health care provider about how to manage them. Healthy cells usually recover after chemotherapy is over, so most side effects gradually go away.

Your treatment plan will depend on the cancer type, the chemotherapy drugs used, the treatment goal, and how your body responds. Chemotherapy may be given alone or with other treatments. You may get treatment every day, every week, or every month. You may have breaks between treatments so that your body has a chance to build new healthy cells. You might take the drugs by mouth, in a shot, as a cream, or intravenously (by IV).

NIH: National Cancer Institute

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OFF LABEL USE treatment research studies

Dilaudid clinical trials, surveys and public health registries


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Dilaudid Side Effects

Nausea (50)
Vomiting (47)
Pain (35)
Pruritus (33)
Overdose (33)
Headache (31)
Dyspnoea (28)
Substance Abuse (27)
Constipation (27)
Unresponsive To Stimuli (26)
Respiratory Arrest (25)
Death (25)
Dizziness (25)
Confusional State (23)
Malaise (22)
Rash (21)
Inadequate Analgesia (21)
Somnolence (20)
Cardio-respiratory Arrest (20)
Abdominal Pain (20)
Loss Of Consciousness (19)
Incorrect Dose Administered (18)
Respiratory Depression (18)
Hyperhidrosis (18)
Dehydration (18)
Back Pain (17)
Fatigue (17)
Hypotension (17)
Hallucination (17)
Weight Decreased (17)
Fall (16)
Diarrhoea (16)
Blood Pressure Decreased (15)
Pneumonia (15)
Condition Aggravated (15)
Lethargy (15)
Sedation (14)
Respiratory Rate Decreased (14)
Cardiac Arrest (14)
Feeling Abnormal (14)
Pulmonary Embolism (13)
Asthenia (13)
Anxiety (12)
Depressed Level Of Consciousness (12)
Cyanosis (11)
Coma (11)
Erythema (11)
Pain In Extremity (11)
Oxygen Saturation Decreased (11)
Insomnia (11)

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Common Meds

Abilify (10132)
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Recent Reviews

Also, Delaudid makes me itch from head to toe with no visable signs or redness or rash. I have to have Benedryl administered with each dose.

Good for pain, memory problems

Had no bad side affects i have hepc got from bodbuilding buy growth homone from china had 7 surgerys tired perocet no help then dilaudid it works get no nausea hardly in pain an i function just normal that god for it cos both my nephew are austic i

Hi laja- i had the exact same experience recently, but worse. i'd love to speak to you further to compare symptoms and what the doctor's are saying. let me know if you have any updates, and i hope you feel better!

I am taking 16 and more dilaudid number 8 mg for cellulits and am still in pain it requires 5 8s just to get out of bed the drug only works for a period of two hours and thats taking two every two hours. Iam more afraid of the pain than i am of any s

I have an interthecal pain pump that gives me 10 mg of Dilaudid every 24 hours contstant. I have severe swelling and edema of the lower legs and feet. Is this a normal side effect of this medication? My medication was recently changed from Morphine

I presented in the ER with severe back pain. I was in such a position to have suggested that I had actually crushed 1 or more vertebrae as a result of a parachuting accident. They gave me dilaudid for a pain level of 9.5/10. When they began the IV

I was treated in er for pain with 2 stacked doses of dilaudid equals 3 mg. given with zofran for nausea. i stopped breathing. they gave me narcan and came out of it, but i had severe trembling legs and extremities with severe hyperventilati

It took away the pain. Left me with depression, constipation, and loss of apetitie. Id take it for pain mgmt again, cause i hate pain. But don't want to ever have to take it again.

Look up Dilaudid Side Effects. Hallucinations and Psych problems have been reported.

45 yr old male, went to dentist had a lot of calc buildup, gave me peridex, told me it might be a little strong might need to cut it down or test it first, he gave this to me, I didnt read the label or anything I thought it was just a mouthwash WARNI

Anthony, thank you. I thought I was going nuts. Weight gain would be an understatement. Bloating and gas too. Not sure I want to continue this and I have not been on the 'full' dose --- misread the label and am happy I d

Hi i need information toward somatropin label price?

I had a devastating experience with this drug. I had been using Flexeril for back and neck pain but found it no longer as effective. I asked my doctor if there was something stronger. He prescribed Baclofen. Having not read the label carefully, m

I have been on 20 mg of Cipralex for over 3 years. It does it's job and I do not experience anxiety. In doing your homework, you will see Cipralex is for anxiety which is part of the 'depression' family. One does not label the other. One of the bigg

I have been sick with allergies/asthma/sinusitis for over a week and when I took Mucinex DM I made sure to read the label carefully. My carton said to take 1 every 12 hours and no more than 2 in 24 hours. After taking the first pill it had no effect

I haven't had an abortion induced but the medicine label clearly states to use two forms of protection. If the patient has unprotected sex, that the patient's problem. Every doctor visit my doctor stressed to me how much the medicine could

I may try Lyrica off label for GAD and PD as well as some antidepressive effects I read in journals, articles. Lyrica has been approved for GAD in Europe but hasn't gotten the FDA approval for it here yet. The above poster, Case Report #Self-49

I take Centrum Silver and wanted a label that I could read.

Is a GG 40 with a Sandoz label made in a different laboratory than a GG 40 with a Geneva label? (I know they are both 10 mg of amitriptyline.) Thank you. Appreciate reply as soon as possible.

OFF LABEL USE Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Not yet recruiting Intrathecal Hydromorphone for Post-cesarean Delivery Pain - a Dose Finding Study
Conditions: Healthy;   Human;   Adult;   Parturient
Interventions: Drug: Hydromorphone 25mcg;   Drug: Hydromorphone 50mcg;   Drug: Hydromorphone 100mcg;   Drug: Hydromorphone 200mcg
Outcome Measures: 24hr post-partum IV opioid requirement;   Oxygen saturation, need for supplemental oxygen;   Nausea and vomiting requiring rescue medication;   Hypothermia (body temperature < 95F/35C);   Visual disturbances;   Pruritus;   Intraoperative vasopressor use
2 Recruiting Study of Respiratory Depression When Using a Hydromorphone Pain Protocol
Conditions: Pain;   Respiratory Depression
Interventions: Drug: Hydromorphone;   Drug: Usual care group
Outcome Measures: Respiratory Depression;   Successful treatment of patient pain;   Change in VAS score;   Hypoxia;   Hypotension;   Allergic reaction to study drug;   Serious Adverse Events
3 Recruiting Association Between Body Size and Response to Hydromorphone in ED
Condition: Pain
Intervention: Drug: Hydromorphone
Outcome Measures: Association between pain scale change and TBW/BMI;   Association between change in pain at 15 minutes,;   pain treatment satisfaction at 30 min;   adverse events (low SatO2<92%, SBP< 90mmHg);   side effects (nausea, vomit, itching);   influence of gender on the association between TBW, BMI and response to iv hydromorphone;   influence of race/ethnicity, and genetic factors on the association between TBW, BMI and response to iv hydromorphone;   influence of genetic factors on the association between TBW, BMI and response to iv hydromorphone;   influence of age on the association between TBW/BMI and response to hydromorphone
4 Not yet recruiting Intrathecal Hydromorphone for Pain Control After Cesarean Section
Conditions: Pain;   Cesarean Section
Interventions: Drug: Intrathecal morphine;   Drug: Intrathecal hydromorphone
Outcome Measures: Post operative fentanyl PCA consumption;   Time to initial PCA use;   Pain score;   Patient satisfaction score;   Side effects
5 Recruiting Titration of Intravenous Hydromorphone
Condition: Acute Severe Pain
Intervention: Drug: Hydromorphone
Outcome Measure: Frequency of different patterns of opioid request
6 Recruiting Methadone and Hydromorphone For Spinal Surgery
Conditions: Hydromorphone Use;   Acute Postoperative Pain;   Patient Satisfaction;   Chronic Persistent Surgical Pain
Interventions: Drug: Methadone;   Drug: Hydromorphone
Outcome Measures: Hydromorphone use at 24 hours;   Hydromorphone use second 24 hours;   Hydromorphone use third 24 hours;   Pain scores postanesthesia care unit (PACU) arrival;   Pain scores 1 hour after PACU arrival;   Pain scores 2 hours after PACU arrival;   Pain scores 4 hours after PACU arrival;   Pain scores on postoperative day one;   Pain scores on postoperative day 2;   Pain scores postoperative day 3;   Patient satisfaction scores;   Chronic persistent surgical pain
7 Recruiting Safety and Efficacy Study of Hydromorphone HCl by Intrathecal Administration Using a Programmable Implantable Pump
Condition: Management of Chronic Pain
Intervention: Drug: Hydromorphone Hydrochloride
Outcome Measures: Superiority of intrathecal hydromorphone hydrochloride as compared to a control arm.;   Functionality based on a Brief Pain Inventory
8 Recruiting Single-arm Study to Assess the Safety of Hydromorphone HCl by Intrathecal Administration
Condition: Chronic Pain
Intervention: Drug: Hydromorphone Hydrochloride
Outcome Measure: Frequency of Adverse Events during a 12-month period of treatment with intrathecal hydromorphone.
9 Unknown  Safety and Efficacy of Intravenous Hydromorphone in Elderly Emergency Department Patients With Acute Severe Pain
Condition: Pain
Interventions: Drug: Hydromorphone;   Drug: Usual care
Outcome Measure: Proportion with successful treatment
10 Recruiting Intrathecal Hydromorphone for Cesarean Section
Condition: Pain
Intervention: Drug: intrathecal hydromorphone (IT hydromorphone)
Outcome Measures: The primary objective is to find the optimal dose of IT hydromorphone for pain relief following C/S.;   A secondary objective is to define the incidence and severity of hydromorphone's side effects.;   A secondary objective is to determine the duration of analgesia
11 Recruiting Fentanyl for Breakthrough Pain in the Emergency Department
Condition: Pain
Interventions: Drug: Fentanyl Nasal Spray;   Drug: Hydromorphone PCA;   Other: Placebo Nasal Spray
Outcome Measure: Total Pain Relief Score
12 Recruiting Use of Intrathecal Hydromorphone in Elective Cesarean Deliveries
Condition: Pain
Interventions: Drug: Hydromorphone;   Drug: Morphine
Outcome Measures: Change in Pain Scores;   Number of Participants with Adverse Events (AEs)
13 Recruiting True Functional Restoration and Analgesia in Non-Radicular Low Back Pain
Condition: Low Back Pain
Intervention: Drug: Hydromorphone ER
Outcome Measures: The efficacy of Exalgo (hydromorphone HCl extended release) in Chronic Non-Radicular Low Back Pain (CNRBP) model syndrome to improve pain, function and activity;   The relationship between pain ratings and functioning
14 Recruiting Intrathecal Opioids for Pain Control After Cesarean Delivery: Determining the Optimal Dose
Conditions: Analgesia, Obstetrical;   Cesarean Section
Interventions: Drug: Morphine;   Drug: Hydromorphone
Outcome Measures: Visual analog pain score following spinal anesthesia administration;   Total opioid medication consumption;   Visual analog pain score following administration of spinal anesthesia;   Side effects: Pruritus;   Side effects: Nausea;   Side effects: Sedation
15 Recruiting Multiple Dose Study of Blockade of Opioid Effects of Subcutaneous Injections of Buprenorphine in Participants With Opioid Use Disorder
Condition: Opioid Use Disorder
Interventions: Drug: Buprenorphine;   Drug: buprenorphine and naloxone;   Drug: hydromorphone;   Drug: placebo
Outcome Measures: Opioid Blockade Following Administration of 0, 6, or 18 mg Intramuscular (IM) Hydromorphone As Measured Using the Subjective Opioid Effects Rating for the Question "Do you like the drug?" Visual Analog Scale (VAS);   Reinforcing Effects Of the Daily Randomized Hydromorphone Challenge as Measured by the Mean Hydromorphone Break Point Value;   Relationship between plasma concentration and predicted mu opioid receptor occupancy of buprenorphine and both the blockade of the subjective effects of hydromorphone post injection of buprenorphine 300 mg (RBP-6000);   Summary of Participants with Adverse Events;   Correlation between the opioid blockade subjective effect when participants are asked "Do you feel any drug effect?" and simulated mu opioid receptor occupancy;   Correlation between the opioid blockade subjective effect when participants are asked "Does the drug have any good effects?" and simulated mu opioid receptor occupancy;   Correlation between the opioid blockade subjective effect when participants are asked "Do you like the drug?" and simulated mu opioid receptor occupancy;   Correlation between the opioid blockade subjective effect when participants are asked "Do you feel sedated?" and simulated mu opioid receptor occupancy;   Correlation between the opioid blockade subjective effect when participants are asked "How high are you right now?" and simulated mu opioid receptor occupancy;   Correlation between the opioid blockade subjective effect when participants are asked "Does the drug have any bad effects?" and simulated mu opioid receptor occupancy
16 Recruiting Postoperative Pain Therapy With Hydromorphone Using TCI-PCA
Condition: Postoperative Pain
Intervention: Drug: Hydromorphone
Outcome Measures: Hydromorphone Plasma Concentrations;   Numerical Rating Score
17 Unknown  Trial Comparing Morphine to Hydromorphone in Elderly Patients With Severe Pain
Condition: Acute Pain
Interventions: Drug: Morphine 0.05 mg/kg Intravenous;   Drug: Hydromorphone 0.0075 mg/kg intravenous
Outcome Measures: The between-group difference in before-after improvement in pain scores measured 30 minutes after medications are infused.;   Pain score comparisons at 15 minutes and 120 minutes;   Total mg of additional pain medications required after initial medication;   Pain relief measurement;   Patient satisfaction measurement;   Comparison of adverse events
18 Recruiting Study of the Treatment of Experimental Pain in Opioid Dependent Persons on Methadone or Buprenorphine Maintenance
Conditions: Opioid Dependence;   Pain;   Addiction
Interventions: Drug: Placebo;   Drug: Hydromorphone;   Drug: Buprenorphine
Outcome Measures: Cold pressor test.;   Innocuous stimulation.;   Pressure pain.;   Thermal pain.;   Temporal summation.;   Diffuse noxious inhibitory controls (DNIC).;   Visual analog scales (VAS) of subjective drug effects.;   Pupil diameter.;   Number of participants with adverse events.;   Profile of Mood States.;   Vital Signs.;   Trait pain catastrophizing.;   Situational pain catastrophizing.
19 Unknown  Clinical Trial Comparing Two Protocols Using Intravenous (IV) Hydromorphone
Condition: Acute Pain
Interventions: Drug: H2O;   Drug: 1+1
Outcome Measures: Decline additional pain medication;   Number of participants with hypotension (SBP < 90 mmHg);   Number of participants with bradycardia (HR < 50/min);   Number of patients with nausea and vomiting;   Number of participants with pruritus;   Number of participants needing naloxone as a reversal agent
20 Recruiting Epidural Analgesia Versus IV Analgesia in Lumbar Spine Fusions
Conditions: Lumbar Spine Fusion;   Pain;   Back Pain
Interventions: Other: Epidural Catheter - Dilaudid;   Drug: Dilaudid
Outcome Measures: Post-operative pain as assessed by Visual Analogue Scale;   Assessing change in patient functional status with regards to depression, anxiety, and pain;   Patient satisfaction with peri-operative care;   Patient satisfaction with perioperative analgesia;   Number of participants with adverse events