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OSTEOARTHRITIS and ACIPHEX

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OSTEOARTHRITIS Symptoms and Causes

Osteoarthritis is the most common form of arthritis. It causes pain, swelling, and reduced motion in your joints. It can occur in any joint, but usually it affects your hands, knees, hips or spine.

Osteoarthritis breaks down the cartilage in your joints. Cartilage is the slippery tissue that covers the ends of bones in a joint. Healthy cartilage absorbs the shock of movement. When you lose cartilage, your bones rub together. Over time, this rubbing can permanently damage the joint.

Risk factors for Osteoarthritis include

  • Being overweight
  • Getting older
  • Injuring a joint

No single test can diagnose Osteoarthritis. Most doctors use several methods, including medical history, a physical exam, x-rays, or lab tests.

Treatments include exercise, medicines, and sometimes surgery.

NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

Check out the latest treatments for OSTEOARTHRITIS

OSTEOARTHRITIS treatment research studies

ACIPHEX clinical trials, surveys and public health registries


Find Drug Side Effect reports



ACIPHEX Side Effects

Pain (30)
Headache (27)
Fatigue (24)
Nausea (24)
Dizziness (23)
Dyspnoea (22)
Chest Pain (22)
Diarrhoea (21)
Abdominal Pain Upper (19)
Pneumonia (18)
Cholecystitis Chronic (18)
Hypertension (17)
Oedema Peripheral (16)
Anxiety (16)
Cholelithiasis (16)
Myocardial Infarction (16)
Pruritus (15)
Pain In Extremity (14)
Depression (14)
Fall (13)
Loss Of Consciousness (13)
Dyspepsia (13)
Death (13)
Gallbladder Disorder (12)
Abdominal Pain (12)
Weight Decreased (12)
Asthenia (11)
Cerebrovascular Accident (11)
Feeling Abnormal (10)
Chronic Obstructive Pulmonary Disease (10)
Hypoaesthesia (10)
Rash (10)
Insomnia (10)
Pulmonary Embolism (10)
Paraesthesia (10)
Palpitations (10)
Injury (10)
Burning Sensation (9)
Muscle Spasms (9)
Chest Discomfort (9)
Arthralgia (9)
Deep Vein Thrombosis (8)
Emotional Distress (8)
Nephritis Interstitial (8)
Vomiting (8)
Cough (8)
Back Pain (8)
Cardiac Failure Congestive (8)
Condition Aggravated (8)
Coronary Artery Disease (8)

➢ More


Common Meds

Abilify (10132)
Adderall (1304)
Amlodipine (6664)
Amoxicillin (4387)
Benadryl (1568)
Celebrex (12876 )
Celexa (1342)
Cialis (2975)
Cipro (8580)
Citalopram (7792)
Crestor (18839)
Cymbalta (14373)
Doxycycline (1757)
Effexor (7289)
Flexeril (435)
Flomax (2177)
Fluoxetine (4261)
Gabapentin (4593)
Hydrocodone (2469)
Ibuprofen (8222)
Lantus (10968)
Lexapro (3499)
Lipitor (17769)
Lisinopril (8919)
Lyrica (27148)
Medrol (650)
Mirena (41254)
Mobic (957)
Morphine (5356)
Naproxen (538)
Neurontin (6501)
Oxycodone (4438)
Pradaxa (13372)
Prednisone (5926)
Prilosec (2631)
Prozac (1954)
Seroquel (27216)
Simvastatin (8348)
Synthroid (4452)
Tamiflu (5585)
Topamax (3748)
Tramadol (5054)
Trazodone (1458)
Viagra (5394)
Vicodin (1153)
Wellbutrin (6324)
Xanax (2847)
Zocor (5718)
Zoloft(6792)
Zyrtec(1669)

Recent Reviews

Have experienced polyneuropathy after taking aciphex this past year

I am a 28 year old female who was diagnosed 3 years ago with a hiatal hernia, 9 stomach ulcers and constant gastritis. They put me on aciphex. I have been on it ever since as it is the only thing that stops the pain. Just recently (within the

I have been taking aciphex for 7 days dont seem to be any different wonder if it takes a bit for it to work anyone else have this problem.

How long should one remain off work with lower leg (both legs) cellulitis? It is my 4th bout of this in past few years. I also have osteoarthritis in my knees.

I am on 20mg side effect sever sweatingi suffer from osteoarthritis in lower back

I am unable to walk following my Lupron treatment. I experienced extreme muscle weakness and loss of function in my right quad muscles. I also had prominent loss of fatty bopne marrow, joint degenerative disease, osteoarthritis, vitamin D deficienc

I got infusion of Reclast in December 2008 and experienced no side affects until a few weeks ago. Now I know I have some osteoarthritis & scoliosis, but have never experienced pain so severe & disabling. I haven't altered my r

I had my infusion in March 2008 and I'm still suffering with shoulder, wrist, fingers, hip and ankle pain. My fingers and wrists are swollen and it is very hard to use my fingers. Reclast has ruined my quality of life. Now I have osteoarthritis th

I have been taking Fenac for Osteoarthritis for a few weeks this time. Every time I take 50-100 I begin to get feel bloated, then I begin to have pain in my feet and hands and they feel tight as though I am retaining fluid in them. In the mornings wa

I have deveolped cellulitis toe nail and funger nails and believe it is because of taking Mobic I have osteoarthritis knee (macerated meniscus)

I have osteoarthritis in both knees and one hip. I do supervised weight-training 3 times a week to strengthen muscles around these joints and for general fitness. This helps immensely but I still experience a lot of pain and stifness most days, espec

I just have had a tooth extraction and implant for a left molar. The dentist asked me if I was taking anything for osteoarthritis. I said Boniva. He stated that boniva and Fosomax was detrimental to wound healing and that it opened the osteoblast

I was taking Mobic for Osteoarthritis in both knees, I am a nurse and by the end of the day I have a great deal of pain from walking all day. My doctor prescribed Celebrex in the hopes it would help, after 1 week on Celebrex I did not have any addit

OSTEOARTHRITIS Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Unknown  Comparison of Oral Rabeprazole vs. iv Omeprazole in Mild to Moderate Nonvariceal Upper Gastrointestinal Bleeding
Condition: Nonvariceal Upper Gastrointestinal Bleeding
Interventions: Drug: Intravenous Omeprazole;   Drug: Oral Rabeprazole
Outcome Measure: This study aims to compare the effect of three-day oral rabeprazole and iv omeprazole on bleeding control in patients with mild to moderate non-variceal UGIB.
2 Unknown  Comparison of Ulcer Healing in Patients Taking Rabeprazole With Different Antiplatelets
Conditions: Gastric Ulcer;   Duodenal Ulcer
Intervention: Drug: rabeprazole plus aspirin versus rabeprazole plus clopidogrel
Outcome Measures: The primary end point is treatment success (ulcer healing rate).;   The secondary end point is incidence of ulcer bleeding within 12 weeks.
3 Recruiting A Pharmacokinetics (PK) Study of the Effects Rabeprazole and Rifampin on Dabrafenib in Subjects With BRAF V600 Mutation Positive Tumors
Condition: Cancer
Interventions: Drug: Dabrafenib 150 mg twice a day (BID);   Drug: Rabeprazole 40 mg once daily (OD);   Drug: Rifampin 600 mg OD
Outcome Measures: PK assessment (Cmax) of Dabrafenib with and without Rabeprazole or Rifampin;   PK assessment (tmax) of Dabrafenib with and without Rabeprazole or Rifampin;   PK assessment (AUC[0-tau]) of Dabrafenib with and without Rabeprazole or Rifampin;   PK assessment of Dabrafenib co administered with rabeprazole or rifampin;   PK assessment (AUC[0-tau]) of hydroxy-dabrafenib, carboxy-dabrafenib, and desmethyl-dabrafenib;   PK assessment (Cmax and Ctau,) of hydroxy-dabrafenib, carboxy-dabrafenib, and desmethyl-dabrafenib;   PK assessment (tmax) of hydroxy-dabrafenib, carboxy-dabrafenib, and desmethyl-dabrafenib;   Ratio of metabolite to Dabrafenib;   Safety and tolerability assessment to measure vital signs;   Safety and tolerability assessment for 12-lead ECG;   Safety and tolerability assessment for laboratory tests;   Safety and tolerability assessment of dabrafenib in combination with rabeprazole or rifampin;   Concentrations of Rabeprazole in the presence of Dabrafenib;   Concentrations of Rifampin in the presence of Dabrafenib
4 Unknown  Rabeprazole Based Sequential-Concommitant Hybrid Therapies for H. Pylori Infections
Condition: Helicobacter Pylori Infection
Interventions: Drug: RA5-RACM7;   Drug: RA3-RACM7;   Drug: RA7-RACM7
Outcome Measure: Eradication rate
5 Recruiting Concomitant Therapy of H. Pylori
Condition: Gastritis, Gastric Ulcer, and Duodenal Ulcer
Intervention: Drug: amoxicillin, clarithromycin, metronidazole, rabeprazole
Outcome Measure: Evaluation of the efficacy of concomitant therapy for eradication of Helicobacter pylori
6 Recruiting Study Of Three Different Stomach Acid Reducing Agents When Given With Palbociclib (PD-0332991) And Food
Condition: Healthy
Interventions: Drug: palbociclib commercial free base;   Drug: famotidine;   Drug: rabeprazole;   Drug: antacid
Outcome Measures: Area Under the Curve From Time Zero to Extrapolated Infinite Time [AUC (0 - 8)];   Maximum Observed Plasma Concentration (Cmax);   Area Under the Curve From Time Zero to Last Quantifiable Concentration (AUClast);   Apparent Oral Clearance (CL/F);   Time to Reach Maximum Observed Plasma Concentration (Tmax);   Apparent Volume of Distribution (Vz/F);   Plasma Decay Half-Life (t1/2)
7 Recruiting H2RA VS PPI for the Prevention of Ulcer Bleeding Associated With Low-dose Aspirin in Patients With Very High Ulcer Risk
Condition: Peptic Ulcer Bleeding
Interventions: Drug: Rabeprazole;   Drug: Famotidine
Outcome Measures: Recurrent ulcer bleeding;   Lower GI bleeding;   serious cardiothrombotic events
8 Recruiting Prognostic Study of Gastric MALT Lymphoma After Eradication of Helicobacter Pylori
Condition: Gastric Low-grade MALT Lymphoma With Helicobacter Pylori Positive
Intervention: Drug: Rabeprazole Sodium
Outcome Measures: Response rate of gastric low-grade MALT lymphoma by eradication of Helicobacter pylori;   Transition rate to secondary therapy for eradication of Helicobacter pylori
9 Unknown  Increased Re-eradication Rate of Helicobacter Pylori by Adding N-acetylcystein or Metronidazole to the Triple Therapy
Condition: Bacterial Infection Due to Helicobacter Pylori (H. Pylori)
Interventions: Drug: 10RAC+acetylcystein;   Drug: 10RAC+metronidazole
Outcome Measures: Re-eradication rate;   Influence of Participant's CYP2C19 genotype on re-eradication rate
10 Unknown  Second Line Therapy for the Cure of Helicobacter Pylori (H. Pylori) Infection
Conditions: Helicobacter Infections;   Gastritis;   Gastric Ulcer;   Duodenal Ulcer
Intervention: Drug: rabeprazole, amoxicillin, clarithromycin, metronidazole
Outcome Measures: Which treatment yields the higher re-eradication rate of H. pylori infection;   Side effects
11 Recruiting The Study to Evaluate Efficacy and Safety of Newrabell® Tab.(Rabeprazole Sodium) 10mg b.i.d in Refractory GERD
Condition: Reflux Esophagitis
Intervention: Drug: Newrabell® Tablet 10mg
Outcome Measures: Time to onset of first 1Day Heartburn free, Days;   Time to onset of first 2Days Heartburn free, Days;   1Day Heartburn free days, %;   Time in Daytime of first Heartburn free, Days;   Time in Nighttime of first Heartburn free, Days;   Weekly Heartburn Improvement Rate, %;   Average Daytime and Nighttime Heartburn Score Change at W4;   Average Daytime and Nighttime Heartburn Score Change at W8
12 Unknown  A Study of the Use of High-dose Proton Pump Inhibitor for the Treatment of Gastro-oesophageal Reflux Related Non-cardiac Chest Pain - a Randomized Double-blind Placebo-controlled Study
Condition: Chest Pain
Intervention: Drug: Rabeprazole 20mg twice daily
Outcome Measures: Symptoms assessment, quality of life.;   Compliance;   Adverse effects
13 Unknown  Endoscopic Fundoplication Versus Proton Pump Inhibitors for GERD Treatment
Condition: Gastroesophageal Reflux Disease (GERD)
Interventions: Procedure: Transoral Incisionless Fundoplication;   Drug: Proton Pump Inhibitors; active control
Outcome Measures: GERD symptoms;   PPI usage;   Lower esophageal acid exposure;   Healed reflux esophagitis;   Rate of adverse events
14 Recruiting The Proton Pump Inhibitor (PPI) Test for the Extraesophageal Manifestation of GERD
Condition: Gastroesophageal Reflux Disease
Intervention: Drug: Proton pump inhibitor (rabeprazole)
Outcome Measure: Symptom responders after PPI trials
15 Unknown  Evaluation of Antiplatelet Drug Resistance in Taiwanese With VASP & Platelet Mapping ™ Assay
Condition: 30 Healthy People
Intervention: Drug: Clopidogrel and proton pump inhibitors
Outcome Measure: Comparison of the antiplatelet drug response apparently shown in TEG & Platelet mapping assay
16 Recruiting The Changes of Ryodoraku and HRV After PPI Treatment in GERD Patients
Conditions: Non-erosive Reflux Disease;   Barrett's Esophagus
Interventions: Device: Ryodoraku;   Device: ANSWatch;   Device: UGI endoscopy;   Other: GerdQ;   Drug: PPI
Outcome Measures: gastroesophageal reflux disease questionnaire;   Upper gastrointestinal endoscopy
17 Recruiting Efficacy of 10-day Concomitant Regimen Versus High Dose Dual Therapy in Anti-Helicobacter Pylori Rescue Therapy
Condition: Helicobacter Pylori Infection
Interventions: Drug: high dose dual therapy;   Drug: concomitant therapy
Outcome Measures: to compare the efficacy of 10-day concomitant regimen versus high dose dual therapy used as atni-Helicobacter pylori rescue therapy;   to compare the adverse effects and patient adherence of 10-day concomitant regimen versus high dose dual therapy used as atni-Helicobacter pylori rescue therapy
18 Unknown  Symptom Assessment for GERD Patients Receiving H. Pylori Eradication
Condition: Gastroesophageal Reflux Disease
Intervention:
Outcome Measure: The incidence and severity of acid-related symptoms with GerdQ