OSTEOARTHRITIS Symptoms and Causes

Osteoarthritis is the most common form of arthritis. It causes pain, swelling, and reduced motion in your joints. It can occur in any joint, but usually it affects your hands, knees, hips or spine.

Osteoarthritis breaks down the cartilage in your joints. Cartilage is the slippery tissue that covers the ends of bones in a joint. Healthy cartilage absorbs the shock of movement. When you lose cartilage, your bones rub together. Over time, this rubbing can permanently damage the joint.

Risk factors for Osteoarthritis include

  • Being overweight
  • Getting older
  • Injuring a joint

No single test can diagnose Osteoarthritis. Most doctors use several methods, including medical history, a physical exam, x-rays, or lab tests.

Treatments include exercise, medicines, and sometimes surgery.

NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

Check out the latest treatments for OSTEOARTHRITIS

OSTEOARTHRITIS treatment research studies

Voltaren clinical trials, surveys and public health registries

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Voltaren Side Effects

Off Label Use (256)
Dyspnoea (171)
Therapeutic Response Unexpected (136)
Blood Creatinine Increased (129)
Aspartate Aminotransferase Increased (122)
Pain (115)
Alanine Aminotransferase Increased (114)
Nausea (114)
Pyrexia (112)
Erythema (108)
Blood Urea Increased (108)
Dizziness (107)
C-reactive Protein Increased (105)
Blood Pressure Decreased (105)
Renal Failure Acute (103)
Haemoglobin Decreased (85)
Blood Lactate Dehydrogenase Increased (84)
Anaemia (84)
Underdose (83)
Abdominal Pain Upper (81)
Diarrhoea (80)
Rash (80)
Oedema Peripheral (77)
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Loss Of Consciousness (74)
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Fall (64)
Hypotension (62)
Pain In Extremity (59)
Gastrointestinal Haemorrhage (57)
Headache (56)
Overdose (56)
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Asthenia (54)
Blood Alkaline Phosphatase Increased (54)
Depressed Level Of Consciousness (53)
Chest Pain (52)
Melaena (51)
Blood Creatine Phosphokinase Increased (51)
Blood Bilirubin Increased (49)
Back Pain (49)
Disseminated Intravascular Coagulation (49)
Haematemesis (49)
Liver Disorder (49)
Blister (48)
Hypertension (47)

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Recent Reviews

It seems as though after I have applied the Voltaren to my hands and feet a couple of hours later or even the next day, I get a migrane headache and slowly but very surely all my joints, from my neck down to my elbows, knees, hips are especially pain

What is dyspnoae

How long should one remain off work with lower leg (both legs) cellulitis? It is my 4th bout of this in past few years. I also have osteoarthritis in my knees.

I am on 20mg side effect sever sweatingi suffer from osteoarthritis in lower back

I am unable to walk following my Lupron treatment. I experienced extreme muscle weakness and loss of function in my right quad muscles. I also had prominent loss of fatty bopne marrow, joint degenerative disease, osteoarthritis, vitamin D deficienc

I got infusion of Reclast in December 2008 and experienced no side affects until a few weeks ago. Now I know I have some osteoarthritis & scoliosis, but have never experienced pain so severe & disabling. I haven't altered my r

I had my infusion in March 2008 and I'm still suffering with shoulder, wrist, fingers, hip and ankle pain. My fingers and wrists are swollen and it is very hard to use my fingers. Reclast has ruined my quality of life. Now I have osteoarthritis th

I have been taking Fenac for Osteoarthritis for a few weeks this time. Every time I take 50-100 I begin to get feel bloated, then I begin to have pain in my feet and hands and they feel tight as though I am retaining fluid in them. In the mornings wa

I have deveolped cellulitis toe nail and funger nails and believe it is because of taking Mobic I have osteoarthritis knee (macerated meniscus)

I have osteoarthritis in both knees and one hip. I do supervised weight-training 3 times a week to strengthen muscles around these joints and for general fitness. This helps immensely but I still experience a lot of pain and stifness most days, espec

I just have had a tooth extraction and implant for a left molar. The dentist asked me if I was taking anything for osteoarthritis. I said Boniva. He stated that boniva and Fosomax was detrimental to wound healing and that it opened the osteoblast

I was taking Mobic for Osteoarthritis in both knees, I am a nurse and by the end of the day I have a great deal of pain from walking all day. My doctor prescribed Celebrex in the hopes it would help, after 1 week on Celebrex I did not have any addit

OSTEOARTHRITIS Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting Osteoarthritis Cardiovascular Risk Factors
Conditions: Osteoarthritis;   Cardiovascular Risk Factors;   Cardiovascular Disease;   Metabolic Syndrome
Interventions: Other: Cardiovascular risk factors diagnoses collection.;   Other: History of cardiovascular disease;   Other: Cardiovascular risk factors association
Outcome Measures: Prevalence of cardiovascular risk factors in hand or knee Osteoarthritis patients;   Prevalence of cardiovascular disease in hand or knee Osteoarthritis.
2 Recruiting Yoga as an Intervention for Women With Knee Osteoarthritis
Condition: Osteoarthritis
Intervention: Other: Yoga For Knee Osteoarthritis
Outcome Measures: Change in Knee Extensor Torque;   Change in Knee Pain;   Change in Six Minute Walk Test (6MWT);   Change in 30-second Chair Stand;   Change in Timed Up and Go (TUG);   Change in Stair Ascent and Descent;   Change in Subjective Scales;   Change in Cardiovascular Fitness;   Change in Biomechanical Outcomes
3 Recruiting The Effect of Structured Information and Individually Adapted Exercise on Levels of Physical Activity Measured by Accelerometer in Patients With Knee or Hip Osteoarthritis
Condition: Osteoarthritis
Intervention: Behavioral: A supported self management of Osteoarthritis program
Outcome Measures: Level of physical activity;   Quality of life;   Physical activity;   Pain;   Charnley score
4 Unknown  Platelet Rich Plasma (PRP) as a Treatment for Knee Osteoarthritis PRP as a Treatment for Knee Osteoarthritis
Condition: Osteoarthritis of the Knee
Interventions: Biological: Platelet Rich Plasma (Preparation Rich in Growth Factors);   Drug: Hyaluronic acid
Outcome Measure: Improvement in pain, function, quality of life and activity level in knee Osteoarthritis
5 Not yet recruiting Study of Association Between Digital Osteoarthritis and Lower Limb Osteoarthritis
Condition: Digital Arthrosis
Intervention: Radiation: Hand X-rays
Outcome Measures: Kellgren and Lawrence score;   Harris score
6 Not yet recruiting Osteoarthritis Structural Changes Assessed by Magnetic Resonance Imaging (MRI) and Neuropathic Pain in Knee Osteoarthritis
Conditions: Neuropathic Pain;   Knee Osteoarthritis
Intervention: Other: MRI
Outcome Measures: To correlate the level of neuropathic pain with the severity of OA structural changes (cartilage volume and defects, bone marrow lesions, meniscal tears and extrusion, synovitis).;   To assess the correlation between the presence of neuropathic pain and the Western Ontario and McMaster Universities Arthritis Index (WOMAC) scores (total, pain, function, stiffness).
7 Unknown  A Comparison of Kneipp Hydrotherapy With Conventional Physiotherapy in the Treatment of Osteoarthritis of the Hip or Knee: Protocol of a Prospective Randomised Controlled Clinical Trial
Condition: Osteoarthritis of the Hip or Knee
Interventions: Procedure: Physiotherapy;   Procedure: Affusion;   Procedure: Affusion/ Physiotherapy
Outcome Measures: The primary outcome measure will be the pain intensity of the affected joint during inpatient care, as assessed by the patient and the investigator;   I) Mobility of the affected joint II) Quality of life rating for the patient with Osteoarthritis, on the basis of the German version of the Arthritis Impact Measurement Scale (AIMS2)
8 Recruiting Internet Intervention to Improve Physical Activity in Early Knee Osteoarthritis
Condition: Knee Osteoarthritis
Intervention: Behavioral: OPEN website
Outcome Measures: Modified Minnesota Leisure Time Physical Activity Questionnaire (MLTPAQ).;   Knee Injury and OA Outcome Score (KOOS).;   Rhode's 7-point Likert-type Theory of Planned Behaviour questionnaire;   Aerobic fitness (V02Peak)
9 Unknown  Intra-Articular Autologous Bone Marrow Mesenchymal Stem Cells Transplantation to Treat Mild to Moderate Osteoarthritis
Condition: Osteoarthritis
Interventions: Drug: Hyaluronic Acid;   Biological: Autologous bone marrow-derived mesenchymal stem cells
Outcome Measures: Change from baseline in cartilage thickness at 12 months by MRI;   Visual Analog Score;   IKDC Subjective Knee Evaluation Form (2000);   Change from baseline in progression of Osteoarthritis at 12 months by plain radiograph (X-ray)
10 Recruiting Transplantation of Bone Marrow Stem Cells Stimulated by Proteins Scaffold to Heal Defects Articular Cartilage of the Knee
Conditions: Osteoarthritis;   Knee Osteoarthritis;   Osteochondritis Dissecans;   Osteonecrosis
Intervention: Procedure: Transplantation of Bone Marrow Stem Cells Activated in Knee Arthrosis
Outcome Measures: IKS, International Knee Score;   KOOS, Knee Injury and Osteoarthritis Outcome Score
11 Recruiting Determination of Adipocytokine in Synovial Fluid of Osteoarthritis Patients
Condition: Osteoarthritis
Interventions: Other: arthrocentesis;   Other: ultrasonography of the knee
Outcome Measures: Determination of adipocytokine levels (adiponectin, leptin, resistin, visfatin, osteopontin) in synovial fluid;   Knee inflammation parameters detected by ultrasonography;   To determine additional classic parameters of inflammation in synovial fluid as Interleukine 1 beta, Interleukine 6 and tumor necrosis factor alfa
12 Recruiting Comparing the Clinical Effects of Posterior Approach Versus Lateral Approach in Osteoarthritis Patients With a THA
Condition: Unilateral Primary Osteoarthritis of Hip
Intervention: Procedure: Total hip arthroplasty
Outcome Measures: Hip Disability and Osteoarthritis Outcome Score (HOOS)-Physical Function Short form(HOOS-PS), 12 month;   Hip Disability and Osteoarthritis Outcome Score (HOOS)-pain, 12 month;   Hip Disability and Osteoarthritis Outcome Score (HOOS)-Hip related quality of life, 12 month;   University of California Los Angeles activity score (UCLA), 12 month;   EQ-5D self-rated health index -(using EQ VAS scores), 12 month;   The 20 meter walk-test (20MeWa);   "Timed Up and Go"- test (TUG), 3 month;   "Repeated chair rise"- test (RCR), 3 month;   30 seconds maximal repeated unilateral knee bending, 3 month;   Opioid consumption, 3 month;   Self-reported pain on a numerical ranking scale(NRS), 3 month;   Hip Disability and Osteoarthritis Outcome Score (HOOS)-pain, 3 month;   Hip Range of motion (ROM), 3 month;   Gait Deviation Index(GDI), 12 month;   Kinematic gait data, 12 month;   Temporospatial parameters, 12 month;   Electromyography (EMG) during walk, 12 month;   Isometric maximal voluntary muscle contraction(MVC), 12 month;   Hip Disability and Osteoarthritis Outcome Score (HOOS)-Activities of daily
13 Recruiting DIGItal Cohort Osteoarthritis Design
Condition: Arthrosis of Hand
Intervention: Other: GENETIC and radiographs
Outcome Measures: Baseline clinical, biological, genetic and imaging factors of clinical aggravation after 3 years of follow-up(AUSCAN VA3.0);   Kallman score, Verbruggen score, Kellgren-Lawrence grading and OARSI scoring (Altman score);   patients above 35 years old with symptomatic and radiographic hand Osteoarthritis
14 Recruiting Influence of Adipocytokines in Osteoarthritis
Conditions: Osteoarthritis, Knee;   Endocrine System Diseases;   Cardiovascular Risk Factors
Intervention: Other: Blood analyse, arthrocentesis, ultrasound examination
Outcome Measures: adipocytokine level;   Ultrasound inflammatory exploration of the knee;   Ultrasound of carotid artery;   Cardiovascular risk factors
15 Recruiting Hip Osteoarthritis: Effects of Exercise Programs on Pain and Disability
Condition: Hip Osteoarthritis
Interventions: Behavioral: Structured exercise program;   Behavioral: Waitlist, delayed intervention
Outcome Measures: Physical function: 6-minute walk test;   Pain: Visual analog scale;   Patient Global Assessment: Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and The Short Form-36 (SF-36);   Joint Imaging: hip radiographs
16 Not yet recruiting Effects of Glucosamine on Joint Fluid in Osteoarthritis Patients
Condition: Knee Osteoarthritis
Interventions: Dietary Supplement: Glucosamine sulphate;   Other: Placebo
Outcome Measures: Changes in synovial fluid viscosity and viscoelasticity compared to baseline;   Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) total score
17 Recruiting APSS-33-00: A Multicenter, Pilot Study of Autologous Protein Solution (APS) in Knee Osteoarthritis (OA)
Condition: Osteoarthritis, Knee
Interventions: Device: APS;   Device: Placebo
Outcome Measures: Visual Analogue Scale - Pain;   Knee injury and Osteoarthritis Outcome Score - Function;   Knee injury and Osteoarthritis Outcome Score - Stiffness;   Radiographic Imaging - Joint Structure;   Quality of Life Questionnaires (QoL);   Number of patients with adverse events (Safety)
18 Unknown  Study With Chondroitin Sulfate and Glucosamine Sulfate (in Dosage Capsule and Sachet) in Treating Osteoarthritis
Condition: Osteoarthritis
Intervention: Drug: Chondroitin sulfate + Glucosamine sulfate
Outcome Measures: Promotion of pain relief in patients with Osteoarthritis.;   Functional capacity, overall assessment of clinical improvement, assessment of adverse events
19 Not yet recruiting Phenotype/Genotype Correlation in a Family With Early Onset Osteoarthritis
Condition: Osteoarthritis
Interventions: Radiation: radiography (X-ray);   Genetic: DNA sampling
Outcome Measure: Identification of new gene mutations associated with early onset of Osteoarthritis using NGS (Next Generation Sequencing)
20 Recruiting Treatment of Knee Osteoarthritis With Allogenic Mesenchymal Stem Cells
Conditions: Osteoarthritis, Knee;   Knee Arthrosis;   Knee Osteoarthritis
Interventions: Other: Injection of Mesenchymal Stromal Cells;   Drug: Hyaluronic Acid
Outcome Measures: Number of participants with adverse events as a measure of safety and tolerability;   Pain and disability evolution (WOMAC and SF-36 scores);   Evolution of cartilage degeneration by T2 relaxation measurements in MRI (Cartigram)