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OSTEONECROSIS and Amitriptyline

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OSTEONECROSIS Symptoms and Causes

Osteonecrosis is a disease caused by reduced blood flow to bones in the joints. In people with healthy bones, new bone is always replacing old bone. In Osteonecrosis, the lack of blood causes the bone to break down faster than the body can make enough new bone. The bone starts to die and may break down.

You can have Osteonecrosis in one or several bones. It is most common in the upper leg. Other common sites are your upper arm and your knees, shoulders and ankles. The disease can affect men and women of any age, but it usually strikes in your thirties, forties or fifties.

At first, you might not have any symptoms. As the disease gets worse, you will probably have joint pain that becomes more severe. You may not be able to bend or move the affected joint very well.

No one is sure what causes the disease. Risk factors include

  • Long-term steroid treatment
  • Alcohol abuse
  • Joint injuries
  • Having certain diseases, including arthritis and cancer

Doctors use imaging tests and other tests to diagnose Osteonecrosis. Treatments include medicines, using crutches, limiting activities that put weight on the affected joints, electrical stimulation and surgery.

NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

Check out the latest treatments for OSTEONECROSIS

OSTEONECROSIS treatment research studies

Amitriptyline clinical trials, surveys and public health registries


Find Drug Side Effect reports



Amitriptyline Side Effects

Completed Suicide (96)
Toxicity To Various Agents (72)
Overdose (61)
Cardiac Arrest (56)
Somnolence (48)
Pain (47)
Convulsion (45)
Anxiety (42)
Death (42)
Headache (42)
Vomiting (40)
Intentional Overdose (39)
Confusional State (39)
Dyspnoea (38)
Dizziness (37)
Loss Of Consciousness (37)
Fatigue (35)
Nausea (34)
Coma (33)
Respiratory Arrest (33)
Depression (32)
Agitation (31)
Hypotension (31)
Hallucination (29)
Malaise (29)
Fall (28)
Cardio-respiratory Arrest (28)
Syncope (27)
Diarrhoea (26)
Insomnia (26)
Tremor (26)
Pyrexia (25)
Grand Mal Convulsion (25)
Asthenia (24)
Delirium (24)
Abdominal Pain (23)
Feeling Abnormal (23)
Suicide Attempt (23)
Dysarthria (22)
Constipation (21)
Deep Vein Thrombosis (21)
Depressed Level Of Consciousness (21)
Electrocardiogram Qt Prolonged (21)
Palpitations (21)
Serotonin Syndrome (21)
Weight Decreased (20)
Gait Disturbance (20)
Back Pain (19)
Dry Mouth (19)
Metabolic Acidosis (19)

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Recent Reviews

im on amitriptyline 25mg,i have my xmas party this weekend and wanted to drink alchol. i wonder is it a good idea

After having been on elavil for 9 years, mostly at 100mg/night, I spent the last 6 months weaning off. Shortly after stopping amitriptyline I now have high blood pressure. Before stopping, and for years before starting, my usual pressure was 115/65,

Be safe !!

Been on amitrip 25mg at night for 8 nights now and have felt and look alot better. although i have diarrihea now and felt abit of nausea here and there . feel a tad tired throughout the day but i think for me the postives outweigh

Can amitriptyline can cause thrombocytopenia ?

Doc gave me 25mg to help me sleep after quitting the weed. not as good as zoplicone though

Does Amtriptyline help tinnitus. I'm taking it at a low dose for jaw problems and fibromyalgia. the 25 mg dose seems to make my tinnitus worse but my pain better. I don't know what to do?

For the past 18 mnths myfifteen year old takes Pizotifen for migraine.Even on low dose it hasvirtually seen off the migraine episodes and apart from initial tiredness for the first few weeks on it, we are not aware of an

Hey i took 500mg of amitriptyline and overdosed and almost Died.. Dont take that much

I have been taken 2 25mg at night for 6 months my mouth is dry all the time i carry water with me everywhere , i have a bloted tummy all the time ! but i die as soon as my head touches the pillow !!i feel fat all the time !!

Began the 1st of 2 three month injections of lupron in preparation for a hysterectomy in sept. 2011. Received the second injection Dec. 9, 2011 and by Dec. 16 began my suffering of ONJ osteonecrosis. I had fibroids and an enlarged uterous. I wish I h

OSTEONECROSIS Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.