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OSTEONECROSIS and Amitriptyline

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OSTEONECROSIS Symptoms and Causes

Osteonecrosis is a disease caused by reduced blood flow to bones in the joints. In people with healthy bones, new bone is always replacing old bone. In Osteonecrosis, the lack of blood causes the bone to break down faster than the body can make enough new bone. The bone starts to die and may break down.

You can have Osteonecrosis in one or several bones. It is most common in the upper leg. Other common sites are your upper arm and your knees, shoulders and ankles. The disease can affect men and women of any age, but it usually strikes in your thirties, forties or fifties.

At first, you might not have any symptoms. As the disease gets worse, you will probably have joint pain that becomes more severe. You may not be able to bend or move the affected joint very well.

No one is sure what causes the disease. Risk factors include

  • Long-term steroid treatment
  • Alcohol abuse
  • Joint injuries
  • Having certain diseases, including arthritis and cancer

Doctors use imaging tests and other tests to diagnose Osteonecrosis. Treatments include medicines, using crutches, limiting activities that put weight on the affected joints, electrical stimulation and surgery.

NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

Check out the latest treatments for OSTEONECROSIS

OSTEONECROSIS treatment research studies

Amitriptyline clinical trials, surveys and public health registries


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Amitriptyline Side Effects

Completed Suicide (98)
Toxicity To Various Agents (72)
Overdose (61)
Cardiac Arrest (57)
Somnolence (48)
Pain (47)
Convulsion (45)
Anxiety (44)
Headache (44)
Death (42)
Confusional State (40)
Vomiting (40)
Dizziness (39)
Intentional Overdose (39)
Dyspnoea (38)
Loss Of Consciousness (38)
Nausea (35)
Fatigue (35)
Coma (33)
Respiratory Arrest (33)
Depression (32)
Hypotension (31)
Agitation (31)
Hallucination (29)
Malaise (29)
Fall (28)
Cardio-respiratory Arrest (28)
Syncope (27)
Diarrhoea (26)
Insomnia (26)
Tremor (26)
Pyrexia (25)
Grand Mal Convulsion (25)
Delirium (24)
Asthenia (24)
Abdominal Pain (23)
Feeling Abnormal (23)
Suicide Attempt (23)
Dysarthria (22)
Depressed Level Of Consciousness (21)
Constipation (21)
Deep Vein Thrombosis (21)
Electrocardiogram Qt Prolonged (21)
Serotonin Syndrome (21)
Palpitations (21)
Weight Decreased (20)
Gait Disturbance (20)
Dry Mouth (19)
Metabolic Acidosis (19)
Rash (19)

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Recent Reviews

im on amitriptyline 25mg,i have my xmas party this weekend and wanted to drink alchol. i wonder is it a good idea

After having been on elavil for 9 years, mostly at 100mg/night, I spent the last 6 months weaning off. Shortly after stopping amitriptyline I now have high blood pressure. Before stopping, and for years before starting, my usual pressure was 115/65,

Be safe !!

Been on amitrip 25mg at night for 8 nights now and have felt and look alot better. although i have diarrihea now and felt abit of nausea here and there . feel a tad tired throughout the day but i think for me the postives outweigh

Can amitriptyline can cause thrombocytopenia ?

Doc gave me 25mg to help me sleep after quitting the weed. not as good as zoplicone though

Does Amtriptyline help tinnitus. I'm taking it at a low dose for jaw problems and fibromyalgia. the 25 mg dose seems to make my tinnitus worse but my pain better. I don't know what to do?

For the past 18 mnths myfifteen year old takes Pizotifen for migraine.Even on low dose it hasvirtually seen off the migraine episodes and apart from initial tiredness for the first few weeks on it, we are not aware of an

Hey i took 500mg of amitriptyline and overdosed and almost Died.. Dont take that much

I have been taken 2 25mg at night for 6 months my mouth is dry all the time i carry water with me everywhere , i have a bloted tummy all the time ! but i die as soon as my head touches the pillow !!i feel fat all the time !!

Began the 1st of 2 three month injections of lupron in preparation for a hysterectomy in sept. 2011. Received the second injection Dec. 9, 2011 and by Dec. 16 began my suffering of ONJ osteonecrosis. I had fibroids and an enlarged uterous. I wish I h

OSTEONECROSIS Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Unknown  Osteonecrosis in Children With Acute Lymphoblastic Leukemia
Conditions: Osteonecrosis;   Acute Lymphoblastic Leukemia
Intervention:
Outcome Measures: Osteonecrosis 1 year post leukemia therapy;   Bone mass density and Osteonecrosis;   Is Bone loss/failure to accure bone mineral and ON;   Glucocorticoid dose and ON;   Methotrexate dose and ON;   Obesity and ON;   Weight bearing and non weight bearing activities and ON;   Hyperlipidemia and On;   Thrombophilia and ON
2 Recruiting Osteonecrosis of the Hip and Bisphosphonate Treatment
Condition: Osteonecrosis
Interventions: Drug: Zoledronic Acid;   Drug: Placebo
Outcome Measures: reducing pain and disability in the hip;   reducing progression to femoral head collapse and the need for surgical intervention
3 Recruiting Mesenchymal Stem Cells in Osteonecrosis of the Femoral Head
Condition: Avascular Necrosis of Femur Head
Interventions: Biological: XCEL-MT-OSTEO-ALPHA;   Procedure: Standard treatment
Outcome Measures: Safety of XCEL-MT-OSTEO-ALPHA in Osteonecrosis of the femoral head;   Feasibility of XCEL-MT-OSTEO-ALPHA in Osteonecrosis of the femoral head;   Bone regeneration by measuring the necrotic angle using the modified Kerboul method;   Dynamic changes of signal intensity;   Clinical outcomes (pain) by Visual Analogue Scale (VAS);   Clinical outcomes (SF-36);   Clinical outcome (WOMAC)
4 Recruiting Phase 3 Study on Autologous Osteoblastic Cells Implantation to Early Stage Osteonecrosis of the Femoral Head
Condition: Osteonecrosis of the Femoral Head
Interventions: Drug: Core decompression/PREOB® implantation;   Drug: Core decompression/placebo implantation
Outcome Measures: WOMAC VA3.1 pain subscale;   Radiological progression to fractural stages, as demonstrated by conventional X-ray with reference to the ARCO Staging;   Potential occurrence of any AE or SAE, related to the product or to the procedure, using patient open non-directive questionnaire, physical examination and laboratory measurements;   WOMAC VA3.1;   Time to arthroplasty
5 Recruiting Osteonecroses in Pediatric Patients With ALL
Conditions: Osteonecrosis;   Acute Lymphoblastic Leukaemia;   Lymphoblastic Lymphoma
Intervention:
Outcome Measures: occurence of early ON stages;   ON incidence
6 Unknown  MBCP Safety and Performance in the Osteonecrosis of Femur Head
Condition: Osteonecrosis
Intervention: Device: MBCP
Outcome Measures: Infection and inflammation of the drilled area (blood and clinical assessment).;   Adverse events.;   Pain (Analogic Visual Scale);   Hip function;   Bone reconstruction evaluation through scanner and radiography
7 Recruiting PHASE II CLINICAL TRIAL Prospective, Open, Nonrandomized Treatment of Osteonecrosis of the Femoral Head by the Administration of Autologous Mesenchymal Stem Cells
Condition: Osteonecrosis of the Femoral Head
Intervention: Procedure: bone marrow aspirate
Outcome Measure:
8 Recruiting Study Into the Effect of Ibandronate for the Treatment of Bone Marrow Edema in Relation to Spontaneous or Non-traumatic Osteonecrosis of the Knee: A Randomized Double-blind, Placebo-controlled Trial
Conditions: Osteonecrosis of the Knee;   Bone Marrow Edema of the Knee
Interventions: Drug: Ibandronate IV;   Drug: Placebo
Outcome Measures: clinical outcome (pain [VAS score]);   radiological outcome (MRI knee);   number of salvage therapies needed in case persistence is observed during placebo therapy
9 Recruiting Osteonecrosis of the Jaw (ONJ) Case Registry
Condition: Osteonecrosis of the Jaw (ONJ)
Intervention:
Outcome Measures: Resolution rate and time to ONJ resolution;   Explore the relationship between rate and time to ONJ resolution with ONJ severity and staging at Registry enrollment;   Explore the relationship between rate and time to ONJ resolution with potential risk factors;   Explore the relationship between rate and time to ONJ resolution and subsequent treatment patterns for ONJ;   Explore the relationship between rate and time to ONJ resolution and treatment patterns of antiresorptive therapy
10 Recruiting Randomized Clinical Trial for the Treatment of Osteonecrosis of the Femoral Head
Condition: Osteonecrosis
Intervention: Procedure: core decompression
Outcome Measures: Magnetic Resonance Imaging (MRI);   Visual Analog Scale (VAS);   Harris Hip Score (HHS);   Western Ontario and McMaster Universities Arthritis Index (WOMAC);   Radiography (RX)
11 Recruiting Hyper Baric Oxygen Therapy (HBOT) for Spontaneous Osteonecrosis of the Knee
Condition: Spontaneous Osteonecrosis of the Knee
Intervention: Biological: Weight reduction
Outcome Measures: Efficacy;   Safety;   Reduction In AVN size by MRI
12 Recruiting Treatment of Medial Compartmental Osteoarthritis Grade 1-4 (Kellgren-Lawrence) or Osteonecrosis With TomoFix™ Small or Conservatively
Conditions: Osteoarthritis, Knee;   Osteonecrosis
Intervention:
Outcome Measures: Knee Injury and Osteoarthritis Outcome Score (KOOS);   Patient-evaluated function of the knee and quality of life, a. assessed with the Oxford-12-item knee score b. assessed with the WOMAC (as calculated from the KOOS);   Clinician-evaluated function of the knee, assessed with the Japanese Orthopaedic Association (JOA) score;   Health-related quality of life assessed by the generic Short Form-36 (SF-36) instrument;   Range of motion (ROM);   Local and general pain, assessed with the Visual Analogue Scale (VAS);   Possibility and duration of the Japanese sitting style;   Surgery details, Postoperative treatment, Postoperative rehabilitation, Utilization;   Evaluation of degenerated and regenerated cartilage (arthroscopic findings assessed according to ICRS and Outerbridge / Koshino);   Radiological parameters (e.g. union, delayed union, Kellgren-Lawrence classification, joint space narrowing, tibial slope, tibia vara, patella height according to Blackburne-Peel, modified Insall-Salvati ratio, subluxation of patella);   Complications and mortality
13 Recruiting Bisphosphonate Biomarker Study
Conditions: Osteoporosis, With or Without Treatment;   Bisphosphonate Treatment;   Atypical Femur Fracture;   Bisphosphonate Related Osteonecrosis of the Jaws (BRONJ);   Healthy Volunteers
Intervention:
Outcome Measures: Absorption, Distribution, Metabolism, Excretion (ADME) Profiling of DNA from all sample types vs. normative data for the ADME panel and across study groups;   Differential expression of miRNA biomarkers across participant groups within the study
14 Not yet recruiting Study Comparing Ibandronate Versus Placebo in Hip Osteonecrosis
Conditions: Aseptic;;   Hip Necrosis
Interventions: Drug: ibandronate;   Drug: Placebo
Outcome Measures: VAS pain;   Imagery assessment;   The Western Ontario and McMaster Universities Arthritis Index (Womac scale);   Gait Analysis;   Hip Harris score;   Health-related quality of life EQ5D questionnaire
15 Recruiting Survey of XGEVA® Presrcibers in Europe to Evaluate Their Knowledge of the Summary of Product Characteristics Pertaining to Osteonecrosis of the Jaw
Conditions: Solid Tumours;   Bone Metastasis
Intervention: Other: Physician Survey
Outcome Measure: Proportion of participating oncology practitioners prescribing XGEVA® who are aware of the SPC statements pertaining to ONJ (each question pertaining to a SPC statement will be assessed seperately at the end of each survey round)
16 Not yet recruiting Genetics in Predicting Risk of Bisphosphonate-Related Osteonecrosis of the Jaw in Patients With Cancer Receiving Zoledronic Acid
Conditions: Malignant Neoplasm;   Musculoskeletal Complications
Interventions: Drug: zoledronic acid;   Other: pharmacological study
Outcome Measures: Plasma concentrations of Zol collected at visits 2, 3, 4, and 5;   Urine concentrations of Zol collected at visits 2, 3, 4, and 5;   Jawbone tissue concentrations of Zol collected during surgical treatment for BRONJ;   Identify potential risk factors for BRONJ
17 Recruiting Focused Registry on the Conservative Treatment of Osteoarthritis of the Knee
Conditions: Osteoarthritis, Knee;   Osteonecrosis
Intervention:
Outcome Measures: Function of the knee;   Patient-evaluated function of the knee and quality of life;   Clinician-evaluated function of the knee;   Health-related quality of life;   Range of motion (ROM);   Local and general pain;   Possibility and duration of the Japanese sitting style;   Return to sport activities;   Utilization;   Evaluation of degenerated and regenerated cartilage;   Radiological parameters;   Complications;   Anatomical alignment
18 Unknown  A Comparison of Two Different Surgical Techniques in Hip Resurfacing Arthroplasty
Conditions: Osteonecrosis;   Femoral Neck Fracture;   Implant Failure
Intervention: Procedure: Surgical approach (ReCap Hip Resurfacing System)
Outcome Measures: femoral head blood flow, evaluated by Laser Doppler Flowmetry;   femoral head metabolism, evaluated by microdialysis;   implant fixation, evaluated by RSA (radiostereogrammetric analysis);   periprosthetic bone mineral density, evaluated by DEXA;   gait function, evaluated by gait analysis;   patient recovery, evaluated by Harris Hip Score and Visual Analogue Scale
19 Recruiting Oxford Signature vs. Conventional Global Study
Conditions: Osteoarthritis;   Osteoarthritis, Knee;   Osteonecrosis
Interventions: Device: Signature Custom Guides;   Procedure: Conventional Instrumentation
Outcome Measures: Percentage of Knees Achieving Optimal Alignment;   Average Number of Instrument Cases Used;   Operative Time;   Patient Satisfaction;   Knee Function, Pain, and Range of Motion;   Radiographic Outcomes;   Tourniquet Time;   Implant Sizing;   Blood Loss;   Transfusion Rate;   Use of Cell-Saver;   Number of Drains Used
20 Recruiting ACI-C Versus AMIC. A Randomized Trial Comparing Two Methods for Repair of Cartilage Defects in the Knee
Conditions: Osteochondritis Dissecans;   Osteoarthritis;   Cartilage Injury;   Osteonecrosis
Intervention: Procedure: Treatment of cartilage defects in the knee
Outcome Measures: Perceived treatment efficacy as change from baseline in KOOS score;   Change from baseline in radiological signs of arthritis progression;   Perceived treatment efficacy as change from baseline in Lysholm score;   Time to failure