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OVERDOSE and Doxycycline

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OVERDOSE Symptoms and Causes

Opioids, sometimes called narcotics, are a type of drug. They include strong prescription pain relievers, such as oxycodone, hydrocodone, fentanyl, and tramadol. The illegal drug heroin is also an opioid. Some opioids are made from the opium plant, and others are synthetic (man-made).

A doctor may give you a prescription opioid to reduce pain after you have had a major injury or surgery. You may get them if you have severe pain from health conditions like cancer. Some doctors prescribe them for chronic pain.

Opioids can cause side effects such as drowsiness, mental fog, nausea, and constipation. They may also cause slowed breathing, which can lead to Overdose deaths. If someone has signs of an Overdose, call 9-1-1:

  • The person's face is extremely pale and/or feels clammy to the touch
  • Their body goes limp
  • Their fingernails or lips have a purple or blue color
  • They start vomiting or making gurgling noises
  • They cannot be awakened or are unable to speak
  • Their breathing or heartbeat slows or stops

Other risks of using prescription opioids include dependence and addiction. Dependence means feeling withdrawal symptoms when not taking the drug. Addiction is a chronic brain disease that causes a person to compulsively seek out drugs, even though they cause harm. The risks of dependence and addiction are higher if you abuse the medicines. Abuse can include taking too much medicine, taking someone else's medicine, taking it in a different way than you are supposed to, or taking the medicine to get high.

Opioid abuse, addiction, and Overdoses are serious public health problems in the United States. Another problem is that more women are abusing opioids during pregnancy. This can lead to babies being addicted and going through withdrawal, known as neonatal abstinence syndrome (NAS). Opioid abuse may sometimes also lead to heroin use, because some people switch from prescription opioids to heroin.

The main treatment for prescription opioid addiction is medication-assisted treatment (MAT). It includes medicines, counseling, and support from family and friends. MAT can help you stop using the drug, get through withdrawal, and cope with cravings. There is also a medicine called naloxone which can reverse the effects of an opioid Overdose and prevent death, if it is given in time.

To prevent problems with prescription opioids, be sure to follow your doctor's instructions when taking them. Do not share your medicines with anyone else. Contact your doctor if you have any concerns about taking the medicines.

NIH: National Institute on Drug Abuse

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OVERDOSE treatment research studies

Doxycycline clinical trials, surveys and public health registries


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Doxycycline Side Effects

Headache (176)
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Pain (125)
Vomiting (125)
Dyspnoea (124)
Dizziness (123)
Haemorrhage (116)
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Depression (41)
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Stevens-johnson Syndrome (35)
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Muscle Spasms (32)
Confusional State (32)
Vision Blurred (31)
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Hypotension (30)
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Blister (26)
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Pancreatitis Acute (25)
Renal Failure Acute (25)
Panic Attack (25)
Hypersensitivity (24)
Swollen Tongue (24)

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Recent Reviews

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OVERDOSE Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting Project OOPEN: Opioid Overdose Prevention, Education and Intervention
Condition: Opioid Overdose
Intervention: Drug: OOPEN+BBCC
Outcome Measures: Opioid Overdose;   Change in Overdose risk;   Health care utilization;   Health care costs;   Change in HIV risk behaviors
2 Not yet recruiting Developing a Prescription Opioid Overdose Prevention Intervention in Addictions Treatment
Conditions: Drug Overdose;   Opioid Related Disorders
Intervention: Behavioral: Therapist-led brief intervention (TBI)
Outcome Measures: Overdose risk behavior;   HIV risk behavor
3 Recruiting Monitoring of Overdose Patients With and Without Supplemental Oxygen in the Emergency Department
Condition: Overdose
Intervention:
Outcome Measures: Airway Interventions Performed by ED Staff;   Pulse oximetry;   End tidal CO2
4 Recruiting Increasing Patient Knowledge of the Signs of Opioid Overdose and Naloxone in a Suburban Treatment Program
Conditions: Opioid Dependence;   Opioid Use Disorder
Intervention: Other: Naloxone Education Intervention
Outcome Measures: Opiate Overdose Knowledge Scale (OOKS);   History Survey;   Guilt and Shame Proneness Scale (GASP)
5 Not yet recruiting Nasal Naloxone for Narcotic Overdose
Condition: Drug Overdose
Interventions: Drug: Intranasal (IN) naloxone;   Drug: Intravenous (IV) naloxone;   Drug: Intramuscular (IM) naloxone;   Drug: Intraosseus (IO) naloxone
Outcome Measures: Proportion of patients with adequate respiration within 10 minutes;   Number of patients requiring second dose of naloxone;   Time to first naloxone administration;   Opioid Withdrawal Symptoms;   Naloxone Adverse Events;   Proportion of Patients breathing unassisted upon arrival to the hospital;   Days of hospitalization following naloxone administration;   Mortality rate
6 Not yet recruiting Repeated-dose Brief Intervention to Reduce Overdose and Risk Behaviors Among Naloxone Recipients
Conditions: Opioid-Related Disorders;   Drug Overdose
Interventions: Behavioral: Brief counseling Intervention;   Other: Information and referrals
Outcome Measures: Feasibility of a randomized trial with REBOOT;   Acceptability of REBOOT;   Influence of egocentric social network characteristics on Overdose events and naloxone use
7 Not yet recruiting Evaluation of a Computerized Opioid Overdose Prevention Program
Conditions: Computer + Fluency;   Computer Only;   Treatment as Usual
Interventions: Behavioral: Computer + Fluency;   Behavioral: Computer Only;   Behavioral: Treatment as Usual
Outcome Measures: Knowledge gain;   Self-reported change in behaviors, participant acceptance
8 Not yet recruiting Clinician-patient Interaction During Addiction Consultation
Condition: Drug Dependency
Intervention: Other: methadone replacement therapy
Outcome Measures: Number of days patients injected non-prescribed drugs;   Patient Satisfaction
9 Unknown  Naloxone Nasal Spray Pharmacokinetic Study
Condition: Opioid Overdose
Interventions: Drug: MVP005;   Drug: Naloxone hydrochloride solution for injection with mucosal atomization device
Outcome Measures: Pharmacokinetics;   Number of subjects with adverse events;   Physical Examination;   Vital signs;   ECGs;   Safety Laboratory Tests
10 Recruiting EtCO2 Monitoring in Acute Self-poisoning
Condition: Acute Intentional Overdose
Intervention:
Outcome Measure: ROC curve of maximal EtCO2 to predict poisoning complication
11 Recruiting Safety Study of Ornithine Phenylacetate to Treat Patients With Acute Liver Failure Due to Acetaminophen
Conditions: Acute Liver Failure;   Acute Liver Injury
Intervention: Drug: Ornithine phenylacetate
Outcome Measures: Number of Participants with Adverse Events as a Measure of Safety and Tolerability;   Measurement of OCR-002 Plasma Concentration;   Change in Venous Ammonia;   Neurological Function measured by the Glasgow Coma Scale (GCS);   Neurological Function measured by the West Haven Criteria (WHC);   Neurological Function measured by the Orientation log (O-log)
12 Recruiting Naltrexone vs Buprenorphine-Naloxone for Opioid Dependence in Norway
Condition: Opioid Dependence
Interventions: Drug: Naltrexone intramuscular suspension;   Drug: Buprenorphine-naloxone
Outcome Measures: Number of biological samples negative/positive for opioid agonists;   Retention;   Mortality;   Use of other substances of abuse;   Mental health;   Somatic health;   Psychosocial problems
13 Recruiting CARE Corrections: Technology for Jail HIV/HCV Testing, Linkage, and Care (TLC)
Condition: Human Immunodeficiency Virus
Interventions: Device: Intervention Arm (computer-based CARE+ Corrections tool);   Other: Educational video on opiate Overdose prevention
Outcome Measures: Plasma Viral Load Suppression;   Linkage to community care
14 Not yet recruiting Optimizing Propofol Dosing for (Preterm) Newborn Infants That Need Endotracheal Intubation
Conditions: Anesthesia Intubation Complication;   Premature Birth of Newborn;   Other Preterm Infants;   Propofol Overdose
Intervention: Drug: Propofol
Outcome Measures: adequate propofol dose;   Determine a valid sedation assessment scale;   to determine an age specific propofol PK/PD model;   aEEG / NIRS
15 Recruiting Acute Acetaminophen Ingestion: Does Repeated Acetaminophen Blood Test Have an Interest?
Condition: Acetaminophen Overdose
Intervention:
Outcome Measure:
16 Recruiting A Trial of Genotype-based Warfarin Initiation in Patients With Mechanical Prosthetic Heart Valve
Conditions: Anticoagulation Treatment Overdose;   Heart Valve Diseases
Interventions: Other: Genotype-based Warfarin Initiation model;   Other: clinical factor-based warfarin initiation model
Outcome Measures: time to steady dosage;   Time in Therapeutic Range;   first time to treatment window;   the ratio of INR≥3.0 and INR≤1.5;   the monitoring frequency of INR;   the whole-cause mortality;   major bleeding event;   major thrombosis rate;   absolute difference between the stable dose and initial dose;   the frequency of dosage change
17 Recruiting Skeletal Muscle Paralysis in Hypothermic Patients After Cardiac Arrest
Conditions: Cardiac Arrest With Successful Resuscitation;   Hypothermia;   Skeletal Muscle Relaxant Overdose
Interventions: Drug: rocuronium;   Other: placebo
Outcome Measures: Number of shivering episodes;   Elapsed time to target temperature;   Dissipated energy to reach the target temperature;   Changes in basal metabolism due to shivering or elevated stress levels;   Depth of relaxation;   Changes in serum levels of midazolam, fentanyl and rocuronium;   Number of necessary boli of rocuronium
18 Recruiting To Establish a Novel Prototype of Clinical Pharmacy Services by Warfarin Consultation in a Pharmacist Clinic
Condition: Intentional Warfarin Sodium Overdose
Intervention: Other: patient education
Outcome Measures: percentage of INR in therapeutic range and incidence of complications;   patient's warfarin knowledge improvement;   Patient's satisfaction to anticoagulation pharmacist clinic
19 Recruiting Safety and Efficacy Study of CENV3 Vaccine to Protect Against HCV Infection
Condition: Vaccine Overdose of Undetermined Intent
Interventions: Biological: prophylactic peptide vaccine;   Biological: therapeutic peptide vaccine
Outcome Measure: Safety and Efficacy Study of CENV3 Vaccine to Protect Against HCV Infection
20 Unknown  Mechanisms of N-acetylcysteine Mediated Vascular Adverse Effects
Condition: Poisoning
Interventions: Drug: Chlorphenamine and Ranitidine;   Drug: Paracetamol
Outcome Measures: Attenuation of NAC induced vasodilatation by histamine antagonists (H1 and H2 antagonists) and/or paracetamol;   Inhibition of the inflammatory cascade contributes to a paracetamol mediated protective role against NAC adverse reactions.